Nature neuroscience最新文献_第3页

Vagus block blocks cachexia 迷走神经阻滞阻滞恶病质

IF 2 1区医学

Nature neuroscience Pub Date : 2025-09-05 DOI: 10.1038/s41593-025-02058-2

Leonie Welberg

引用次数: 0

The brain’s body map does not forget lost limbs 大脑的身体地图不会忘记失去的肢体

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-29 DOI: 10.1038/s41593-025-02051-9

引用次数: 0

Author Correction: Dynamics of mature myelin 作者更正：成熟髓磷脂动力学

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-27 DOI: 10.1038/s41593-025-02061-7

Lindsay A. Osso, Ethan G. Hughes

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Large-scale cortical functional networks are organized in structured cycles 大规模的皮质功能网络以结构化的循环组织

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-27 DOI: 10.1038/s41593-025-02052-8

Mats W. J. van Es, Cameron Higgins, Chetan Gohil, Andrew J. Quinn, Diego Vidaurre, Mark W. Woolrich

{"title":"Large-scale cortical functional networks are organized in structured cycles","authors":"Mats W. J. van Es, Cameron Higgins, Chetan Gohil, Andrew J. Quinn, Diego Vidaurre, Mark W. Woolrich","doi":"10.1038/s41593-025-02052-8","DOIUrl":"10.1038/s41593-025-02052-8","url":null,"abstract":"The brain seamlessly performs a diverse set of cognitive functions like attention, memory and sensory processing, yet it is unclear how it ensures that each of these is fulfilled within a reasonable period. One way in which this requirement can be met is if each of these cognitive functions occurs as part of a repeated cycle. Here we studied the temporal evolution of canonical, large-scale, cortical functional networks that are thought to underlie cognition. We showed that, although network dynamics are stochastic, the overall ordering of their activity forms a robust cyclical pattern. This cyclical structure groups states with similar function and spectral content at specific phases of the cycle and occurs at timescales of 300–1,000 ms. These results are reproduced in five large magnetoencephalography datasets. Moreover, we show that metrics that characterize the cycle strength and speed are heritable and relate to age, cognition and behavioral performance. These results show that the activations of a canonical set of large-scale cortical functional networks are organized in an inherently cyclical manner, ensuring periodic activation of essential cognitive functions. The human brain cycles through a repertoire of brain networks on a 1-second timescale during rest and tasks. This cycling appears to allow periodic engagement of essential cognitive functions, with the speed of cycling linked to genetics and age.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 10","pages":"2118-2128"},"PeriodicalIF":20.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02052-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Internal and external codes for location 内部和外部的位置代码

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-26 DOI: 10.1038/s41593-025-02045-7

Michael E. Hasselmo, Patrick A. LaChance, Jennifer C. Robinson

引用次数: 0

Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells 同种和独特的空间线索控制着位置细胞的多路θ相位编码

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-26 DOI: 10.1038/s41593-025-02038-6

Yotaro Sueoka, Ravikrishnan P. Jayakumar, Manu S. Madhav, Francesco Savelli, Noah J. Cowan, James J. Knierim

