Neurobiology of Learning and Memory最新文献_第5页

Aversive social learning with a dead conspecific is achieved by Pavlovian conditioning in crickets 蟋蟀通过巴甫洛夫条件反射实现了与死亡同类的厌恶社会学习。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-01-01 DOI: 10.1016/j.nlm.2024.108019

Kohei Hashimoto , Kanta Terao , Makoto Mizunami

{"title":"Aversive social learning with a dead conspecific is achieved by Pavlovian conditioning in crickets","authors":"Kohei Hashimoto , Kanta Terao , Makoto Mizunami","doi":"10.1016/j.nlm.2024.108019","DOIUrl":"10.1016/j.nlm.2024.108019","url":null,"abstract":"<div><div>Social learning, learning from other individuals, has been demonstrated in many animals, including insects, but its detailed neural mechanisms remain virtually unknown. We showed that crickets (<em>Gryllus bimaculatus</em>) exhibit aversive social learning with a dead conspecific. When a learner cricket was trained to observe a dead cricket on a drinking apparatus, the learner avoided the odor of that apparatus thereafter. Here we investigated the hypothesis that this social learning is achieved by first-order Pavlovian conditioning of an odor (conditioned stimulus) and a dead conspecific (unconditioned stimulus, US). Injection of a dopamine receptor antagonist (flupentixol) before training or testing impaired the learning or execution of the response to the learned odor, as we reported in aversive non-social Pavlovian conditioning in crickets. Moreover, crickets that were trained with a dead conspecific and then received revaluation of the dead conspecific by pairing it with water reward exhibited an appetitive conditioned response (CR) to the odor paired with the dead conspecific. This suggests that execution of the CR is governed by the current value of the US as in non-social Pavlovian conditioning. In addition, we previously suggested that appetitive social learning with a living conspecific is based on second-order conditioning (SOC), and here we showed that SOC is achieved when crickets experienced pairing of a dead conspecific with water reward before experiencing social learning training with a dead conspecific. We conclude that social learning with a dead conspecific is based on Pavlovian conditioning and that this learning can be extended to second-order social learning.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"217 ","pages":"Article 108019"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task 内侧前额叶皮层到团圆核回路对操作性延迟非匹配位置任务的表现至关重要。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-11-23 DOI: 10.1016/j.nlm.2024.108007

Evan J. Ciacciarelli , Scott D. Dunn , Taqdees Gohar , T. Joseph Sloand , Mark Niedringhaus , Elizabeth A. West

{"title":"Medial prefrontal cortex to nucleus reuniens circuit is critical for performance in an operant delayed nonmatch to position task","authors":"Evan J. Ciacciarelli , Scott D. Dunn , Taqdees Gohar , T. Joseph Sloand , Mark Niedringhaus , Elizabeth A. West","doi":"10.1016/j.nlm.2024.108007","DOIUrl":"10.1016/j.nlm.2024.108007","url":null,"abstract":"<div><div>Working memory refers to the temporary retention of a small amount of information used in the execution of a cognitive task. The prefrontal cortex and its connections with thalamic subregions are thought to mediate specific aspects of working memory, including engaging with the hippocampus to mediate memory retrieval. We used an operant delayed-non match to position task, which does not require the hippocampus, to determine roles of the rodent medial prefrontal cortex (mPFC), the nucleus reuniens thalamic region (RE), and their connection. We found that transient inactivation of the mPFC and RE using the GABA-A agonist muscimol led to a delay-independent reduction in behavioral performance in the delayed non-match to position paradigm. We used a chemogenetic approach to determine the directionality of the necessary circuitry for behavioral performance reliant on working memory. Specifically, when we targeted mPFC neurons that project to the RE (mPFC-RE) we found a delay-independent reduction in the delayed non-match to position task, but not when we targeted RE neurons that project to the mPFC (RE-mPFC). Our results suggest a broader role for the mPFC-RE circuit in mediating working memory beyond the connection with the hippocampus.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"217 ","pages":"Article 108007"},"PeriodicalIF":2.2,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How predictability and individual alpha frequency shape memory: Insights from an event-related potential investigation 可预测性和个体阿尔法频率如何形成记忆：事件相关电位调查的启示

