Neuroscience Research最新文献_第3页

High-resolution optogenetics generates distinguishable neocortical activity patterns in awake mice 高分辨率光遗传学在清醒小鼠中产生可区分的新皮层活动模式。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-02-01 Epub Date: 2025-12-23 DOI: 10.1016/j.neures.2025.105012

Ryosuke Yoshida , Yamato Ishii , Kotaro Yamashiro , Kei Furuya , Tianben Ding , Keisuke Goda , Nobuyoshi Matsumoto , Yuji Ikegaya

引用次数: 0

Comprehensive DNA methylation analysis of brain and peripheral tissues following chronic risperidone treatment in common marmosets 普通狨猴慢性利培酮治疗后脑和外周组织的综合DNA甲基化分析。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1016/j.neures.2025.105000

Yui Murata , Ayaka Fujii , Yutaka Nakachi , Jianbin Du , Kiyoto Kasai , Miki Bundo , Kazuya Iwamoto

{"title":"Comprehensive DNA methylation analysis of brain and peripheral tissues following chronic risperidone treatment in common marmosets","authors":"Yui Murata , Ayaka Fujii , Yutaka Nakachi , Jianbin Du , Kiyoto Kasai , Miki Bundo , Kazuya Iwamoto","doi":"10.1016/j.neures.2025.105000","DOIUrl":"10.1016/j.neures.2025.105000","url":null,"abstract":"<div><div>Antipsychotic drugs are increasingly recognized to exert therapeutic effects not only through neurotransmitter modulation but also, in part, through epigenetic mechanisms. Risperidone is an atypical antipsychotic drug widely used to treat schizophrenia, yet its <em>in vivo</em> epigenomic effects remain poorly understood. We investigated genome-wide DNA methylation changes induced by chronic risperidone administration in the common marmoset, a non-human primate with high translational relevance. Adult males were treated orally with risperidone for 28 days. DNA methylation was analyzed in four brain regions (frontal cortex, hippocampus, cerebellum, and caudate nucleus) and two peripheral tissues (blood and liver) using a HumanMethylation450K BeadChip adapted to the marmoset genome. Risperidone induced region- and tissue-specific methylation alterations. The brain showed predominant hypermethylation, and the hippocampus had the largest number of differentially methylated probes. Rank-rank hypergeometric overlap analysis revealed partial hypermethylation–hypermethylation concordance between the hippocampus or caudate and peripheral tissues, indicating partially coordinated changes. We also found that risperidone-treated neuroblastoma cells showed methylation patterns closely resembling those of the hippocampus, suggesting that the epigenetic changes are partly conserved in the cell models. These findings offer a framework for understanding the molecular basis of antipsychotic actions and for identifying potential epigenetic markers relevant to clinical effects.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 105000"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug discovery research with iPSC models of neurodegenerative diseases 神经退行性疾病iPSC模型的药物发现研究。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-08 DOI: 10.1016/j.neures.2025.104985

Masahiro Adachi , Haruhiko Banno , Haruhisa Inoue

引用次数: 0

Neurodegenerative disease and autophagy in iPSC-based models iPSC模型中的神经退行性疾病和自噬。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-26 DOI: 10.1016/j.neures.2025.104991

Sodbileg Odonchimed , Keiko Imamura , Haruhisa Inoue

{"title":"Neurodegenerative disease and autophagy in iPSC-based models","authors":"Sodbileg Odonchimed , Keiko Imamura , Haruhisa Inoue","doi":"10.1016/j.neures.2025.104991","DOIUrl":"10.1016/j.neures.2025.104991","url":null,"abstract":"<div><div>Neurodegenerative diseases are characterized by the gradual deterioration of specific neuronal populations, ultimately resulting in motor, cognitive, or behavioral impairments. Despite the worldwide increase in disease incidence, effective therapies remain unavailable. A common pathological hallmark of neurodegenerative diseases is the accumulation of misfolded protein aggregates. Accordingly, numerous studies and therapeutic strategies have focused on targeting these toxic aggregates and protein quality control via autophagy, a vital cellular recycling mechanism. Autophagy dysregulation has been implicated in the pathogenesis of several neurodegenerative diseases. Induced pluripotent stem cell (iPSC) technology has emerged as a powerful platform for modeling neurodegenerative diseases, and iPSC-based models provide human-relevant systems for studying autophagic dysfunction in vitro. In this review, we discuss the key findings of recent studies investigating autophagy in iPSC-based models of neurodegenerative diseases, including Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and other diseases.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 104991"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145636820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The neurobiology of human sequential signal prediction: Insights from language, music, and mathematics 人类序列信号预测的神经生物学：来自语言、音乐和数学的见解。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-12-02 DOI: 10.1016/j.neures.2025.105001

