Neuroscience Research最新文献_第5页

MicroRNA-33 regulates the synaptic plasticity-related gene ARC in temporal lobe epilepsy. MicroRNA-33调控颞叶癫痫的突触可塑性相关基因ARC

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-28 DOI: 10.1016/j.neures.2024.08.003

Yuchen Xu, Lily Zhang, Yan Yan, Wenbiao Xiao, Wei Zou, Zhaohui Luo, Bo Xiao, Hongyu Long

{"title":"MicroRNA-33 regulates the synaptic plasticity-related gene ARC in temporal lobe epilepsy.","authors":"Yuchen Xu, Lily Zhang, Yan Yan, Wenbiao Xiao, Wei Zou, Zhaohui Luo, Bo Xiao, Hongyu Long","doi":"10.1016/j.neures.2024.08.003","DOIUrl":"10.1016/j.neures.2024.08.003","url":null,"abstract":"<p><p>This study aimed to elucidate the expression patterns of miR-33 and ARC in both a rat model of temporal lobe epilepsy (TLE) and human TLE patients, to explore the role of miR-33 in epilepsy onset through its regulation of ARC expression in the hippocampus. Our findings, supported by a Dual-Luciferase reporter assay, suggest that miR-33 can bind to the 3' UTR region of ARC. We observed that miR-33 levels were reduced at 1 hour and 60 days post-seizure, while ARC expression notably increased at these time points. In the hippocampal CA1 and CA3 regions of post-seizure rats, ARC expression significantly exceeded that of control groups. Following the transfection of HEK cells with a miR-33 mimic, there was a decrease in both ARC mRNA and protein levels, whereas the group treated with a miR-33 inhibitor displayed the opposite effect. RNA sequencing in TLE patients revealed a similar miR-33 and ARC interaction. The regulation of Arc expression by miR-33 suggests that Arc may be a target gene of miR-33 in the context of epilepsy. Our findings indicate that miR-33 downregulation could contribute to the dysregulation of Arc expression observed in TLE, potentially influencing the disease process. Further studies are required to establish the exact role of miR-33-mediated Arc regulation in the development of epilepsy.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142109950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic activity changes in transcription factors: Unlocking the mechanisms regulating physiological changes in the brain. 转录因子的动态活性变化：揭开大脑生理变化的调节机制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-10 DOI: 10.1016/j.neures.2024.08.001

Kentaro Abe

引用次数: 0

Deciphering the spectrum of astrocyte diversity: Insights into molecular, morphological, and functional dimensions in health and neurodegenerative diseases. 解密星形胶质细胞多样性的光谱：洞察健康和神经退行性疾病中的分子、形态和功能层面。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-03 DOI: 10.1016/j.neures.2024.07.008

Fumito Endo

引用次数: 0

A data augmentation procedure to improve detection of spike ripples in brain voltage recordings. 改进脑电压记录中尖峰波纹检测的数据增强程序。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-03 DOI: 10.1016/j.neures.2024.07.005

Emily D Schlafly, Daniel Carbonero, Catherine J Chu, Mark A Kramer

{"title":"A data augmentation procedure to improve detection of spike ripples in brain voltage recordings.","authors":"Emily D Schlafly, Daniel Carbonero, Catherine J Chu, Mark A Kramer","doi":"10.1016/j.neures.2024.07.005","DOIUrl":"10.1016/j.neures.2024.07.005","url":null,"abstract":"<p><p>Epilepsy is a major neurological disorder characterized by recurrent, spontaneous seizures. For patients with drug-resistant epilepsy, treatments include neurostimulation or surgical removal of the epileptogenic zone (EZ), the brain region responsible for seizure generation. Precise targeting of the EZ requires reliable biomarkers. Spike ripples - high-frequency oscillations that co-occur with large amplitude epileptic discharges - have gained prominence as a candidate biomarker. However, spike ripple detection remains a challenge. The gold-standard approach requires an expert manually visualize and interpret brain voltage recordings, which limits reproducibility and high-throughput analysis. Addressing these limitations requires more objective, efficient, and automated methods for spike ripple detection, including approaches that utilize deep neural networks. Despite advancements, dataset heterogeneity and scarcity severely limit machine learning performance. Our study explores long-short term memory (LSTM) neural network architectures for spike ripple detection, leveraging data augmentation to improve classifier performance. We highlight the potential of combining training on augmented and in vivo data for enhanced spike ripple detection and ultimately improving diagnostic accuracy in epilepsy treatment.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inference of monosynaptic connections from parallel spike trains: A review. 从平行尖峰序列推断单突触连接：综述。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-02 DOI: 10.1016/j.neures.2024.07.006

Ryota Kobayashi, Shigeru Shinomoto

引用次数: 0

Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with sweetener consumption in mice 丘脑前室旁核的神经元活动与小鼠甜味剂摄入量呈正相关。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-01 DOI: 10.1016/j.neures.2024.02.002

