Neuroscience Research最新文献_第4页

SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons. SARM1对海马神经元中NMDA受体依赖性AMPA受体的内吞作用至关重要。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-28 DOI: 10.1016/j.neures.2024.09.005

Misaki Morishita, Shinji Matsuda

{"title":"SARM1 is essential for NMDA receptor-dependent endocytosis of AMPA receptors in hippocampal neurons.","authors":"Misaki Morishita, Shinji Matsuda","doi":"10.1016/j.neures.2024.09.005","DOIUrl":"10.1016/j.neures.2024.09.005","url":null,"abstract":"<p><p>Long-term depression (LTD) is a form of synaptic plasticity thought to be the cellular basis of experience-dependent learning and memory. LTD is caused by an activity-dependent decrease in cell surface α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPA receptors) at the postsynaptic sites. However, the mechanism through which AMPA receptors are removed from the cell surface via neuronal activity is not fully understood. In this study, we showed that small interfering RNA (siRNA)-mediated knockdown of sterile alpha and toll/interleukin receptor motif containing 1 (SARM1) in cultured hippocampal neurons prevented the N-methyl-d-aspartate (NMDA)-induced reduction in cell surface AMPA receptors. However, the control RNA did not affect NMDA-mediated AMPA receptor trafficking. Overexpression of the siRNA-resistant form of SARM1 in SARM1-knocked-down neurons restored AMPA receptor trafficking. However, overexpression of SARM1, which lacks the mitochondrial transport signal, in the SARM1-knocked-down neurons did not restore NMDA-dependent AMPA receptor endocytosis. Moreover, the inhibition of the NADase activity of SARM1 blocked the NMDA-induced reduction of cell surface AMPA receptors. These results suggest that both the mitochondrial localization and NADase activity of SARM1 are essential for NMDA receptor-dependent AMPA receptor internalization in the hippocampal neurons.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive circuits for action and value information in rodent operant learning. 啮齿动物操作学习中的行动和价值信息适应回路

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-26 DOI: 10.1016/j.neures.2024.09.003

Alain Rios, Kyohei Fujita, Yoshikazu Isomura, Nobuya Sato

引用次数: 0

Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice. 氟西汀（而非帕罗西汀）会改变小鼠非快速眼动睡眠时下颌闭合肌肉的活动。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-24 DOI: 10.1016/j.neures.2024.09.004

Minako Ikeda, Ayako Mochizuki, Takafumi Kato, Shiro Nakamura, Kiyomi Nakayama, Masanori Dantsuji, Kazuyoshi Baba, Tomio Inoue

{"title":"Fluoxetine, but not paroxetine, alters the jaw-closing muscle activity during non-rapid eye movement sleep in mice.","authors":"Minako Ikeda, Ayako Mochizuki, Takafumi Kato, Shiro Nakamura, Kiyomi Nakayama, Masanori Dantsuji, Kazuyoshi Baba, Tomio Inoue","doi":"10.1016/j.neures.2024.09.004","DOIUrl":"10.1016/j.neures.2024.09.004","url":null,"abstract":"<p><p>Sleep bruxism is an involuntary, exaggerated jaw-closing activity during sleep. Selective serotonin reuptake inhibitor (SSRI) use is a risk factor for bruxism. However, the effect of various SSRIs on masseter (jaw-closing) muscle activity remains unclear. Here, we examined the effects of long-term administration of two SSRIs, fluoxetine (FLX) and paroxetine (PRX), for 14 days on masseter muscle activity during wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep for 24 h in mice. Vigilance states were scored based on electroencephalographic, electrooculography and neck electromyographic (EMG) activities. The EMG activity of the masseter muscle was quantified in 6 h periods. FLX and PRX did not affect the duration of the three vigilance states. Both drugs significantly prolonged the REM sleep episode duration while decreasing the number of episodes. FLX significantly increased REM sleep onset latency. Neither FLX nor PRX affected the mean masseter EMG activity during wakefulness. FLX significantly increased the relative time of masseter muscle activity in NREM sleep during 02:00-08:00 and 08:00-14:00, while PRX did not affect three vigilance states. Overall, FLX had a limited but significant effect on masseter muscle activity in NREM sleep during specific periods.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional segregation and dynamic integration of the corticotectal descending signal in rat. 大鼠皮质下行信号的功能分隔和动态整合

