Neurobiology of Learning and Memory最新文献

{"title":"The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits","authors":"Scott La Tour ,&nbsp;Hassan Shaikh ,&nbsp;Joy H Beardwood ,&nbsp;Agatha S Augustynski ,&nbsp;Marcelo A. Wood ,&nbsp;Ashley A. Keiser","doi":"10.1016/j.nlm.2024.107971","DOIUrl":"10.1016/j.nlm.2024.107971","url":null,"abstract":"<div><p>Exercise provides a range of cognitive benefits, including improved memory performance. Previously, we demonstrated that 14 days of continuous voluntary wheel-running exercise enables learning in a hippocampus-dependent Object Location Memory (OLM) task under insufficient, subthreshold training conditions in adult mice. Whether similar exercise benefits can be obtained from consistent intermittent exercise as continuous exercise is unknown. Here, we examine whether intermittent exercise (the weekend warrior effect: 2 days of exercise a week for 7 weeks) displays similar or distinct cognitive benefits as previously examined with 14 days of continuous exercise. We find that both continuous and intermittent exercise parameters similarly enable hippocampus-dependent OLM compared to the 2-day exercise control group. Mice receiving intermittent exercise maintained cognitive benefits following a 7-day sedentary delay, whereas mice that underwent 14 continuous days of exercise showed diminished cognitive benefits as previously reported. Further, compared to continuous exercise, intermittent exercise mice exhibited persistently elevated levels of the genes <em>Acvr1c</em> and <em>Bdnf</em> which we know to be critically involved in hippocampus-dependent long-term memory in the dorsal hippocampus. Together findings suggest that consistent intermittent exercise persistently enables hippocampal-dependent long-term memory. Understanding the optimal parameters for persistent cognitive function and the mechanisms mediating persistent effects will aid in therapeutic pursuits investigating the mitigation of cognitive ailments.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"214 ","pages":"Article 107971"},"PeriodicalIF":2.2,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manipulations of the context-response relationship reduce the expression of response habits","authors":"Zachary J. Pierce-Messick,&nbsp;Laura H. Corbit","doi":"10.1016/j.nlm.2024.107962","DOIUrl":"10.1016/j.nlm.2024.107962","url":null,"abstract":"<div><p>Habitual instrumental behaviour is believed to rely on stimulus–response (S–R) associations. However, the method most commonly used to identify habitual behaviour, outcome devaluation, provides only indirect evidence of S-R control. Therefore, it is important to have a better understanding of the S-R association believed to underlie habitual responding. Under free-operant conditions, the context itself likely serves as at least part of the relevant stimuli in the association, and so modifications to the predictive power of the context should alter the expression of habits. The following experiments investigated how changes to the relationship between the training context and performance of the response, either by changing the context during testing or by exposing animals to the context alone, without the response lever present, impacted behavioural control during a devaluation test. We found evidence that the training context is important for the expression of habits; testing animals in a different context than where they were trained resulted in increased goal-directed control (Experiment 1). Furthermore, context alone exposure also increased goal-directed control with animals that received context alone exposure showing stronger devaluation effects, whether the context alone exposure happened on the last day of training (Experiment 2) or throughout training (Experiment 3). These findings are consistent with prior reports that the training context is important for the expression of habits and extends these findings by using sensory-specific satiety as a means for devaluation and by using context alone exposure to alter behavioural control.