小胶质细胞是阿尔茨海默病免疫患者清除淀粉样蛋白β的基础

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-04-10 DOI:10.1038/s41582-025-01084-9

Lisa Kiani

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引用次数: 0

摘要

发表在《自然医学》杂志上的一项研究发现，小胶质细胞对阿尔茨海默病（AD）患者接受Aβ免疫疗法治疗的淀粉样蛋白-β (Aβ)清除负责。额叶皮层切片的转录组学分析显示，与未治疗的个体相比，接受活性Aβ免疫疗法AN1792治疗的AD患者中参与小胶质细胞功能的基因的脑区域特异性差异表达。参与小胶质细胞反应的已建立的AD风险基因，包括TREM2和APOE，在治疗个体中都是上调的基因，它们的表达与Aβ去除呈正相关。在接受批准的单克隆抗体lecanamab治疗的一个个体中观察到类似的结果。

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Microglia underlie amyloid-β clearance in immunized people with Alzheimer disease

A study published in Nature Medicine has found that microglia are responsible for amyloid-β (Aβ) clearance in people with Alzheimer disease (AD) treated with Aβ immunotherapies.

Transcriptomic analysis of frontal cortex sections revealed brain region-specific differential expression of genes involved in microglial function in people with AD treated with active Aβ immunotherapy AN1792, as compared with untreated individuals. Established AD risk genes that are involved in the microglial response, including TREM2 and APOE, were among the upregulated genes in treated individuals, and their expression correlated positively with Aβ removal. Similar results were observed in one individual treated with the approved monoclonal antibody lecanamab.

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.