更年期，记忆和分子途径：对女性阿尔茨海默病风险的日益深入的了解

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-05-12 DOI:10.1038/s41582-025-01093-8

Erin E. Sundermann

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引用次数: 0

摘要

越来越多的证据表明更年期与女性患阿尔茨海默病（AD）的风险有关，但更年期激素治疗（MHT）对这种风险的影响尚不清楚。两项新的研究阐明了更年期和MHT如何影响突触健康和tau病理，为AD风险中的性别特异性机制和MHT时间考虑提供了新的见解。

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Menopause, memory and molecular pathways: growing insights into Alzheimer disease risk in women

Growing evidence links menopause to the risk of Alzheimer disease (AD) in women, but the effect of menopause hormone therapy (MHT) on this risk remain unclear. Two new studies illuminate how menopause and MHT influence synaptic health and tau pathology, offering new insights into sex-specific mechanisms and MHT timing considerations in AD risk.

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.