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-20 DOI: 10.1016/j.neures.2024.09.002

Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira

{"title":"Functional segregation and dynamic integration of the corticotectal descending signal in rat.","authors":"Hikaru Sugino, Sho Tanno, Tatsumi Yoshida, Yoshikazu Isomura, Riichiro Hira","doi":"10.1016/j.neures.2024.09.002","DOIUrl":"10.1016/j.neures.2024.09.002","url":null,"abstract":"<p><p>The superior colliculus (SC) receives inputs from various brain regions in a layer- and radial subregion-specific manner, but whether the SC exhibits subregion-specific dynamics remains unclear. To address this issue, we recorded the spiking activity of single SC neurons while photoactivating cortical areas in awake head-fixed Thy1-ChR2 rats. We classified 309 neurons that responded significantly into 8 clusters according to the response dynamics. Among them, neurons with monophasic excitatory responses (7-12 ms latency) that returned to baseline within 20 ms were commonly observed in the optic and intermediate gray layers of centromedial and centrolateral SC. In contrast, neurons with complex polyphasic responses were commonly observed in the deep layers of the anterolateral SC. Cross-correlation analysis suggested that the complex pattern could be only partly explained by an internal circuit of the deep gray layer. Our results indicate that medial to centrolateral SC neurons simply relay cortical activity, whereas neurons in the deep layers of the anterolateral SC dynamically integrate inputs from the cortex, SNr, CN, and local circuits. These findings suggest a spatial gradient in SC integration, with a division of labor between simple relay circuits and those integrating complex dynamics.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of empathic abilities by the interplay between estrogen receptors and arginine vasopressin. 雌激素受体与精氨酸加压素相互作用对移情能力的调节

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-06 DOI: 10.1016/j.neures.2024.09.001

Rui Du, Ting Liang, Guofang Lu

{"title":"Modulation of empathic abilities by the interplay between estrogen receptors and arginine vasopressin.","authors":"Rui Du, Ting Liang, Guofang Lu","doi":"10.1016/j.neures.2024.09.001","DOIUrl":"10.1016/j.neures.2024.09.001","url":null,"abstract":"<p><p>This review examines the complex interactions between estrogen receptors α and β (ERα and ERβ) and arginine vasopressin (AVP), delving into their significant roles in modulating empathy, a critical psychological component in human social dynamics. Empathy, integrating affective and cognitive elements, is anchored in neural regions like the amygdala and prefrontal cortex. ERα and ERβ, pivotal in estrogen regulation, influence neurotransmitter dynamics and neural network activities, crucial for empathic development. AVP, key in regulating water balance, blood pressure, and social behaviors, interplays with these receptors, profoundly impacting empathic responses. The study highlights that ERα predominantly enhances empathy, especially affective empathy, by stimulating AVP synthesis and release. In contrast, ERβ may diminish empathy in certain contexts by suppressing AVP expression and activity. The intricate interplay, homeostatic balance, and mutual conversion between ERα and ERβ in AVP regulation are identified as challenging yet crucial areas for future research. These findings provide essential insights into the neurobiological underpinnings of empathy, offering new avenues for therapeutic interventions in social cognitive disorders and emotional dysregulation.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automatic detection of foot-strike onsets in a rhythmic forelimb movement 自动检测有节奏的前肢运动中的击脚起始点

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.002

引用次数: 0

Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model 在大鼠模型中，体温升高可能会增加皮层扩散抑制的易感性

