Neurobiology of Learning and Memory最新文献_第3页

The impact of systemic blockade of dopamine receptors on the acquisition of two-way active avoidance in male rats 全身阻断多巴胺受体对雄性大鼠获得双向主动回避的影响

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-07 DOI: 10.1016/j.nlm.2025.108039

L. Vercammen , A. Lopez-Moraga , T. Beckers , B. Vervliet , L. Luyten

{"title":"The impact of systemic blockade of dopamine receptors on the acquisition of two-way active avoidance in male rats","authors":"L. Vercammen , A. Lopez-Moraga , T. Beckers , B. Vervliet , L. Luyten","doi":"10.1016/j.nlm.2025.108039","DOIUrl":"10.1016/j.nlm.2025.108039","url":null,"abstract":"<div><div>Active threat avoidance is a core aspect of adaptive and maladaptive behavior, yet its underlying mechanisms are not fully understood. Prior studies concluded that pharmacologically blocking dopaminergic receptors (DRs) disrupted avoidance acquisition, but it remains unclear whether such effects on learning persist during a drug-free follow-up test. To assess the involvement of D1R and D2R in avoidance acquisition, we conducted two experiments. In Experiment 1, thirty-six male Wistar rats underwent a single avoidance training session involving 30 tone-shock pairings. Rats could avoid the shock by moving to the opposite compartment of the shuttle box. Twenty minutes before training, rats received either D1R antagonist SCH23390 (0.05 mg/kg), D2R antagonist sulpiride (20 mg/kg), or vehicle. While sulpiride did not affect avoidance, 0.05 mg/kg SCH23390 significantly reduced the number of avoidance responses. In a separate test, 0.05 mg/kg SCH23390 also reduced locomotor activity. In Experiment 2 (N = 24), a lower dose of SCH23390 (0.025 mg/kg) was administered, and a drug-free avoidance test under continued reinforcement was added 24 h later to test for sustained effects of D1R blockade on avoidance in the absence of acute drug effects. Although animals avoided less with SCH23390 in the system, this effect did not persist 24 h later, suggesting that effects of D1R blockade during avoidance training might reflect an acute disruption of secondary processes involved in the performance of avoidance behavior rather than an actual impairment of avoidance learning.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108039"},"PeriodicalIF":2.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developmental changes in brain-wide fear memory networks 全脑恐惧记忆网络的发育变化。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-01 DOI: 10.1016/j.nlm.2025.108037

Benita Jin , Michael W. Gongwer , Laura A. DeNardo

{"title":"Developmental changes in brain-wide fear memory networks","authors":"Benita Jin , Michael W. Gongwer , Laura A. DeNardo","doi":"10.1016/j.nlm.2025.108037","DOIUrl":"10.1016/j.nlm.2025.108037","url":null,"abstract":"<div><div>Memory retrieval involves coordinated activity across multiple brain regions. Yet how the organization of memory networks evolves throughout development remains poorly understood. In this study, we compared whole-brain functional networks that are active during contextual fear memory recall in infant, juvenile, and adult mice. Our analyses revealed that long-term memory networks change significantly across postnatal development. Infant fear memory networks are dense and heterogeneous, whereas adult networks are sparse and have a small-world topology. While hippocampal subregions were highly connected nodes at all ages, the cortex gained many functional connections across development. Different functional connections matured at different rates, but their developmental timing fell into three major categories: stepwise change between two ages, linear change across all ages, or inverted-U, with elevated functional connectivity in juveniles. Our work highlights how a subset of brain regions likely maintain important roles in fear memory encoding, but the functional connectivity of fear memory networks undergoes significant reorganization across development. Together, these results provide a blueprint for studying how correlated cellular activity in key areas distinctly regulates memory storage and retrieval across development.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108037"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task 复杂的嗅觉记忆任务需要边缘下皮层，而不是边缘前皮层。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-01 DOI: 10.1016/j.nlm.2025.108038