Tomoya Nakai , Tatsuya Daikoku , Yohei Oseki

{"title":"The neurobiology of human sequential signal prediction: Insights from language, music, and mathematics","authors":"Tomoya Nakai , Tatsuya Daikoku , Yohei Oseki","doi":"10.1016/j.neures.2025.105001","DOIUrl":"10.1016/j.neures.2025.105001","url":null,"abstract":"<div><div>Humans use various sequential signals, such as language, music, and mathematics, to convey complex information and facilitate communication. Previous research has identified two fundamental frameworks underlying human sequential signal processing: a structural framework, emphasizing rule-based hierarchical organization (e.g., syntax), and a predictive framework, which focuses on the brain’s capacity to anticipate upcoming inputs based on statistical regularities. While the structural approach underscores human-specific abilities, the predictive approach highlights mechanisms shared with non-human animals. We review behavioral and neural evidence across domains, demonstrating overlapping neural substrates, particularly in the inferior frontal gyrus, involved in structural processing of language, music, and mathematics. Likewise, predictive processing, indexed by ERP components such as N400 and P600, operates across domains to detect violations of expectation. Importantly, we argue that these frameworks are not mutually exclusive: structural knowledge can inform prediction, and predictive processes can, in turn, influence perceived structure. Cross-domain experiments and computational modeling suggest shared cognitive mechanisms, although domain-specific variations remain. We propose that the human brain integrates hierarchical structures with statistical learning to support flexible and generalized sequence processing. Future research should aim to develop unified models across domains, leveraging neuroimaging techniques and large language models.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 105001"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145678218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding semantic impairments in schizophrenia from a predictive coding perspective 从预测编码的角度理解精神分裂症的语义障碍

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.neures.2025.104990

Yukiko Matsumoto , Ryusuke Hayashi , Hidehiko Takahashi

{"title":"Understanding semantic impairments in schizophrenia from a predictive coding perspective","authors":"Yukiko Matsumoto , Ryusuke Hayashi , Hidehiko Takahashi","doi":"10.1016/j.neures.2025.104990","DOIUrl":"10.1016/j.neures.2025.104990","url":null,"abstract":"<div><div>Schizophrenia is characterized by profound semantic impairments that manifest as disrupted language and thought. We provide empirical support for the hypothesis that predictive coding forms a unifying framework for understanding these deficits by reinforcing theoretical ideas with quantitative neuroimaging evidence. According to predictive coding theory, the brain continuously generates predictions about incoming information, and prediction errors drive model updates when expectations diverge from sensory input. This review synthesizes evidence from cognitive neuroscience, computational psychiatry, and neurolinguistics to demonstrate how aberrant prediction error signaling disrupts hierarchical semantic processing in schizophrenia. Behavioral studies have revealed atypical semantic processing in priming and fluency tasks. Electrophysiological studies have shown altered neural responses to semantic incongruence, particularly reduced N400 effects. Furthermore, we have used voxel-wise modeling, graph theory, and topological analysis to demonstrate fundamentally disorganized semantic networks in schizophrenia, characterized by reduced small-worldness, excessive homogenization, and diminished representational variability. These converging findings are consistent with a neurocomputational account wherein semantic deficits reflect disrupted predictive mechanisms. This theoretical framework suggests that miscalibrated precision weighting of prediction errors leads to either over-activation of irrelevant semantic associations or impoverished semantic processing. This perspective offers insights into schizophrenia pathophysiology and guidance for targeted interventions to restore predictive coding function.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 104990"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice Lipocalin-2通过Nrf2信号抑制诱导小鼠脑出血后巨噬细胞/小胶质细胞促炎表型。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-22 DOI: 10.1016/j.neures.2025.104988

Tengfei Zhang , Chunhui Wang , Ying Li , Xiaowei Fei , Yanan Dou , Junbin Liu , Junyu Wang , Danfeng Zhang , Lei Jiang , Liang Zhao , Jialiang Wei , Lijun Hou

{"title":"Lipocalin-2 induces macrophage/microglia pro-inflammatory phenotype after intracerebral hemorrhage via Nrf2 signaling inhibition in young and aged mice","authors":"Tengfei Zhang , Chunhui Wang , Ying Li , Xiaowei Fei , Yanan Dou , Junbin Liu , Junyu Wang , Danfeng Zhang , Lei Jiang , Liang Zhao , Jialiang Wei , Lijun Hou","doi":"10.1016/j.neures.2025.104988","DOIUrl":"10.1016/j.neures.2025.104988","url":null,"abstract":"<div><div>Microglia and macrophages (M/M) play significant roles in intracerebral hemorrhage (ICH) injury, but the underlying mechanism is complicated and remains largely unknown. Lipocalin-2 (LCN2) expression elevates in M/M after ICH, yet its role in M/M-induced inflammation after ICH has not been fully elucidated. In the current study, a mouse ICH model was established in LCN2<sup>fl/fl,CX3CR1-Cre</sup> male (LCN2 cKO) mice and LCN2<sup>fl/fl</sup> male mice. We then aimed to inject LCN2 protein or the Nrf2 inhibitor brusatol groups for mechanism study, and the BV2 and Raw264.7 cell lines were used for <em>in vitro</em> study. LCN2 induces pro-inflammatory phenotype and promotes pro-inflammatory secretion in M/M after blood injury, and M/M LCN2 knockout reduced the pro-inflammatory phenotype after ICH. The Nrf2 protein is activated and nuclear-translocated by LCN2 knockout/downregulation, and the Nrf2 inhibition abrogates the anti-inflammatory effect induced by LCN2 knockout/downregulation. LCN2 knockout/downregulation boosts M/M phagocytosis after ICH, which is partially reversed by Nrf2 inhibition. The LCN2 expression also increases in aged mouse brains and participates in pro-inflammation induction and phagocytosis inhibition after ICH. Our study demonstrates that post-ICH LCN2 expression in M/M induces pro-inflammatory phenotype via inhibiting Nrf2 signaling pathway.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 104988"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145588144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance evaluation of the earphone-type electroencephalogram for alpha wave detection 耳机型脑电图检测α波的性能评价

