Nature neuroscience最新文献_第4页

Wiring of a low-dimensional integrator network 低维积分器网络布线

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-26 DOI: 10.1038/s41593-024-01702-7

Bo Hu, Rainer W. Friedrich

引用次数: 0

Klaus A. Miczek (1945–2024) 克劳斯-米切克（1945-2024）

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-26 DOI: 10.1038/s41593-024-01837-7

Elise M. Weerts, Margaret Haney, Jennifer W. Tidey, Jeffrey A. Vivian

{"title":"Klaus A. Miczek (1945–2024)","authors":"Elise M. Weerts, Margaret Haney, Jennifer W. Tidey, Jeffrey A. Vivian","doi":"10.1038/s41593-024-01837-7","DOIUrl":"https://doi.org/10.1038/s41593-024-01837-7","url":null,"abstract":"Klaus Miczek was born in Germany and earned his BA degree at the Padagogische Hochschule-Berlin in 1966. He completed his graduate training at the University of Chicago, Illinois, where he began studying aggressive behavior and operant models of conditioned aversion under the mentorship of Sebastian P. Grossman. After receiving his PhD in 1972, he accepted a faculty position at Carnegie-Mellon University in Pittsburgh, Pennsylvania, where he was an Assistant and then Associate Professor. In 1979, he accepted a position at Tufts University, Massachusetts, in the Department of Psychology and was promoted to Professor in 1984. Klaus remained at Tufts for the duration of his career, becoming the Moses Hunt Professor of Psychology, Psychiatry, Pharmacology and Neuroscience. He was 79 years old when he died. He is survived by his beloved wife Christiane and son Nikolai Miczek.<picture><source srcset=\"//media.springernature.com/w300/springer-static/image/art%3A10.1038%2Fs41593-024-01837-7/MediaObjects/41593_2024_1837_Figa_HTML.png?as=webp\" type=\"image/webp\"/><img alt=\"\" aria-describedby=\"i1-desc\" src=\"//media.springernature.com/w300/springer-static/image/art%3A10.1038%2Fs41593-024-01837-7/MediaObjects/41593_2024_1837_Figa_HTML.png\" width=\"300\"/></picture> Credit: Anna Miller/Tufts University","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"71 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142713108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle 下流去甲肾上腺素能区域小脑活动波动是 NREM-REM 睡眠周期的守门员

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-25 DOI: 10.1038/s41593-024-01822-0

Alejandro Osorio-Forero, Georgios Foustoukos, Romain Cardis, Najma Cherrad, Christiane Devenoges, Laura M. J. Fernandez, Anita Lüthi

{"title":"Infraslow noradrenergic locus coeruleus activity fluctuations are gatekeepers of the NREM–REM sleep cycle","authors":"Alejandro Osorio-Forero, Georgios Foustoukos, Romain Cardis, Najma Cherrad, Christiane Devenoges, Laura M. J. Fernandez, Anita Lüthi","doi":"10.1038/s41593-024-01822-0","DOIUrl":"https://doi.org/10.1038/s41593-024-01822-0","url":null,"abstract":"The noradrenergic locus coeruleus (LC) regulates arousal levels during wakefulness, but its role in sleep remains unclear. Here, we show in mice that fluctuating LC neuronal activity partitions non-rapid-eye-movement sleep (NREMS) into two brain–autonomic states that govern the NREMS–REMS cycle over ~50-s periods; high LC activity induces a subcortical–autonomic arousal state that facilitates cortical microarousals, whereas low LC activity is required for NREMS-to-REMS transitions. This functional alternation regulates the duration of the NREMS–REMS cycle by setting permissive windows for REMS entries during undisturbed sleep while limiting these entries to maximally one per ~50-s period during REMS restriction. A stimulus-enriched, stress-promoting wakefulness was associated with longer and shorter levels of high and low LC activity, respectively, during subsequent NREMS, resulting in more microarousal-induced NREMS fragmentation and delayed REMS onset. We conclude that LC activity fluctuations are gatekeepers of the NREMS–REMS cycle and that this role is influenced by adverse wake experiences.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"62 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predicting modular functions and neural coding of behavior from a synaptic wiring diagram 从突触线路图预测行为的模块功能和神经编码

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-22 DOI: 10.1038/s41593-024-01784-3

