Nature Reviews Neurology最新文献

Imperatives and co-benefits of research into climate change and neurological disease 气候变化和神经疾病研究的必要性和共同利益

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-20 DOI: 10.1038/s41582-024-01055-6

Medine I. Gulcebi, Sara Leddy, Katherine Behl, Derk-Jan Dijk, Eve Marder, Mark Maslin, Anna Mavrogianni, Michael Tipton, David J. Werring, Sanjay M. Sisodiya

{"title":"Imperatives and co-benefits of research into climate change and neurological disease","authors":"Medine I. Gulcebi, Sara Leddy, Katherine Behl, Derk-Jan Dijk, Eve Marder, Mark Maslin, Anna Mavrogianni, Michael Tipton, David J. Werring, Sanjay M. Sisodiya","doi":"10.1038/s41582-024-01055-6","DOIUrl":"https://doi.org/10.1038/s41582-024-01055-6","url":null,"abstract":"Evidence suggests that anthropogenic climate change is accelerating and is affecting human health globally. Despite urgent calls to address health effects in the context of the additional challenges of environmental degradation, biodiversity loss and ageing populations, the effects of climate change on specific health conditions are still poorly understood. Neurological diseases contribute substantially to the global burden of disease, and the possible direct and indirect consequences of climate change for people with these conditions are a cause for concern. Unaccustomed temperature extremes can impair the systems of resilience of the brain, thereby exacerbating or increasing susceptibility to neurological disease. In this Perspective, we explore how changing weather patterns resulting from climate change affect sleep — an essential restorative human brain activity, the quality of which is important for people with neurological diseases. We also consider the pervasive and complex influences of climate change on two common neurological conditions: stroke and epilepsy. We highlight the urgent need for research into the mechanisms underlying the effects of climate change on the brain in health and disease. We also discuss how neurologists can respond constructively to the climate crisis by raising awareness and promoting mitigation measures and research — actions that will bring widespread co-benefits.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MS drug beneficial in an underrepresented group 多发性硬化症药物在代表性不足的群体中有益

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-17 DOI: 10.1038/s41582-025-01060-3

Ian Fyfe

引用次数: 0

Neuron–tumour networks targeted 靶向神经元肿瘤网络

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-17 DOI: 10.1038/s41582-025-01059-w

Ian Fyfe

引用次数: 0

Brain stimulation aids walking after spinal injury 脑刺激有助于脊髓损伤后的行走

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-17 DOI: 10.1038/s41582-025-01057-y

Ian Fyfe

引用次数: 0

Exploring the long-term neurological consequences of COVID-19 探索COVID-19的长期神经系统后果

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-17 DOI: 10.1038/s41582-025-01056-z

Heather Wood

引用次数: 0

Markers help to predict dementia with Lewy bodies 标记物有助于预测路易体痴呆

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-17 DOI: 10.1038/s41582-025-01058-x

Ian Fyfe

引用次数: 0

Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder — recommendations from ECTRIMS and the EBMT 自体造血干细胞移植治疗多发性硬化症和视神经脊髓炎谱系障碍- ECTRIMS和EBMT的建议

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-15 DOI: 10.1038/s41582-024-01050-x

Paolo A. Muraro, Alice Mariottini, Raffaella Greco, Joachim Burman, Ellen Iacobaeus, Matilde Inglese, John A. Snowden, Tobias Alexander, Maria Pia Amato, Lars Bø, Giacomo Boffa, Olga Ciccarelli, Jeffrey A. Cohen, Tobias Derfuss, Dominique Farge, Mark S. Freedman, Maria Gaughan, Christoph Heesen, Majid Kazmi, Kirill Kirzigov, Per Ljungman, Gianluigi Mancardi, Roland Martin, Varun Mehra, Lucia Moiola, Riccardo Saccardi, Mar Tintoré, Bruno Stankoff, Basil Sharrack

{"title":"Autologous haematopoietic stem cell transplantation for treatment of multiple sclerosis and neuromyelitis optica spectrum disorder — recommendations from ECTRIMS and the EBMT","authors":"Paolo A. Muraro, Alice Mariottini, Raffaella Greco, Joachim Burman, Ellen Iacobaeus, Matilde Inglese, John A. Snowden, Tobias Alexander, Maria Pia Amato, Lars Bø, Giacomo Boffa, Olga Ciccarelli, Jeffrey A. Cohen, Tobias Derfuss, Dominique Farge, Mark S. Freedman, Maria Gaughan, Christoph Heesen, Majid Kazmi, Kirill Kirzigov, Per Ljungman, Gianluigi Mancardi, Roland Martin, Varun Mehra, Lucia Moiola, Riccardo Saccardi, Mar Tintoré, Bruno Stankoff, Basil Sharrack","doi":"10.1038/s41582-024-01050-x","DOIUrl":"https://doi.org/10.1038/s41582-024-01050-x","url":null,"abstract":"Autologous haematopoietic stem cell transplantation (AHSCT) is a treatment option for relapsing forms of multiple sclerosis (MS) that are refractory to disease-modifying therapy (DMT). AHSCT after failure of high-efficacy DMT in aggressive forms of relapsing–remitting MS is a generally accepted indication, yet the optimal placement of this approach in the treatment sequence is not universally agreed upon. Uncertainties also remain with respect to other indications, such as in rapidly evolving, severe, treatment-naive MS, progressive MS, and neuromyelitis optica spectrum disorder (NMOSD). Furthermore, treatment and monitoring protocols, rehabilitation and other supportive care before and after AHSCT need to be optimized. To address these issues, we convened a European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop in partnership with the European Society for Blood and Marrow Transplantation Autoimmune Diseases Working Party, in which evidence and key questions were presented and discussed by experts in these diseases and in AHSCT. Based on the workshop output and subsequent written interactions, this Consensus Statement provides practical guidance and recommendations on the use of AHSCT in MS and NMOSD. Recommendations are based on the available evidence, or on consensus when evidence was insufficient. We summarize the key evidence, report the final recommendations, and identify areas for further research.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"30 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dementia is a neglected noncommunicable disease and leading cause of death 痴呆症是一种被忽视的非传染性疾病，也是导致死亡的主要原因

