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Precision neuroimmunology in multiple sclerosis — the horizon is near 多发性硬化症的精准神经免疫学--地平线近在眼前
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-04 DOI: 10.1038/s41582-024-00992-6
Jiwon Oh, Amit Bar-Or
{"title":"Precision neuroimmunology in multiple sclerosis — the horizon is near","authors":"Jiwon Oh, Amit Bar-Or","doi":"10.1038/s41582-024-00992-6","DOIUrl":"10.1038/s41582-024-00992-6","url":null,"abstract":"Immunological profiling has revealed biological signatures of multiple sclerosis (MS) that could help with early, accurate diagnosis of the disease and with identifying disease subtypes that could inform treatment decisions. The findings are important steps along the path towards precision medicine for people with MS.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141521512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal cord stimulation for the treatment of chronic pain 脊髓刺激治疗慢性疼痛
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-01 DOI: 10.1038/s41582-024-00981-9
Cecile C. de Vos, Kaare Meier
{"title":"Spinal cord stimulation for the treatment of chronic pain","authors":"Cecile C. de Vos, Kaare Meier","doi":"10.1038/s41582-024-00981-9","DOIUrl":"10.1038/s41582-024-00981-9","url":null,"abstract":"Spinal cord stimulation is an invasive therapy for chronic neuropathic pain, usually used as a last-resort treatment when all other treatments have been tried and failed. The clinical value of the therapy has been much debated in recent years; here, we summarize the therapy and discuss the core controversies. Spinal cord stimulation is seen as a last-resort therapy for the treatment of chronic pain. Controversies surrounding the treatment might be addressed through collaborative efforts to conduct innovative clinical trials and reach consensus on treatment guidelines.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focused ultrasound brain therapy is a new tool in the box 聚焦超声脑疗法是一种新工具
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-01 DOI: 10.1038/s41582-024-00975-7
Raúl Martínez-Fernández
{"title":"Focused ultrasound brain therapy is a new tool in the box","authors":"Raúl Martínez-Fernández","doi":"10.1038/s41582-024-00975-7","DOIUrl":"10.1038/s41582-024-00975-7","url":null,"abstract":"Similar to any innovation that disrupts the status quo, the advent of magnetic resonance-guided focused ultrasound in neurology was accompanied by controversy and debate. However, evidence suggests that this therapeutic tool, which is already widely used to treat tremor and Parkinson disease, is gaining acceptance and will become a viable therapeutic option for various other neurological conditions in the near future.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory feedback in upper limb prosthetics: advances and challenges 上肢假肢的感觉反馈：进步与挑战
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-30 DOI: 10.1038/s41582-024-00987-3
Nebojša Malešević, Christian Antfolk
{"title":"Sensory feedback in upper limb prosthetics: advances and challenges","authors":"Nebojša Malešević, Christian Antfolk","doi":"10.1038/s41582-024-00987-3","DOIUrl":"10.1038/s41582-024-00987-3","url":null,"abstract":"Advanced sensory feedback from upper limb prostheses would provide multiple benefits to people with upper limb amputations, but achieving functional and natural-feeling sensation is technologically challenging. Advances are being made with invasive and non-invasive stimulation approaches, but considerable challenges need to be addressed with technological innovation.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141463915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromodulation for severe brain injury: time for a paradigm shift? 严重脑损伤的神经调控：范式转变的时机已到？
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-30 DOI: 10.1038/s41582-024-00980-w
Aurore Thibaut, Géraldine Martens
{"title":"Neuromodulation for severe brain injury: time for a paradigm shift?","authors":"Aurore Thibaut, Géraldine Martens","doi":"10.1038/s41582-024-00980-w","DOIUrl":"10.1038/s41582-024-00980-w","url":null,"abstract":"Neuromodulation represents a promising approach for promoting neural plasticity following a brain injury, especially for non-communicative patients with prolonged disorders of consciousness. However, so far, the outcomes have been limited and inconsistent, driving researchers to explore alternative strategies to improve the efficacy of brain stimulation techniques.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141463931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders 无创深部脑刺激：针对神经系统疾病的深部脑区进行介入治疗
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-29 DOI: 10.1038/s41582-024-00990-8
Friedhelm C. Hummel, Maximilian J. Wessel
{"title":"Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders","authors":"Friedhelm C. Hummel, Maximilian J. Wessel","doi":"10.1038/s41582-024-00990-8","DOIUrl":"10.1038/s41582-024-00990-8","url":null,"abstract":"Recently developed non-invasive deep brain stimulation methods have sufficient focal specificity to target deep brain structures. These techniques show particular promise as treatment strategies for neuropsychiatric disorders in which deep brain structures have critical roles in pathophysiology or in mediating recovery. A non-invasive technique using transcranial electrical stimulation offers an improvement in focality over other non-invasive techniques, presenting an opportunity to target deep brain structures for the treatment of neurological disorders.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive stimulation for treating cognitive impairment in Alzheimer disease 治疗阿尔茨海默病认知障碍的非侵入性刺激疗法
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-29 DOI: 10.1038/s41582-024-00976-6
Irena Rektorová
