Neurobiology of Learning and Memory最新文献_第2页

The molecular and cellular basis of memory engrams: Mechanisms of synaptic and systems consolidation 记忆印记的分子和细胞基础：突触和系统巩固的机制

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-04-19 DOI: 10.1016/j.nlm.2025.108057

Janina Kupke , Ana M.M. Oliveira

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DREADD-mediated inhibition of anterior retrosplenial cortex: Effects on novelty recognition of objects, locations, and object-in-place associations in male and female Long Evans rats dreadd介导的前脾后皮质抑制：对雄性和雌性Long Evans大鼠对物体、位置和物体原位关联的新奇识别的影响

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-04-19 DOI: 10.1016/j.nlm.2025.108055

Dan L. McElroy, Ilne L. Barnard, Aiden E. Glass, Kaylen M. Young, Veronica Kryachko, Justin J. Botterill, John G. Howland

{"title":"DREADD-mediated inhibition of anterior retrosplenial cortex: Effects on novelty recognition of objects, locations, and object-in-place associations in male and female Long Evans rats","authors":"Dan L. McElroy, Ilne L. Barnard, Aiden E. Glass, Kaylen M. Young, Veronica Kryachko, Justin J. Botterill, John G. Howland","doi":"10.1016/j.nlm.2025.108055","DOIUrl":"10.1016/j.nlm.2025.108055","url":null,"abstract":"<div><div>Previous research suggests ionotropic glutamate receptors in anterior retrosplenial cortex (aRSC) are important for short-term (1-hour) object-in-place (OiP) novelty recognition, indicated by enhanced interaction with novel object-location pairs during OiP test phases. Here, male and female rats were repeatedly tested in three 1-hour delay novelty recognition tests: object recognition (OR), object location (OL), and OiP. Prior to behavioral testing, control (AAV5-CaMKIIα-mCherry) or active (AAV5-CaMKIIα-hM4D(Gi)-mCherry) viral vectors were bilaterally infused into the aRSC of male (8 control, 13 active) and female (8 control, 13 active) Long Evans rats, enabling selective inhibition of aRSC neurons with the hM4D agonist Compound 21 (C-21). Following recovery from surgery, rats were repeatedly tested in recognition tests following injection of either saline or C-21 (1.0 mg/kg; i.p.) ∼45-min prior to test phases (6 tests/rat). Analyses of exploration times indicated that total object interaction times did not differ between phase, sex, or treatment. Further analyses revealed that C-21 treatment of rats infused with the active vector reduced novelty recognition in the OR test yet had no influence in the OL test, regardless of sex. Interestingly, C-21 also reduced novelty recognition in OiP recognition test phases, an effect only observed in male rats infused with the active vector. Findings highlight a nuanced influence of aRSC neurons in supporting novelty recognition which varies by sex and type of stimuli assayed.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108055"},"PeriodicalIF":2.2,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Sensitivity of associative priming to semantic relations: Insights from behavior and event-related potentials 联想启动对语义关系的敏感性：来自行为和事件相关电位的见解

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-04-16 DOI: 10.1016/j.nlm.2025.108056

