Neuroscience Research最新文献_第3页

Editorial: Does big data change neuroscience? 社论：大数据会改变神经科学吗？

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.007

Ryota Kobayashi , Ken Nakae

引用次数: 0

Behavioral competition between infant care and sexual behavior in male but not female common marmosets 雄性而非雌性普通狨猴的育婴和性行为之间的行为竞争。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.003

Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda

{"title":"Behavioral competition between infant care and sexual behavior in male but not female common marmosets","authors":"Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda","doi":"10.1016/j.neures.2025.04.003","DOIUrl":"10.1016/j.neures.2025.04.003","url":null,"abstract":"<div><div>Sexual desire and parenthood sometimes compete in a sexually dimorphic manner, but the neural mechanism for this remains to be clarified. Here we show that, in the family-living primate common marmoset, fathers temporarily reduce infant care during the postpartum mating period leading to conception, whereas mothers do not. Functional suppression of the calcitonin receptor-expressing MPOA subregion (cMPOA) scalably disrupts infant care in both sexes and abolishes sexual behavior in males. The neuronal activation pattern induced by infant care is not identical to, but overlaps with that induced by male mating in the medial preoptic area (MPOA) of the forebrain. These data suggest that the commonality of the neural mechanism required for infant care and sexual behavior in the MPOA may lead to competition between these behaviors in fathers. Further studies are needed to identify the precise neuronal mechanism regulating this phenomenon in marmosets.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104900"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) 急性给药α -甲基色胺（AMT）、5-甲氧基- α -甲基色胺（5-MeO-AMT）和5-甲氧基- n， n -二异丙基色胺（5-MeO-DiPT）后大鼠脑内单胺类神经递质变化的系统研究

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.006

Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu

{"title":"A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT)","authors":"Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu","doi":"10.1016/j.neures.2025.04.006","DOIUrl":"10.1016/j.neures.2025.04.006","url":null,"abstract":"<div><div>Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT<sub>2A</sub> receptor is the key receptor for hallucinogenic effects. In the present study, the monoamine neurotransmitters DA and its metabolites 3,4-Dihydroxyphenylacetic Acid (DOPAC) and homovanillic acid (HVA), 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were systematically investigated in the prefrontal cortex (PFC), nucleus accumbent (NAc), dorsolateral striatum (DLS) and hippocampus (HIP) using a validated HPLC-ECD analytical method after administration of the three tryptamines at different doses. The results showed that the three tryptamines had certain effects and the effects were different in different brain regions and showed that AMT, 5-MeO-AMT and 5-MeO-DiPT had significant effects on monoaminergic neurotransmitters in rat brains. Among them, DAergic and serotonergic play important roles, and this study provides valuable information for further research on the neurochemical effects of tryptamine hallucinogens in the brain.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104903"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus 代谢综合征和2型糖尿病鼠模型周围神经的炎症和自噬。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-17 DOI: 10.1016/j.neures.2025.04.002

Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka

引用次数: 0

The impact of brand longevity on consumers’ purchase intention: An ERP study 品牌寿命对消费者购买意愿的影响：一项ERP研究。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-15 DOI: 10.1016/j.neures.2025.04.001

Jianhua Liu

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Lateralized local circuit tuning in female mouse auditory cortex 雌性小鼠听觉皮层的局部偏侧电路调谐。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-04 DOI: 10.1016/j.neures.2025.03.009

Soomin C. Song , Robert C. Froemke

{"title":"Lateralized local circuit tuning in female mouse auditory cortex","authors":"Soomin C. Song , Robert C. Froemke","doi":"10.1016/j.neures.2025.03.009","DOIUrl":"10.1016/j.neures.2025.03.009","url":null,"abstract":"<div><div>Most offspring are born helpless, requiring intense caregiving from parents especially during the first few days of neonatal life. For many species, infant cries are a primary signal used by parents to provide caregiving. Previously we and others documented how maternal left auditory cortex rapidly becomes sensitized to pup calls over hours of parental experience, enabled by oxytocin. The speed and robustness of this maternal plasticity suggests cortical pre-tuning or initial bias for pup call stimulus features. Here we examine the circuit basis of left-lateralized tuning to vocalization features with whole-cell recordings in brain slices. We found that layer 2/3 pyramidal cells of female left auditory cortex show selective suppression of inhibitory inputs with repeated stimulation at the fundamental pup call rate (inter-stimulus interval ∼150 msec) in pup-naïve females and expanded with maternal experience. However, optogenetic stimulation of cortical inhibitory cells showed that inputs from somatostatin-positive and oxytocin-receptor-expressing interneurons were less suppressed at these rates. This suggested that disynaptic inhibition rather than monosynaptic depression was a major mechanism underlying pre-tuning of cortical excitatory neurons, confirmed with simulations. Thus cortical interneuron specializations can augment neuroplasticity mechanisms to ensure fast appropriate caregiving in response to infant cries.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104897"},"PeriodicalIF":2.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A practical guide for single-cell transcriptome data analysis in neuroscience 神经科学中单细胞转录组数据分析的实用指南。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-03-29 DOI: 10.1016/j.neures.2025.03.006