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"214 ","pages":"Article 107962"},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual fear conditioning in zebrafish: Influence of different shock frequencies, context, and pharmacological modulation on behavior","authors":"Laura W. Santos ,&nbsp;Julia Canzian ,&nbsp;Cássio M. Resmim ,&nbsp;Barbara D. Fontana ,&nbsp;Denis B. Rosemberg","doi":"10.1016/j.nlm.2024.107963","DOIUrl":"10.1016/j.nlm.2024.107963","url":null,"abstract":"<div><p>Contextual fear conditioning is a protocol used to assess associative learning across species, including fish. Here, our goal was to expand the analysis of behavioral parameters that may reflect aversive behaviors in a contextual fear conditioning protocol using adult zebrafish (<em>Danio rerio</em>) and to verify how such parameters can be modulated. First, we analyzed the influence of an aversive stimulus (3 mild electric shocks for 5 s each at frequencies of 10, 100 or 1000 Hz) on fish behavior, and their ability to elicit fear responses in the absence of shock during a test session. To confirm whether the aversive responses are context-dependent, behaviors were also measured in a different experimental environment in a test session. Furthermore, we investigated the effects of dizocilpine (MK-801, 2 mg/kg, <em>i.p.</em>) on fear-related responses. Zebrafish showed significant changes in baseline activity immediately after shock exposure in the training session, in which 100 Hz induced robust contextual fear responses during the test session. Importantly, when introduced to a different environment, animals exposed to the aversive stimulus did not show any differences in locomotion and immobility-related parameters. MK-801 administered after the training session reduced fear responses during the test, indicating that glutamate NMDA-receptors play a key role in the consolidation of contextual fear-related memory in zebrafish. In conclusion, by further exploring fear-related behaviors in a contextual fear conditioning task, we show the effects of different shock frequencies and confirm the importance of context on aversive responses for associative learning in zebrafish. Additionally, our data support the use of zebrafish in contextual fear conditioning tasks, as well as for advancing pharmacological studies related to associative learning in translational neurobehavioral research.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"214 ","pages":"Article 107963"},"PeriodicalIF":2.2,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Random interval schedule of reinforcement influences punishment resistance for cocaine in rats","authors":"Bradley O. Jones ,&nbsp;Haley F. Spencer ,&nbsp;Adelis M. Cruz ,&nbsp;Morgan S. Paladino ,&nbsp;Sophia N. Handel ,&nbsp;Rachel J. Smith","doi":"10.1016/j.nlm.2024.107961","DOIUrl":"10.1016/j.nlm.2024.107961","url":null,"abstract":"<div><p>In an animal model of compulsive drug use, a subset of rats continues to self-administer cocaine despite footshock consequences and is considered punishment resistant. We recently found that punishment resistance is associated with habits that persist under conditions that typically encourage a transition to goal-directed control. Given that random ratio (RR) and random interval (RI) schedules of reinforcement influence whether responding is goal-directed or habitual, we investigated the influence of these schedules on punishment resistance for cocaine or food. Male and female Sprague Dawley rats were trained to self-administer either intravenous cocaine or food pellets on a seeking-taking chained schedule of reinforcement, with the seeking lever requiring completion of either an RR20 or RI60 schedule. Rats were then given four days of punishment testing with footshock administered at the completion of seeking on a random one-third of trials. For cocaine-trained rats, the RI60 schedule led to greater punishment resistance (i.e., more trials completed) than the RR20 schedule in males and females. For food-trained rats, the RI60 schedule led to greater punishment resistance (i.e., higher reward rates) than the RR20 schedule in female rats, although male rats showed punishment resistance on both RR20 and RI60 schedules. For both cocaine and food, we found that seeking responses were suppressed to a greater degree than reward rate with the RI60 schedule, whereas response rate and reward rate were equally suppressed with the RR20 schedule. This dissociation between punishment effects on reward rate and response rate with the RI60 schedule can be explained by the nonlinear relation between these variables on RI schedules, but it does not account for the enhanced resistance to punishment. Overall, the results show greater punishment resistance with the RI60 schedule as compared to the RR20 schedule, indicating that schedules of reinforcement are an influencing factor on resistance to negative consequences.