Neuroscience Research最新文献_第4页

The blues and rhythm 蓝调和节奏。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-02-01 DOI: 10.1016/j.neures.2023.11.004

Kiyomichi Imamura , Ayaka Bota , Toshihiko Shirafuji , Toru Takumi

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Editorial: Neuroscience of resilience for mental health 社论：心理健康复原力的神经科学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-02-01 DOI: 10.1016/j.neures.2024.11.006

Tomoyuki Furuyashiki, Scott J. Russo

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Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions 前额叶对心理复原力的贡献：啮齿动物压力和抗抑郁作用研究的启示。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-02-01 DOI: 10.1016/j.neures.2022.12.015

Ryota Shinohara, Tomoyuki Furuyashiki

{"title":"Prefrontal contributions to mental resilience: Lessons from rodent studies of stress and antidepressant actions","authors":"Ryota Shinohara, Tomoyuki Furuyashiki","doi":"10.1016/j.neures.2022.12.015","DOIUrl":"10.1016/j.neures.2022.12.015","url":null,"abstract":"<div><div>Individual variability of stress susceptibility led to the concept of stress resilience to adapt well upon stressors. However, the neural mechanisms of stress resilience and its relevance to antidepressant actions remain elusive. In rodents, chronic stress induces dendritic atrophy and decreases dendritic spine density in the medial prefrontal cortex (mPFC), recapitulating prefrontal alterations in depressive patients, and the mPFC promotes stress resilience. Whereas dopamine neurons projecting to the nucleus accumbens potentiated by chronic stress promote stress susceptibility, dopamine neurons projecting to the mPFC activated upon acute stress contribute to dendritic growth of mPFC neurons via dopamine D1 receptors, leading to stress resilience. Rodent studies have also identified the roles of prefrontal D1 receptors as well as D1 receptor-expressing mPFC neurons projecting to multiple subcortical areas and dendritic spine formation in the mPFC for the sustained antidepressant-like effects of low-dose ketamine. Thus, understanding the cellular and neural-circuit mechanism of prefrontal D1 receptor actions paves the way for bridging the gap between stress resilience and the sustained antidepressant-like effects. The mechanistic understanding of stress resilience might be exploitable for developing antidepressants based on a naturally occurring mechanism, thus safer than low-dose ketamine.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"211 ","pages":"Pages 16-23"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10844241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The role of social isolation stress in escalated aggression in rodent models 在啮齿动物模型中，社会隔离压力在攻击行为升级中的作用。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-02-01 DOI: 10.1016/j.neures.2022.07.009

Aki Takahashi

{"title":"The role of social isolation stress in escalated aggression in rodent models","authors":"Aki Takahashi","doi":"10.1016/j.neures.2022.07.009","DOIUrl":"10.1016/j.neures.2022.07.009","url":null,"abstract":"<div><div>Anti-social behavior and violence are major public health concerns. Globally, violence contributes to more than 1.6 million deaths each year. Previous studies have reported that social rejection or neglect exacerbates aggression. In rodent models, social isolation stress is used to demonstrate the adverse effects of social deprivation on physiological, endocrinological, immunological, and behavioral parameters, including aggressive behavior. This review summarizes recent rodent studies on the effect of social isolation stress during different developmental periods on aggressive behavior and the underlying neural mechanisms. Social isolation during adulthood affects the levels of neurosteroids and neuropeptides and increases aggressive behavior. These changes are ethologically relevant for the adaptation to changes in local environmental conditions in the natural habitats. Chronic deprivation of social interaction after weaning, especially during the juvenile to adolescent periods, leads to the disruption of the development of appropriate social behavior and the maladaptive escalation of aggressive behavior. The understanding of neurobiological mechanisms underlying social isolation-induced escalated aggression will aid in the development of therapeutic interventions for escalated aggression.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"211 ","pages":"Pages 75-84"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40675769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positive allosteric modulator of GLT-1 reduces methamphetamine hyperlocomotion, sensitization and conditioned place preference in mice.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-01-31 DOI: 10.1016/j.neures.2025.01.008

Prateek Mokkarala, Sonita Wiah, Ellen M Unterwald, Xiangdang Shi, Danielle R Stern, Andreia C K Fontana, Joseph M Salvino, Scott M Rawls

引用次数: 0

In vivo recording from calcitonin receptor-expressing neurons in the medial preoptic area during affiliative social behaviors.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-01-31 DOI: 10.1016/j.neures.2025.01.007

Kansai Fukumitsu, Chihiro Yoshihara, Arthur J Huang, Thomas J McHugh, Kumi O Kuroda