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.004

{"title":"Elevation in body temperature may increase susceptibility to cortical spreading depression in a rat model","authors":"","doi":"10.1016/j.neures.2024.04.004","DOIUrl":"10.1016/j.neures.2024.04.004","url":null,"abstract":"<div><p>One characteristic of migraine is recurrent headache attacks, which are known to be induced by changes in climatic variables such as atmospheric pressure, humidity, and outside temperature. However, the relationship between temperature changes and migraine remains unclear. Therefore, we investigated the relationship between body temperature changes and cortical spreading depression (CSD) using KCl-induced rat models of CSD. We initially induced CSD under controlled conditions at a room temperature of 28°C on an operating table maintained at 37°C. Subsequently, we controlled the operating table temperature to induce a second round of CSD under conditions of either a 10 ± 1% increase or decrease in body temperature. We ensured 1 h rest period between the first and second inductions of CSD. The results indicated that the number of CSDs significantly increased after body temperature elevation (before, 8.8 ± 1.2 times vs. after, 13.4 ± 1.3 times; p = 0.0003). The mean percentage change in cerebral blood flow decreased after body temperature increased (before, 33.1 ± 2.4% vs. after, 18.2 ± 1.4%; p = 0.006). There were no significant changes in CSD after body temperature decreased. The susceptibility of the cortex to CSD may increase under conditions of elevated body temperature.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 30-34"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000555/pdfft?md5=fb4552627cc27f3e7fc8c8301ab611b7&pid=1-s2.0-S0168010224000555-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140801170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the human conflict processing network: A review of the literature on direct neural recordings during performance of a modified stroop task 了解人类冲突处理网络：在执行修改后的 stroop 任务时进行直接神经记录的文献综述

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.03.006

{"title":"Understanding the human conflict processing network: A review of the literature on direct neural recordings during performance of a modified stroop task","authors":"","doi":"10.1016/j.neures.2024.03.006","DOIUrl":"10.1016/j.neures.2024.03.006","url":null,"abstract":"<div><p>The Stroop Task is a well-known neuropsychological task developed to investigate conflict processing in the human brain. Our group has utilized direct intracranial neural recordings in various brain regions during performance of a modified color-word Stroop Task to gain a mechanistic understanding of non-emotional human conflict processing. The purpose of this review article is to: 1) synthesize our own studies into a model of human conflict processing, 2) review the current literature on the Stroop Task and other conflict tasks to put our research in context, and 3) describe how these studies define a network in conflict processing. The figures presented are reprinted from our prior publications and key publications referenced in the manuscript. We summarize all studies to date that employ invasive intracranial recordings in humans during performance of conflict-inducing tasks. For our own studies, we analyzed local field potentials (LFPs) from patients with implanted stereotactic electroencephalography (SEEG) electrodes, and we observed intracortical oscillation patterns as well as intercortical temporal relationships in the hippocampus, amygdala, and orbitofrontal cortex (OFC) during the cue-processing phase of a modified Stroop Task. Our findings suggest that non-emotional human conflict processing involves modulation across multiple frequency bands within and between brain structures.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 1-19"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000518/pdfft?md5=456561bd46c338ddde0006f6ca04bfab&pid=1-s2.0-S0168010224000518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140581118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recovery of node of ranvier structure in optic nerve under visual deprivation 视觉剥夺下视神经 Ranvier 节结构的恢复

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.03.005

引用次数: 0

Structural MRI analysis of age-related changes and sex differences in marmoset brain volume 对狨猴脑容量与年龄有关的变化和性别差异的结构性核磁共振成像分析

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-09-01 DOI: 10.1016/j.neures.2024.04.003

{"title":"Structural MRI analysis of age-related changes and sex differences in marmoset brain volume","authors":"","doi":"10.1016/j.neures.2024.04.003","DOIUrl":"10.1016/j.neures.2024.04.003","url":null,"abstract":"<div><p>The field of aging biology, which aims to extend healthy lifespans and prevent age-related diseases, has turned its focus to the Callithrix jacchus (common marmoset) to understand the aging process better. This study utilized magnetic resonance imaging (MRI) to non-invasively analyze the brains of 216 marmosets, investigating age-related changes in brain structure; the relationship between body weight and brain volume; and potential differences between males and females. The key findings revealed that, similar to humans, Callithrix jacchus experiences a reduction in total intracranial volume, cortex, subcortex, thalamus, and cingulate volumes as they age, highlighting site-dependent changes in brain tissue. Notably, the study also uncovered sex differences in cerebellar volume. These insights into the structural connectivity and volumetric changes in the marmoset brain throughout aging contribute to accumulating valuable knowledge in the field, promising to inform future aging research and interventions for enhancing healthspan.</p></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"206 ","pages":"Pages 20-29"},"PeriodicalIF":2.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0168010224000531/pdfft?md5=c778303959df20403d55a45a215246a9&pid=1-s2.0-S0168010224000531-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140763283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0