Nature Reviews Neurology最新文献_第3页

Brain asymmetry patterns associated with age-related disease 与年龄相关疾病相关的大脑不对称模式

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-11 DOI: 10.1038/s41582-026-01258-z

Ian Fyfe

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Shared mechanism of mutagenesis in neurodegeneration 神经变性中突变的共同机制。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-11 DOI: 10.1038/s41582-026-01257-0

Ian Fyfe

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Complex regional diversity in synucleinopathies 突触核蛋白病的复杂区域多样性。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-11 DOI: 10.1038/s41582-026-01256-1

Ian Fyfe

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Circular RNAs outperform established Alzheimer disease biomarkers 环状rna优于已建立的阿尔茨海默病生物标志物。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-11 DOI: 10.1038/s41582-026-01259-y

Ian Fyfe

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Menopause and neurological disorders: a roadmap for research 更年期和神经系统疾病：研究路线图。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-10 DOI: 10.1038/s41582-026-01244-5

Riley Bove, Ruth Dobson

{"title":"Menopause and neurological disorders: a roadmap for research","authors":"Riley Bove, Ruth Dobson","doi":"10.1038/s41582-026-01244-5","DOIUrl":"10.1038/s41582-026-01244-5","url":null,"abstract":"Menopause is under-recognized as a biological and sociocultural contributor to brain health, and scientific understanding of the impact that the menopausal transition has on the brain is minimal. This knowledge gap is particularly detrimental for women who live with neurological conditions. We lack sufficient data to understand the experience of women with established neurological conditions during perimenopause, the mechanisms associated with postmenopausal changes in disease course and how to improve management of neurological conditions in a sex-specific way. Furthermore, approximately two thirds of women experience cognitive concerns during the menopausal transition. Although earlier menopause is associated with a greater risk of cognitive decline, the influence of the menopausal transition on subsequent risk of neurological conditions remains unclear. In this Roadmap, we identify key areas in which research is limited and highlight historical and scientific challenges that have hindered progress in understanding brain health in the context of menopause. To address these challenges, we consider existing knowledge and propose priorities and future research directions to advance our understanding of the relationship between menopause and neurological health and disease. Menopause is under-recognized as a contributor to brain health, and we lack understanding of its interactions with neurological conditions. In this Roadmap, Bove and Dobson identify where research is limited and propose future research directions to further our understanding of the relationship between menopause and neurological health and disease.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 9","pages":"581-601"},"PeriodicalIF":31.2,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumour and microenvironment targeting of glioblastoma with dual-acting CAR T cells 双作用CAR - T细胞靶向胶质母细胞瘤的肿瘤和微环境。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-05 DOI: 10.1038/s41582-026-01254-3

Lisa Kiani

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Losing sleep over glia: new mechanisms for Alzheimer-related sleep disruption 神经胶质导致睡眠不足：阿尔茨海默病相关睡眠中断的新机制。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-04 DOI: 10.1038/s41582-026-01255-2

Brendan P. Lucey, Michael J. Howell

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White matter disorders at the intersection of transcription, RNA processing and translation 转录、RNA加工和翻译交叉处的白质紊乱。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-03 DOI: 10.1038/s41582-026-01248-1

