腹侧被盖区淀粉样蛋白/降钙素受体信号传导可抑制雌性大鼠的摄食和体重增加。

IF 2.4 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2024-10-09 DOI:10.1016/j.neures.2024.10.001

Tyler J Gustafson, Lauren E McGrath, Matthew R Hayes, Elizabeth G Mietlicki-Baase

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引用次数: 0

摘要

胰腺肽淀粉样蛋白促进能量负平衡的部分原因是通过激活腹侧被盖区（VTA）表达的淀粉样蛋白受体（AmyRs），但相关研究仅限于雄性啮齿动物。我们评估了腹侧被盖区淀粉样蛋白信号是否会影响雌性大鼠的摄食和体重。事实上，药物激活VTA淀粉酶抑制了雌鼠的进食量和体重。病毒介导的 VTA 降钙素受体（AmyR 的 GPCR）敲除支持了 VTA 淀粉素信号在雌鼠能量平衡控制中的生理相关性。总之，这些数据支持VTA淀粉样蛋白信号与两性能量平衡控制的相关性。

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Ventral tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats.

The pancreatic peptide amylin promotes negative energy balance in part through activation of amylin receptors (AmyRs) expressed in the ventral tegmental area (VTA), but studies have been limited to male rodents. We evaluated whether VTA amylin signaling governs feeding and body weight in female rats. Indeed, pharmacological VTA AmyR activation suppressed chow intake and body weight in females. Viral-mediated knockdown of VTA calcitonin receptor (GPCR of AmyR) supports the physiological relevance of VTA amylin signaling for energy balance control in females. Collectively, these data support the relevance of VTA amylin signaling for energy balance control in both sexes.

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.