Quantitative analysis of the interaction between NMDA and AMPA receptors in glutamatergic synapses based on mathematical model.

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Qingchen Guo
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引用次数: 0

Abstract

NMDA and AMPA receptors are co-localized at most glutamatergic synapses, where their numbers and distribution undergo dynamic changes. Glutamate binds to both the NMDA and AMPA receptors. Initially, I investigated whether there is competition between AMPA receptors and N-methyl-D-aspartic acid (NMDA) receptors for glutamate. Subsequently, I examined how these dynamic receptor changes affect synaptic response. To test the hypothesis, a synaptic model incorporating coexisting NMDA and AMPA receptors within the postsynaptic density (PSD) was developed. During long-term potentiation (LTP) induction, the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the PSD increase. If there is competition for glutamate between AMPA receptors and NMDA receptors, the number of activated NMDA receptor channels will decrease. Since LTP induction relies on the activation of NMDA receptors, reducing their activation will raise the threshold for LTP induction. Consequently, the LTP of the synapse itself can establish negative feedback, preventing excessive dynamics and maintaining the stability of the neural network.

基于数学模型的谷氨酸能突触中 NMDA 和 AMPA 受体相互作用的定量分析。
NMDA 和 AMPA 受体共同定位在大多数谷氨酸能突触上,它们的数量和分布会发生动态变化。谷氨酸同时与 NMDA 和 AMPA 受体结合。最初,我研究了 AMPA 受体和 N-甲基-D-天冬氨酸(NMDA)受体之间是否存在对谷氨酸的竞争。随后,我研究了这些受体的动态变化如何影响突触反应。为了验证这一假设,我建立了一个突触模型,其中包含突触后密度(PSD)中共存的 NMDA 和 AMPA 受体。在长期电位诱导(LTP)过程中,突触后密度中的α-氨基-3-羟基-5-甲基-4-异恶唑丙酸(AMPA)受体会增加。如果 AMPA 受体和 NMDA 受体之间存在对谷氨酸的竞争,激活的 NMDA 受体通道数量就会减少。由于 LTP 的诱导依赖于 NMDA 受体的激活,减少其激活将提高 LTP 诱导的阈值。因此,突触本身的 LTP 可以建立负反馈,防止过度的动态变化,维持神经网络的稳定。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Neuroscience Research
Neuroscience Research 医学-神经科学
CiteScore
5.60
自引率
3.40%
发文量
136
审稿时长
28 days
期刊介绍: The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.
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