Dahae J. Jun, Rebecca Shannon, Katherine Tschida, David M. Smith

{"title":"The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task","authors":"Dahae J. Jun, Rebecca Shannon, Katherine Tschida, David M. Smith","doi":"10.1016/j.nlm.2025.108038","DOIUrl":"10.1016/j.nlm.2025.108038","url":null,"abstract":"<div><div>The medial prefrontal cortex (mPFC) plays a key role in memory and behavioral flexibility, and a growing body of evidence suggests that the prelimbic (PL) and infralimbic (IL) subregions contribute differently to these processes. Studies of fear conditioning and goal-directed learning suggest that the PL promotes behavioral responses and memory retrieval, while the IL inhibits them. Other studies have shown that the mPFC is engaged under conditions of high interference. This raises the possibility that the PL and IL play differing roles in resolving interference. To examine this, we first used chemogenetics (DREADDs) to suppress mPFC neuronal activity and tested subjects on a conditional discrimination task known to be sensitive to muscimol inactivation. After confirming the effectiveness of the DREADD procedures, we conducted a second experiment to examine the PL and IL roles in a high interference memory task. We trained rats on two consecutive sets of conflicting odor discrimination problems, A and B, followed by test sessions involving a mid-session switch between the problem sets. Controls repeatedly performed worse on Set A, suggesting that learning Set B inhibited the rats’ ability to retrieve Set A memories (i.e. retroactive interference). PL inactivation rats performed similarly to controls. However, IL inactivation rats did not show this effect, suggesting that the IL plays a critical role in suppressing the retrieval of previously acquired memories that may interfere with retrieval of more recent memories. These results suggest that the IL plays a critical role in memory control processes needed for resolving interference.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108038"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engrams across diseases: Different pathologies – unifying mechanisms? 跨越疾病的印记：不同的病理-统一的机制？

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-02-27 DOI: 10.1016/j.nlm.2025.108036

Greta Leonore Balmer , Shuvrangshu Guha , Stefanie Poll

{"title":"Engrams across diseases: Different pathologies – unifying mechanisms?","authors":"Greta Leonore Balmer , Shuvrangshu Guha , Stefanie Poll","doi":"10.1016/j.nlm.2025.108036","DOIUrl":"10.1016/j.nlm.2025.108036","url":null,"abstract":"<div><div>Memories are our reservoir of knowledge and thus, are crucial for guiding decisions and defining our self. The physical correlate of a memory in the brain is termed an engram and since decades helps researchers to elucidate the intricate nature of our imprinted experiences and knowledge. Given the importance that memories have for our lives, their impairment can present a tremendous burden. In this review we aim to discuss engram malfunctioning across diseases, covering dementia-associated pathologies, epilepsy, chronic pain and psychiatric disorders. Current neuroscientific tools allow to witness the emergence and fate of engram cells and enable their manipulation. We further suggest that specific mechanisms of mnemonic malfunction can be derived from engram cell readouts. While depicting the way diseases act on the mnemonic component – specifically, on the cellular engram – we emphasize a differentiation between forms of amnesia and hypermnesia. Finally, we highlight commonalities and distinctions of engram impairments on the cellular level across diseases independent of their pathogenic origins and discuss prospective therapeutic measures.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108036"},"PeriodicalIF":2.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated detection of c-Fos-expressing neurons using inhomogeneous background subtraction in fluorescent images 在荧光图像中使用不均匀背景减法自动检测表达c- fos的神经元

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-02-20 DOI: 10.1016/j.nlm.2025.108035

Hisayuki Osanai , Mary Arai , Takashi Kitamura , Sachie K. Ogawa

引用次数: 0

The effect of fasting on human memory consolidation 禁食对人类记忆巩固的影响。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-02-10 DOI: 10.1016/j.nlm.2025.108034

Xuefeng Yang , Xiu Miao , Franziska Schweiggart , Sophia Großmann , Karsten Rauss , Manfred Hallschmid , Jan Born , Nicolas D. Lutz

