Whole-brain long-range connectivity of glutamatergic, GABAergic, parvalbumin-expressing and somatostatin-expressing neurons in mouse somatosensory cortex

IF 2.4 4区医学 Q3 NEUROSCIENCES

Neuroscience Research Pub Date : 2025-05-26 DOI:10.1016/j.neures.2025.104912

Zhaoxin Zhu , Tao Jiang , Xueyan Jia , Xiaojun Wang , Miao Ren

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Abstract

Understanding the composition of cortical circuits at the whole-brain scale is crucial. However, the specific ways in which particular neuronal types in the primary somatosensory cortex (SSp) establish connections with upstream and downstream brain regions remain unclear. In this study, we used whole-brain imaging technology with submicron resolution to systematically reveal the long-range connectivity patterns of glutamatergic, GABAergic, parvalbumin-expressing (PV+), and somatostatin-expressing (SOM+) neurons in the SSp. Our results show that while glutamatergic, GABAergic, PV+ , and SOM+ neurons receive similar upstream afferent, specific thalamic subregions showed numerically stronger afferent to GABAergic, PV+ , and SOM+ neurons compared to glutamatergic neurons. Additionally, glutamatergic neurons exhibit a more complex collateral projection pattern in subcortical axonal pathways compared to PV+ neurons. These findings elucidate the long-range connectivity patterns of specific neuronal types in the SSp, offering new insights into the cell-type-specific mechanisms of sensory information processing.

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小鼠体感觉皮层谷氨酸能、gaba能、小蛋白表达和生长抑素表达神经元的全脑远程连通性

在全脑范围内了解皮层回路的组成是至关重要的。然而，初级体感觉皮层（SSp）中特定神经元类型与大脑上游和下游区域建立联系的具体方式尚不清楚。在这项研究中，我们使用亚微米分辨率的全脑成像技术系统地揭示了SSp中谷氨酸能、gaba能、小蛋白表达（PV+）和生长抑素表达（SOM+）神经元的远程连接模式。我们的研究结果表明，虽然谷氨酸能、GABAergic、PV+ 和SOM+ 神经元接受类似的上游传入信号，但与谷氨酸能神经元相比，特定的丘脑亚区对GABAergic、PV+ 和SOM+ 神经元的传入信号在数值上更强。此外，与PV+ 神经元相比，谷氨酸能神经元在皮层下轴突通路中表现出更复杂的侧支投射模式。这些发现阐明了SSp中特定神经元类型的远程连接模式，为了解感觉信息处理的细胞类型特异性机制提供了新的见解。

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来源期刊

Neuroscience Research 医学-神经科学

CiteScore

5.60

自引率

3.40%

发文量

136

审稿时长

28 days

期刊介绍： The international journal publishing original full-length research articles, short communications, technical notes, and reviews on all aspects of neuroscience Neuroscience Research is an international journal for high quality articles in all branches of neuroscience, from the molecular to the behavioral levels. The journal is published in collaboration with the Japan Neuroscience Society and is open to all contributors in the world.