{"title":"In vivo recording from calcitonin receptor-expressing neurons in the medial preoptic area during affiliative social behaviors.","authors":"Kansai Fukumitsu, Chihiro Yoshihara, Arthur J Huang, Thomas J McHugh, Kumi O Kuroda","doi":"10.1016/j.neures.2025.01.007","DOIUrl":"10.1016/j.neures.2025.01.007","url":null,"abstract":"<p><p>Social animals, including mice, are motivated to seek social contact and avoid being alone due to the benefit of the group living in survival and reproductive values. We have previously reported that pup exposure and co-housing with adult female mice can induce the expression of c-Fos in calcitonin receptor (Calcr) neurons located in the medial preoptic area (MPOA) of female mice. These neurons mediate maternal and social contact behaviors among adult virgin females. However, the correlation of the activity of MPOA<sup>Calcr+</sup> neurons with specific social behaviors remains unclear. In this study, we used in vivo fiber photometry to study MPOA<sup>Calcr+</sup> neuron activity during affiliative social behaviors. We found that MPOA<sup>Calcr+</sup> neurons are activated during proactive contact with adult female mice but not during passive contact, suggesting that motivation to seek social contacts is associated with the activation of these neurons. MPOA<sup>Calcr+</sup> neurons are not activated during contact with non-social objects, such as novel foods and nesting materials, supporting their specific involvement in social behavior. Furthermore, these neurons are more robustly activated during alloparental behaviors such as pup retrieval. Overall, this study demonstrates the involvement of MPOA<sup>Calcr+</sup> neurons in motivated social interactions with pups and peer females.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-01-29 DOI: 10.1016/j.neures.2025.01.006

Yuting Bian, Yusuke Fukui, Ricardo Satoshi Ota-Elliott, Xinran Hu, Hongming Sun, Zhihong Bian, Yun Zhai, Haibo Yu, Xiao Hu, Hangping An, Hongzhi Liu, Ryuta Morihara, Hiroyuki Ishiura, Toru Yamashita

{"title":"The potential mechanism maintaining transactive response DNA binding protein 43 kDa in the mouse stroke model.","authors":"Yuting Bian, Yusuke Fukui, Ricardo Satoshi Ota-Elliott, Xinran Hu, Hongming Sun, Zhihong Bian, Yun Zhai, Haibo Yu, Xiao Hu, Hangping An, Hongzhi Liu, Ryuta Morihara, Hiroyuki Ishiura, Toru Yamashita","doi":"10.1016/j.neures.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.neures.2025.01.006","url":null,"abstract":"<p><p>The disruption of transactive response DNA binding protein 43 kDa (TDP-43) shuttling leads to the depletion of nuclear localization and the cytoplasmic accumulation of TDP-43. We aimed to evaluate the mechanism underlying the behavior of TDP-43 in ischemic stroke. Adult male C57BL/6 J mice were subjected to 30 or 60 min of transient middle cerebral artery occlusion (tMCAO), and examined at 1, 6, and 24 h post reperfusion. Immunostaining was used to evaluate the expression of TDP-43, G3BP1, HDAC6, and RAD23B. The total and cytoplasmic number of TDP-43-positive cells increased compared with sham operation group and peaked at 6 h post reperfusion after tMCAO. The elevated expression of G3BP1 protein peaked at 6 h after reperfusion and decreased at 24 h after reperfusion in ischemic mice brains. We also observed an increase of expression level of HDAC6 and the number of RAD23B-positive cells increased after tMCAO. RAD23B was colocalized with TDP-43 24 h after tMCAO. We proposed that the formation of stress granules might be involved in the mislocalization of TDP-43, based on an evaluation of G3BP1 and HDAC6. Subsequently, RAD23B, may also contribute to the downstream degradation of mislocalized TDP-43 in mice tMCAO model.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premovement neuronal activity in the primary motor cortex is associated with the initiation of ipsilateral hand movements in monkeys.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-01-21 DOI: 10.1016/j.neures.2025.01.005

Yoshihisa Nakayama, Osamu Yokoyama, Eiji Hoshi, Yukio Nishimura

{"title":"Premovement neuronal activity in the primary motor cortex is associated with the initiation of ipsilateral hand movements in monkeys.","authors":"Yoshihisa Nakayama, Osamu Yokoyama, Eiji Hoshi, Yukio Nishimura","doi":"10.1016/j.neures.2025.01.005","DOIUrl":"10.1016/j.neures.2025.01.005","url":null,"abstract":"<p><p>The primary motor cortex (M1) is believed to be a cortical center for the execution of limb movements. Although M1 neurons mainly project to the spinal cord on the contralateral side, some M1 neurons project to the ipsilateral side via the uncrossed corticospinal pathway. Moreover, some M1 neurons are activated during ipsilateral forelimb movements. However, the extent to which M1 neurons are involved in ipsilateral movement execution has not been determined. Therefore, we investigated the involvement of M1 neurons in the initiation of ipsilateral and contralateral hand movements by examining trial-by-trial correlations between premovement neuronal spikes and hand movement reaction times in monkeys. Overall, the activity of M1 neurons was more strongly correlated with the reaction times for contralateral hand movements than those for ipsilateral hand movements. However, the activity of some M1 neurons was correlated with reaction times for ipsilateral hand movements, and these correlations were as strong as those between the activity of other M1 neurons and reaction times for contralateral hand movements. This finding suggests that one subset of M1 neurons sends motor commands for ipsilateral hand movements to the same extent as another subset of M1 neurons sends motor commands for contralateral hand movements.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of neuronal activity facilitates surface accumulation of p75NTR and cell death in avian cochlear nucleus.