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107961"},"PeriodicalIF":2.2,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000728/pdfft?md5=b0d9e1d6bf2bd4cbf8cc649a23614926&pid=1-s2.0-S1074742724000728-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141640507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting fear memories: Examining pharmacological disruption in a generalized fear framework","authors":"Marcelo Giachero,&nbsp;Agostina Belén Sacson,&nbsp;María Belén Vitullo,&nbsp;Pedro Bekinschtein,&nbsp;Noelia Weisstaub","doi":"10.1016/j.nlm.2024.107960","DOIUrl":"10.1016/j.nlm.2024.107960","url":null,"abstract":"<div><p>Labilization-reconsolidation, which relies on retrieval, has been considered an opportunity to attenuate the negative aspects of traumatic memories. A therapeutic strategy based on reconsolidation blockade is deemed more effective than current therapies relying on memory extinction. Nevertheless, extremely stressful memories frequently prove resistant to this process. Here, after inducing robust fear memory in mice through strong fear conditioning, we examined the possibility of rendering it susceptible to pharmacological modulation based on the degree of generalized fear (GF). To achieve this, we established an ordered gradient of GF, determined by the perceptual similarity between the associated context (CA) and non-associated contexts (CB, CC, CD, and CE) to the aversive event. We observed that as the exposure context became less similar to CA, the defensive pattern shifted from passive to active behaviors in both male and female mice. Subsequently, in conditioned animals, we administered propranolol after exposure to the different contexts (CA, CB, CC, CD or CE). In males, propranolol treatment resulted in reduced freezing time and enhanced risk assessment behaviors when administered following exposure to CA or CB, but not after CC, CD, or CE, compared to the control group. In females, a similar change in behavioral pattern was observed with propranolol administered after exposure to CC, but not after the other contexts. These results highlight the possibility of indirectly manipulating a robust contextual fear memory by controlling the level of generalization during recall. Additionally, it was demonstrated that the effect of propranolol on reconsolidation would not lead to a reduction in fear memory per se, but rather to its reorganization resulting in greater behavioral flexibility (from passive to active behaviors). Finally, from a clinical viewpoint, this would be of considerable relevance since following this strategy could make the treatment of psychiatric disorders associated with traumatic memory formation more effective and less stressful.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107960"},"PeriodicalIF":2.2,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial electrical stimulation for procedural learning and rehabilitation","authors":"Olivia Morgan Lapenta ,&nbsp;Gabriel Gaudencio Rêgo ,&nbsp;Paulo Sérgio Boggio","doi":"10.1016/j.nlm.2024.107958","DOIUrl":"10.1016/j.nlm.2024.107958","url":null,"abstract":"<div><p>Procedural learning is the acquisition of motor and non-motor skills through a gradual process that increases with practice. Impairments in procedural learning have been consistently demonstrated in neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. Considering that noninvasive brain stimulation modulates brain activity and boosts neuroplastic mechanisms, we reviewed the effects of coupling transcranial direct current stimulation (tDCS) with training methods for motor and non-motor procedural learning to explore tDCS potential use as a tool for enhancing implicit learning in healthy and clinical populations. The review covers tDCS effects over i. motor procedural learning, from basic to complex activities; ii. non-motor procedural learning; iii. procedural rehabilitation in several clinical populations. We conclude that targeting the primary motor cortex and prefrontal areas seems the most promising for motor and non-motor procedural learning, respectively. For procedural rehabilitation, the use of tDCS is yet at an early stage but some effectiveness has been reported for implicit motor and memory learning. Still, systematic comparisons of stimulation parameters and target areas are recommended for maximising the effectiveness of tDCS and its robustness for procedural rehabilitation.