{"title":"Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with sweetener consumption in mice","authors":"","doi":"10.1016/j.neures.2024.02.002","DOIUrl":"10.1016/j.neures.2024.02.002","url":null,"abstract":"<div><p>Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD), high sucrose diet (HSD), high stevioside diet (HSSD), high xylitol diet (HXD), high glycyrrhizin diet (HGD), and high mogroside diet (HMD). The mice exhibited a marked preference specifically for the HSD and HSSD. Following consumption of these diets, c-Fos expression levels in the aPVT were significantly higher in these two groups compared to the others. Utilizing fiber photometry calcium imaging, we observed rapid activation of aPVT neurons in response to sucrose and stevioside intake, but not to xylitol or water. Our findings suggest that aPVT activity aligns with sweet preference in mice, and notably, stevioside is the sole plant-based sweetener that elicits an aPVT response comparable to that of sucrose.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"205 ","pages":"Pages 16-26"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000269/pdfft?md5=61234f8f1288f304b09f74dfdc1ff41f&pid=1-s2.0-S0168010224000269-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation 短暂的睡眠呼吸暂停会导致β-淀粉样蛋白生成和tau过度磷酸化的长期增加。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-01 DOI: 10.1016/j.neures.2024.03.003

引用次数: 0

The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish 源自菱形丘 2 的血清素能神经元定位于斑马鱼的正中剑突区，并投射到背侧丘。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-01 DOI: 10.1016/j.neures.2024.03.001

{"title":"The serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project to the dorsal pallium in zebrafish","authors":"","doi":"10.1016/j.neures.2024.03.001","DOIUrl":"10.1016/j.neures.2024.03.001","url":null,"abstract":"<div><p>The serotonergic neurons in the raphe nucleus are implicated in various cognitive functions such as learning and emotion. In vertebrates, the raphe nucleus is divided into the dorsal raphe and the median raphe. In contrast to the abundance of knowledge on the functions of the dorsal raphe, the roles of the serotonergic neurons in the median raphe are relatively unknown. The studies using zebrafish revealed that the median raphe serotonergic neurons receive input from the two distinct pathways from the habenula and the IPN. The use of zebrafish may reveal the function of the Hb-IPN-median raphe pathway. To clarify the functions of the median raphe serotonergic neurons, it is necessary to distinguish them from those in the dorsal raphe. Most median raphe serotonergic neurons originate from rhombomere 2 in mice, and we generated the transgenic zebrafish which can label the serotonergic neurons derived from rhombomere 2. In this study, we found the serotonergic neurons derived from rhombomere 2 are localized in the median raphe and project axons to the rostral dorsal pallium in zebrafish. This study suggests that this transgenic system has the potential to specifically reveal the function and information processing of the Hb-IPN-raphe-telencephalon circuit in learning.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"205 ","pages":"Pages 27-33"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000397/pdfft?md5=2a8f8ef156a124a750176322e8ee3ce3&pid=1-s2.0-S0168010224000397-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140049984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fatty acid amides present in Camembert cheese improved cognitive decline after oral administration in mice 金文奶酪中的脂肪酸酰胺改善了小鼠口服后认知能力的下降。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-01 DOI: 10.1016/j.neures.2024.03.002

引用次数: 0

Anxiety control by astrocytes in the lateral habenula 侧叶星形胶质细胞对焦虑的控制

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-08-01 DOI: 10.1016/j.neures.2024.01.006

{"title":"Anxiety control by astrocytes in the lateral habenula","authors":"","doi":"10.1016/j.neures.2024.01.006","DOIUrl":"10.1016/j.neures.2024.01.006","url":null,"abstract":"<div><p>The potential role of astrocytes in lateral habenula (LHb) in modulating anxiety was explored in this study. The habenula are a pair of small nuclei located above the thalamus, known for their involvement in punishment avoidance and anxiety. Herein, we observed an increase in theta-band oscillations of local field potentials (LFPs) in the LHb when mice were exposed to anxiety-inducing environments. Electrical stimulation of LHb at theta-band frequency promoted anxiety-like behavior. Calcium (Ca<sup>2+</sup>) levels and pH in the cytosol of astrocytes and local brain blood volume changes were studied in mice expressing either a Ca<sup>2+</sup> or a pH sensor protein specifically in astrocytes and mScarlet fluorescent protein in the blood plasma using fiber photometry. An acidification response to anxiety was observed. Photoactivation of archaerhopsin-T (ArchT), an optogenetic tool that acts as an outward proton pump, results in intracellular alkalinization. Photostimulation of LHb in astrocyte-specific ArchT-expressing mice resulted in dissipation of theta-band LFP oscillation in an anxiogenic environment and suppression of anxiety-like behavior. These findings provide evidence that LHb astrocytes modulate anxiety and may offer a new target for treatment of anxiety disorders.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"205 ","pages":"Pages 1-15"},"PeriodicalIF":2.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000105/pdfft?md5=f0e2392d15e283e1c6433b7b01e7ad3e&pid=1-s2.0-S0168010224000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0