发布求助
文献互助 智能选刊 最新文献

Nature Reviews Neurology最新文献

筛选
英文 中文
Implications of AD plasma and PET biomarker discordance AD血浆和PET生物标志物不一致的意义
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-05-01 DOI: 10.1038/s41582-025-01091-w
Charlotte E. Teunissen, Lisa Vermunt
{"title":"Implications of AD plasma and PET biomarker discordance","authors":"Charlotte E. Teunissen, Lisa Vermunt","doi":"10.1038/s41582-025-01091-w","DOIUrl":"https://doi.org/10.1038/s41582-025-01091-w","url":null,"abstract":"Plasma biomarker tests for Alzheimer disease are becoming increasingly reliable, which enables implementation in clinical settings in which cerebrospinal fluid analysis and PET scans are unavailable. However, a new study shows that some patients have discordant plasma and PET biomarker results. Clinicians need clear guidance to identify and manage patients who do not fit into standard clinical or biological categories.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"95 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alzheimer disease seen through the lens of sex and gender 从性和性别角度看阿尔茨海默病
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-14 DOI: 10.1038/s41582-025-01071-0
Laura Castro-Aldrete, Melanie Einsiedler, Julie Novakova Martinkova, Herman Depypere, Ting Fang Alvin Ang, Michelle M. Mielke, Shireen Sindi, Harris A. Eyre, Rhoda Au, Anne Marie Schumacher Dimech, Anna Dé, Cassandra Szoeke, Maria Carmela Tartaglia, Antonella Santuccione Chadha
{"title":"Alzheimer disease seen through the lens of sex and gender","authors":"Laura Castro-Aldrete, Melanie Einsiedler, Julie Novakova Martinkova, Herman Depypere, Ting Fang Alvin Ang, Michelle M. Mielke, Shireen Sindi, Harris A. Eyre, Rhoda Au, Anne Marie Schumacher Dimech, Anna Dé, Cassandra Szoeke, Maria Carmela Tartaglia, Antonella Santuccione Chadha","doi":"10.1038/s41582-025-01071-0","DOIUrl":"https://doi.org/10.1038/s41582-025-01071-0","url":null,"abstract":"<p>Alzheimer disease (AD) is a life-limiting neurodegenerative disorder that disproportionately affects women. Indeed, sex and gender are emerging as crucial modifiers of diagnostic and therapeutic pathways in AD. This Review provides an overview of the interactions of sex and gender with important developments in AD and offers insights into priorities for future research to facilitate the development and implementation of personalized approaches in the shifting paradigm of AD care. In particular, this Review focuses on the influence of sex and gender on important advances in the treatment and diagnosis of AD, including disease-modifying therapies, fluid-based biomarkers, cognitive assessment tools and multidomain lifestyle interventional studies.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"39 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Women’s neurology: a growing subspeciality to tackle sex and gender disparities 女性神经病学：应对性和性别差异的不断发展的亚专科
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-14 DOI: 10.1038/s41582-025-01088-5
Lisa Kiani
{"title":"Women’s neurology: a growing subspeciality to tackle sex and gender disparities","authors":"Lisa Kiani","doi":"10.1038/s41582-025-01088-5","DOIUrl":"https://doi.org/10.1038/s41582-025-01088-5","url":null,"abstract":"Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with neurologist Esther Bui from Canada about her work to improve neurological health for women. We spoke with neurologist Esther Bui from Canada about her work to improve neurological health for women.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"5 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglia underlie amyloid-β clearance in immunized people with Alzheimer disease 小胶质细胞是阿尔茨海默病免疫患者清除淀粉样蛋白β的基础
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-10 DOI: 10.1038/s41582-025-01084-9
Lisa Kiani
{"title":"Microglia underlie amyloid-β clearance in immunized people with Alzheimer disease","authors":"Lisa Kiani","doi":"10.1038/s41582-025-01084-9","DOIUrl":"https://doi.org/10.1038/s41582-025-01084-9","url":null,"abstract":"<p>A study published in <i>Nature Medicine</i> has found that microglia are responsible for amyloid-β (Aβ) clearance in people with Alzheimer disease (AD) treated with Aβ immunotherapies.</p><p>Transcriptomic analysis of frontal cortex sections revealed brain region-specific differential expression of genes involved in microglial function in people with AD treated with active Aβ immunotherapy AN1792, as compared with untreated individuals. Established AD risk genes that are involved in the microglial response, including <i>TREM2</i> and <i>APOE</i>, were among the upregulated genes in treated individuals, and their expression correlated positively with Aβ removal. Similar results were observed in one individual treated with the approved monoclonal antibody lecanamab.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"23 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological rehabilitation for stroke 脑卒中的药物康复
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-10 DOI: 10.1038/s41582-025-01087-6
Lisa Kiani
{"title":"Pharmacological rehabilitation for stroke","authors":"Lisa Kiani","doi":"10.1038/s41582-025-01087-6","DOIUrl":"https://doi.org/10.1038/s41582-025-01087-6","url":null,"abstract":"<p>Synapse formation in parvalbumin-expressing interneurons underlies motor improvements following post-stroke rehabilitation and offers a drug target for stroke recovery, new research suggests. Task-based rehabilitation training in a mouse model of stroke selectively enhanced the synaptic input from parvalbumin interneurons to neurons that projected to the site of stroke induction, which resulted in motor recovery. Furthermore, the same outcome was achieved through pharmacological enhancement of parvalbumin interneuron function. The results demonstrate the potential of developing a rehabilitation drug for stroke — an area in which pharmacological therapies are currently lacking.</p><blockquote><p>“The results demonstrate the potential of developing a rehabilitation drug for stroke”</p></blockquote>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"43 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurofilament light chain induces neuroinflammation 神经丝轻链诱导神经炎症
