Elvisha Dhamala, Jocelyn A. Ricard, Lucina Q. Uddin, Liisa A. M. Galea, Emily G. Jacobs, Sarah W. Yip, B. T. Thomas Yeo, M. Mallar Chakravarty, Avram J. Holmes
{"title":"Considering the interconnected nature of social identities in neuroimaging research","authors":"Elvisha Dhamala, Jocelyn A. Ricard, Lucina Q. Uddin, Liisa A. M. Galea, Emily G. Jacobs, Sarah W. Yip, B. T. Thomas Yeo, M. Mallar Chakravarty, Avram J. Holmes","doi":"10.1038/s41593-024-01832-y","DOIUrl":"https://doi.org/10.1038/s41593-024-01832-y","url":null,"abstract":"<p>Considerable heterogeneity exists in the expression of complex human behaviors across the cognitive, personality and mental health domains. It is increasingly evident that individual variability in behavioral expression is substantially affected by sociodemographic factors that often interact with life experiences. Here, we formally address the urgent need to incorporate intersectional identities in neuroimaging studies of behavior, with a focus on research in mental health. We highlight how diverse sociodemographic factors influence the study of psychiatric conditions, focusing on how interactions between those factors might contribute to brain biology and illness expression, including prevalence, symptom burden, help seeking, treatment response and tolerance, and relapse and remission. We conclude with a discussion of the considerations and actionable items related to participant recruitment, data acquisition and data analysis to facilitate the inclusion and incorporation of diverse intersectional identities in neuroimaging.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"15 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naoto Watamura, Martha S. Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel, Naoko Kamano, Mika Takahashi, Javier Rueda-Carrasco, Loukia Katsouri, Stephanie Fowler, Emir Turkes, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, AFM Saiful Islam, Seico Benner, Toshihiro Endo, Katsuji Kobayashi, Chiho Ishida, Michele Vendruscolo, Masahito Yamada, Karen E. Duff, Takaomi C. Saido
{"title":"In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds","authors":"Naoto Watamura, Martha S. Foiani, Sumi Bez, Mathieu Bourdenx, Alessia Santambrogio, Claire Frodsham, Elena Camporesi, Gunnar Brinkmalm, Henrik Zetterberg, Saisha Patel, Naoko Kamano, Mika Takahashi, Javier Rueda-Carrasco, Loukia Katsouri, Stephanie Fowler, Emir Turkes, Shoko Hashimoto, Hiroki Sasaguri, Takashi Saito, AFM Saiful Islam, Seico Benner, Toshihiro Endo, Katsuji Kobayashi, Chiho Ishida, Michele Vendruscolo, Masahito Yamada, Karen E. Duff, Takaomi C. Saido","doi":"10.1038/s41593-024-01829-7","DOIUrl":"https://doi.org/10.1038/s41593-024-01829-7","url":null,"abstract":"<p>Tau pathology is a hallmark of several neurodegenerative diseases, including frontotemporal dementia and Alzheimer’s disease. However, the sequence of events and the form of tau that confers toxicity are still unclear, due in large part to the lack of physiological models of tauopathy initiation and progression in which to test hypotheses. We have developed a series of targeted mice expressing frontotemporal-dementia-causing mutations in the humanized <i>MAPT</i> gene to investigate the earliest stages of tauopathy. <i>MAPT</i><sup>Int10+3G>A</sup> and <i>MAPT</i><sup>S305N;Int10+3G>A</sup> lines show abundant hyperphosphorylated tau in the hippocampus and entorhinal cortex, but they do not develop seed-competent fibrillar structures. Accumulation of hyperphosphorylated tau was accompanied by neurite degeneration, loss of viable synapses and indicators of behavioral abnormalities. Our results demonstrate that neuronal toxicity can occur in the absence of fibrillar, higher-order structures and that tau hyperphosphorylation is probably involved in the earliest etiological events in tauopathies showing isoform ratio imbalance.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"126 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142879932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cagney E. Coomer, Daria Naumova, Mustafa Talay, Bence Zolyomi, Nathaniel J. Snell, Altar Sorkaç, Jean Michel Chanchu, Ji Cheng, Ivana Roman, Jennifer Li, Drew Robson, David L. McLean, Gilad Barnea, Marnie E. Halpern
