Nature Reviews Neurology最新文献

Translating lifestyle interventions for optimal brain health in Africa 将生活方式干预转化为非洲最佳的大脑健康

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-07-11 DOI: 10.1038/s41582-025-01104-8

Chinedu T. Udeh-Momoh, Celeste A. de Jager Loots, Tamlyn J. Watermeyer, Udunna C. Anazodo, Catherine Ajalo, Edna N. Bosire, Ameenah Sorefan, Christine Musyimi, Chido Rwafa, Njideka Okubadejo, Miia Kivipelto

{"title":"Translating lifestyle interventions for optimal brain health in Africa","authors":"Chinedu T. Udeh-Momoh, Celeste A. de Jager Loots, Tamlyn J. Watermeyer, Udunna C. Anazodo, Catherine Ajalo, Edna N. Bosire, Ameenah Sorefan, Christine Musyimi, Chido Rwafa, Njideka Okubadejo, Miia Kivipelto","doi":"10.1038/s41582-025-01104-8","DOIUrl":"https://doi.org/10.1038/s41582-025-01104-8","url":null,"abstract":"Global dementia cases are rising, particularly in low- and middle-income countries with limited health-care access and scarce resources, calling for preventive strategies that align with local capital and cultural practices. The Africa-FINGERS project, an adaptation of the Finnish FINGER trial, pioneers a culturally relevant, multidomain approach to dementia risk reduction for African settings. This Perspective article explores the efficacy of multimodal lifestyle interventions in reducing risks associated with cognitive decline, addressing the unique challenges involved and examining opportunities for implementing such programmes in Africa. Drawing on preliminary insights from ongoing implementation efforts in Africa and lessons from the World Wide FINGERS global network, we describe a standardized, evidence-based precision brain health model that aims to dynamically and equitably optimize protective factors for brain health in Africa. This model is tailored to accommodate the diverse cultural, socioeconomic and logistical contexts of Africa, emphasizing culturally adapted, scalable and resource-sensitive solutions for sustainable implementation. Building on the successful execution of regional lifestyle-based interventions for other non-communicable diseases, we highlight the potential of the Africa-FINGERS programme to improve brain health and mitigate dementia risks across diverse global settings.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"72 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of combining multimodal data in assessment of people with traumatic brain injury 将多模态数据结合评估创伤性脑损伤患者的挑战

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-07-11 DOI: 10.1038/s41582-025-01121-7

Paul M. Brennan, Graham M. Teasdale

引用次数: 0

Limitations of neurocentric models for near-death experiences 濒死体验的神经中心模型的局限性

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-07-10 DOI: 10.1038/s41582-025-01117-3

Greg O’Grady, Chris Varghese

{"title":"Limitations of neurocentric models for near-death experiences","authors":"Greg O’Grady, Chris Varghese","doi":"10.1038/s41582-025-01117-3","DOIUrl":"https://doi.org/10.1038/s41582-025-01117-3","url":null,"abstract":"We read with great interest the recent proposal by Martial and colleagues (Martial, C. et al. A neuroscientific model of near-death experiences. Nat. Rev. Neurol. 21, 297–311; 2025)1 for a neuroscientific model of near-death experiences (NDEs). We commend the authors for integrating multiple neurophysiological and putative evolutionary perspectives. However, we respectfully submit that their model, though ambitious, omits key phenomenological features that are central to the core NDE experience and overextends certain neurochemical correlates into causal explanations.In establishing their neurocentric model, Martial et al. attempt to reframe many defining features of NDEs2,3. NDEs characteristically involve a distinct constellation of features that sets them apart from dreams, fantasies, hallucinations or epileptic phenomena. These features include veridical out-of-body observations (often corroborated by medical personnel); transitions to ‘otherworldly realms’; panoramic life reviews (including re-experiencing past events from multiple vantage points); and encounters with deceased (but not living) relatives or ‘beings of light’4. Many experiencers also undergo lifelong transformative changes in personal values and a marked loss of fear of death2,4,5. Such features appear with remarkable consistency across cultures and times2,4,6, and merely equating them with phenomena on the spectra of hallucinations or stress-induced fantasies misses precisely what distinguishes NDEs in terms of their specificity, coherence and intensity7.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"21 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to ‘Limitations of neurocentric models for near-death experiences’ 回复“濒死体验的神经中心模型的局限性”

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-07-10 DOI: 10.1038/s41582-025-01119-1

Charlotte Martial, Pauline Fritz, Olivia Gosseries, Vincent Bonhomme, Daniel Kondziella, Kevin Nelson, Nicolas Lejeune