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-10 DOI: 10.1038/s41582-025-01085-8
Lisa Kiani
{"title":"Neurofilament light chain induces neuroinflammation","authors":"Lisa Kiani","doi":"10.1038/s41582-025-01085-8","DOIUrl":"https://doi.org/10.1038/s41582-025-01085-8","url":null,"abstract":"<p>Neurofilament light chain (NfL) released from damaged neurons induces neuroinflammation, according to new research. NfL is used as a biomarker for many neurodegenerative diseases, but was not previously known to contribute to disease processes.</p><p>Glutamate-induced stress in primary neuronal cultures resulted in a twofold increase in NfL release from baseline, which was dependent on calpain proteolysis and correlated with neuronal degradation. Transcriptomic analysis of mouse hippocampal cells showed activation of microglia following NfL injection. Moreover, NfL knockout in the SOD1 mouse model of amyotrophic lateral sclerosis (ALS) reduced microgliosis and motor neuron loss, and delayed symptom onset.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"272 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Walking the Talk for Dementia — an experience to break down barriers 为痴呆症说话-一个打破障碍的经验
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-10 DOI: 10.1038/s41582-025-01082-x
Ian Fyfe
{"title":"Walking the Talk for Dementia — an experience to break down barriers","authors":"Ian Fyfe","doi":"10.1038/s41582-025-01082-x","DOIUrl":"https://doi.org/10.1038/s41582-025-01082-x","url":null,"abstract":"Walking the Talk for Dementia is no ordinary conference, but an experience that is designed to bring together people with diverse perspectives on dementia, including people with lived experience, and to foster new ways of thinking and collaborating. We asked founder Fernando Aguzzoli-Peres to tell us more about his unique initiative.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"25 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-ancestry GWAS identifies 16 novel Alzheimer disease risk loci 多祖先GWAS鉴定出16个新的阿尔茨海默病风险位点
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-10 DOI: 10.1038/s41582-025-01086-7
Lisa Kiani
{"title":"Multi-ancestry GWAS identifies 16 novel Alzheimer disease risk loci","authors":"Lisa Kiani","doi":"10.1038/s41582-025-01086-7","DOIUrl":"https://doi.org/10.1038/s41582-025-01086-7","url":null,"abstract":"<p>A genome-wide association study (GWAS) of people with Alzheimer disease (AD) from diverse ancestral backgrounds has identified 16 genetic loci previously unknown to be associated with the disease. The study included individuals from the All of Us cohort, 78% of whom are from non-white groups that are underrepresented in biomedical research, alongside the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS), National Institute of Mental Health and the UK Biobank. The GWAS revealed 5 common and 11 rare AD-associated loci, and the study highlights the benefit of using data from diverse cohorts.</p><blockquote><p>“The GWAS revealed 5 common and 11 rare AD-associated loci”</p></blockquote>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"217 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multiple sclerosis: an immune attack on astrocyte-mediated ion and water homeostasis 多发性硬化症：星形胶质细胞介导的离子和水稳态的免疫攻击
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-04 DOI: 10.1038/s41582-025-01081-y
Marjo S. van der Knaap, Rogier Min
{"title":"Multiple sclerosis: an immune attack on astrocyte-mediated ion and water homeostasis","authors":"Marjo S. van der Knaap, Rogier Min","doi":"10.1038/s41582-025-01081-y","DOIUrl":"https://doi.org/10.1038/s41582-025-01081-y","url":null,"abstract":"<p>Multiple sclerosis (MS) is an inflammatory demyelinating disease of the CNS. The chain of events that results in demyelinating lesions is not understood, although most theories assume a primary immune attack on myelin. However, the glial cell adhesion molecule GlialCAM, which forms part of a protein complex in astrocytic endfeet that is crucial for brain ion and water homeostasis, was recently identified as a target for autoimmunity in patients with MS. This complex also includes the astrocytic transmembrane protein MLC1, the water channel aquaporin 4 (AQP4) and the potassium channel KIR4.1. Autoimmunity against AQP4 underlies another demyelinating disorder, neuromyelitis optica, and autoimmunity against KIR4.1 has been implicated in a subtype of MS. Genetic defects in any of these proteins cause leukodystrophies with disruption of brain ion and water homeostasis, which is regulated by astrocytes and secondarily affects myelin. In this Perspective, we argue that an immune attack on the ion and water homeostasis machinery in astrocytic endfeet, rather than directly on myelin, is the primary event in MS and that myelin damage is a consequence of astrocyte dysfunction. This hypothesis is supported by pathological studies on tissue from people with MS and has important implications for disease models and therapy targets.</p>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"37 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic reprogramming of glioblastoma to overcome chemotherapy resistance 对胶质母细胞瘤进行表观遗传学重编程以克服化疗耐药性
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2025-04-04 DOI: 10.1038/s41582-025-01083-w
Heather Wood
{"title":"Epigenetic reprogramming of glioblastoma to overcome chemotherapy resistance","authors":"Heather Wood","doi":"10.1038/s41582-025-01083-w","DOIUrl":"https://doi.org/10.1038/s41582-025-01083-w","url":null,"abstract":"Researchers have developed a CRISPR–Cas9-based epigenetic editing approach that sensitizes glioblastoma cells to standard chemotherapy drugs and could improve the treatment of tumours that have developed resistance to these drugs.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"183 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信