Menopause, memory and molecular pathways: growing insights into Alzheimer disease risk in women

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-05-12 DOI:10.1038/s41582-025-01093-8

Erin E. Sundermann

引用次数: 0

Abstract

Growing evidence links menopause to the risk of Alzheimer disease (AD) in women, but the effect of menopause hormone therapy (MHT) on this risk remain unclear. Two new studies illuminate how menopause and MHT influence synaptic health and tau pathology, offering new insights into sex-specific mechanisms and MHT timing considerations in AD risk.

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更年期，记忆和分子途径：对女性阿尔茨海默病风险的日益深入的了解

越来越多的证据表明更年期与女性患阿尔茨海默病（AD）的风险有关，但更年期激素治疗（MHT）对这种风险的影响尚不清楚。两项新的研究阐明了更年期和MHT如何影响突触健康和tau病理，为AD风险中的性别特异性机制和MHT时间考虑提供了新的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

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