Alexandra Chapleau, Felipe Villa Tobón, Geneviève Bernard

{"title":"White matter disorders at the intersection of transcription, RNA processing and translation","authors":"Alexandra Chapleau, Felipe Villa Tobón, Geneviève Bernard","doi":"10.1038/s41582-026-01248-1","DOIUrl":"10.1038/s41582-026-01248-1","url":null,"abstract":"Hereditary white matter disorders, encompassing leukodystrophies and genetically determined leukoencephalopathies, are a heterogeneous group of conditions characterized by white matter signal abnormalities on neuroimaging. An increasing number of these disorders are now associated with defects in genes that encode proteins involved in transcription, RNA processing and translation. Pathogenic variants in these genes disrupt fundamental processes of the central dogma yet manifest primarily as neurological diseases, often presenting with diverse clinical and radiological features. Although many of these conditions have been recognized for over a decade, their underlying pathophysiological mechanisms and the selective vulnerability of the CNS and myelin remain incompletely understood. Here we provide a comprehensive overview of white matter disorders arising from defects in protein biosynthesis pathways. We summarize known disease-causing genes and their molecular consequences and associated clinical and radiological phenotypes, and highlight emerging mechanistic themes and therapeutic strategies across this expanding class of disorders. This Review provides a comprehensive overview of white matter disorders, encompassing leukodystrophies and genetically determined leukoencephalopathies, that arise from defects in protein biosynthesis pathways. The authors highlight the role of causal genes across transcription, RNA processing and translation and summarize the clinical and radiological features of these disorders, as well as emerging therapeutic strategies.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 10","pages":"625-651"},"PeriodicalIF":31.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a biologically informed description of multiple sclerosis disease course — a roadmap for transition 迈向多发性硬化症病程的生物学信息描述-过渡路线图。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-08-03 DOI: 10.1038/s41582-026-01249-0

Alan J. Thompson, Fred D. Lublin, Lindsay Rechtman, James Quinn, Maria Pia Amato, Bruce Bebo, Peter A. Calabresi, Julie Fiol, Marcia Finlayson, Annie Hawton, Tanja Kuhlmann, Ruth Ann Marrie, Marcello Moccia, Xavier Montalban, Michael Panzara, Kathy Smith, Maria Pia Sormani, Jon Strum, Barbara G. Vickrey, Timothy Coetzee, on behalf of the 2025 International Advisory Committee on Clinical Trials in Multiple Sclerosis

{"title":"Towards a biologically informed description of multiple sclerosis disease course — a roadmap for transition","authors":"Alan J. Thompson, Fred D. Lublin, Lindsay Rechtman, James Quinn, Maria Pia Amato, Bruce Bebo, Peter A. Calabresi, Julie Fiol, Marcia Finlayson, Annie Hawton, Tanja Kuhlmann, Ruth Ann Marrie, Marcello Moccia, Xavier Montalban, Michael Panzara, Kathy Smith, Maria Pia Sormani, Jon Strum, Barbara G. Vickrey, Timothy Coetzee, on behalf of the 2025 International Advisory Committee on Clinical Trials in Multiple Sclerosis","doi":"10.1038/s41582-026-01249-0","DOIUrl":"10.1038/s41582-026-01249-0","url":null,"abstract":"Contemporary management of multiple sclerosis is based on the clinical course descriptors of relapsing–remitting, secondary progressive and primary progressive. However, recognition is growing in the field that these clinical course descriptors do not capture the full disease spectrum of multiple sclerosis or reflect the underlying biological mechanisms of disease, and that biologically informed course descriptors are needed. In this Roadmap, participants in an International Advisory Committee on Clinical Trials in Multiple Sclerosis workshop discuss the problems with the existing course descriptors, highlight considerations for developing new course descriptors and propose a roadmap for transitioning towards a more dynamic, biologically informed description of the multiple sclerosis disease course. The current clinical course descriptors of multiple sclerosis do not capture the full disease spectrum or reflect the underlying biological mechanisms. In this Roadmap, the International Advisory Committee on Clinical Trials in Multiple Sclerosis proposes a roadmap for transitioning towards biologically informed descriptors of the multiple sclerosis disease course.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 10","pages":"652-660"},"PeriodicalIF":31.2,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to ‘Low-field MRI for equitable epilepsy diagnosis in resource-limited settings’ 回复“低场MRI在资源有限的环境中用于公平的癫痫诊断”。

IF 31.2 1区医学

Nature Reviews Neurology Pub Date : 2026-07-29 DOI: 10.1038/s41582-026-01253-4

Tavia E. Evans, Joshua Harper, Aram Salehi, Andrew G. Webb, James H. Cole, Ana Correa, Hieab H. H. Adams, Dave M. Cash, Derek K. Jones

引用次数: 0