{"title":"The effect of fasting on human memory consolidation","authors":"Xuefeng Yang , Xiu Miao , Franziska Schweiggart , Sophia Großmann , Karsten Rauss , Manfred Hallschmid , Jan Born , Nicolas D. Lutz","doi":"10.1016/j.nlm.2025.108034","DOIUrl":"10.1016/j.nlm.2025.108034","url":null,"abstract":"<div><div>The consolidation of long-term memory is thought to critically rely on sleep. However, first evidence from a study in <em>Drosophila</em> suggests that hunger, as another brain state, can benefit memory consolidation as well. Here, we report two human (within-subjects crossover) experiments examining the effects of fasting (versus satiated conditions) during a 10-hour post-encoding consolidation period on subsequent recall of declarative and procedural memories in healthy men. In Experiment 1, participants (n = 16), after an 18.5-hour fasting period, encoded 3 memory tasks (word paired associates, a visual version of the Deese-Roediger-McDermott task, finger tapping) and subsequently either continued to fast or received standardized meals. Recall was tested 48 h later in a satiated state. Experiment 2 (n = 16 participants) differed from Experiment 1 in that a What-Where-When episodic memory task replaced the Deese-Roediger-McDermott task and recall was tested only 24 h later in a fasted state. Compared with the satiated state, fasting enhanced cued recall of word paired associates (more correct and faster responses) and item recognition in the What-Where-When task. By contrast, fasting impaired recall of episodic context memory, i.e., spatial context in the Deese-Roediger-McDermott task, and temporal-spatial context in the What-Where-When task. Procedural memory (finger tapping) remained unaffected. This pattern suggests a differential effect of fasting selectively promoting consolidation of semantic-like representations in cortical networks whereas hippocampal representations of episodic context are weakened. We speculate that hunger strengthens cortical representations by suppressing hippocampal interference during wake consolidation. Yet, the underlying mechanism remains to be clarified.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"218 ","pages":"Article 108034"},"PeriodicalIF":2.2,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GluA1-containing AMPA receptors are necessary for sparse memory engram formation 含有glua1的AMPA受体是稀疏记忆印迹形成所必需的。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-02-07 DOI: 10.1016/j.nlm.2025.108031

Thije S. Willems , Hui Xiong , Helmut W. Kessels , Sylvie L. Lesuis

{"title":"GluA1-containing AMPA receptors are necessary for sparse memory engram formation","authors":"Thije S. Willems , Hui Xiong , Helmut W. Kessels , Sylvie L. Lesuis","doi":"10.1016/j.nlm.2025.108031","DOIUrl":"10.1016/j.nlm.2025.108031","url":null,"abstract":"<div><div>Memory formation depends on the selective recruitment of neuronal ensembles into circuits known as engrams, which represent the physical substrate of memory. Sparse encoding of these ensembles is essential for memory specificity and efficiency. AMPA receptor (AMPAR) subunits, particularly GluA1, play a central role in synaptic plasticity, which underpins memory encoding. This study investigates how GluA1 expression influences the recruitment of neurons into memory engrams. Using global GluA1 knockout (GluA1<sup>KO</sup>) mice, localized knockout models, and contextual fear-conditioning paradigms, we evaluated the role of GluA1 in memory formation and engram sparsity.</div><div>GluA1<sup>KO</sup> mice exhibited impaired short-term memory retention but preserved 24-hour contextual memory. Despite this, these mice displayed increased expression of the immediate early gene Arc in hippocampal neurons, indicative of a denser engram network. Electrophysiological analyses revealed reduced synaptic strength in GluA1-deficient neurons, irrespective of Arc expression. Localized GluA1 knockout in the hippocampus confirmed that GluA1 deficiency increases neuronal recruitment into engrams, disrupting the sparse encoding typically observed in wild-type mice.</div><div>These findings demonstrate that GluA1-containing AMPARs constrain engram size, ensuring selective recruitment of neurons for efficient memory encoding. By regulating synaptic plasticity, GluA1 facilitates both the encoding and size of memory circuits. This study highlights the critical role of GluA1 in maintaining sparse engram formation and provides insight into mechanisms underlying memory deficits in conditions where synaptic composition is altered.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"218 ","pages":"Article 108031"},"PeriodicalIF":2.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells 情景记忆检索-再激活海马印染细胞的结构突触特征。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-02-07 DOI: 10.1016/j.nlm.2025.108033

