Neuroscience Research最新文献_第3页

Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task 直接伸臂任务中人类杏仁核的β波段功率调制。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-05-11 DOI: 10.1016/j.neures.2025.05.001

Jonathon Cavaleri , Shivani Sundaram , Roberto Martin Del Campo-Vera , Xiecheng Shao , Ryan S. Chung , Miguel Parra , Adith Swarup , Selena Zhang , Alexandra Kammen , Angad Gogia , Xenos Mason , Ryan McGinn , Christi Heck , Charles Y. Liu , Spencer S. Kellis , Brian Lee

{"title":"Beta-band power modulation in the human amygdala during a Direct Reach arm reaching task","authors":"Jonathon Cavaleri , Shivani Sundaram , Roberto Martin Del Campo-Vera , Xiecheng Shao , Ryan S. Chung , Miguel Parra , Adith Swarup , Selena Zhang , Alexandra Kammen , Angad Gogia , Xenos Mason , Ryan McGinn , Christi Heck , Charles Y. Liu , Spencer S. Kellis , Brian Lee","doi":"10.1016/j.neures.2025.05.001","DOIUrl":"10.1016/j.neures.2025.05.001","url":null,"abstract":"<div><div>The human amygdala is primarily known for its involvement in processing emotional and fearful responses, but newer evidence has identified a role for this structure in motor processing. Our lab previously utilized an arm-reaching task and observed significant beta-band (13–30 Hz) modulation in the hippocampus. Given these results, we sought to characterize the role of beta-band modulation in the amygdala during movement execution in participants with stereoelectroencephalography (SEEG) depth electrodes in the amygdala for seizure localization. We show that 9 of 13 participants (69.2 %) showed decreased beta-band power in the amygdala during the Response (movement execution) phase of an arm-reaching task when compared to Fixation (baseline). Secondary analyses show that there are no statistically significant differences in beta-band modulation between ipsilateral and contralateral implanted electrodes, but there is a small difference between male and female participants. The decrease in beta-band power in the amygdala during the Response phase of a Direct Reach task is consistent with our previous findings in the hippocampus. Our study is the first to report beta-band modulation in the amygdala during motor processing and sets the stage for further studies into the involvement of the amygdala in motor control.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104906"},"PeriodicalIF":2.4,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels 年轻粪便微生物群移植通过增加白细胞介素-4和白细胞介素-17水平改善老年受体大鼠的工作记忆。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-30 DOI: 10.1016/j.neures.2025.04.005

Yiru Yin , Meiqi Guan , Shufen Wu , Chenlong Cui , Rui Wang , Xin Zhao , Xiaorong Yang , Lingran Qiao , Yanli Li , Ce Zhang

{"title":"Young fecal microbiota transplantation improves working memory in aged recipient rats by increasing interleukin-4 and interleukin-17 levels","authors":"Yiru Yin , Meiqi Guan , Shufen Wu , Chenlong Cui , Rui Wang , Xin Zhao , Xiaorong Yang , Lingran Qiao , Yanli Li , Ce Zhang","doi":"10.1016/j.neures.2025.04.005","DOIUrl":"10.1016/j.neures.2025.04.005","url":null,"abstract":"<div><div>While transplanting the fecal microbiota from young to aged rodents has been extensively studied (that is, young FMT [yFMT]), its mechanism of alleviating working memory decline has not been fully elucidated. In this report, we aimed to investigate the effect of yFMT on the working memory of aged recipient rats performing delayed match-to-position (DMTP) tasks and the associated cellular and molecular mechanisms. The results revealed that yFMT mitigated the decline in DMTP task performance of aged recipients. This improvement was associated with a reshaped gut microbiota and increased levels of brain-derived neurotrophic factor, N-methyl-D-aspartate receptor subunit 1, and synaptophysin, enhancing synaptic formation and transmission. The remodeling of the gut microbiome influenced peripheral circulation and the hippocampus and medial prefrontal cortex by regulating the Th17/Treg ratio and microglial polarization. Ultimately, interleukin-4 and interleukin-17 emerged as potential key molecules driving the beneficial effects of FMT. These observations provide new insights into the gut<img>brain axis, emphasizing the connection between the gut and brain through the circulation system, and suggest an immunological mechanism that may help reverse age-related declines in the gut microbiota.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104902"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications 突触核蛋白病的原纤维种子动物模型：病理机制，疾病建模和治疗意义。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-30 DOI: 10.1016/j.neures.2025.04.008

