Neurobiology of Learning and Memory最新文献_第4页

Optogenetic stimulation of medial septal glutamatergic neurons modulates theta-gamma coupling in the hippocampus 光遗传刺激内侧隔谷氨酸能神经元可调节海马的θ-γ耦合

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-05-01 DOI: 10.1016/j.nlm.2024.107929

Elena Dmitrieva, Anton Malkov

{"title":"Optogenetic stimulation of medial septal glutamatergic neurons modulates theta-gamma coupling in the hippocampus","authors":"Elena Dmitrieva, Anton Malkov","doi":"10.1016/j.nlm.2024.107929","DOIUrl":"https://doi.org/10.1016/j.nlm.2024.107929","url":null,"abstract":"<div><p>Hippocampal cross-frequency theta-gamma coupling (TGC) is a basic mechanism for information processing, retrieval, and consolidation of long-term and working memory. While the role of entorhinal afferents in the modulation of hippocampal TGC is widely accepted, the influence of other main input to the hippocampus, from the medial septal area (MSA, the pacemaker of the hippocampal theta rhythm) is poorly understood. Optogenetics allows us to explore how different neuronal populations of septohippocampal circuits control neuronal oscillations in vivo. Rhythmic activation of septal glutamatergic neurons has been shown to drive hippocampal theta oscillations, but the role of these neuronal populations in information processing during theta activation has remained unclear. Here we investigated the influence of phasic activation of MSA glutamatergic neurons expressing channelrhodopsin II on theta-gamma coupling in the hippocampus. During the experiment, local field potentials of MSA and hippocampus of freely behaving mice were modulated by 470 nm light flashes with theta frequency (2–10) Hz. It was shown that both the power and the strength of modulation of gamma rhythm nested on hippocampal theta waves depend on the frequency of stimulation. The modulation of the amplitude of slow gamma rhythm (30–50 Hz) prevailed over modulation of fast gamma (55–100 Hz) during flash trains and the observed effects were specific for theta stimulation of MSA. We discuss the possibility that phasic depolarization of septal glutamatergic neurons controls theta-gamma coupling in the hippocampus and plays a role in memory retrieval and consolidation.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consolidation of emotional memory during waking rest depends on trait anxiety 清醒休息时情绪记忆的巩固取决于特质焦虑

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-05-01 DOI: 10.1016/j.nlm.2024.107940

Lauren Hudachek, E. Wamsley

引用次数: 0

Effect of positive social comparative feedback on the resting state connectivity of dopaminergic neural pathways: A preliminary investigation 社会比较正反馈对多巴胺能神经通路静息状态连通性的影响：初步调查

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-04-30 DOI: 10.1016/j.nlm.2024.107930

Allison F. Lewis , Rachel Bohnenkamp , Makenzie Myers , Dirk B. den Ouden , Stacy L. Fritz , Jill Campbell Stewart

{"title":"Effect of positive social comparative feedback on the resting state connectivity of dopaminergic neural pathways: A preliminary investigation","authors":"Allison F. Lewis , Rachel Bohnenkamp , Makenzie Myers , Dirk B. den Ouden , Stacy L. Fritz , Jill Campbell Stewart","doi":"10.1016/j.nlm.2024.107930","DOIUrl":"10.1016/j.nlm.2024.107930","url":null,"abstract":"<div><p>Positive social comparative feedback is hypothesized to generate a dopamine response in the brain, similar to reward, by enhancing expectancies to support motor skill learning. However, no studies have utilized neuroimaging to examine this hypothesized dopaminergic mechanism. Therefore, the aim of this preliminary study was to investigate the effect of positive social comparative feedback on dopaminergic neural pathways measured by resting state connectivity. Thirty individuals practiced an implicit, motor sequence learning task and were assigned to groups that differed in feedback type. One group received feedback about their actual response time to complete the task (RT ONLY), while the other group received feedback about their response time with positive social comparison (RT + POS). Magnetic resonance imaging was acquired at the beginning and end of repetitive motor practice with feedback to measure practice-dependent changes in resting state brain connectivity. While both groups showed improvements in task performance and increases in performance expectancies, ventral tegmental area and the left nucleus accumbens (mesolimbic dopamine pathway) resting state connectivity increased in the RT + POS group but not in the RT ONLY group. Instead, the RT ONLY group showed increased connectivity between ventral tegmental area and primary motor cortex. Positive social comparative feedback during practice of a motor sequence task may induce a dopaminergic response in the brain along the mesolimbic pathway. However, given that absence of effects on expectancies and motor learning, more robust and individualized approaches may be needed to provide beneficial psychological and behavioral effects.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No evidence that arousal affects reactivated memories 没有证据表明唤醒会影响重新激活的记忆