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-11-19 DOI: 10.1016/j.nlm.2024.108006

Sophie Jano , Alex Chatburn , Zachariah R. Cross , Matthias Schlesewsky , Ina Bornkessel-Schlesewsky

{"title":"How predictability and individual alpha frequency shape memory: Insights from an event-related potential investigation","authors":"Sophie Jano , Alex Chatburn , Zachariah R. Cross , Matthias Schlesewsky , Ina Bornkessel-Schlesewsky","doi":"10.1016/j.nlm.2024.108006","DOIUrl":"10.1016/j.nlm.2024.108006","url":null,"abstract":"<div><div>Prediction and memory are strongly intertwined, with predictions relying on memory retrieval, whilst also influencing memory encoding. However, it is unclear how predictability influences explicit memory performance, and how individual neural factors may modulate this relationship. The current study sought to investigate the effect of predictability on memory processing with an analysis of the N400 event-related potential in a context extending beyond language. Participants (<em>N</em> = 48, females = 33) completed a study-test paradigm where they first viewed predictable and unpredictable four-item ‘ABCD’ sequences of outdoor scene images, whilst their brain activity was recorded using electroencephalography. Subsequently, their memory for the images was tested, and N400 patterns during learning were compared with memory outcomes. Behavioural results revealed better memory for images in predictable sequences in contrast to unpredictable sequences. Memory was also strongest for predictable images in the ‘B’ position, suggesting that when processing longer sequences, the brain may prioritise the data deemed most informative. Strikingly, greater N400 amplitudes during learning were associated with enhanced memory at test for individuals with low versus high individual alpha frequencies. In light of the relationship between the N400 and stimulus predictability, this finding may imply that predictive processing differs between individuals to influence the extent of memory encoding. Finally, exploratory analyses provided evidence for a later positivity that was predictive of subsequent memory performance. Ultimately, the results highlight the complex and interconnected relationship between predictive processing and memory, whilst shedding light on the accumulation of predictions across longer sequences.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"216 ","pages":"Article 108006"},"PeriodicalIF":2.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The retrosplenial cortical role in delayed spatial alternation 后脾皮层在延迟空间交替中的作用

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-11-13 DOI: 10.1016/j.nlm.2024.108005

Dev Laxman Subramanian, Adam M.P. Miller, David M. Smith

{"title":"The retrosplenial cortical role in delayed spatial alternation","authors":"Dev Laxman Subramanian, Adam M.P. Miller, David M. Smith","doi":"10.1016/j.nlm.2024.108005","DOIUrl":"10.1016/j.nlm.2024.108005","url":null,"abstract":"<div><div>The retrosplenial cortex (RSC) plays an important role in spatial cognition. RSC neurons exhibit a variety of spatial firing patterns and lesion studies have found that the RSC is necessary for spatial working memory tasks. However, little is known about how RSC neurons might encode spatial memory during a delay period. In the present study, we trained control rats and rats with excitotoxic lesions of the RSC on spatial alternation task with varying delay durations and in a separate group of rats, we recorded RSC neuronal activity as the rats performed the alternation task. We found that RSC lesions significantly impaired alternation performance, particularly at the longest delay duration. We also found that RSC neurons exhibited reliably different firing patterns throughout the delay periods preceding left and right trials, consistent with a working memory signal. These differential firing patterns were absent during the delay periods preceding errors. We also found that many RSC neurons exhibit a large spike in firing rate leading up to the start of the trial. Many of these trial start responses also differentiated left and right trials, suggesting that they could play a role in priming the ‘go left’ or ‘go right’ behavioral responses. Our results suggest that these firing patterns represent critical memory information that underlies the RSC role in spatial working memory.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"216 ","pages":"Article 108005"},"PeriodicalIF":2.2,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142624624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attentional processing in the rat dorsal posterior parietal cortex 大鼠背侧后顶叶皮层的注意加工。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-10-31 DOI: 10.1016/j.nlm.2024.108004

Victoria R. Heimer-McGinn , Taylor B. Wise , Emma R. Halter , Dominique Martin , Victoria L. Templer