Ashwin Vishwanathan, Alex Sood, Jingpeng Wu, Alexandro D. Ramirez, Runzhe Yang, Nico Kemnitz, Dodam Ih, Nicholas Turner, Kisuk Lee, Ignacio Tartavull, William M. Silversmith, Chris S. Jordan, Celia David, Doug Bland, Amy Sterling, H. Sebastian Seung, Mark S. Goldman, Emre R. F. Aksay, the Eyewirers

{"title":"Predicting modular functions and neural coding of behavior from a synaptic wiring diagram","authors":"Ashwin Vishwanathan, Alex Sood, Jingpeng Wu, Alexandro D. Ramirez, Runzhe Yang, Nico Kemnitz, Dodam Ih, Nicholas Turner, Kisuk Lee, Ignacio Tartavull, William M. Silversmith, Chris S. Jordan, Celia David, Doug Bland, Amy Sterling, H. Sebastian Seung, Mark S. Goldman, Emre R. F. Aksay, the Eyewirers","doi":"10.1038/s41593-024-01784-3","DOIUrl":"10.1038/s41593-024-01784-3","url":null,"abstract":"A long-standing goal in neuroscience is to understand how a circuit’s form influences its function. Here, we reconstruct and analyze a synaptic wiring diagram of the larval zebrafish brainstem to predict key functional properties and validate them through comparison with physiological data. We identify modules of strongly connected neurons that turn out to be specialized for different behavioral functions, the control of eye and body movements. The eye movement module is further organized into two three-block cycles that support the positive feedback long hypothesized to underlie low-dimensional attractor dynamics in oculomotor control. We construct a neural network model based directly on the reconstructed wiring diagram that makes predictions for the cellular-resolution coding of eye position and neural dynamics. These predictions are verified statistically with calcium imaging-based neural activity recordings. This work demonstrates how connectome-based brain modeling can reveal previously unknown anatomical structure in a neural circuit and provide insights linking network form to function. The authors determine the synaptic wiring diagram of a vertebrate circuit and reveal behaviorally associated modules. A model based on this connectome predicts neural coding and dynamics that are verified with calcium imaging data.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"27 12","pages":"2443-2454"},"PeriodicalIF":21.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-024-01784-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142684165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of methyl-CpG-binding protein 2 (MeCP2) with distinct enhancers in the mouse cortex 甲基-CpG 结合蛋白 2（MeCP2）与小鼠皮层中不同增强子的相互作用

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-22 DOI: 10.1038/s41593-024-01808-y

Gyan Prakash Mishra, Eric X. Sun, Tiffany Chin, Mandy Eckhardt, Michael E. Greenberg, Hume Stroud

引用次数: 0

The BRAIN initiative: a pioneering program on the precipice 脑神经网络计划：濒临绝境的开创性计划

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-22 DOI: 10.1038/s41593-024-01811-3

Cory T. Miller, Xiaoke Chen, Zoe R. Donaldson, Bianca Jones Marlin, Doris Y. Tsao, Ziv M. Williams, Moriel Zelikowsky, Hongkui Zeng, Weizhe Hong

引用次数: 0

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease 阿尔茨海默氏症患者脑细胞外囊泡内的 Tau 细丝被拴住了

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-21 DOI: 10.1038/s41593-024-01801-5

Stephanie L. Fowler, Tiana S. Behr, Emir Turkes, Darragh P. O’Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa Edmonds, Martha S. Foiani, Ari Schaler, Gerard Crowley, Sumi Bez, Elena Ficulle, Eliona Tsefou, Roman Fischer, Beth Geary, Pallavi Gaur, Chelsea Miller, Pasquale D’Acunzo, Efrat Levy, Karen E. Duff, Benjamin Ryskeldi-Falcon

{"title":"Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease","authors":"Stephanie L. Fowler, Tiana S. Behr, Emir Turkes, Darragh P. O’Brien, Paula Maglio Cauhy, Isadora Rawlinson, Marisa Edmonds, Martha S. Foiani, Ari Schaler, Gerard Crowley, Sumi Bez, Elena Ficulle, Eliona Tsefou, Roman Fischer, Beth Geary, Pallavi Gaur, Chelsea Miller, Pasquale D’Acunzo, Efrat Levy, Karen E. Duff, Benjamin Ryskeldi-Falcon","doi":"10.1038/s41593-024-01801-5","DOIUrl":"https://doi.org/10.1038/s41593-024-01801-5","url":null,"abstract":"The abnormal assembly of tau protein in neurons is a pathological hallmark of multiple neurodegenerative diseases, including Alzheimer’s disease (AD). Assembled tau associates with extracellular vesicles (EVs) in the central nervous system of individuals with AD, which is linked to its clearance and prion-like propagation. However, the identities of the assembled tau species and EVs, as well as how they associate, are not known. Here, we combined quantitative mass spectrometry, cryo-electron tomography and single-particle cryo-electron microscopy to study brain EVs from individuals with AD. We found tau filaments composed mainly of truncated tau that were enclosed within EVs enriched in endo-lysosomal proteins. We observed multiple filament interactions, including with molecules that tethered filaments to the EV limiting membrane, suggesting selective packaging. Our findings will guide studies into the molecular mechanisms of EV-mediated secretion of assembled tau and inform the targeting of EV-associated tau as potential therapeutic and biomarker strategies for AD.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"14 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Converging cortical axes 汇聚的皮层轴