Aiqing Nie , Yuanying Wu , Xia Zheng

{"title":"Sensitivity of associative priming to semantic relations: Insights from behavior and event-related potentials","authors":"Aiqing Nie , Yuanying Wu , Xia Zheng","doi":"10.1016/j.nlm.2025.108056","DOIUrl":"10.1016/j.nlm.2025.108056","url":null,"abstract":"<div><div>The priming effects have raised significant concerns. Previous research has solely focused on the priming of individual items, where both the prime and the target are single items. This study innovatively examines the priming effect for pairs and also considers the pair type for the target. In this experiment, the semantic relations of the prime and target pairs were categorized into thematic, taxonomic, and unrelated cases. The prime pairs were considered new, while the target pairs consisted of intact, rearranged, and “old + new” pairs. Behaviorally, we found that the priming effects were more pronounced when considering thematic relations compared to taxonomic relations. This indicates a stronger unitization between the items in taxonomic relations. Neurally, the N300 and N400 amplitudes were significantly larger for thematic relations compared to taxonomic relations. These results suggest that both object identification and semantic processing were more influenced by the semantic relation within the pairs. Moreover, we observed that the pair type exhibited distinct patterns in the ERP priming effect across different semantic relations. This indicates that semantic priming and repetition priming of associative pairs result in different effects.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108056"},"PeriodicalIF":2.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A long-term mild high-fat diet facilitates rabbit discrimination learning and alters glycerophospholipid metabolism 长期轻度高脂饲粮促进家兔辨别学习，改变甘油磷脂代谢

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-04-12 DOI: 10.1016/j.nlm.2025.108053

Desheng Wang, Ezekiel A. Irewole, Logan D. Bays, MacKinzie D. Smith, Bernard G. Schreurs

{"title":"A long-term mild high-fat diet facilitates rabbit discrimination learning and alters glycerophospholipid metabolism","authors":"Desheng Wang, Ezekiel A. Irewole, Logan D. Bays, MacKinzie D. Smith, Bernard G. Schreurs","doi":"10.1016/j.nlm.2025.108053","DOIUrl":"10.1016/j.nlm.2025.108053","url":null,"abstract":"<div><div>Previous reports have shown an association between a Western high-fat diet (HFD) and poor cognitive performance. So far, there are no reports of whether a mild HFD can affect rabbit learning and hippocampal metabolic profile. This study was designed to explore whether feeding a mild HFD (5 % lard and 5 % soy oil) for 20 weeks affected eyeblink discrimination and discrimination reversal learning and hippocampal metabolic profiles. After 20 weeks on the HFD or a normal control diet, all rabbits received one day of adaptation, 20 daily sessions of two-tone discrimination (1-kHz CS + followed by air puff and 8-kHz CS- not followed by air puff), a rest day, and then 40 daily sessions of discrimination reversal (8-kHz CS + and 1-kHz CS-). Compared to rabbits fed a regular chow diet, rabbits fed a mild HFD showed better discrimination evidenced by higher responding to CS+, lower responding to CS-, and a larger discrimination index (CS+ − CS-). Widely targeted metabolomics analysis identified 1805 metabolites in the hippocampus, and significant HFD-induced changes in 162 and 165 differential metabolites in males and females, respectively. These included glycerophospholipids and fatty acyls. KEGG enrichment analysis showed glycerophospholipid metabolism (ko00564) was significantly enriched in the HFD group notably lysophosphatidylethanolamine and lysophosphatidylcholine. In summary, our data show a long-term mild HFD facilitated discrimination learning in rabbits without inducing a metabolic syndrome, and altered the hippocampal metabolic profile, which may affect neuronal cell membrane lipids and behavioral performance.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108053"},"PeriodicalIF":2.2,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms 半夜睡眠限制后观察到的记忆损伤不是由工作记忆、注意力或抑制控制机制介导的

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-04-11 DOI: 10.1016/j.nlm.2025.108054