{"title":"Allothetic and idiothetic spatial cues control the multiplexed theta phase coding of place cells","authors":"Yotaro Sueoka, Ravikrishnan P. Jayakumar, Manu S. Madhav, Francesco Savelli, Noah J. Cowan, James J. Knierim","doi":"10.1038/s41593-025-02038-6","DOIUrl":"10.1038/s41593-025-02038-6","url":null,"abstract":"Theta oscillation is considered a temporal scaffold for hippocampal computations that organizes the activity of spatially tuned cells known as place cells. Late phases of theta support prospective spatial representation via phase ‘precession’. In contrast, some studies have hypothesized that early phases of theta may subserve both retrospective spatial representation via phase ‘procession’ and the encoding of new associations. Here, combining virtual reality, electrophysiology and computational modeling, we provide experimental evidence for such a functionally multiplexed phase code and describe how distinct spatial inputs control its manifestation. Specifically, when rats continuously learned new associations between external landmark (allothetic) cues and self-motion (idiothetic) cues, phase ‘precession’ remained intact, allowing continuous prediction of future positions. Conversely, phase ‘procession’ was diminished, matching the putative role in encoding at the early theta phase. This multiplexed phase code may serve as a general circuit logic for alternating different computations at a sub-second scale. Using a virtual reality apparatus in rats that dissociates external landmarks from self-motion cues, the authors describe how the two modes of theta phase coding in the hippocampus during navigation are controlled via distinct computations.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 10","pages":"2106-2117"},"PeriodicalIF":20.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes 通过AAV片段测序（CrAAVe-seq）进行CRISPR筛选：可扩展的细胞类型特异性体内平台揭示神经元必需基因

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-22 DOI: 10.1038/s41593-025-02043-9

Biswarathan Ramani, Indigo V. L. Rose, Noam Teyssier, Andrew Pan, Spencer Danner-Bocks, Tanya Sanghal, Lin Yadanar, Ruilin Tian, Keran Ma, Jorge J. Palop, Martin Kampmann

{"title":"CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes","authors":"Biswarathan Ramani, Indigo V. L. Rose, Noam Teyssier, Andrew Pan, Spencer Danner-Bocks, Tanya Sanghal, Lin Yadanar, Ruilin Tian, Keran Ma, Jorge J. Palop, Martin Kampmann","doi":"10.1038/s41593-025-02043-9","DOIUrl":"10.1038/s41593-025-02043-9","url":null,"abstract":"There is a substantial need for scalable CRISPR-based genetic screening methods that can be applied in mammalian tissues in vivo while enabling cell-type-specific analysis. Here we developed an adeno-associated virus (AAV)-based CRISPR screening platform, CrAAVe-seq, that incorporates a Cre-sensitive sgRNA construct for pooled screening within targeted cell populations in mouse tissues. We used this approach to screen two large sgRNA libraries, which collectively target over 5,000 genes, in mouse brains and uncovered genes essential for neuronal survival, of which we validated Rabggta and Hspa5. We highlight the reproducibility and scalability of the platform and show that it is sufficiently sensitive for screening in a restricted subset of neurons. We systematically characterize the impact of sgRNA library size, mouse cohort size, the size of the targeted cell population, viral titer, and coinfection rate on screen performance to establish general guidelines for large-scale in vivo screens. The authors developed an adeno-associated virus-based high-throughput in vivo CRISPR screening platform for endogenous mouse brain cell types. Using this platform, they define genes and pathways essential for neuronal survival.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 10","pages":"2129-2140"},"PeriodicalIF":20.0,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02043-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits 弓形虫感染和慢性IL-1升高驱动海马DNA双链断裂信号，导致认知缺陷

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-21 DOI: 10.1038/s41593-025-02041-x

Marcy Belloy, Benjamin A. M. Schmitt, Florent H. Marty, Charlotte Paut, Emilie Bassot, Amel Aïda, Marine Alis, Margot Zahm, Adeline Chaubet, Hugo Garnier, Thelma Flores-Aguilar, Elisa Roitg, Renzo Gutierrez-Loli, Sophie Allart, Romain Ecalard, Raphaël Boursereau, Gaëtan Ligat, Daniel Gonzalez-Dunia, Nicolas Blanchard, Elsa Suberbielle