Norihito Uemura

{"title":"Fibril-seeded animal models of synucleinopathies: Pathological mechanisms, disease modeling, and therapeutic implications","authors":"Norihito Uemura","doi":"10.1016/j.neures.2025.04.008","DOIUrl":"10.1016/j.neures.2025.04.008","url":null,"abstract":"<div><div>Accumulating evidence suggests that prion-like spread of misfolded α-Synuclein (αSyn) underlies the pathological progression of Lewy body diseases (LBD). Animal models injected with αSyn preformed fibrils (PFFs) have provided strong evidence for the prion hypothesis in LBD. Moreover, αSyn PFFs can be administered to various hosts and regions, contributing to the elucidation of pathological mechanisms and disease modeling. These models have also been used to identify biomarkers and develop new disease-modifying therapies for LBD. In contrast, it remains unknown how the prion-like properties of αSyn contribute to the pathogenesis of multiple system atrophy (MSA). Recent studies indicate that conformationally distinct αSyn fibrils induce different pathological features in animals, supporting the strain hypothesis, which suggests that conformational variations in αSyn fibrils contribute to the clinicopathological heterogeneity in synucleinopathies. However, the study of disease-specific αSyn fibrils in pathological mechanisms and disease modeling is still in its early stages. This review aims to highlight recent advances in αSyn fibril-seeded animal models with an emphasis on their unique features and utility in exploring pathological mechanisms and identifying novel disease-modifying therapies. In addition, I discuss future directions for refining these models in light of the emerging strain hypothesis in synucleinopathies.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104905"},"PeriodicalIF":2.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglial colonization routes and their impacts on cellular diversity 小胶质细胞定植途径及其对细胞多样性的影响。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.004

Yuki Hattori

{"title":"Microglial colonization routes and their impacts on cellular diversity","authors":"Yuki Hattori","doi":"10.1016/j.neures.2025.04.004","DOIUrl":"10.1016/j.neures.2025.04.004","url":null,"abstract":"<div><div>Microglia are the resident immune cells of the central nervous system. Unlike other glial cells—such as astrocytes and oligodendrocytes—which originate from neural stem cells alongside neurons, microglia derive from erythromyeloid progenitors that emerge in the yolk sac during early embryonic development. Once they reach the brain, microglia expand their population through proliferation during development. A growing body of research has revealed that microglia play diverse roles throughout life, both in physiological and pathological contexts. With recent advancements in single-cell transcriptomics, it has become increasingly evident that microglia exhibit substantial heterogeneity in their gene expression patterns. While various functions and subtypes of microglia are being uncovered, the mechanisms underlying their diversity remain largely unknown. Two key hypotheses may explain how microglial diversity arises. One possibility is that their diversity is influenced by the different colonization routes they take before settling in the brain. Alternatively, microglia may acquire distinct properties in response to their local environment. This review explores both possibilities, with a particular focus on the first hypothesis, drawing on recent findings that highlight the multiple routes microglia utilize to colonize the brain. It discusses how these processes contribute to the establishment of microglial diversity during brain development.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104901"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Does big data change neuroscience? 社论：大数据会改变神经科学吗？

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.007

Ryota Kobayashi , Ken Nakae

引用次数: 0

Behavioral competition between infant care and sexual behavior in male but not female common marmosets 雄性而非雌性普通狨猴的育婴和性行为之间的行为竞争。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.003

Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda

{"title":"Behavioral competition between infant care and sexual behavior in male but not female common marmosets","authors":"Takuma Kurachi , Kazutaka Shinozuka , Chihiro Yoshihara , Saori Yano-Nashimoto , Ayako Y. Murayama , Junichi Hata , Hideyuki Okano , Atsuko Saito , Kumi O. Kuroda","doi":"10.1016/j.neures.2025.04.003","DOIUrl":"10.1016/j.neures.2025.04.003","url":null,"abstract":"<div><div>Sexual desire and parenthood sometimes compete in a sexually dimorphic manner, but the neural mechanism for this remains to be clarified. Here we show that, in the family-living primate common marmoset, fathers temporarily reduce infant care during the postpartum mating period leading to conception, whereas mothers do not. Functional suppression of the calcitonin receptor-expressing MPOA subregion (cMPOA) scalably disrupts infant care in both sexes and abolishes sexual behavior in males. The neuronal activation pattern induced by infant care is not identical to, but overlaps with that induced by male mating in the medial preoptic area (MPOA) of the forebrain. These data suggest that the commonality of the neural mechanism required for infant care and sexual behavior in the MPOA may lead to competition between these behaviors in fathers. Further studies are needed to identify the precise neuronal mechanism regulating this phenomenon in marmosets.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104900"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) 急性给药α -甲基色胺（AMT）、5-甲氧基- α -甲基色胺（5-MeO-AMT）和5-甲氧基- n， n -二异丙基色胺（5-MeO-DiPT）后大鼠脑内单胺类神经递质变化的系统研究