{"title":"Non-invasive stimulation for treating cognitive impairment in Alzheimer disease","authors":"Irena Rektorová","doi":"10.1038/s41582-024-00976-6","DOIUrl":"10.1038/s41582-024-00976-6","url":null,"abstract":"Some device-based non-invasive brain stimulation methods have been recommended as probably effective for cognitive treatment in Alzheimer disease. New targets and novel transcranial electrical stimulation techniques enable physiology-inspired modulation of oscillatory activity and precise targeting of deep brain structures. The use of non-invasive brain stimulation techniques to treat mild cognitive impairment and dementia in Alzheimer disease is expanding. Trials have produced varying results depending on the differing stimulation techniques, targeted brain regions and degrees of cognitive impairment among the treated cohorts.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifaceted roles of APOE in Alzheimer disease APOE 在阿尔茨海默病中的多方面作用
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-21 DOI: 10.1038/s41582-024-00988-2
Rosemary J. Jackson, Bradley T. Hyman, Alberto Serrano-Pozo
{"title":"Multifaceted roles of APOE in Alzheimer disease","authors":"Rosemary J. Jackson, Bradley T. Hyman, Alberto Serrano-Pozo","doi":"10.1038/s41582-024-00988-2","DOIUrl":"10.1038/s41582-024-00988-2","url":null,"abstract":"For the past three decades, apolipoprotein E (APOE) has been known as the single greatest genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age of onset and the lifetime risk of developing AD. The APOEε4 allele significantly increases AD risk, whereas the ε2 allele is protective relative to the most common ε3 allele. However, large differences in effect size exist across ethnoracial groups that are likely to depend on both global genetic ancestry and local genetic ancestry, as well as gene–environment interactions. Although early studies linked APOE to amyloid-β — one of the two culprit aggregation-prone proteins that define AD — in the past decade, mounting work has associated APOE with other neurodegenerative proteinopathies and broader ageing-related brain changes, such as neuroinflammation, energy metabolism failure, loss of myelin integrity and increased blood–brain barrier permeability, with potential implications for longevity and resilience to pathological protein aggregates. Novel mouse models and other technological advances have also enabled a number of therapeutic approaches aimed at either attenuating the APOEε4-linked increased AD risk or enhancing the APOEε2-linked AD protection. This Review summarizes this progress and highlights areas for future research towards the development of APOE-directed therapeutics. Apolipoprotein E (APOE) is the greatest genetic modulator of sporadic Alzheimer disease risk. This Review provides a comprehensive update on our current knowledge of the genetics of APOE and its role in Alzheimer and other neurodegenerative diseases, and summarizes emerging APOE-targeted therapies designed to prevent or slow down Alzheimer disease.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141435860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurology under the midnight sun: EAN Congress 2024 comes to Helsinki 午夜阳光下的神经学：2024年欧洲神经科学大会将在赫尔辛基举行。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-21 DOI: 10.1038/s41582-024-00982-8
Heather Wood
{"title":"Neurology under the midnight sun: EAN Congress 2024 comes to Helsinki","authors":"Heather Wood","doi":"10.1038/s41582-024-00982-8","DOIUrl":"10.1038/s41582-024-00982-8","url":null,"abstract":"The 10th Congress of the European Academy of Neurology is being held in Helsinki, Finland from 29 June to 2 July 2024, and Nature Reviews Neurology is publishing a series of Comments on the overarching theme, neuromodulation. We asked Programme Committee Chairs Ulf Kallweit and Reetta Kälviäinen about their roles and their expectations for the congress.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy 从扩展性去极化到血脑屏障功能障碍：探索创伤性脑损伤的新型诊断和治疗方法
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-17 DOI: 10.1038/s41582-024-00973-9
Gerben van Hameren, Refat Aboghazleh, Ellen Parker, Jens P. Dreier, Daniela Kaufer, Alon Friedman
{"title":"From spreading depolarization to blood–brain barrier dysfunction: navigating traumatic brain injury for novel diagnosis and therapy","authors":"Gerben van Hameren, Refat Aboghazleh, Ellen Parker, Jens P. Dreier, Daniela Kaufer, Alon Friedman","doi":"10.1038/s41582-024-00973-9","DOIUrl":"10.1038/s41582-024-00973-9","url":null,"abstract":"Considerable strides in medical interventions during the acute phase of traumatic brain injury (TBI) have brought improved overall survival rates. However, following TBI, people often face ongoing, persistent and debilitating long-term complications. Here, we review the recent literature to propose possible mechanisms that lead from TBI to long-term complications, focusing particularly on the involvement of a compromised blood–brain barrier (BBB). We discuss evidence for the role of spreading depolarization as a key pathological mechanism associated with microvascular dysfunction and the transformation of astrocytes to an inflammatory phenotype. Finally, we summarize new predictive and diagnostic biomarkers and explore potential therapeutic targets for treating long-term complications of TBI. Overall survival rates for traumatic brain injury have improved, but affected individuals often experience persistent and debilitating long-term complications. In this Review, the authors discuss recent evidence for the role of spreading depolarization in the initiation of long-term pathology in traumatic brain injury, including effects on blood–brain barrier dysfunction and neuroinflammation.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141333717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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