{"title":"Toxoplasma gondii infection and chronic IL-1 elevation drive hippocampal DNA double-strand break signaling, leading to cognitive deficits","authors":"Marcy Belloy, Benjamin A. M. Schmitt, Florent H. Marty, Charlotte Paut, Emilie Bassot, Amel Aïda, Marine Alis, Margot Zahm, Adeline Chaubet, Hugo Garnier, Thelma Flores-Aguilar, Elisa Roitg, Renzo Gutierrez-Loli, Sophie Allart, Romain Ecalard, Raphaël Boursereau, Gaëtan Ligat, Daniel Gonzalez-Dunia, Nicolas Blanchard, Elsa Suberbielle","doi":"10.1038/s41593-025-02041-x","DOIUrl":"10.1038/s41593-025-02041-x","url":null,"abstract":"Chronic inflammation, resulting from infections, is characterized by increased levels of cytokines including interleukin-1 (IL-1), but little is known about how IL-1 contributes to cognitive impairment, potentially via epigenetic processes. Here we demonstrate that mice chronically infected with the parasite Toxoplasma gondii exhibit impaired spatial memory, which is dependent on neuronal IL-1 signaling and mimicked by chronic exposure to IL-1β. Both T. gondii infection and chronic IL-1β drive H2A.X-dependent DNA double-strand break signaling in hippocampal neurons and invalidating neuronal H2A.X-dependent signaling blocks memory impairments caused by either exposure. Our results highlight the instrumental role of cytokine-induced double-strand-break-dependent signaling in spatial memory defects, which may be relevant to multiple brain diseases. Chronic brain infection and IL-1 exposure impair spatial memory by triggering DNA double-strand break signaling in hippocampal neurons. Blocking this pathway prevents memory deficits, suggesting new therapeutic prospects for various brain diseases.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 10","pages":"2067-2077"},"PeriodicalIF":20.0,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144900472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stable cortical body maps before and after arm amputation 手臂截肢前后的稳定皮质体图

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-21 DOI: 10.1038/s41593-025-02037-7

Hunter R. Schone, Roni O. Maimon-Mor, Mathew Kollamkulam, Malgorzata A. Szymanska, Craig Gerrand, Alexander Woollard, Norbert V. Kang, Chris I. Baker, Tamar R. Makin

引用次数: 0

FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis FOXP基因调控浦肯野细胞多样性和小脑形态发生。

IF 2 1区医学

Nature neuroscience Pub Date : 2025-08-18 DOI: 10.1038/s41593-025-02042-w

Nagham Khouri-Farah, Qiuxia Guo, Thomas A. Perry, Ryan Dussault, James Y. H. Li

{"title":"FOXP genes regulate Purkinje cell diversity and cerebellar morphogenesis","authors":"Nagham Khouri-Farah, Qiuxia Guo, Thomas A. Perry, Ryan Dussault, James Y. H. Li","doi":"10.1038/s41593-025-02042-w","DOIUrl":"10.1038/s41593-025-02042-w","url":null,"abstract":"Cerebellar Purkinje cells (PCs), the sole output neurons of the cerebellar cortex, are essential for motor coordination, learning and circuit formation. While functionally diverse, the extent of PC heterogeneity and the molecular drivers of this diversity remain unclear. Using single-cell RNA sequencing, we identified at least 11 molecularly distinct PC subtypes in the embryonic mouse cerebellum. Spatial reconstruction revealed that these subtypes are organized in embryonic patterns that predict key features of adult cerebellar architecture, including longitudinal stripes and lobular specificities. PC-subtype identity is defined by the combinatorial expression of Foxp1, Foxp2 and Foxp4. Genetic deletion of Foxp1 and Foxp2 disrupts PC diversification and cerebellar patterning, including the loss of a Foxp1+ subtype and the failure of cerebellar hemisphere formation. Foxp1+ PCs are enriched in the fetal human cerebellum but are rare in chick, suggesting a role in cerebellar evolution. These findings uncover early PC diversification and identify Foxp1+ PCs as critical regulators of cerebellar hemispheric development. The Li lab mapped molecularly distinct Purkinje cell (PC) subtypes in 3D and linked them to adult cerebellar architecture. They found that Foxp1/Foxp2 are essential for PC diversity and that Foxp1+ PCs are required for the formation of the cerebellar hemisphere.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 10","pages":"2022-2033"},"PeriodicalIF":20.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02042-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0