Neuroscience Research最新文献_第3页

Gait rhythm analysis as a new continuous scale for cerebellar ataxia: Power law and lognormal components represent the ataxic gait quantity 步态节律分析是小脑共济失调的一种新的连续量表：幂律和对数正态成分代表共济失调步态量。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.07.001

引用次数: 0

Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity 海马沃伯格效应介导硫化氢改善糖尿病相关认知功能障碍：涉及促进海马突触可塑性。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.07.002

Run-Qi Li , Wei-Wen Zhu , Cheng Li , Ke-Bin Zhan , Ping Zhang , Fan Xiao , Jia-Mei Jiang , Wei Zou

{"title":"Hippocampal warburg effect mediates hydrogen sulfide-ameliorated diabetes-associated cognitive dysfunction: Involving promotion of hippocampal synaptic plasticity","authors":"Run-Qi Li , Wei-Wen Zhu , Cheng Li , Ke-Bin Zhan , Ping Zhang , Fan Xiao , Jia-Mei Jiang , Wei Zou","doi":"10.1016/j.neures.2024.07.002","DOIUrl":"10.1016/j.neures.2024.07.002","url":null,"abstract":"<div><div>Our previous studies have reported that hydrogen sulfide (H<sub>2</sub>S) has ability to improve diabetes-associated cognitive dysfunction (DACD), but the exact mechanisms remain unknown. Recent research reveals that Warburg effect is associated with synaptic plasticity which plays a key role in cognition promotion. Herein, the present study was aimed to demonstrate whether hippocampal Warburg effect contributes to H<sub>2</sub>S-ameliorated DACD and further explore its potential mechanism. We found that H<sub>2</sub>S promoted the hippocampal Warburg effect and inhibited the OxPhos in the hippocampus of STZ-induced diabetic rats. It also improved the hippocampal synaptic plasticity in STZ-induced diabetic rats, as evidenced by the change of microstructures and the expression of different key-enzymes. Furthermore, inhibited hippocampal Warburg effect induced by DCA markedly abolished the improvement of H<sub>2</sub>S on synaptic plasticity in the hippocampus of STZ-induced diabetic rats. DCA blocked H<sub>2</sub>S-attenuated the cognitive dysfunction in STZ-induced diabetic rats, according to the Y-maze, Novel Objective Recognition, and Morris Water Maze tests. Collectively, these findings indicated that the hippocampal Warburg effect mediates H<sub>2</sub>S-ameliorated DACD by improving hippocampal synaptic plasticity.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 15-28"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REELIN ameliorates Alzheimer's disease, but how? REELIN 可改善阿尔茨海默病，但如何改善？

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.07.004

Yu Katsuyama , Mitsuharu Hattori

{"title":"REELIN ameliorates Alzheimer's disease, but how?","authors":"Yu Katsuyama , Mitsuharu Hattori","doi":"10.1016/j.neures.2024.07.004","DOIUrl":"10.1016/j.neures.2024.07.004","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is the most prevalent type of dementia; therefore, there is a high demand for therapeutic medication targeting it. In this context, extensive research has been conducted to identify molecular targets for drugs. AD manifests through two primary pathological signs: senile plaques and neurofibrillary tangles, caused by accumulations of amyloid-beta (Aβ) and phosphorylated tau, respectively. Thus, studies concerning the molecular mechanisms underlying AD etiology have primarily focused on Aβ generation and tau phosphorylation, with the anticipation of uncovering a signaling pathway impacting these molecular processes. Over the past two decades, studies using not only experimental model systems but also examining human brains have accumulated fragmentary evidences suggesting that REELIN signaling pathway is deeply involved in AD. Here, we explore REELIN signaling pathway and its involvement in memory function within the brain and review studies investigating molecular connections between REELIN signaling pathway and AD etiology. This review aims to understand how the manipulation (activation) of this pathway might ameliorate the disease’s etiology.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 8-14"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141879197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models 新型胆固醇 24- 羟化酶抑制剂索替列司他在急性和慢性神经变性模型中的特性分析

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-11-01 DOI: 10.1016/j.neures.2024.06.005

