{"title":"Pharmacological rehabilitation for stroke","authors":"Lisa Kiani","doi":"10.1038/s41582-025-01087-6","DOIUrl":null,"url":null,"abstract":"<p>Synapse formation in parvalbumin-expressing interneurons underlies motor improvements following post-stroke rehabilitation and offers a drug target for stroke recovery, new research suggests. Task-based rehabilitation training in a mouse model of stroke selectively enhanced the synaptic input from parvalbumin interneurons to neurons that projected to the site of stroke induction, which resulted in motor recovery. Furthermore, the same outcome was achieved through pharmacological enhancement of parvalbumin interneuron function. The results demonstrate the potential of developing a rehabilitation drug for stroke — an area in which pharmacological therapies are currently lacking.</p><blockquote><p>“The results demonstrate the potential of developing a rehabilitation drug for stroke”</p></blockquote>","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"43 1","pages":""},"PeriodicalIF":28.2000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Neurology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41582-025-01087-6","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Synapse formation in parvalbumin-expressing interneurons underlies motor improvements following post-stroke rehabilitation and offers a drug target for stroke recovery, new research suggests. Task-based rehabilitation training in a mouse model of stroke selectively enhanced the synaptic input from parvalbumin interneurons to neurons that projected to the site of stroke induction, which resulted in motor recovery. Furthermore, the same outcome was achieved through pharmacological enhancement of parvalbumin interneuron function. The results demonstrate the potential of developing a rehabilitation drug for stroke — an area in which pharmacological therapies are currently lacking.
“The results demonstrate the potential of developing a rehabilitation drug for stroke”
期刊介绍：
Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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