Pim R.A. Heckman , Robbert Havekes , Arjan Blokland

{"title":"Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms","authors":"Pim R.A. Heckman , Robbert Havekes , Arjan Blokland","doi":"10.1016/j.nlm.2025.108054","DOIUrl":"10.1016/j.nlm.2025.108054","url":null,"abstract":"<div><div>Sleep restriction is a growing issue in our modern society and thus it is crucial to uncover its neurocognitive consequences. Especially declarative memory is negatively affected by sleep loss due to its critical dependence on the hippocampus, a brain area known to be susceptible to sleep loss. Studies have shown that even a half night sleep restriction is sufficient to induce impairments in a range of hippocampus-dependent forms of memory. Nevertheless, memory performance is, at least to some extent, dependent on other cognitive functions. The aim of the current study was to reveal whether memory deficits observed after one night sleep deprivation, as observed in animal studies, translate to man, and whether these effects are mediated by impairments in other cognitive domains. We hypothesized that the memory paradigms would be affected but that, due to the short nature of the sleep restriction, this effect would not be mediated by other cognitive functions. To this end, fifty-five healthy participants conducted a test battery containing paradigms measuring verbal learning, spatial memory, attention, working memory, and response inhibition after a night of regular sleep or acute partial sleep restriction. The results of the study showed an impairment in both hippocampus-dependent memory tests, while no negative consequences of sleep deprivation were revealed on the other cognitive domains. In conclusion, our data indicate that the observed deficit in memory performance after a half night sleep deprivation is not mediated by impairments in attention (alerting, orienting, and executive control), working memory, or motor inhibitory control mechanisms.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108054"},"PeriodicalIF":2.2,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Memory formation following appetitive conditioning is variably dependent on retinoid signaling 食欲调节后的记忆形成不同程度地依赖于类视黄醛信号。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-04-01 DOI: 10.1016/j.nlm.2025.108048

Raymond K. Wong , Gaynor E. Spencer

{"title":"Memory formation following appetitive conditioning is variably dependent on retinoid signaling","authors":"Raymond K. Wong , Gaynor E. Spencer","doi":"10.1016/j.nlm.2025.108048","DOIUrl":"10.1016/j.nlm.2025.108048","url":null,"abstract":"<div><div>Retinoic acid (RA), the metabolite of Vitamin A, plays an important role in central nervous system development and regeneration, as well as learning and memory in vertebrates. We have previously shown that RA signaling is also important for consolidation of long-term memory (LTM) in the invertebrate mollusc, <em>Lymnaea stagnalis</em>, following operant conditioning of the aerial respiratory behaviour. Here, we examine whether retinoids also play a role in classical reward conditioning in this mollusc. A single-trial appetitive conditioning paradigm was used, with amyl acetate as the conditioned stimulus (CS) and sucrose as the unconditioned stimulus (US). This produced an acquired conditioned response whereby the animal exhibited a feeding response to amyl acetate. A single-pairing of CS with US produced long-term memory at both 1d and 6d after training. Pharmacological treatments that disrupt RA signaling did not block the formation of long term memory when a 6-day food deprivation period was implemented before training. However, two different paradigms induced susceptibility of the conditioned response (memory) to retinoid signaling inhibitors. The first paradigm change involved using a shorter, 3-day food deprivation period in order to reduce motivational drive to feed, whereas the second paradigm manipulation reduced the strength of the unconditioned stimulus (sucrose). These findings suggest different susceptibility of memories to retinoid inhibition, depending on shifts in both external parameters of the experiment, as well as internal motivational states of the animal.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108048"},"PeriodicalIF":2.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Glutamate receptor expression in the PL-BLA circuit is associated with susceptibility to showing the PTSD-like phenotype PL-BLA回路中的谷氨酸受体表达与ptsd样表型的易感性相关

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-27 DOI: 10.1016/j.nlm.2025.108051

