Neurofilament light chain induces neuroinflammation

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-04-10 DOI:10.1038/s41582-025-01085-8

Lisa Kiani

引用次数: 0

Abstract

Neurofilament light chain (NfL) released from damaged neurons induces neuroinflammation, according to new research. NfL is used as a biomarker for many neurodegenerative diseases, but was not previously known to contribute to disease processes.

Glutamate-induced stress in primary neuronal cultures resulted in a twofold increase in NfL release from baseline, which was dependent on calpain proteolysis and correlated with neuronal degradation. Transcriptomic analysis of mouse hippocampal cells showed activation of microglia following NfL injection. Moreover, NfL knockout in the SOD1 mouse model of amyotrophic lateral sclerosis (ALS) reduced microgliosis and motor neuron loss, and delayed symptom onset.

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神经丝轻链诱导神经炎症

根据一项新的研究，受损神经元释放的神经丝轻链（NfL）会诱发神经炎症。NfL被用作许多神经退行性疾病的生物标志物，但以前并不知道它与疾病过程有关。在原代神经元培养中，谷氨酸诱导的应激导致NfL释放比基线增加两倍，这依赖于钙蛋白酶的蛋白水解，并与神经元降解相关。小鼠海马细胞转录组学分析显示，注射NfL后小胶质细胞被激活。此外，在肌萎缩性侧索硬化症（ALS） SOD1小鼠模型中，NfL敲除可减少小胶质细胞增生和运动神经元损失，并延迟症状发作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

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