代谢综合征和2型糖尿病鼠模型周围神经的炎症和自噬。

IF 2.3 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2025-04-17 DOI:10.1016/j.neures.2025.04.002

Petra Baum , Thomas Ebert , Nora Klöting , Sontje Krupka , Matthias König , Sabine Paeschke , Peggy Stock , Michal Bulc , Matthias Blüher , Katarzyna Palus , Marcin Nowicki , Joanna Kosacka

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引用次数: 0

摘要

代谢综合征（MetS）和2型糖尿病（T2D）与周围神经的炎症和巨噬细胞积聚有关，这增加了发生周围神经病变（PN）的风险。我们之前研究了T2D动物（瘦素缺乏的ob/ob小鼠，瘦素受体缺乏的db/db）周围神经中的巨噬细胞浸润与PN相关，而met动物（Wistar Ottawa Karlsburg W (RT1u) WOKW大鼠）的这一过程不会导致神经性改变。本研究提供的其他数据表明，抗炎标志物IL-10 mRNA表达增加与自噬预防神经病变之间存在关联。

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Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus

Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.