Nature Reviews Neurology最新文献

{"title":"Neuron–tumour networks targeted","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01059-w","DOIUrl":"10.1038/s41582-025-01059-w","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 2","pages":"66-66"},"PeriodicalIF":28.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain stimulation aids walking after spinal injury","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01057-y","DOIUrl":"10.1038/s41582-025-01057-y","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 2","pages":"66-66"},"PeriodicalIF":28.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the long-term neurological consequences of COVID-19","authors":"Heather Wood","doi":"10.1038/s41582-025-01056-z","DOIUrl":"10.1038/s41582-025-01056-z","url":null,"abstract":"Two recently published studies have provided new insights into the long-term effects of COVID-19 on the nervous system.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 2","pages":"65-65"},"PeriodicalIF":28.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers help to predict dementia with Lewy bodies","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01058-x","DOIUrl":"10.1038/s41582-025-01058-x","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 2","pages":"66-66"},"PeriodicalIF":28.2,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142987293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder — recommendations from ECTRIMS and the EBMT","authors":"Paolo A. Muraro, Alice Mariottini, Raffaella Greco, Joachim Burman, Ellen Iacobaeus, Matilde Inglese, John A. Snowden, Tobias Alexander, Maria Pia Amato, Lars Bø, Giacomo Boffa, Olga Ciccarelli, Jeffrey A. Cohen, Tobias Derfuss, Dominique Farge, Mark S. Freedman, Maria Gaughan, Christoph Heesen, Majid Kazmi, Kirill Kirzigov, Per Ljungman, Gianluigi Mancardi, Roland Martin, Varun Mehra, Lucia Moiola, Riccardo Saccardi, Mar Tintoré, Bruno Stankoff, Basil Sharrack, on behalf of Attendees of the ECTRIMS Focused Workshop on HSCT","doi":"10.1038/s41582-024-01050-x","DOIUrl":"10.1038/s41582-024-01050-x","url":null,"abstract":"Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment option for relapsing forms of multiple sclerosis (MS) that are refractory to disease-modifying therapy (DMT). AHSCT after failure of high-efficacy DMT in aggressive forms of relapsing–remitting MS is a generally accepted indication, yet the optimal placement of this approach in the treatment sequence is not universally agreed upon. Uncertainties also remain with respect to other indications, such as in rapidly evolving, severe, treatment-naive MS, progressive MS, and neuromyelitis optica spectrum disorder (NMOSD). Furthermore, treatment and monitoring protocols, rehabilitation and other supportive care before and after AHSCT need to be optimized. To address these issues, we convened a European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop in partnership with the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party, in which evidence and key questions were presented and discussed by experts in these diseases and in AHSCT. Based on the workshop output and subsequent written interactions, this Consensus Statement provides practical guidance and recommendations on the use of AHSCT in MS and NMOSD. Recommendations are based on the available evidence, or on consensus when evidence was insufficient. We summarize the key evidence, report the final recommendations, and identify areas for further research. Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment option for some forms of multiple sclerosis (MS), but uncertainties remain about its implementation in clinical practice and treatment protocols need to be optimized. This Consensus Statement provides guidance and recommendations for the use of AHSCT in MS and neuromyelitis optica spectrum disorders.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 3","pages":"140-158"},"PeriodicalIF":28.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41582-024-01050-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia is a neglected noncommunicable disease and leading cause of death","authors":"Lewis Arthurton, Paola Barbarino, Robert Anderson, Ben Schlaepfer, Nazak Salehi, Martin Knapp","doi":"10.1038/s41582-024-01051-w","DOIUrl":"10.1038/s41582-024-01051-w","url":null,"abstract":"Dementia is largely excluded from discussion of noncommunicable diseases, which limits its inclusion in health policies and allocation of resources — yet it is already a leading cause of mortality and its effects are set to increase. Alzheimer’s Disease International calls for changes in policies to address the effects of dementia now and in the future.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 2","pages":"63-64"},"PeriodicalIF":28.2,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloid-related imaging abnormalities: manifestations, metrics and mechanisms","authors":"Steven M. Greenberg, Francesco Bax, Susanne J. van Veluw","doi":"10.1038/s41582-024-01053-8","DOIUrl":"10.1038/s41582-024-01053-8","url":null,"abstract":"Three monoclonal antibodies directed against specific forms of the amyloid-β (Aβ) peptide have been granted accelerated or traditional approval by the FDA as treatments for Alzheimer disease, representing the first step towards bringing disease-modifying treatments for this disease into clinical practice. Here, we review the detection, underlying pathophysiological mechanisms and clinical implications of amyloid-related imaging abnormalities (ARIA), the most impactful adverse effect of anti-Aβ immunotherapy. ARIA appears as regions of oedema or effusions (ARIA-E) in brain parenchyma or sulci or as haemorrhagic lesions (ARIA-H) in the form of cerebral microbleeds, convexity subarachnoid haemorrhage, cortical superficial siderosis or intracerebral haemorrhage. Analysis of the radiographic appearance of ARIA, its clinical risk factors and underlying neuropathology, and results from animal models point to a central role for cerebral amyloid angiopathy — a condition characterized by