Nature Reviews Neurology最新文献_第4页

Mechanistic insights into the interaction between epilepsy and sleep 癫痫与睡眠之间相互作用的机制研究

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-03-10 DOI: 10.1038/s41582-025-01064-z

Laurent Sheybani, Birgit Frauscher, Christophe Bernard, Matthew C. Walker

{"title":"Mechanistic insights into the interaction between epilepsy and sleep","authors":"Laurent Sheybani, Birgit Frauscher, Christophe Bernard, Matthew C. Walker","doi":"10.1038/s41582-025-01064-z","DOIUrl":"10.1038/s41582-025-01064-z","url":null,"abstract":"Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. If sleep affects the pathophysiology of epilepsy and the risk of seizures, as suggested by correlative evidence, then understanding these effects could provide crucial insight into the basic mechanisms that underlie the development of epilepsy and the generation of seizures. In this Review, we provide in-depth discussion of the associations between epilepsy and sleep at the cellular, network and system levels and consider the mechanistic underpinnings of these associations. We also discuss the clinical relevance of these associations, highlighting how they could contribute to improvements in the management of epilepsy. A better understanding of the mechanisms that govern the interactions between epilepsy and sleep could guide further research and the development of novel approaches to the management of epilepsy. Epidemiological evidence has demonstrated associations between sleep and epilepsy, but we lack a mechanistic understanding of these associations. In this Review, Sheybani et al. consider the associations between epilepsy and sleep at the cellular, network and system levels, the mechanistic underpinnings of these associations and their clinical relevance to the management of epilepsy.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 4","pages":"177-192"},"PeriodicalIF":28.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychosis-causing lesions mapped to a hippocampal circuit 导致精神疾病的病变映射到海马体回路

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-03-10 DOI: 10.1038/s41582-025-01074-x

Heather Wood

引用次数: 0

Prognostic plasma biomarkers for spinal cord injury 脊髓损伤的预后血浆生物标志物

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-03-10 DOI: 10.1038/s41582-025-01075-w

Heather Wood

引用次数: 0

Spinal muscular atrophy treatment in utero 子宫内脊髓性肌萎缩症治疗

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-03-10 DOI: 10.1038/s41582-025-01076-9

Heather Wood

引用次数: 0

A global perspective on research advances and future challenges in Friedreich ataxia 弗里德赖希共济失调研究进展及未来挑战的全球视角

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-03-03 DOI: 10.1038/s41582-025-01065-y

Elisabetta Indelicato, Martin B. Delatycki, Jennifer Farmer, Marcondes C. França Jr, Susan Perlman, Myriam Rai, Sylvia Boesch

{"title":"A global perspective on research advances and future challenges in Friedreich ataxia","authors":"Elisabetta Indelicato, Martin B. Delatycki, Jennifer Farmer, Marcondes C. França Jr, Susan Perlman, Myriam Rai, Sylvia Boesch","doi":"10.1038/s41582-025-01065-y","DOIUrl":"10.1038/s41582-025-01065-y","url":null,"abstract":"Friedreich ataxia (FRDA) is a rare multisystem, life-limiting disease and is the most common early-onset inherited ataxia in populations of European, Arab and Indian descent. In recent years, substantial progress has been made in dissecting the pathogenesis and natural history of FRDA, and several clinical trials have been initiated. A particularly notable recent achievement was the approval of the nuclear factor erythroid 2-related factor 2 activator omaveloxolone as the first disease-specific therapy for FRDA. In light of these developments, we review milestones in FRDA translational and clinical research over the past 10 years, as well as the various therapeutic strategies currently in the pipeline. We also consider the lessons that have been learned from failed trials and other setbacks. We conclude by presenting a global roadmap for future research, as outlined by the recently established Friedreich’s Ataxia Global Clinical Consortium, which covers North and South America, Europe, India, Australia and New Zealand. Friedreich ataxia (FRDA) is a rare multisystem disorder and is the most common early-onset hereditary ataxia in populations of European, Arab and Indian descent. This article reviews the milestones in FRDA translational and clinical research over the past 10 years and outlines the priorities for future FRDA research.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 4","pages":"204-215"},"PeriodicalIF":28.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of neurons involved in schizophrenia 鉴定与精神分裂症有关的神经元

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-02-17 DOI: 10.1038/s41582-025-01067-w

Ian Fyfe

引用次数: 0

Degeneration decades before disease onset 在发病前几十年退行性变

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-02-17 DOI: 10.1038/s41582-025-01069-8

Ian Fyfe

引用次数: 0

Parkinson disease pathology can originate in the kidney 帕金森病的病理可以起源于肾脏

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-02-17 DOI: 10.1038/s41582-025-01066-x

Lisa Kiani

引用次数: 0

CNS drug delivery improves chemotherapy 中枢神经系统给药改善化疗

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-02-17 DOI: 10.1038/s41582-025-01070-1

Ian Fyfe

引用次数: 0

Neurogenesis altered by disease and stimulation 神经发生因疾病和刺激而改变

IF 28.2 1区医学

Nature Reviews Neurology Pub Date : 2025-02-17 DOI: 10.1038/s41582-025-01068-9

Ian Fyfe

引用次数: 0