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-04-13 DOI: 10.1016/j.nlm.2024.107928

Olivier T. de Vries , Sascha B. Duken , Merel Kindt , Vanessa A. van Ast

{"title":"No evidence that arousal affects reactivated memories","authors":"Olivier T. de Vries , Sascha B. Duken , Merel Kindt , Vanessa A. van Ast","doi":"10.1016/j.nlm.2024.107928","DOIUrl":"10.1016/j.nlm.2024.107928","url":null,"abstract":"<div><p>Memory for inherently neutral elements of emotional events is often enhanced on delayed tests - an effect that has been attributed to noradrenergic arousal. Reactivation of a memory is thought to return its corresponding neural ensemble to a state that is similar to when it was originally experienced. Therefore, we hypothesized that neutral elements of memories, too, can be enhanced through reactivation concurrent with heightened arousal. Participants (n = 94) visited the lab for three sessions. During the first session, they encoded 120 neutral memories consisting of an object presented in unique context images. In session two, the 80 objects were reactivated by presenting their corresponding context images, 40 of which were immediately followed by an arousal-inducing shock. Finally, recognition memory for all objects was tested. It was found that memory for reactivated objects was enhanced, but even though the shocks elicited elevations in arousal as indexed by skin conductance, there was no difference between memory of objects reactivated with and without heightened arousal. We thus conclude that arousal, when isolated from other cognitive and affective variables that might impact memory, has no enhancing effect on reactivated memories.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S107474272400039X/pdfft?md5=cfa1f4bcb9f0e2aac6643fcc214c7c63&pid=1-s2.0-S107474272400039X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central amygdala contributes to stimulus facilitation and pre-stimulus vigilance during cerebellar learning 杏仁核中枢有助于小脑学习过程中的刺激促进和刺激前警觉

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-04-04 DOI: 10.1016/j.nlm.2024.107925

Sean J. Farley, John H. Freeman

{"title":"Central amygdala contributes to stimulus facilitation and pre-stimulus vigilance during cerebellar learning","authors":"Sean J. Farley, John H. Freeman","doi":"10.1016/j.nlm.2024.107925","DOIUrl":"https://doi.org/10.1016/j.nlm.2024.107925","url":null,"abstract":"<div><p>Our previous studies found that the central amygdala (CeA) modulates cerebellum-dependent eyeblink conditioning (EBC) using muscimol inactivation. We also found that CeA inactivation decreases cerebellar neuronal activity during the conditional stimulus (CS) from the start of training. Based on these findings, we hypothesized that the CeA facilitates CS input to the cerebellum. The current study tested the CS facilitation hypothesis using optogenetic inhibition with archaerhodopsin (Arch) and excitation with channelrhodopsin (ChR2) of the CeA during EBC in male rats. Optogenetic manipulations were administered during the 400 ms tone CS or during a 400 ms pre-CS period. As predicted by the CS facilitation hypothesis CeA inhibition during the CS impaired EBC and CeA excitation during the CS facilitated EBC. Unexpectedly, CeA inhibition just prior to the CS also impaired EBC, while CeA excitation during the pre-CS pathway did not facilitate EBC. The results suggest that the CeA contributes to CS facilitation and vigilance during the pre-CS period. These putative functions of the CeA may be mediated through separate output pathways from the CeA to the cerebellum.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140540616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perceived stress and renewal: The effects of long-term stress on the renewal effect 感知压力与更新：长期压力对更新效应的影响