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-25 DOI: 10.1016/j.neures.2025.04.006

Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu

{"title":"A systematic study of changes in monoamine neurotransmitters in the rat brain following acute administration of alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT) and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT)","authors":"Kaixi Li , Nan Li , Yuanyuan Chen , Xiangyu Li , Yanling Qiao , Dan Wang , Bin Di , Peng Xu","doi":"10.1016/j.neures.2025.04.006","DOIUrl":"10.1016/j.neures.2025.04.006","url":null,"abstract":"<div><div>Alpha-methyltryptamine (AMT), 5-methoxy-alpha-methyltryptamine (5-MeO-AMT), and 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DiPT) are three synthetic tryptamines with hallucinogenic properties that are widely abused worldwide. The hallucinogenic effects of tryptamines are primarily related to activation of the 5-HT receptor, and among the many subtypes of 5-HT receptors, the 5-HT<sub>2A</sub> receptor is the key receptor for hallucinogenic effects. In the present study, the monoamine neurotransmitters DA and its metabolites 3,4-Dihydroxyphenylacetic Acid (DOPAC) and homovanillic acid (HVA), 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) were systematically investigated in the prefrontal cortex (PFC), nucleus accumbent (NAc), dorsolateral striatum (DLS) and hippocampus (HIP) using a validated HPLC-ECD analytical method after administration of the three tryptamines at different doses. The results showed that the three tryptamines had certain effects and the effects were different in different brain regions and showed that AMT, 5-MeO-AMT and 5-MeO-DiPT had significant effects on monoaminergic neurotransmitters in rat brains. Among them, DAergic and serotonergic play important roles, and this study provides valuable information for further research on the neurochemical effects of tryptamine hallucinogens in the brain.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104903"},"PeriodicalIF":2.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144021644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus 代谢综合征和2型糖尿病鼠模型周围神经的炎症和自噬。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-17 DOI: 10.1016/j.neures.2025.04.002

Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka

引用次数: 0

The impact of brand longevity on consumers’ purchase intention: An ERP study 品牌寿命对消费者购买意愿的影响：一项ERP研究。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-15 DOI: 10.1016/j.neures.2025.04.001

Jianhua Liu

引用次数: 0

Lateralized local circuit tuning in female mouse auditory cortex 雌性小鼠听觉皮层的局部偏侧电路调谐。

IF 2.4 4区医学

Neuroscience Research Pub Date : 2025-04-04 DOI: 10.1016/j.neures.2025.03.009

Soomin C. Song , Robert C. Froemke

{"title":"Lateralized local circuit tuning in female mouse auditory cortex","authors":"Soomin C. Song , Robert C. Froemke","doi":"10.1016/j.neures.2025.03.009","DOIUrl":"10.1016/j.neures.2025.03.009","url":null,"abstract":"<div><div>Most offspring are born helpless, requiring intense caregiving from parents especially during the first few days of neonatal life. For many species, infant cries are a primary signal used by parents to provide caregiving. Previously we and others documented how maternal left auditory cortex rapidly becomes sensitized to pup calls over hours of parental experience, enabled by oxytocin. The speed and robustness of this maternal plasticity suggests cortical pre-tuning or initial bias for pup call stimulus features. Here we examine the circuit basis of left-lateralized tuning to vocalization features with whole-cell recordings in brain slices. We found that layer 2/3 pyramidal cells of female left auditory cortex show selective suppression of inhibitory inputs with repeated stimulation at the fundamental pup call rate (inter-stimulus interval ∼150 msec) in pup-naïve females and expanded with maternal experience. However, optogenetic stimulation of cortical inhibitory cells showed that inputs from somatostatin-positive and oxytocin-receptor-expressing interneurons were less suppressed at these rates. This suggested that disynaptic inhibition rather than monosynaptic depression was a major mechanism underlying pre-tuning of cortical excitatory neurons, confirmed with simulations. Thus cortical interneuron specializations can augment neuroplasticity mechanisms to ensure fast appropriate caregiving in response to infant cries.</div></div>","PeriodicalId":19146,"journal":{"name":"Neuroscience Research","volume":"216 ","pages":"Article 104897"},"PeriodicalIF":2.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0