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107958"},"PeriodicalIF":2.2,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000698/pdfft?md5=9e0202b7be748978a78e32f87ae7458c&pid=1-s2.0-S1074742724000698-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential effects of clonazepam on declarative memory formation and face recognition","authors":"Candela S. Leon ,&nbsp;Agustina L. Lo Celso ,&nbsp;Facundo A. Urreta Benítez ,&nbsp;Matías Bonilla ,&nbsp;Natividad Olivar ,&nbsp;Jaqueline Toledo ,&nbsp;Luis I. Brusco ,&nbsp;Cecilia Forcato","doi":"10.1016/j.nlm.2024.107956","DOIUrl":"10.1016/j.nlm.2024.107956","url":null,"abstract":"<div><p>Benzodiazepines are commonly used drugs to treat anxiety in crime witnesses. These increase GABA inhibitory effects, which impairs aversive memory encoding and consolidation. Eyewitness memory is essential in justice. However, memory is malleable leading to false memories that could cause a selection of an innocent in a lineup. Here, we studied whether a low dose of Clonazepam impairs memory encoding as well as consolidation of faces and narrative of the event. We performed two experiments using a double-blind and between subject design (<em>N</em> = 216). Day 1: subjects watched a crime video and received Clonazepam 0.25 mg (CLZ group) or placebo (PLC group) before (Exp. 1) or after the video (Exp. 2) to assess the effect on encoding and consolidation. One week later, the memory was assessed using a present and absent target lineup and asking for a free recall. Regarding encoding, we found that in the CLZ group memory was impaired in the free recall task, while no differences were found for recognition memory. Regarding consolidation, we did not observe memory measures that were affected by this dose of benzodiazepines. The results suggest that while some aspects of eyewitness memory could be modulated even with low doses of benzodiazepine, others could not be affected. More studies should be performed with higher doses of CLZ similar to those administered in real life. These results are relevant in the judicial field to assess the reliability of the eyewitness elections under the effects of this drug.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107956"},"PeriodicalIF":2.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypersensitivity of the nicotinic acetylcholine receptor subunit (CHRNA2L9′S/L9′S) in female adolescent mice produces deficits in nicotine-induced facilitation of hippocampal-dependent learning and memory","authors":"Alicia C. Wells ,&nbsp;Celina Mojica ,&nbsp;Shahrdad Lotfipour","doi":"10.1016/j.nlm.2024.107959","DOIUrl":"10.1016/j.nlm.2024.107959","url":null,"abstract":"<div><p>Adolescence is characterized by a critical period of maturation and growth, during which regions of the brain are vulnerable to long-lasting cognitive disturbances. Adolescent exposure to nicotine can lead to deleterious neurological and psychological outcomes. Moreover, the nicotinic acetylcholine receptor (nAChR) has been shown to play a functionally distinct role in the development of the adolescent brain. <em>CHRNA2</em> encodes for the <span><math><mrow><mi>α</mi><mn>2</mn></mrow></math></span> subunit of nicotinic acetylcholine receptors associated with CA1 oriens lacunosum moleculare GABAergic interneurons and is associated with learning and memory. Previously, we found that adolescent male hypersensitive <em>CHRNA</em>2<em>^L9′S/L9′</em> mice had impairments in learning and memory during a pre-exposure-dependent contextual fear conditioning task that could be rescued by low-dose nicotine exposure. In this study, we assessed learning and memory in female adolescent hypersensitive <em>CHRNA</em>2<em>^L9′S/L9′</em> mice exposed to saline or a subthreshold dose of nicotine using a hippocampus-dependent task of pre-exposure-dependent contextual fear conditioning. We found that nicotine-treated wild-type female mice had significantly greater improvements in learning and memory than both saline-treated wild-type mice and nicotine-treated <em>CHRNA</em>2<em>^L9′S/L9′</em> female mice. Thus, hyperexcitability of <em>CHRNA</em>2 in female adolescent mice ablated the nicotine-mediated potentiation of learning and memory seen in wild-types. Our results indicate that nicotine exposure during adolescence mediates sexually dimorphic patterns of learning and memory, with wild-type female adolescents being more susceptible to the effects of sub-threshold nicotine exposure. To understand the mechanism underlying sexually dimorphic behavior between hyperexcitable <em>CHRNA</em>2 mice, it is critical that further research be conducted.