Multi-ancestry GWAS identifies 16 novel Alzheimer disease risk loci

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-04-10 DOI:10.1038/s41582-025-01086-7

Lisa Kiani

引用次数: 0

Abstract

A genome-wide association study (GWAS) of people with Alzheimer disease (AD) from diverse ancestral backgrounds has identified 16 genetic loci previously unknown to be associated with the disease. The study included individuals from the All of Us cohort, 78% of whom are from non-white groups that are underrepresented in biomedical research, alongside the National Institute on Aging Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS), National Institute of Mental Health and the UK Biobank. The GWAS revealed 5 common and 11 rare AD-associated loci, and the study highlights the benefit of using data from diverse cohorts.

“The GWAS revealed 5 common and 11 rare AD-associated loci”

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多祖先GWAS鉴定出16个新的阿尔茨海默病风险位点

一项针对来自不同祖先背景的阿尔茨海默病（AD）患者的全基因组关联研究（GWAS）发现了16个以前未知的与该疾病相关的基因位点。该研究包括来自“我们所有人”队列的个人，其中78%来自生物医学研究中代表性不足的非白人群体，以及国家阿尔茨海默病数据存储站点老化遗传学研究所（NIAGADS），国家心理健康研究所和英国生物银行。GWAS揭示了5个常见和11个罕见的ad相关位点，该研究强调了使用不同队列数据的好处。“GWAS发现了5个常见和11个罕见的ad相关位点”

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

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