{"title":"Characterization of soticlestat, a novel cholesterol 24-hydroxylase inhibitor, in acute and chronic neurodegeneration models","authors":"","doi":"10.1016/j.neures.2024.06.005","DOIUrl":"10.1016/j.neures.2024.06.005","url":null,"abstract":"<div><div>We investigated whether soticlestat (TAK-935), a newly discovered cholesterol 24-hydroxylase (CH24H) inhibitor now in phase 3 clinical trials for Dravet and Lennox-Gastaut syndromes, has effects on neurodegeneration in both chronic and acute animal models associated with glutamate hyperexcitation. Soticlestat was administered at doses that approximately halve 24S-hydroxycholesterol in both experiments. In the kainic acid (KA)-induced acute hippocampal degeneration model, soticlestat ameliorated inflammatory cytokine expression, hippocampal degeneration, and memory impairment. We ruled out the possibility that soticlestat directly interferes with KA binding to the KA receptor, or that 24S-hydroxycholesterol modulates KA receptor signaling, by conducting receptor binding and cell death assays. In the PS19 chronic degeneration model of tauopathy, treatment effects were observed in neurodegeneration markers. Notably, there was a significant correlation between the levels of brain 24S-hydroxycholesterol and a proinflammatory cytokine, tumor necrosis factor-α, which is implicated in cognitive decline and lowering of seizure threshold. This is the first study demonstrating that CH24H inhibition can alleviate neurodegeneration concomitant with neuroinflammation. Herein, we discuss the interplay among 24S-hydroxycholesterol production, neuroinflammation, and excitotoxicity. Effects on neurodegeneration and neuroinflammation demonstrated in two preclinical models suggest that soticlestat is effective in ameliorating seizures and addressing cognitive dysfunction in seizure disorders.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"208 ","pages":"Pages 29-38"},"PeriodicalIF":2.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Medaka approach to evolutionary social neuroscience. 社会神经科学进化的青鳉方法。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-30 DOI: 10.1016/j.neures.2024.10.005

Satoshi Ansai, Towako Hiraki-Kajiyama, Ryutaro Ueda, Takahide Seki, Saori Yokoi, Takafumi Katsumura, Hideaki Takeuchi

{"title":"The Medaka approach to evolutionary social neuroscience.","authors":"Satoshi Ansai, Towako Hiraki-Kajiyama, Ryutaro Ueda, Takahide Seki, Saori Yokoi, Takafumi Katsumura, Hideaki Takeuchi","doi":"10.1016/j.neures.2024.10.005","DOIUrl":"10.1016/j.neures.2024.10.005","url":null,"abstract":"<p><p>Previously, the integration of comparative biological and neuroscientific approaches has led to significant advancements in social neuroscience. This review highlights the potential and future directions of evolutionary social neuroscience research utilizing medaka fishes (the family Adrianichthyidae) including Japanese medaka (Oryzias latipes). We focus on medaka social cognitive capabilities and mate choice behavior, particularly emphasizing mate preference using visual cues. Medaka fishes are also advantageous due to their abundant genetic resources, extensive genomic information, and the relative ease of laboratory breeding and genetic manipulation. Here we present some research examples of both the conventional neuroscience approach and evolutionary approach involving medaka fishes and other species. We also discuss the prospects of uncovering the molecular and cellular mechanisms underlying the diversity of visual mate preference among species. Especially, we introduce that the single-cell transcriptome technology, particularly in conjunction with 'Adaptive Circuitry Census', is an innovative tool that bridges comparative biological methods and neuroscientific approaches. Evolutionary social neuroscience research using medaka has the potential to unveil fundamental principles in neuroscience and elucidate the mechanisms responsible for generating diversity in mating strategies.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurexin1 level in Huntington's Disease and decreased Neurexin1 in disease progression. 亨廷顿氏病的 Neurexin1 水平以及 Neurexin1 在疾病进展过程中的减少。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-30 DOI: 10.1016/j.neures.2024.10.006