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-12-03 DOI: 10.1016/j.neures.2025.105004

Mao Otake , Takuya Ibaraki , Ming Chang , Masaki Iwasaki , Go Taniguchi , Toshitaka Yamakawa , Shunsuke Takagi , Takashi Takeuchi , Hidehiko Takahashi , Miho Miyajima

{"title":"Performance evaluation of the earphone-type electroencephalogram for alpha wave detection","authors":"Mao Otake , Takuya Ibaraki , Ming Chang , Masaki Iwasaki , Go Taniguchi , Toshitaka Yamakawa , Shunsuke Takagi , Takashi Takeuchi , Hidehiko Takahashi , Miho Miyajima","doi":"10.1016/j.neures.2025.105004","DOIUrl":"10.1016/j.neures.2025.105004","url":null,"abstract":"<div><div>Electroencephalography (EEG) is useful for monitoring brain functions. Recently, wearable earphone-type EEG devices that can be easily used at home have emerged. Although their application scope is expanding, their comfort and detection validity have yet to be sufficiently validated. Herein, we examined the capability of an earphone-type EEG device to record EEG phenomena and compared with conventional scalp EEG. Simultaneous scalp and earphone-type EEG measurements were performed for 30 min, including eyes-open /eye-closed and sleeping tasks, on 25 healthy participants. We compared the detection validity of alpha waves using power spectrum analysis and statistical procedures. Among the 25 participants, 11 participants with available sleep EEG data were included in the final analysis. Compared with the eyes-closed, a reduction in alpha power was observed under the eyes-open condition in the alpha frequency band (8–13 Hz). Similarly, most participants exhibited decreased alpha power during sleep compared with wakefulness. These results indicate that the earphone-type EEG systems record canonical brainwaves in healthy individuals.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 105004"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding 急性应激通过PVN激活抑制饥饿驱动的食物寻找：通过抗焦虑药物和胃饥饿素受体激动剂逆转，具有抗焦虑样的再进食作用。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-17 DOI: 10.1016/j.neures.2025.104989

Ryusei Tojo , Mayuka Tashiro , Haruka Takahashi , Hideki Tamura

{"title":"Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding","authors":"Ryusei Tojo , Mayuka Tashiro , Haruka Takahashi , Hideki Tamura","doi":"10.1016/j.neures.2025.104989","DOIUrl":"10.1016/j.neures.2025.104989","url":null,"abstract":"<div><div>Feeding behavior is influenced by both metabolic drive and emotional context, yet how acute stress interferes with hunger-driven motivation remains poorly understood. Using a conflict-based open-field feeding paradigm, we examined how 30-min restraint stress alters food-seeking behavior in fasted mice and how pharmacological or physiological interventions modulate this effect. Acute restraint abolished fasting-induced increases in food seeking and intake, an effect that was reversed by intraperitoneal diazepam, an anxiolytic, and by MK-677, a ghrelin receptor agonist that enhances appetite. To identify neural correlates, we quantified c-Fos (neuronal activation) and phosphorylated pyruvate dehydrogenase (pPDH; neuronal inhibition) in the paraventricular hypothalamic nucleus (PVN). Diazepam suppressed restraint-induced c-Fos expression, whereas MK-677 increased pPDH, revealing distinct PVN signatures for anxiolysis and enhanced feeding drive. Notably, refeeding after fasting induced a similar pPDH-dominant pattern and attenuated stress-induced anxiety-related behaviors, indicating that restoration of energy balance exerts intrinsic anti-stress effects through PVN inhibition. Together, these findings reveal that acute stress suppresses hunger-driven food seeking via PVN activation, pharmacological inhibition reverses this suppression, and physiological refeeding promotes stress resilience via PVN-medicated inhibition, highlighting PVN modulation as a shared mechanism linking emotional and metabolic homeostasis.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"222 ","pages":"Article 104989"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145557556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The application of directly induced neurons into neurodegenerative disease modeling 直接诱导神经元在神经退行性疾病建模中的应用。

IF 2.3 4区医学

Neuroscience Research Pub Date : 2026-01-01 Epub Date: 2025-11-28 DOI: 10.1016/j.neures.2025.104993

Keita Matsumoto, Sumihiro Maeda

引用次数: 0