cerebrovascular Aβ deposits — as a key component, either as a direct target for antibody-mediated inflammation or as recipient of Aβ mobilized from plaques in the Alzheimer brain parenchyma. The great majority of ARIA occurrences are associated with mild or no clinical symptoms. However, ~5% of all ARIA events are severe enough to result in hospitalization, permanent disability or death and thus raise challenging clinical questions regarding patient selection and use of concomitant agents. Therefore, identifying novel approaches to predicting, modelling, preventing and treating ARIA remains a key step towards allowing safe use of anti-Aβ immunotherapy for the world’s rapidly ageing population. Amyloid-related imaging abnormalities are the most impactful adverse effect of anti-amyloid-β immunotherapies. Here, the authors review the detection, underlying mechanisms and clinical implications of amyloid-related imaging abnormalities and highlight the need for further research to predict, prevent and treat the condition.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 4","pages":"193-203"},"PeriodicalIF":28.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and circadian disturbances in children with neurodevelopmental disorders","authors":"Oliviero Bruni, Maria Breda, Valeria Mammarella, Maria Paola Mogavero, Raffaele Ferri","doi":"10.1038/s41582-024-01052-9","DOIUrl":"10.1038/s41582-024-01052-9","url":null,"abstract":"Sleep is essential for brain development and overall health, particularly in children with neurodevelopmental disorders (NDDs). Sleep disruptions can considerably impact brain structure and function, leading to dysfunction of neurotransmitter systems, metabolism, hormonal balance and inflammatory processes, potentially contributing to the pathophysiology of NDDs. This Review examines the prevalence, types and mechanisms of sleep disturbances in children with NDDs, including autism spectrum disorder, attention-deficit hyperactivity disorder and various genetic syndromes. Common sleep disorders in these populations include insomnia, hypersomnia, circadian rhythm disorders, sleep-related breathing disorders and parasomnias, with underlying factors often involving genetic, neurobiological, environmental and neurophysiological influences. Sleep problems such as insomnia, night awakenings and sleep fragmentation are closely linked to both internalizing symptoms such as anxiety and depression, and externalizing behaviours such as hyperactivity and aggression. Assessment of sleep in children with NDDs presents unique challenges owing to communication difficulties, comorbid conditions and altered sensory processing. The Review underscores the importance of further research to unravel the complex interactions between sleep and neurodevelopment, advocating for longitudinal studies and the identification of predictive biomarkers. Understanding and addressing sleep disturbances in NDDs is crucial for improving developmental outcomes and the overall quality of life for affected individuals and their families. In this Review, the authors provide a comprehensive overview of the prevalence and impact of various sleep disturbances in children with neurodevelopmental disorders. The authors discuss potential underlying mechanisms of sleep disorders in this population, with clues from genetic disorders, and highlight the complex bidirectional relationship between sleep and neurodevelopment.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 2","pages":"103-120"},"PeriodicalIF":28.2,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternating hemiplegia of childhood: challenges in a changing climate","authors":"Katherine Behl","doi":"10.1038/s41582-024-01054-7","DOIUrl":"10.1038/s41582-024-01054-7","url":null,"abstract":"Katherine Behl is a physician and the mother of a child with alternating hemiplegia of childhood (AHC) — an ultra-rare neurological disease that is exacerbated by temperature changes. Here, she highlights the day-to-day challenges of living with AHC and considers what stakeholders in climate action can learn from people with lived experience of disease.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 4","pages":"171-172"},"PeriodicalIF":28.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inclusion in neurological research: empowering people living with neurological diseases","authors":"Maria Teresa Ferretti, Maria Bonaria Uccheddu, Richelle Flanagan, Iracema Leroi, Elena Moro","doi":"10.1038/s41582-024-01047-6","DOIUrl":"10.1038/s41582-024-01047-6","url":null,"abstract":"The value of involving people living with diseases in the research process is increasingly recognized by professional associations and regulatory agencies alike. Patient contributions range from disease prevention and diagnosis to medication planning, and from advocacy to guideline production and clinical trial design. Thanks to the efforts of activists and advocates, new models of patient inclusion in medical research are being developed to replace outdated non-participative and tokenistic paradigms. New modalities of patient participation in research — for example, the introduction of patient experts, who work closely with researchers and clinicians — have progressively empowered individuals who are living with diseases. In this Perspective, we provide an overview of the current status of patient involvement in medical research, with a specific focus on neurology. We also discuss the existing and future roles of patient experts in neurological research. The importance of active involvement of people living with diseases in various aspects of medicine, including disease management and follow-up, regulatory issues, health advocacy and clinical research, is increasingly recognized. This Perspective reviews the current status of patient involvement in neurological and other medical research, highlighting the role of patient experts.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 3","pages":"159-170"},"PeriodicalIF":28.2,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}