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-04-04 DOI: 10.1016/j.nlm.2024.107927

Borja Nevado, James Byron Nelson

{"title":"Perceived stress and renewal: The effects of long-term stress on the renewal effect","authors":"Borja Nevado, James Byron Nelson","doi":"10.1016/j.nlm.2024.107927","DOIUrl":"https://doi.org/10.1016/j.nlm.2024.107927","url":null,"abstract":"<div><p>Two online experiments evaluated the relationship between long-term stress, as measured with the Perceived Stress Scale-10, and the Renewal Effect. In the first experiment renewal was assessed with a behavioral suppression task in a science-fiction based video game. Participants learned to suppress mouse clicking during a signal for an upcoming attack to avoid losing points. The signal was first paired with an attack in Context A and extinguished in Context B and tested back in Context A. The contexts were different space galaxies where the gameplay took place. Experiment 2 used a food/illness predictive-learning paradigm. Two food items were paired with stomachache in one restaurant (A) and extinguished in Context B prior to testing in both contexts without feedback. Positive correlations were obtained between renewal and stress in each experiment. Unlike acute stress (<span>Drexler et al., 2017</span>), long term stress was associated with greater renewal. The effects of stress, both chronic and punctual, on renewal are discussed.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000388/pdfft?md5=061ca2c85d95aca14e04601fd544546e&pid=1-s2.0-S1074742724000388-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140548549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infralimbic cortex plays a similar role in the punishment and extinction of instrumental behavior 下边缘皮层在工具行为的惩罚和消退过程中也起着类似的作用

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-04-04 DOI: 10.1016/j.nlm.2024.107926

Matthew C. Broomer, Mark E. Bouton

{"title":"Infralimbic cortex plays a similar role in the punishment and extinction of instrumental behavior","authors":"Matthew C. Broomer, Mark E. Bouton","doi":"10.1016/j.nlm.2024.107926","DOIUrl":"https://doi.org/10.1016/j.nlm.2024.107926","url":null,"abstract":"<div><p>Learning to stop responding is a fundamental process in instrumental learning. Animals may learn to stop responding under a variety of conditions that include punishment—where the response earns an aversive stimulus in addition to a reinforcer—and extinction—where a reinforced response now earns nothing at all. Recent research suggests that punishment and extinction may be related manifestations of a common retroactive interference process. In both paradigms, animals learn to stop performing a specific response in a specific context, suggesting direct inhibition of the response by the context. This process may depend on the infralimbic cortex (IL), which has been implicated in a variety of interference-based learning paradigms including extinction and habit learning. Despite the behavioral parallels between extinction and punishment, a corresponding role for IL in punishment has not been identified. Here we report that, in a simple arrangement where either punishment or extinction was conducted in a context that differed from the context in which the behavior was first acquired, IL inactivation reduced response suppression in the inhibitory context, but not responding when it “renewed” in the original context. In a more complex arrangement in which two responses were first trained in different contexts and then extinguished or punished in the opposite one, IL inactivation had no effect. The results advance our understanding of the effects of IL in retroactive interference and the behavioral mechanisms that can produce suppression of a response.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140350027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian reinforcement learning: A basic overview 贝叶斯强化学习：基本概述

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-04-03 DOI: 10.1016/j.nlm.2024.107924

Pyungwon Kang , Philippe N. Tobler , Peter Dayan

引用次数: 0

Impaired free recall of neutral but not negative material tested 105 min after cortisol administration 给药皮质醇 105 分钟后，对中性而非阴性材料的自由回忆能力受损。

