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Neuronal activity stimulates a genetic program to rapidly generate synapses during development 神经元活动刺激基因程序在发育过程中快速产生突触
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-08 DOI: 10.1038/s41593-024-01729-w
{"title":"Neuronal activity stimulates a genetic program to rapidly generate synapses during development","authors":"","doi":"10.1038/s41593-024-01729-w","DOIUrl":"10.1038/s41593-024-01729-w","url":null,"abstract":"In Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 — orthologs of human FOS and MECOM, respectively — severely reduces presynaptic gene expression in dopaminergic neurons. These transcription factors form an activity-regulated positive feedback loop, which modulates the expression of synaptic genes and genetic programs to promote synapse formation.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141904652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In conversation with Lucas Cheadle 与卢卡斯-切德尔对话
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01719-y
Shari Wiseman
{"title":"In conversation with Lucas Cheadle","authors":"Shari Wiseman","doi":"10.1038/s41593-024-01719-y","DOIUrl":"10.1038/s41593-024-01719-y","url":null,"abstract":"As part of our special issue focused on glia, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. Here, we speak with Lucas Cheadle, assistant professor at Cold Spring Harbor Laboratory and Freeman Hrabowski Scholar at Howard Hughes Medical Institute. We spoke about his passion for studying glia and synapses, and about his experiences as an Indigenous and transgender neuroscientist.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In conversation with Andrea Volterra 与 Andrea Volterra 对话。
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01721-4
Elisa Floriddia
{"title":"In conversation with Andrea Volterra","authors":"Elisa Floriddia","doi":"10.1038/s41593-024-01721-4","DOIUrl":"10.1038/s41593-024-01721-4","url":null,"abstract":"As part of our special issue focused on glia, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. Here, we speak with Andrea Volterra (visiting faculty at the Wyss Center and honorary professor at the Department of Fundamental Neuroscience, University of Lausanne, Switzerland), an astrocyte biologist, who dedicated his research career to uncovering astrocyte–synapse communications in physiology and disease, and a strong advocate of the Socratic method.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In conversation with Sonia Mayoral 与索尼娅-马约拉尔对话
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01716-1
George Andrew S. Inglis
{"title":"In conversation with Sonia Mayoral","authors":"George Andrew S. Inglis","doi":"10.1038/s41593-024-01716-1","DOIUrl":"10.1038/s41593-024-01716-1","url":null,"abstract":"As part of our special issue focused on glia, Nature Neuroscience is having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. Here, we speak with Sonia Mayoral, the Robert J. and Nancy D. Carney Assistant Professor of Neuroscience at Brown University in Providence, RI, USA. We spoke about her work on oligodendrocytes and their interactions with neurons, the importance of exploring glia in brain health and function, and her own academic journey and advice for early-career researchers.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Astrocytes know when to feed neurons 星形胶质细胞知道何时为神经元提供营养。
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01734-z
George Andrew S. Inglis
{"title":"Astrocytes know when to feed neurons","authors":"George Andrew S. Inglis","doi":"10.1038/s41593-024-01734-z","DOIUrl":"10.1038/s41593-024-01734-z","url":null,"abstract":"","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orexin neurons mediate temptation-resistant voluntary exercise 催产素神经元介导耐受诱惑的自主运动
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01696-2
Alexander L. Tesmer, Xinyang Li, Eva Bracey, Cyra Schmandt, Rafael Polania, Daria Peleg-Raibstein, Denis Burdakov
{"title":"Orexin neurons mediate temptation-resistant voluntary exercise","authors":"Alexander L. Tesmer, Xinyang Li, Eva Bracey, Cyra Schmandt, Rafael Polania, Daria Peleg-Raibstein, Denis Burdakov","doi":"10.1038/s41593-024-01696-2","DOIUrl":"10.1038/s41593-024-01696-2","url":null,"abstract":"Despite the well-known health benefits of physical activity, many people underexercise; what drives the prioritization of exercise over alternative options is unclear. We developed a task that enabled us to study how mice freely and rapidly alternate between wheel running and other voluntary activities, such as eating palatable food. When multiple alternatives were available, mice chose to spend a substantial amount of time wheel running without any extrinsic reward and maintained this behavior even when palatable food was added as an option. Causal manipulations and correlative analyses of appetitive and consummatory processes revealed this preference for wheel running to be instantiated by hypothalamic hypocretin/orexin neurons (HONs). The effect of HON manipulations on wheel running and eating was strongly context-dependent, being the largest in the scenario where both options were available. Overall, these data suggest that HON activity enables an eat–run arbitration that results in choosing exercise over food. What makes the brain maintain voluntary exercise despite attractive alternative options such as eating? Tesmer et al. show that orexin/hypocretin neurons are crucial for implementing the underlying valuation of eating versus running in mice.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-024-01696-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141895363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
That’s a wrap 到此为止。
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01733-0
Henrietta Howells
{"title":"That’s a wrap","authors":"Henrietta Howells","doi":"10.1038/s41593-024-01733-0","DOIUrl":"10.1038/s41593-024-01733-0","url":null,"abstract":"","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil–microglia interactions in AD 注意力缺失症中中性粒细胞与小胶质细胞的相互作用
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01732-1
Leonie Welberg
{"title":"Neutrophil–microglia interactions in AD","authors":"Leonie Welberg","doi":"10.1038/s41593-024-01732-1","DOIUrl":"10.1038/s41593-024-01732-1","url":null,"abstract":"","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glia move to the foreground 胶质细胞移至前景。
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01735-y
{"title":"Glia move to the foreground","authors":"","doi":"10.1038/s41593-024-01735-y","DOIUrl":"10.1038/s41593-024-01735-y","url":null,"abstract":"In this special issue of Nature Neuroscience, we shine a spotlight on glia. Research into glia has become one of the most exciting and dynamic subfields of neuroscience, yet there is still much to be discovered about the diverse forms and functions of these cells.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-024-01735-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In conversation with Beth Stevens 与贝丝-史蒂文斯对话
IF 21.2 1区 医学
Nature neuroscience Pub Date : 2024-08-06 DOI: 10.1038/s41593-024-01717-0
Shari Wiseman
{"title":"In conversation with Beth Stevens","authors":"Shari Wiseman","doi":"10.1038/s41593-024-01717-0","DOIUrl":"10.1038/s41593-024-01717-0","url":null,"abstract":"As part of our special issue focused on glia, we are having conversations with both established leaders in the field and those earlier in their careers to discuss how the field has evolved and where it is heading. Here, we speak with Beth Stevens, Associate Professor of Neurology at the F. M. Kirby Neurobiology Center at Boston Children’s Hospital and at the Broad Institute of MIT and Harvard. We spoke about how she initially became fascinated with glia, her work to understand how glia interact with synapses, and the technologies that are needed to usher in the next era of discoveries in the field.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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