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-21 DOI: 10.1038/s41593-024-01722-3

Konrad Wagstyl, Armin Raznahan

引用次数: 0

The cell-type underpinnings of the human functional cortical connectome 人类大脑皮层功能连接体的细胞类型基础

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-21 DOI: 10.1038/s41593-024-01812-2

Xi-Han Zhang, Kevin M. Anderson, Hao-Ming Dong, Sidhant Chopra, Elvisha Dhamala, Prashant S. Emani, Mark B. Gerstein, Daniel S. Margulies, Avram J. Holmes

{"title":"The cell-type underpinnings of the human functional cortical connectome","authors":"Xi-Han Zhang, Kevin M. Anderson, Hao-Ming Dong, Sidhant Chopra, Elvisha Dhamala, Prashant S. Emani, Mark B. Gerstein, Daniel S. Margulies, Avram J. Holmes","doi":"10.1038/s41593-024-01812-2","DOIUrl":"https://doi.org/10.1038/s41593-024-01812-2","url":null,"abstract":"The functional properties of the human brain arise, in part, from the vast assortment of cell types that pattern the cerebral cortex. The cortical sheet can be broadly divided into distinct networks, which are embedded into processing streams, or gradients, that extend from unimodal systems through higher-order association territories. Here using microarray data from the Allen Human Brain Atlas and single-nucleus RNA-sequencing data from multiple cortical territories, we demonstrate that cell-type distributions are spatially coupled to the functional organization of cortex, as estimated through functional magnetic resonance imaging. Differentially enriched cells follow the spatial topography of both functional gradients and associated large-scale networks. Distinct cellular fingerprints were evident across networks, and a classifier trained on postmortem cell-type distributions was able to predict the functional network allegiance of cortical tissue samples. These data indicate that the in vivo organization of the cortical sheet is reflected in the spatial variability of its cellular composition.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"36 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142678282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A top-down slow breathing circuit that alleviates negative affect in mice 缓解小鼠负面情绪的自上而下缓慢呼吸回路

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-19 DOI: 10.1038/s41593-024-01799-w

Jinho Jhang, Seahyung Park, Shijia Liu, David D. O’Keefe, Sung Han

{"title":"A top-down slow breathing circuit that alleviates negative affect in mice","authors":"Jinho Jhang, Seahyung Park, Shijia Liu, David D. O’Keefe, Sung Han","doi":"10.1038/s41593-024-01799-w","DOIUrl":"10.1038/s41593-024-01799-w","url":null,"abstract":"Although breathing is primarily automatic, its modulation by behavior and emotions suggests cortical inputs to brainstem respiratory networks, which hitherto have received little characterization. Here we identify in mice a top-down breathing pathway from dorsal anterior cingulate cortex (dACC) neurons to pontine reticular nucleus GABAergic inhibitory neurons (PnCGABA), which then project to the ventrolateral medulla (VLM). dACC→PnC activity correlates with slow breathing cycles and volitional orofacial behaviors and is influenced by anxiogenic conditions. Optogenetic stimulation of the dACC→PnCGABA→VLM circuit simultaneously slows breathing and suppresses anxiety-like behaviors, whereas optogenetic inhibition increases both breathing rate and anxiety-like behaviors. These findings suggest that the dACC→PnCGABA→VLM circuit has a crucial role in coordinating slow breathing and reducing negative affect. Our study elucidates a circuit basis for top-down control of breathing, which can influence emotional states. Jhang et al. identify a prefrontal–pontomedullary pathway that slows breathing and reduces anxiety in mice, where the pontine reticular nucleus converts excitatory prefrontal inputs into inhibitory signals to brainstem respiratory networks.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"27 12","pages":"2455-2465"},"PeriodicalIF":21.2,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0