{"title":"Attentional processing in the rat dorsal posterior parietal cortex","authors":"Victoria R. Heimer-McGinn , Taylor B. Wise , Emma R. Halter , Dominique Martin , Victoria L. Templer","doi":"10.1016/j.nlm.2024.108004","DOIUrl":"10.1016/j.nlm.2024.108004","url":null,"abstract":"<div><div>The human posterior parietal cortex (PPC) is known to support sustained attention. Specifically, top-down attention is generally processed in dorsal regions while bottom-up regulation occurs more ventrally. In rodent models, however, it is still unclear whether the PPC is required for sustained attention, or whether there is a similar functional dissociation between anatomical regions. Consequently, the aim of this study was to investigate the contribution of the rodent dorsal PPC (dPPC) in sustained attention. We used the five-choice serial reaction time task (5CSRTT) and compared rats with neurotoxic dPPC lesions to sham operated rats. We found that rats with dPPC lesions were less accurate and took longer to make correct choices, indicating impaired attention and reduced processing speed. This effect, however, was limited to the first few days of post-operative testing. After an apparent recovery, omissions became elevated in the lesion group, which, in the absence of reduced motivation and mobility, can also be interpreted as impaired attention. In subsequent challenge probes, the lesion group displayed globally elevated latency to make a correct response, indicating reduced processing speed. No differences in premature responses or perseverative responses were observed at any time, demonstrating that dPPC lesions did not affect impulsivity and compulsivity. This pattern of behavior suggests that while intact dPPC supports goal-driven (top-down) modulation of attention, it likely does not play a central role in processing stimulus-driven (bottom-up) attention. Furthermore, compensatory mechanisms can support sustained attention in the absence of a fully functioning dPPC, although this occurs at the expense of processing speed. Our results inform the literature by confirming that rodent PPC is involved in regulating sustained attention and providing preliminary evidence for a functional dissociation between top-down and bottom-up attentional processing.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"216 ","pages":"Article 108004"},"PeriodicalIF":2.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-10-30 DOI: 10.1016/j.nlm.2024.108003

Yvonne Y. Chen , Kathryn J.M. Lambert , Christopher R. Madan , Anthony Singhal

{"title":"Motor-related oscillations reveal the involvement of sensorimotor processes during recognition memory","authors":"Yvonne Y. Chen , Kathryn J.M. Lambert , Christopher R. Madan , Anthony Singhal","doi":"10.1016/j.nlm.2024.108003","DOIUrl":"10.1016/j.nlm.2024.108003","url":null,"abstract":"<div><div>Certain object properties may render an item as more memorable than others. One such property is manipulability, or the extent to which an object can be interacted with using our hands. This study sought to determine if the manipulability of an item modulates memory task performance on both a behavioural and neural level. We recorded electroencephalography (EEG) from a large sample of right-handed individuals (N = 53) during a visual item recognition memory task. The task contained stimuli of both high and low manipulability. Analysis focused on activity in the theta rhythm (3.5–7 Hz), which has been implicated in sensorimotor integration, and the mu rhythm (8–14 Hz), the primary oscillation associated with sensorimotor related behaviours. At both encoding and retrieval, theta oscillations were greater over the left motor region for high manipulability stimuli, suggesting that an item’s sensorimotor properties are assessed immediately upon presentation. Manipulability did not affect activity in the mu rhythm. However, mu oscillations over the left motor region were lower during the retrieval of old versus new items and response time was faster for old items, aligning with the cortical reinstatement hypothesis. These results collectively reveal an association between motor oscillations and memory processes, highlight the involvement of sensorimotor processing at both encoding and retrieval.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"216 ","pages":"Article 108003"},"PeriodicalIF":2.2,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern separation during encoding and Subsequent Memory Effect 编码过程中的图案分离与后续记忆效应

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-10-20 DOI: 10.1016/j.nlm.2024.107995