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-01-21 DOI: 10.1016/j.neures.2025.01.004

Ryosuke Sato, Ryota Adachi, Norihiko Yokoi, Keita Tsujimura, Ryo Egawa, Yuichiro Hara, Yuko Fukata, Masaki Fukata, Tomoo Ogi, Michihiko Sone, Hiroshi Kuba

{"title":"Loss of neuronal activity facilitates surface accumulation of p75NTR and cell death in avian cochlear nucleus.","authors":"Ryosuke Sato, Ryota Adachi, Norihiko Yokoi, Keita Tsujimura, Ryo Egawa, Yuichiro Hara, Yuko Fukata, Masaki Fukata, Tomoo Ogi, Michihiko Sone, Hiroshi Kuba","doi":"10.1016/j.neures.2025.01.004","DOIUrl":"10.1016/j.neures.2025.01.004","url":null,"abstract":"<p><p>Sensorineural hearing loss causes cell death in central auditory neurons, but molecular mechanisms of triggering this process are not fully understood. We report here that loss of afferent activity promotes cell death by facilitating proBDNF-p75NTR signals in cochlear nucleus of chicks around hatch. RNA-seq analyses revealed up-regulation of genes related to proBDNF-p75NTR-JNK signals as well as apoptosis at the nucleus within 24 h after unilateral cochlea deprivation. Western blotting confirmed a high level of proBDNF protein at the nucleus. Moreover, FLAG-tagged p75NTR accumulated at the plasma membrane of the neurons within 6 h after the deprivation, well before the upregulation of apoptotic genes. Cell viability assay using propidium iodide in organ culture showed that proBDNF increased the fraction of dying neurons in a dose-dependent manner. In addition, pharmacological blockades of synaptic and spike activities in the culture reproduced the surface accumulation of p75NTR in vivo and increased the fraction of dying neurons, while genetic inhibition of p75NTR signals occluded the cell death during the activity blockades. These results indicate that afferent activity is crucial for suppressing surface accumulation of p75NTR and hence proBDNF-p75NTR signals and that the loss of this suppression would contribute to triggering cell death after deafferentation in the developing brainstem auditory circuit.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroanatomical distribution of endogenous huntingtin and its immunohistochemical relationships with STB/HAP1 in the adult mouse brain and spinal cord. 内源性亨廷顿蛋白在成年小鼠脑和脊髓中的神经解剖分布及其与STB/HAP1的免疫组化关系

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-01-18 DOI: 10.1016/j.neures.2025.01.003

Md Nabiul Islam, Mizuki Maruyama, Mir Rubayet Jahan, Marya Afrin, Mirza Mienur Meher, Kanako Nozaki, Koh-Hei Masumoto, Akie Yanai, Koh Shinoda

{"title":"Neuroanatomical distribution of endogenous huntingtin and its immunohistochemical relationships with STB/HAP1 in the adult mouse brain and spinal cord.","authors":"Md Nabiul Islam, Mizuki Maruyama, Mir Rubayet Jahan, Marya Afrin, Mirza Mienur Meher, Kanako Nozaki, Koh-Hei Masumoto, Akie Yanai, Koh Shinoda","doi":"10.1016/j.neures.2025.01.003","DOIUrl":"10.1016/j.neures.2025.01.003","url":null,"abstract":"<p><p>Huntingtin-associated protein 1 (HAP1) is an essential constituent of the stigmoid body (STB) and is known as a neuroprotective interactor with causal agents for several neurodegenerative disorders, including huntingtin (HTT) in Huntington's disease. Previous in vitro studies showed that compared to normal HTT, STB/HAP1 exhibited a higher binding affinity for mutant HTT. The detailed in vivo relationships of STB/HAP1 with endogenous HTT, however, have not been clarified yet. This study examined the distribution of endogenous HTT and its relationships with STB/HAP1 in the adult mouse brain and spinal cord using light/fluorescence microscopy. Our results show that HTT immunoreactivity is highly distributed in the striatum, medial septal nucleus (MS), nucleus of the horizontal limb/ vertical limb of the diagonal band of Broca (HDB, VDB), substantia innominata basal part (SIB), pedunculopontine tegmental nucleus (PPTg), laterodorsal tegmental nucleus (LDTg), autonomic preganglionic neurons, and brainstem/spinal motoneurons. More than 90 % of HTT-immunoreactive (ir) neurons contain STB/HAP1 immunoreactivity in MS, VBD/HDB, SIB, PPTg, LDTg, and autonomic preganglionic nuclei. HTT-ir neurons in the striatal and motor nuclei, however, do not exhibit HAP1 immunoreactivity. These suggest that due to the absence of STB/HAP1-protectivity, HTT-ir striatal/motor neurons are more vulnerable to neurodegeneration than other HAP1-expressing HTT neurons. Our current findings might provide a framework for elucidating the pathophysiological functions of endogenous HTT and HAP1 in the central nervous system.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0