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107959"},"PeriodicalIF":2.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000704/pdfft?md5=e7b6fe4d1b7f4758395cd46d678e5470&pid=1-s2.0-S1074742724000704-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of post-learning nap in the recognition memory for faces in habitual nappers","authors":"Jue Wu ,&nbsp;Sze Chai Kwok ,&nbsp;Huimin Wang ,&nbsp;Zhaoxin Wang","doi":"10.1016/j.nlm.2024.107957","DOIUrl":"10.1016/j.nlm.2024.107957","url":null,"abstract":"<div><p>This study investigated the effects of diurnal nap in the recognition memory for faces in habitual nappers. Thirty volunteers with habitual midday napping (assigned as the sleep group) and 28 non-nappers (assigned as the wake group) participated in this study. Participants were instructed to memorize faces, and subsequently to perform two recognition tasks before and after nap/wakefulness, i.e., an immediate recognition and a delayed recognition. There were three experimental conditions: same faces with the same view angle (S-S condition); same faces with a different view angle (22.5°) (S-D condition); and novel faces (NF condition). A mixed repeated-measures ANOVA revealed that the sleep group exhibited significantly longer reaction times (RT) following their nap compared to those of the wake group; no significant between-group differences were observed in accuracy or sensitivity (d’). Furthermore, both groups were more conservative in the delayed recognition task compared to the immediate recognition task, but the sleep group was more conservative after their nap (<em>vs</em> pre-nap), reflected by the criterion (β, O_hit/O_{false alarm}). Further stepwise regression analysis revealed a positive relationship between duration of stage N3 sleep and normalized RT difference before/after nap on the S-S condition. These findings suggest that an immediate nap following face learning is associated with memory reorganization during N3 sleep in habitual nappers, rendering the memories not readily accessible.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107957"},"PeriodicalIF":2.2,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1074742724000686/pdfft?md5=69a43066799b65df1d43e1b3ef0b5ccf&pid=1-s2.0-S1074742724000686-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manipulated overlapping reactivation of multiple memories promotes explicit gist abstraction","authors":"Xiaoxia Zhao,&nbsp;Po-han Chen,&nbsp;Jie Chen,&nbsp;Hongqiang Sun","doi":"10.1016/j.nlm.2024.107953","DOIUrl":"10.1016/j.nlm.2024.107953","url":null,"abstract":"<div><p>Sleep is considered to promote gist abstraction on the basis of spontaneous memory reactivation. As speculated in the theory of ‘information overlap to abstract (iOtA)’, ‘overlap’ between reactivated memories, beyond reactivation, is crucial to gist abstraction. Yet so far, empirical research has not tested this theory by manipulating the factor of ‘overlap’. In the current study, ‘overlap’ itself was manipulated by targeted memory reactivation (TMR), through simultaneously reactivating multiple memories that either contain or do not contain spatially overlapped gist information, to investigate the effect of overlapping reactivation on gist abstraction. This study had a factorial design of 2 factors with 2 levels respectively (spatial overlap/no spatial overlap, TMR/no-TMR). Accordingly, 82 healthy college students (aged 19 ∼ 25, 57 females) were randomized into four groups. After learning 16 pictures, paired with 4 auditory cues (4 pictures – 1 cue) according to the grouping, participants were given a 90-minute nap opportunity. Then TMR cueing was conducted during N2 and slow wave sleep of the nap. Performance in memory task was used to measure gist abstraction. The results showed a significant main effect of TMR on both implicit and explicit gist abstraction, and a marginally significant interaction effect on explicit gist abstraction. Further analyses showed that explicit gist abstraction in the spatial overlap &amp; TMR group was significantly better than in the control group. Moreover, explicit gist abstraction was positively correlated with spindle density. The current study thus indicates that TMR facilitates gist abstraction, and explicit gist abstraction may benefit more from overlapping reactivation.</p></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"213 ","pages":"Article 107953"},"PeriodicalIF":2.2,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}