Panthea Nemat, Salimat Semenova, Rolinka J. van der Loo, August B. Smit, Sabine Spijker, Michel C. van den Oever, Priyanka Rao-Ruiz

{"title":"Structural synaptic signatures of contextual memory retrieval-reactivated hippocampal engram cells","authors":"Panthea Nemat, Salimat Semenova, Rolinka J. van der Loo, August B. Smit, Sabine Spijker, Michel C. van den Oever, Priyanka Rao-Ruiz","doi":"10.1016/j.nlm.2025.108033","DOIUrl":"10.1016/j.nlm.2025.108033","url":null,"abstract":"<div><div>Learning enhances hippocampal engram cell synaptic connectivity which is crucial for engram reactivation and recall to natural cues. Memory retrieval engages only a subset of the learning-activated ensemble, indicating potential differences in synaptic connectivity signatures of reactivated and non-reactivated cells. We probed these differences in structural synaptic connectivity patterns after recent memory retrieval, 72 h after either neutral Context Exploration (CE) or aversive Contextual Fear Conditioning (CFC). Using a combination of eGRASP (enhanced green fluorescent protein (GFP) reconstitution across synaptic partners) and viral-TRAP (targeted recombination in activated populations) to label CA3 synapses onto CA1 engram cells, we investigated differences in spine density, clusters, and morphology between the reactivated and non-reactivated population of the learning ensemble. In doing so, we developed a pipeline for reconstruction and analysis of dendrites and spines, taking nested data structure into account. Our data demonstrate an interplay between reactivation status, context valence or both factors on the number, distribution, and morphology of CA1 engram cell synapses. Despite a lack of differences in spine density, reactivated engram cells encoding an aversive context were characterised by a higher probability of forming spine clusters and a more dynamic spine type signature compared to their non-reactivated counterparts or engram cells encoding a neutral context. Together, our data indicate that the learning-activated ensemble undergoes different trajectories in structural synaptic connectivity during engram refinement.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"218 ","pages":"Article 108033"},"PeriodicalIF":2.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain-wide immunolabeling and tissue clearing applications for engram research 全脑免疫标记和组织清除在印迹研究中的应用。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-02-06 DOI: 10.1016/j.nlm.2025.108032

Alessandra Franceschini , Michelle Jin , Claire W. Chen , Ludovico Silvestri , Alessia Mastrodonato , Christine Ann Denny

{"title":"Brain-wide immunolabeling and tissue clearing applications for engram research","authors":"Alessandra Franceschini , Michelle Jin , Claire W. Chen , Ludovico Silvestri , Alessia Mastrodonato , Christine Ann Denny","doi":"10.1016/j.nlm.2025.108032","DOIUrl":"10.1016/j.nlm.2025.108032","url":null,"abstract":"<div><div>In recent years, there has been significant progress in memory research, driven by genetic and imaging technological advances that have given unprecedented access to individual memory traces or engrams. Although Karl Lashley argued since the 1930s that an engram is not confined to a particular area but rather distributed across the entire brain, most current studies have focused exclusively on a single or few brain regions. However, this compartmentalized approach overlooks the interactions between multiple brain regions, limiting our understanding of engram mechanisms. More recently, several studies have begun to investigate engrams across the brain, but research is still limited by a lack of standardized techniques capable of reconstructing multiple ensembles at single-cell resolution across the entire brain. In this review, we guide researchers through the latest technological advancements and discoveries in immediate early gene (IEG) techniques, tissue clearing methods, microscope modalities, and automated large-scale analysis. These innovations could propel the field forward in building brain-wide engram maps of normal and disease states, thus, providing unprecedented new insights. Ultimately, this review aims to bridge the gap between research focused on single brain regions and the need for a comprehensive understanding of whole-brain engrams, revealing new approaches for exploring the neuronal mechanisms underlying engrams.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"218 ","pages":"Article 108032"},"PeriodicalIF":2.2,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Rescorla-Wagner model: It is not what you think it is Rescorla-Wagner模型：它不是你想的那样。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-01-01 DOI: 10.1016/j.nlm.2025.108021

Guillem R. Esber, Geoffrey Schoenbaum, Mihaela D. Iordanova

引用次数: 0