Laura García-Rueda , Claudia Poch , Pablo Campo

{"title":"Pattern separation during encoding and Subsequent Memory Effect","authors":"Laura García-Rueda , Claudia Poch , Pablo Campo","doi":"10.1016/j.nlm.2024.107995","DOIUrl":"10.1016/j.nlm.2024.107995","url":null,"abstract":"<div><div>Memory retrieval has been extensively studied in relation to the encoding processes that precede access to stored information. Event related potentials (ERP) research has compared brain potentials elicited during the study phase of successful and unsuccessful retrieval, finding greater activation for the subsequent retrieval information. In this work we were interested in exploring the neural markers associated to subsequent recognition when similar memories are subsequently encoded. We used a Subsequent Memory paradigm in which we manipulated the number of similar items within a category (2 or 6) that participants encoded. Manipulating the number of similar encoded items within a category allowed us to test whether encoding markers of subsequent recognition depend solely on memory trace strength or, on the contrary, successful recognition is influenced by subsequently presented similar memories, and consequently may not be reflected in higher activation in such cases. After a 20-minute period, participants performed a recognition task providing one of a three-option judgement: “old”, “similar” and “new”, which allowed us to test if the amplitude of ERP waveforms varied based on the similarity judgement of the unrecognized encoded item. We did not observe a significant parietal subsequent memory effect, however, old hits and similar false alarms were both significantly different from similar correct rejections and old false alarms in ERP retrieval. These findings suggest that differences in brain responses between conditions are specifically related to the retrieval process and not the encoding process, indicating potential differential effects on memory during retrieval. Moreover, it is also possible that differences in brain responses develop or change over the rest time between phases, influencing how these conditions manifest across different stages of information processing.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"216 ","pages":"Article 107995"},"PeriodicalIF":2.2,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Out with the bad, in with the good: A review on augmented extinction learning in humans 去其糟粕，取其精华：人类增强灭绝学习回顾。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-10-18 DOI: 10.1016/j.nlm.2024.107994

Elizabeth A. Bauer , Patrick A.F. Laing , Samuel E. Cooper , Josh M. Cisler , Joseph E. Dunsmoor

引用次数: 0

Clustering of synaptic engram: Functional and structural basis of memory 突触印记的聚类：记忆的功能和结构基础

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-10-16 DOI: 10.1016/j.nlm.2024.107993

Chaery Lee , Bong-Kiun Kaang

引用次数: 0

Activation, but not inactivation, of the medial or lateral orbitofrontal cortex impaired context-specific fear encoding 激活内侧或外侧眶额皮层会损害特定情境下的恐惧编码，而非失活。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-10-15 DOI: 10.1016/j.nlm.2024.107991

Yu-Rui Liu , Chun-hui Chang

{"title":"Activation, but not inactivation, of the medial or lateral orbitofrontal cortex impaired context-specific fear encoding","authors":"Yu-Rui Liu , Chun-hui Chang","doi":"10.1016/j.nlm.2024.107991","DOIUrl":"10.1016/j.nlm.2024.107991","url":null,"abstract":"<div><div>In laboratories, classical fear conditioning and extinction procedures are commonly used to study the behavioral and neural mechanisms underlying fear regulation. Contextual fear conditioning involves the association of an aversive event with the environment where it occurs, which engages the hippocampus and its interactions with the amygdala. The orbitofrontal cortex (OFC), divided into the lateral OFC (lOFC) and medial OFC (mOFC) subregions, plays a crucial role in integrating contextual information from the hippocampus and modulating behavioral responses based on the anticipated outcomes of the context. Because of the extensive anatomical connections of the OFC with the fear circuit, including the hippocampus, the amygdala, and the medial prefrontal cortex, and the reasoning that proper retrieval of fear-related memory is context-dependent, we raised the question to investigate the ability of the animals to discriminate between contexts when they were trained under differential OFC activation levels during the encoding of contextual fear memory. In this study, we conducted a contextual fear conditioning procedure in rats using footshock as an unconditioned stimulus (US), followed by the test of their fear levels in contexts same (dangerous) or different (safe) from the conditioning context. We used a pharmacological approach to modulate the activation levels of the lOFC or the mOFC during conditioning to examine their roles on context-specific fear encoding. Our findings showed that the animals could accurately distinguish between the two contexts in control and OFC hypoactivation groups, but failed to do so if they were trained under OFC hyperactivation. Therefore, OFC hyperactivity disturbed the encoding of contextual information during fear acquisition.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"215 ","pages":"Article 107991"},"PeriodicalIF":2.2,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0