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-03-28 DOI: 10.1016/j.nlm.2024.107916

Daniela Barros Rodrigues , Despina Antypa , Ulrike Rimmele

{"title":"Impaired free recall of neutral but not negative material tested 105 min after cortisol administration","authors":"Daniela Barros Rodrigues , Despina Antypa , Ulrike Rimmele","doi":"10.1016/j.nlm.2024.107916","DOIUrl":"10.1016/j.nlm.2024.107916","url":null,"abstract":"<div><p>Pharmacological studies have consistently shown memory retrieval impairment after administration of cortisol, particularly pronounced for emotional laboratory material (i.e. list of emotional words). However, it is unclear how pharmacological elevation of cortisol affects memory retrieval of ecologically-relevant emotional material (i.e. similar to a newspaper article about an emotional event). In the present study, we aimed to explore whether cortisol administration affects the recall of ecologically-relevant emotional and neutral material, and when memory retrieval occurs after a longer delay (105 min). In this double-blind, pseudo-randomized, placebo-control study, 79 participants learned a negative text and a neutral text. Twenty-four hours later, they were administrated either 10 mg of hydrocortisone or placebo. After 105 min, participants engaged in free recall of both texts. The group with cortisol administration showed significantly reduced free recall compared to the placebo group. Interestingly, this memory retrieval impairment was driven by significantly lower recall after cortisol vs. placebo administration for neutral texts, but not negative texts. The current finding suggests that cortisol administration impairs neutral ecologically-relevant material while leaving emotional material unaffected. These divergent findings, compared to existing literature, emphasize the necessity of employing more ecologically validated material to gain a more comprehensive understanding of the intricate interplay between cortisol administration and memory for ecological material.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000273/pdfft?md5=3fa22e9bcb1054d41a7f51da2ea16850&pid=1-s2.0-S1074742724000273-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140329998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in the effectiveness of reinforcement and nonreinforcement in generating different conditioned behaviors 强化和非强化在产生不同条件行为时的效果差异

IF 2.7 4区心理学

Neurobiology of Learning and Memory Pub Date : 2024-03-23 DOI: 10.1016/j.nlm.2024.107915

Victor Navarro, Dominic M. Dwyer, Robert C. Honey

{"title":"Variation in the effectiveness of reinforcement and nonreinforcement in generating different conditioned behaviors","authors":"Victor Navarro, Dominic M. Dwyer, Robert C. Honey","doi":"10.1016/j.nlm.2024.107915","DOIUrl":"10.1016/j.nlm.2024.107915","url":null,"abstract":"<div><p>Rat autoshaping procedures generate two readily measurable conditioned responses: During lever presentations that have previously signaled food, rats approach the food well (called goal-tracking) and interact with the lever itself (called sign-tracking). We investigated how reinforced and nonreinforced trials affect the overall and temporal distributions of these two responses across 10-second lever presentations.</p><p>In two experiments, reinforced trials generated more goal-tracking than sign-tracking, and nonreinforced trials resulted in a larger reduction in goal-tracking than sign-tracking. The effect of reinforced trials was evident as an increase in goal-tracking and reduction in sign-tracking across the duration of the lever presentations, and nonreinforced trials resulted in this pattern transiently reversing and then becoming less evident with further training.</p><p>These dissociations are consistent with a recent elaboration of the Rescorla-Wagner model, HeiDI (Honey, R.C., Dwyer, D.M., & Iliescu, A.F. (2020a). HeiDI: A model for Pavlovian learning and performance with reciprocal associations. <em>Psychological Review</em>, <em>127</em>, 829–852.), a model in which responses related to the nature of the unconditioned stimulus (e.g., goal-tracking) have a different origin than those related to the nature of the conditioned stimulus (e.g., sign-tracking).</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000261/pdfft?md5=aba5a28e366da93f850c3e5b3bf8d3aa&pid=1-s2.0-S1074742724000261-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140211263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0