{"title":"Reply to ‘Limitations of neurocentric models for near-death experiences’","authors":"Charlotte Martial, Pauline Fritz, Olivia Gosseries, Vincent Bonhomme, Daniel Kondziella, Kevin Nelson, Nicolas Lejeune","doi":"10.1038/s41582-025-01119-1","DOIUrl":"https://doi.org/10.1038/s41582-025-01119-1","url":null,"abstract":"We thank O’Grady and Varghese for their comments on our recent Review (Martial, C. et al. A neuroscientific model of near-death experiences. Nat. Rev. Neurol. 21, 297–311; 2025)1. We appreciate their engagement (O’Grady, G. & Varghese, C. Limitations of neurocentric models for near-death experiences. Nat. Rev. Neurol. https://doi.org/10.1038/s41582-025-01117-3; 2025)2 and agree wholeheartedly that near-death experiences (NDEs) “remain one of the most intriguing experiences in modern clinical science.”We recognize the need for multidisciplinary discourse that considers all available evidence. However, such inclusivity must extend to contemporary knowledge from neuroscience and cognitive psychology — key fields for understanding NDEs. Intellectual honesty and methodological rigour are essential in this belief-laden field. In this spirit, our NEPTUNE model1 was not intended to diminish the phenomenological richness or personal value of NDEs, but rather to propose a cognitive-neurobiologically plausible integrative framework grounded in empirical findings. Far from precluding neuroscientific explanation, the compelling phenomenology and profound impact of these experiences call for investigation into how such effects can emerge from extreme states, thereby motivating our evolutionary perspective1,3.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"37 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain–computer interface restores naturalistic speech to a man with ALS 脑机接口恢复ALS患者的自然语言

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-07-08 DOI: 10.1038/s41582-025-01122-6

Heather Wood

引用次数: 0

Neurological complications of CAR T cell therapy for cancers CAR - T细胞治疗癌症的神经系统并发症

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-06-25 DOI: 10.1038/s41582-025-01112-8

Philipp Karschnia, Jörg Dietrich

{"title":"Neurological complications of CAR T cell therapy for cancers","authors":"Philipp Karschnia, Jörg Dietrich","doi":"10.1038/s41582-025-01112-8","DOIUrl":"https://doi.org/10.1038/s41582-025-01112-8","url":null,"abstract":"Genetically engineered chimeric antigen receptor (CAR) T cells have emerged as a powerful treatment option in patients with B cell malignancies, but neurological adverse effects are common and hamper the success of such therapies. Immune effector cell-associated neurotoxicity syndrome encompasses a wide range of acute neurological adverse effects, including encephalopathy with alterations in cognition and behaviour, language, motor function and coordination. In patients treated with CAR T cells for CNS malignancies, a more localized on-tumour, on-target neurotoxicity syndrome termed tumour inflammation-associated neurotoxicity can develop acutely, resulting in localized oedema with mass effect or in electrophysiological dysfunction with neurological symptoms. Following B cell maturation antigen-targeting CAR T cell therapies, delayed neurological complications, including cranial nerve palsies and a unique delayed-onset parkinsonism syndrome, are increasingly recognized. Management of neurological complications includes symptomatic treatments such as antiepileptic drugs or cerebrospinal fluid diversion, temporary immunosuppression with corticosteroids, various cytokine-targeting agents, and other distinct approaches depending on the nature of the toxicity. As our understanding of the mechanisms that contribute to the various neurological adverse effects of CAR T cell and other T cell-engaging therapies increases, novel treatment strategies to alleviate symptoms, as well as innovative CAR designs, promise to improve the safety and neurotoxicity of these powerful immunotherapies.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"53 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AI, neurotechnology and society - a question of trust. 人工智能、神经技术和社会——一个信任的问题。

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-06-24 DOI: 10.1038/s41582-025-01114-6

Georg Starke,Marcello Ienca

引用次数: 0

Influence of sleep and chronotypes: are we adapted to today’s society? 睡眠和生物钟的影响：我们适应当今社会了吗？

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-06-21 DOI: 10.1038/s41582-025-01106-6

Ambra Stefani, Diego A. Golombek

引用次数: 0

Epigenetic clocks and DNA methylation biomarkers of brain health and disease 脑健康和疾病的表观遗传时钟和DNA甲基化生物标志物

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-06-18 DOI: 10.1038/s41582-025-01105-7

Eleanor L. S. Conole, Josephine A. Robertson, Hannah M. Smith, Simon R. Cox, Riccardo E. Marioni

{"title":"Epigenetic clocks and DNA methylation biomarkers of brain health and disease","authors":"Eleanor L. S. Conole, Josephine A. Robertson, Hannah M. Smith, Simon R. Cox, Riccardo E. Marioni","doi":"10.1038/s41582-025-01105-7","DOIUrl":"https://doi.org/10.1038/s41582-025-01105-7","url":null,"abstract":"Ageing has profound effects on the human brain across the lifespan. Cognitive testing and brain imaging are currently used to monitor healthy and pathological brain ageing. However, peripheral markers of cognitive function, cognitive ageing and neurological disease could provide a valuable, minimally invasive approach to tracking these processes longitudinally. In this Review, we introduce the concept of DNA methylation-based biomarkers and present current evidence of their potential to address the challenge of monitoring brain ageing and stratifying the risk of neurological disease. We focus on epigenetic clocks, which can be applied across multiple tissues and organs to estimate biological ageing, as well as on blood-based epigenetic scores (EpiScores) that can directly track brain-based phenotypes, such as cognitive function, and risk factors for neurological diseases, such as lifestyle behaviours and proteomic markers of inflammation. We discuss the associations between these epigenetic biomarkers and multiple measures of cognitive health, including cognitive test data, brain MRI measures and dementia.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"39 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

α-Synuclein pathology in LRRK2 Parkinson disease α-突触核蛋白与LRRK2帕金森病的病理关系

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-06-18 DOI: 10.1038/s41582-025-01113-7

Ian Fyfe

引用次数: 0