Yoshinori Hayakawa , Haruka Ozaki

{"title":"A practical guide for single-cell transcriptome data analysis in neuroscience","authors":"Yoshinori Hayakawa , Haruka Ozaki","doi":"10.1016/j.neures.2025.03.006","DOIUrl":"10.1016/j.neures.2025.03.006","url":null,"abstract":"<div><div>Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the single-cell level, providing unprecedented insights into cellular heterogeneity, rare cell populations, and dynamic cellular processes. In neuroscience, scRNA-seq has enabled the identification of diverse brain cell types, elucidation of developmental pathways, and discovery of mechanisms underlying neurological diseases. This tutorial provides a practical guide to scRNA-seq data analysis in neuroscience, focusing on the essential workflows and theoretical foundations. Key steps covered include quality control, data preprocessing, integration, cell clustering, and differential expression analysis. Using the Seurat R package, the tutorial demonstrates a comparative analysis approach for identifying differentially expressed genes between conditions, emphasizing the biological interpretation of results. By addressing the unique challenges of scRNA-seq data and illustrating methods for robust analysis, this work aims to enhance the reliability and reproducibility of scRNA-seq studies in neuroscience, supporting the exploration of cellular mechanisms and advancing research into brain function and disease.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"214 ","pages":"Pages 9-15"},"PeriodicalIF":2.4,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency 经颅交流电刺激对感觉运动皮层本体感觉刺激诱发的β反弹的增强。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-03-28 DOI: 10.1016/j.neures.2025.03.008

Mayu Akaiwa , Ryo Kurokawa , Yuya Matsuda , Yasushi Sugawara , Rin Kosuge , Hidekazu Saito , Eriko Shibata , Takeshi Sasaki , Kazuhiro Sugawara

{"title":"Enhancement of beta rebound elicited by proprioceptive stimulation in the sensorimotor cortex by transcranial alternating current stimulation matched to the dominant beta frequency","authors":"Mayu Akaiwa , Ryo Kurokawa , Yuya Matsuda , Yasushi Sugawara , Rin Kosuge , Hidekazu Saito , Eriko Shibata , Takeshi Sasaki , Kazuhiro Sugawara","doi":"10.1016/j.neures.2025.03.008","DOIUrl":"10.1016/j.neures.2025.03.008","url":null,"abstract":"<div><div>Transcranial alternating current stimulation (tACS) can modulate endogenous brain oscillations in a frequency-specific manner. Previous studies have reported that beta tACS modulates the excitability of primary motor cortex and improves task performance. Tactile and proprioceptive stimuli also elicit event-related synchronization of the beta rhythm in contralateral sensorimotor cortex, termed beta rebound, and a strong correlation was reported between proprioception-induced rebound strength and clinical recovery in stroke patients. We investigated the effects of tACS matched to the dominant beta frequency on the strength of proprioception-induced beta rebound.We recorded the beta rebound from 14 healthy young adults in response to passive index finger movement by electroencephalography to determine individual peak beta frequency. Electroencephalograms (EEG) were recorded during passive movements before and after active or sham tACS. We recorded beta rebound of all participants to determine their individual peak frequency of beta rebound prior to this experiment. Active tACS at individually matched frequencies increased beta rebound strength during subsequent passive movement compared to sham tACS in the majority of participants, while the remaining participants demonstrated no significant change or a decrease. These findings on healthy participants provide an essential foundation for further studies on the effects of beta frequency-matched tACS for stroke patient rehabilitation.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104896"},"PeriodicalIF":2.4,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building neuroscience with adaptive circuit census 社论：用自适应电路普查建立神经科学。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-03-27 DOI: 10.1016/j.neures.2025.03.007

Yoshikazu Isomura

引用次数: 0

Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression 尽管自噬上调和TDP-43表达异常，optinineurin敲除形成TDP-43聚集体来调节TDP-43蛋白水平。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-03-22 DOI: 10.1016/j.neures.2025.03.005

Yuta Maetani , Takashi Kurashige , Yui Tada , Kodai Kume , Tomoaki Watanabe , Yusuke Sotomaru , Koji Yamanaka , Hirofumi Maruyama , Hideshi Kawakami

{"title":"Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression","authors":"Yuta Maetani , Takashi Kurashige , Yui Tada , Kodai Kume , Tomoaki Watanabe , Yusuke Sotomaru , Koji Yamanaka , Hirofumi Maruyama , Hideshi Kawakami","doi":"10.1016/j.neures.2025.03.005","DOIUrl":"10.1016/j.neures.2025.03.005","url":null,"abstract":"<div><div><em>Optineurin</em> is a causative gene of amyotrophic lateral sclerosis (ALS) and has many roles in processes such as autophagy and inflammation. However, it is unclear how optineurin causes ALS. <em>Optineurin</em> knock-out (<em>Optn</em>-KO) mice, which have been generated by several researchers, exhibit motor neuron degeneration and TDP-43 aggregates, but no motor deficits. Motor dysfunction in ALS model mice is associated with TDP-43 in the spinal cord. We bred <em>Optn</em>-KO mice with TDP-43 overexpression transgenic mice and evaluated whether increased TDP-43 protein causes motor deficits and whether <em>Optn</em>-KO affects TDP-43 protein level. <em>Optn</em>-KO mice had spinal TDP-43 protein levels and motor function comparable to wild-type mice, and TDP-43-transgenic (TDP-43-tg) mice resulted in motor dysfunction and early death. However, double-mutant TDP-43-tg / <em>Optn</em>-KO mice had lower TDP-43 protein levels than TDP-43-tg mice at 18 months age, and showed inhibition of the TBK1-optinerurin autophagic pathway with aging. Furthermore, <em>Optn</em>-KO caused TDP-43-positive cytoplasmic aggregates. TDP-43 overexpression by itself induced spinal microgliosis, but <em>Optn</em>-KO suppressed that microgliosis. Finally, we showed that <em>Optn</em>-KO mice could not exhibit behavioral dysfunction because TDP-43 protein levels were not elevated despite autophagy inhibition. Thus, downregulation of <em>Optn</em> may suppress TDP-43 toxicity by regulating its abundance through aggregate formation.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104893"},"PeriodicalIF":2.4,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0