Kyoungjoo Cho, Gyung Whan Kim

{"title":"Neurexin1 level in Huntington's Disease and decreased Neurexin1 in disease progression.","authors":"Kyoungjoo Cho, Gyung Whan Kim","doi":"10.1016/j.neures.2024.10.006","DOIUrl":"10.1016/j.neures.2024.10.006","url":null,"abstract":"<p><p>Huntington's disease (HD) is a neurodegenerative disorder characterized by the presence of abnormally expanded polyglutamine tracts in huntingtin protein (HTT). Mutant HTT disrupts synaptic transmission and plasticity, particularly in the striatum and cortex, leading to early dysfunctions, such as altered neurotransmitter release, impaired synaptic vesicle recycling, and disrupted postsynaptic receptor function. Synaptic loss precedes neuronal degeneration and contributes to disease progression. Neurexin1 (NRXN1), a synaptic cell adhesion molecule primarily located in the presynaptic membrane, plays a crucial role in maintaining synaptic integrity. The present study investigated the role of NRXN1 in HD. This study researched whether the changed level has been related to expanded polyQ stretch and disease progression. Here, we report a reduction in NRXN1 levels in post-symptomatic HD mice and in neuronal cells expressing abnormally expanded polyQ tracts. Mutant HTT was found to decrease NRXN1 levels while increasing LAMP2A levels, which promotes lysosomal degradation of NRXN1. In HD cells expressing Q111, downregulated LAMP2A restored NRXN1 levels and maintained cell proliferation compared with cells expressing Q7. These findings suggest that NRXN1 is regulated by LAMP2A-mediated way and that decreased NRXN1 levels are associated with symptomatic progression and neuronal cell loss in HD.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety evaluations for transtympanic laser stimulation of the cochlea in Mongolian gerbils (Meriones unguiculatus). 蒙古沙鼠（Meriones unguiculatus）经耳膜激光刺激耳蜗的安全性评估。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-22 DOI: 10.1016/j.neures.2024.10.004

Aya Okamoto, Miku Uenaka, Yuki Ito, Yuta Kuroki, Tomohiro Miyasaka, Koji Toda, Shizuko Hiryu, Kohta I Kobayasi, Yuta Tamai

{"title":"Safety evaluations for transtympanic laser stimulation of the cochlea in Mongolian gerbils (Meriones unguiculatus).","authors":"Aya Okamoto, Miku Uenaka, Yuki Ito, Yuta Kuroki, Tomohiro Miyasaka, Koji Toda, Shizuko Hiryu, Kohta I Kobayasi, Yuta Tamai","doi":"10.1016/j.neures.2024.10.004","DOIUrl":"10.1016/j.neures.2024.10.004","url":null,"abstract":"<p><p>Infrared laser stimulation of the cochlea has been proposed as a possible alternative to conventional auditory prostheses. Whereas previous studies have focused primarily on the short-term effects of laser stimulation, the practical application of this technics requires an investigation into whether prolonged laser exposure can induce neural responses and safely. This study assessed the effect of laser-induced damage to the cochlea on auditory perception using Mongolian gerbils (Meriones unguiculatus) trained with a classical conditioning task. The broadband noise was presented as a conditioned stimulus, and reward licking was recorded as a conditioned response. After training, the subject's cochlea was exposed to a continuous pulsed laser for 15 h. Broadband noise of various intensities was presented without pairing it with water before and after laser exposure to assess the decrease in auditory perception due to laser-induced injury. The licking rate did not change after laser exposure of 6.6 W/cm<sup>2</sup> or weaker but drastically decreased after 26.4 W/cm<sup>2</sup> or higher. These findings showed, for the first time, that the safety margin of long-term, at least several hours, cochlear laser stimulation exists and will contribute to the appropriate delimitation of the safe and effective laser stimulation parameters in future research.</p>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian estimation of trunk-leg coordination during walking using phase oscillator models. 利用相位振荡器模型对行走过程中躯干-腿协调性进行贝叶斯估计。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-22 DOI: 10.1016/j.neures.2024.10.002

Haruma Furukawa, Takahiro Arai, Tetsuro Funato, Shinya Aoi, Toshio Aoyagi

引用次数: 0

Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model. 基于数学模型的谷氨酸能突触中 NMDA 和 AMPA 受体相互作用的定量分析。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2024-10-19 DOI: 10.1016/j.neures.2024.10.003

Qingchen Guo

引用次数: 0

Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats. 腹侧被盖区淀粉样蛋白/降钙素受体信号传导可抑制雌性大鼠的摄食和体重增加。