Charlotte S. Rye , Amy L. Milton

{"title":"Glutamate receptor expression in the PL-BLA circuit is associated with susceptibility to showing the PTSD-like phenotype","authors":"Charlotte S. Rye , Amy L. Milton","doi":"10.1016/j.nlm.2025.108051","DOIUrl":"10.1016/j.nlm.2025.108051","url":null,"abstract":"<div><div>While many individuals experience traumatic events during their lifetimes, only some go on to develop post-traumatic stress disorder (PTSD). This susceptibility and resilience to developing PTSD can be modelled in rodents using the stress-enhanced fear learning (SEFL) procedure, in which rats are exposed to a session of massed, unpredictable footshocks and subsequently assessed on tasks of adaptive fear learning. It has previously been observed that subpopulations of rats are susceptible and resilient to showing the PTSD-like phenotype following SEFL, and that these rats show differences in glutamate receptor expression in the basolateral amygdala. However, it is currently unknown whether structural differences are observed in other brain regions implicated in stress responding and memory. Using the refined SEFL procedure, this study aimed to determine whether expression of GluN2B, GluA1 and GluA2 receptor subunits in the prelimbic and infralimbic cortices, and dorsal hippocampus could be correlated to the SEFL-phenotype or shock experience in male rats. Here we show that following SEFL, differences can be observed in receptor subunit expression in the infralimbic cortex and dorsal hippocampus as a function of shock experience, whilst differences in the prelimbic cortex are associated with susceptibility. Importantly, these structural changes can be observed in male rats that are group-housed and exposed to 13-shocks rather than 15-shocks, indicating that the refined SEFL procedure offers a robust animal analogue of the non-associative fear sensitisation that occurs in PTSD. Future studies using this procedure could pave the way to the eventual development of pharmacological treatments to alleviate or prevent stress-induced psychopathology in susceptible individuals.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108051"},"PeriodicalIF":2.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cortisol modulates hippocampus activation during semantic substitution in men 皮质醇调节男性语义替代过程中的海马体激活。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-25 DOI: 10.1016/j.nlm.2025.108049

Nicole Klein, Carina Zöllner, Tobias Otto, Oliver Tobias Wolf, Christian Josef Merz

{"title":"Cortisol modulates hippocampus activation during semantic substitution in men","authors":"Nicole Klein, Carina Zöllner, Tobias Otto, Oliver Tobias Wolf, Christian Josef Merz","doi":"10.1016/j.nlm.2025.108049","DOIUrl":"10.1016/j.nlm.2025.108049","url":null,"abstract":"<div><div>In the case of incomplete episodic memory retrieval, semantic knowledge may play a vital role compared to random memory errors in filling in memory gaps (semantic substitution). Stress impairs (episodic) memory retrieval via stress hormones (mainly cortisol) targeting the hippocampus. This preregistered neuroimaging study aimed to examine the neural mechanisms of the interplay between episodic memories and prior knowledge during the reconstruction of a past scenario under elevated cortisol levels in men. During encoding, sixty men prepared a virtual apartment for having guests over by using button presses to interact with household objects (e.g., toasting a slice of bread) that were placed congruently to semantic knowledge (e.g., a coffee machine in the kitchen) or incongruently (e.g., a toaster in the bathroom). One day later, participants received (order randomized, double-blind) either 20 mg of cortisol (n = 30) or a placebo (n = 30) before a recognition task. After identifying objects as old, we included a room recall using a forced-choice question in which room the objects were remembered. For incongruent objects this allowed us to differentiate the involvement of episodic, semantic, or random memory. Cortisol did not impair general recognition memory. The manipulation of stimuli during encoding, as being congruent and interactable (relevant to the goal) appears to be predictive of later accurate room recall. Semantic substitution in case of episodic memory failure was associated with anterior parahippocampal and gyrus rectus activation. Cortisol administration increased hippocampal activation during semantic substitution, suggesting a compensatory effect. The results characterized the neural correlates of semantic substitution and speak for an intertwined view of episodic memory and semantic knowledge, which is further shaped by the stress hormone cortisol.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108049"},"PeriodicalIF":2.2,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cutting-edge RNA technologies to advance the understanding of learning and memory 先进的RNA技术促进对学习和记忆的理解

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-25 DOI: 10.1016/j.nlm.2025.108050

Joshua William Ashley Davies , Timothy William Bredy , Paul Robert Marshall

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Engram and behavior: How memory is stored in the brain 印迹与行为：记忆如何在大脑中储存。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-11 DOI: 10.1016/j.nlm.2025.108047

Kisang Eom , Donguk Kim , Jung Ho Hyun

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