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Rubella virus might increase risk of MS 风疹病毒可能会增加多发性硬化症的风险。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-01009-y
Lisa Kiani
{"title":"Rubella virus might increase risk of MS","authors":"Lisa Kiani","doi":"10.1038/s41582-024-01009-y","DOIUrl":"10.1038/s41582-024-01009-y","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared glial pathology in HD and schizophrenia HD 和精神分裂症的共同神经胶质病理学。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-01010-5
Lisa Kiani
{"title":"Shared glial pathology in HD and schizophrenia","authors":"Lisa Kiani","doi":"10.1038/s41582-024-01010-5","DOIUrl":"10.1038/s41582-024-01010-5","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food is brain medicine — relevance and translation to neurology 食物是大脑的良药--与神经学的相关性和转化
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-02 DOI: 10.1038/s41582-024-01003-4
Mitchell S. V. Elkind, Kevin G. Volpp
{"title":"Food is brain medicine — relevance and translation to neurology","authors":"Mitchell S. V. Elkind, Kevin G. Volpp","doi":"10.1038/s41582-024-01003-4","DOIUrl":"https://doi.org/10.1038/s41582-024-01003-4","url":null,"abstract":"The importance of diet for brain health is increasingly recognized by neurologists, but many neurological disorders impair the ability of individuals to eat healthily. A new initiative known as ‘Food Is Medicine’ has the potential to facilitate healthier eating among people with neurological disorders to improve and maintain brain health.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":38.1,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental–genetic interactions in ageing and dementia across Latin America 拉丁美洲老龄化和痴呆症的环境-遗传相互作用
IF 38.1 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-12 DOI: 10.1038/s41582-024-00998-0
Agustin Ibanez, Andrea Slachevsky
{"title":"Environmental–genetic interactions in ageing and dementia across Latin America","authors":"Agustin Ibanez, Andrea Slachevsky","doi":"10.1038/s41582-024-00998-0","DOIUrl":"https://doi.org/10.1038/s41582-024-00998-0","url":null,"abstract":"Current dementia research has developed complex models of environmental–genetic interactions to better address multimodal disease phenotypes. New evidence highlights a stronger effect of social determinants of health than ancestry effects specific to Latin America and the Caribbean, which opens new agendas to address the diversity of these interactions in ageing and dementia. A new study on dementia prevalence in Latin America has found a stronger effect of social determinants of health than ancestry effects specific to this region, highlighting the need for interventions involving lifestyle changes, healthcare access and education.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":38.1,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive effects of EBV and HHV-6A on MS risk EBV 和 HHV-6A 对多发性硬化症风险的叠加效应。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00993-5
Heather Wood
{"title":"Additive effects of EBV and HHV-6A on MS risk","authors":"Heather Wood","doi":"10.1038/s41582-024-00993-5","DOIUrl":"10.1038/s41582-024-00993-5","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma extracellular vesicle biomarkers for frontotemporal dementia and related disorders 额颞叶痴呆症及相关疾病的血浆细胞外囊泡生物标记物。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00997-1
Lisa Kiani
{"title":"Plasma extracellular vesicle biomarkers for frontotemporal dementia and related disorders","authors":"Lisa Kiani","doi":"10.1038/s41582-024-00997-1","DOIUrl":"10.1038/s41582-024-00997-1","url":null,"abstract":"Concentrations of TDP-43 and tau in extracellular vesicles extracted from blood show potential as biomarkers for frontotemporal dementia, amyotrophic lateral sclerosis and progressive supranuclear palsy.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune rejuvenation — a potential AD therapy 免疫返老还童--一种潜在的抗衰老疗法。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00996-2
Heather Wood
{"title":"Immune rejuvenation — a potential AD therapy","authors":"Heather Wood","doi":"10.1038/s41582-024-00996-2","DOIUrl":"10.1038/s41582-024-00996-2","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAB32 variant is associated with PD susceptibility RAB32 变异与帕金森病易感性有关。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00995-3
Heather Wood
{"title":"RAB32 variant is associated with PD susceptibility","authors":"Heather Wood","doi":"10.1038/s41582-024-00995-3","DOIUrl":"10.1038/s41582-024-00995-3","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes could hasten MCI-to-AD conversion 糖尿病会加速 MCI 向AD 的转化。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00994-4
Heather Wood
{"title":"Diabetes could hasten MCI-to-AD conversion","authors":"Heather Wood","doi":"10.1038/s41582-024-00994-4","DOIUrl":"10.1038/s41582-024-00994-4","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis 脑-体机制导致肌萎缩性脊髓侧索硬化症的性双态性
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-04 DOI: 10.1038/s41582-024-00991-7
Sarah M. Jacob, Sukyoung Lee, Seung Hyun Kim, Keith A. Sharkey, Gerald Pfeffer, Minh Dang Nguyen
{"title":"Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis","authors":"Sarah M. Jacob, Sukyoung Lee, Seung Hyun Kim, Keith A. Sharkey, Gerald Pfeffer, Minh Dang Nguyen","doi":"10.1038/s41582-024-00991-7","DOIUrl":"10.1038/s41582-024-00991-7","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron disease. It is characterized by the progressive degeneration of upper and lower motor neurons, leading to generalized motor weakness and, ultimately, respiratory paralysis and death within 3–5 years. The disease is shaped by genetics, age, sex and environmental stressors, but no cure or routine biomarkers exist for the disease. Male individuals have a higher propensity to develop ALS, and a different manifestation of the disease phenotype, than female individuals. However, the mechanisms underlying these sex differences remain a mystery. In this Review, we summarize the epidemiology of ALS, examine the sexually dimorphic presentation of the disease and highlight the genetic variants and molecular pathways that might contribute to sex differences in humans and animal models of ALS. We advance the idea that sexual dimorphism in ALS arises from the interactions between the CNS and peripheral organs, involving vascular, metabolic, endocrine, musculoskeletal and immune systems, which are strikingly different between male and female individuals. Finally, we review the response to treatments in ALS and discuss the potential to implement future personalized therapeutic strategies for the disease. Amyotrophic lateral sclerosis (ALS) differs considerably in prevalence and manifestation between sexes. This Review summarizes sexual dimorphism in the epidemiology, clinical presentation and disease mechanisms of ALS and explores the role of brain–body interactions in driving sex-dependent pathogenesis.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":28.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141521513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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