Endogenously generated patterns of neural activity sculpt axon connectivity.

Abstract

Neural activity is crucial in establishing functional circuit connectivity in the central nervous system. Prior to the onset of sensory experience, sensory organs spontaneously generate patterned neural activity, which is essential for sculpting and refining immature circuit connectivity coordinating functional and physiological responses to the external world in advance. How these endogenous patterns of neural activity drive circuit refinement is a major long-standing question; however, it has been impeded, at least partly, by technical difficulties in visualizing circuit refinement and patterned spontaneous activity in living animals. In this review, I discuss recent progress in visualizing circuit refinement processes and patterned spontaneous activity at the single-axon level in the mammalian visual system and consider how endogenous patterns of spontaneous activity drive fine-scale axon refinement during development.