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-13 DOI: 10.1038/s41582-024-01051-w

Lewis Arthurton, Paola Barbarino, Robert Anderson, Ben Schlaepfer, Nazak Salehi, Martin Knapp

引用次数: 0

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-10 DOI: 10.1038/s41582-024-01053-8

Steven M. Greenberg, Francesco Bax, Susanne J. van Veluw

{"title":"Amyloid-related imaging abnormalities: manifestations, metrics and mechanisms","authors":"Steven M. Greenberg, Francesco Bax, Susanne J. van Veluw","doi":"10.1038/s41582-024-01053-8","DOIUrl":"https://doi.org/10.1038/s41582-024-01053-8","url":null,"abstract":"Three monoclonal antibodies directed against specific forms of the amyloid-β (Aβ) peptide have been granted accelerated or traditional approval by the FDA as treatments for Alzheimer disease, representing the first step towards bringing disease-modifying treatments for this disease into clinical practice. Here, we review the detection, underlying pathophysiological mechanisms and clinical implications of amyloid-related imaging abnormalities (ARIA), the most impactful adverse effect of anti-Aβ immunotherapy. ARIA appears as regions of oedema or effusions (ARIA-E) in brain parenchyma or sulci or as haemorrhagic lesions (ARIA-H) in the form of cerebral microbleeds, convexity subarachnoid haemorrhage, cortical superficial siderosis or intracerebral haemorrhage. Analysis of the radiographic appearance of ARIA, its clinical risk factors and underlying neuropathology, and results from animal models point to a central role for cerebral amyloid angiopathy — a condition characterized by cerebrovascular Aβ deposits — as a key component, either as a direct target for antibody-mediated inflammation or as recipient of Aβ mobilized from plaques in the Alzheimer brain parenchyma. The great majority of ARIA occurrences are associated with mild or no clinical symptoms. However, ~5% of all ARIA events are severe enough to result in hospitalization, permanent disability or death and thus raise challenging clinical questions regarding patient selection and use of concomitant agents. Therefore, identifying novel approaches to predicting, modelling, preventing and treating ARIA remains a key step towards allowing safe use of anti-Aβ immunotherapy for the world’s rapidly ageing population.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"36 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep and circadian disturbances in children with neurodevelopmental disorders 神经发育障碍儿童的睡眠和昼夜节律紊乱

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2025-01-08 DOI: 10.1038/s41582-024-01052-9

Oliviero Bruni, Maria Breda, Valeria Mammarella, Maria Paola Mogavero, Raffaele Ferri

{"title":"Sleep and circadian disturbances in children with neurodevelopmental disorders","authors":"Oliviero Bruni, Maria Breda, Valeria Mammarella, Maria Paola Mogavero, Raffaele Ferri","doi":"10.1038/s41582-024-01052-9","DOIUrl":"https://doi.org/10.1038/s41582-024-01052-9","url":null,"abstract":"Sleep is essential for brain development and overall health, particularly in children with neurodevelopmental disorders (NDDs). Sleep disruptions can considerably impact brain structure and function, leading to dysfunction of neurotransmitter systems, metabolism, hormonal balance and inflammatory processes, potentially contributing to the pathophysiology of NDDs. This Review examines the prevalence, types and mechanisms of sleep disturbances in children with NDDs, including autism spectrum disorder, attention-deficit hyperactivity disorder and various genetic syndromes. Common sleep disorders in these populations include insomnia, hypersomnia, circadian rhythm disorders, sleep-related breathing disorders and parasomnias, with underlying factors often involving genetic, neurobiological, environmental and neurophysiological influences. Sleep problems such as insomnia, night awakenings and sleep fragmentation are closely linked to both internalizing symptoms such as anxiety and depression, and externalizing behaviours such as hyperactivity and aggression. Assessment of sleep in children with NDDs presents unique challenges owing to communication difficulties, comorbid conditions and altered sensory processing. The Review underscores the importance of further research to unravel the complex interactions between sleep and neurodevelopment, advocating for longitudinal studies and the identification of predictive biomarkers. Understanding and addressing sleep disturbances in NDDs is crucial for improving developmental outcomes and the overall quality of life for affected individuals and their families.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"35 1","pages":""},"PeriodicalIF":38.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0