{"title":"Transsynaptic labeling and transcriptional control of zebrafish neural circuits","authors":"Cagney E. Coomer, Daria Naumova, Mustafa Talay, Bence Zolyomi, Nathaniel J. Snell, Altar Sorkaç, Jean Michel Chanchu, Ji Cheng, Ivana Roman, Jennifer Li, Drew Robson, David L. McLean, Gilad Barnea, Marnie E. Halpern","doi":"10.1038/s41593-024-01815-z","DOIUrl":"10.1038/s41593-024-01815-z","url":null,"abstract":"Deciphering the connectome, the ensemble of synaptic connections that underlie brain function, is a central goal of neuroscience research. Here we report the in vivo mapping of connections between presynaptic and postsynaptic partners in zebrafish, by adapting the trans-Tango genetic approach that was first developed for anterograde transsynaptic tracing in Drosophila. Neural connections were visualized between synaptic partners in larval retina, brain and spinal cord and followed over development. The specificity of labeling was corroborated by functional experiments in which optogenetic activation of presynaptic spinal cord interneurons elicited responses in known motor neuronal postsynaptic targets, as measured by trans-Tango-dependent expression of a genetically encoded calcium indicator or by electrophysiology. Transsynaptic signaling through trans-Tango reveals synaptic connections in the zebrafish nervous system, providing a valuable in vivo tool to monitor and interrogate neural circuits over time. The trans-Tango genetic strategy, which mediates signaling across synapses, was adapted to identify neural connections in a vertebrate nervous system, with synaptic partners confirmed in the retina and spinal cord of larval zebrafish.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 1","pages":"189-200"},"PeriodicalIF":21.2,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amy L. Van Deusen, Sushanth Kumar, O. Yipkin Calhan, Sarah M. Goggin, Jiachen Shi, Corey M. Williams, Austin B. Keeler, Kristen I. Fread, Irene C. Gadani, Christopher D. Deppmann, Eli R. Zunder
{"title":"A single-cell mass cytometry-based atlas of the developing mouse brain","authors":"Amy L. Van Deusen, Sushanth Kumar, O. Yipkin Calhan, Sarah M. Goggin, Jiachen Shi, Corey M. Williams, Austin B. Keeler, Kristen I. Fread, Irene C. Gadani, Christopher D. Deppmann, Eli R. Zunder","doi":"10.1038/s41593-024-01786-1","DOIUrl":"10.1038/s41593-024-01786-1","url":null,"abstract":"Development of the mammalian brain requires precise molecular changes across diverse cell lineages. While single-cell RNA abundances in the developing brain have been characterized by single-cell RNA sequencing (scRNA-seq), single-cell protein abundances have not been characterized. To address this gap, we performed mass cytometry on the whole brain at embryonic day (E)11.5–E12.5 and the telencephalon, the diencephalon, the mesencephalon and the rhombencephalon at E13.5–postnatal day (P)4 from C57/BL6 mice. Using a 40-antibody panel to analyze 24,290,787 cells from two to four biological replicates per sample, we identify 85 molecularly distinct cell clusters from distinct lineages. Our analyses confirm canonical molecular pathways of neurogenesis and gliogenesis, and predict two distinct trajectories for cortical oligodendrogenesis. Differences in protein versus RNA expression from mass cytometry and scRNA-seq, validated by immunohistochemistry and RNAscope in situ hybridization (ISH), demonstrate the value of protein-level measurements for identifying functional cell states. Our findings show the utility of mass cytometry as a scalable platform for single-cell profiling of brain tissues. In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling of the developing embryonic and postnatal mouse brain.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 1","pages":"174-188"},"PeriodicalIF":21.2,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Heat acclimation induces hypothalamic temperature sensitivity that promotes heat tolerance","authors":"","doi":"10.1038/s41593-024-01835-9","DOIUrl":"https://doi.org/10.1038/s41593-024-01835-9","url":null,"abstract":"After long-term heat exposure, a discrete group of hypothalamic neurons in the anterior ventromedial preoptic area become hyperactive and acquire temperature sensitivity. This reversible plasticity mechanism renders mice heat tolerant, meaning they can keep their body temperature within physiological limits when ambient temperatures are high.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"43 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MeCP2 goes into unmethylated territories","authors":"Jun Young Sonn, Huda Y. Zoghbi","doi":"10.1038/s41593-024-01846-6","DOIUrl":"10.1038/s41593-024-01846-6","url":null,"abstract":"Methyl-CpG-binding protein 2 (MeCP2) is a chromatin regulator whose loss of function causes Rett syndrome. It has been unclear how the gene-expression changes caused by loss of MeCP2 relate to the protein’s DNA-binding sites. New work uses the ‘CUT&RUN’ technique to identify DNA-binding sites that are largely devoid of methylation — a modification known to recruit MeCP2 to DNA.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 1","pages":"4-5"},"PeriodicalIF":21.2,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boyan Bonev, Gonçalo Castelo-Branco, Fei Chen, Simone Codeluppi, M. Ryan Corces, Jean Fan, Myriam Heiman, Kenneth Harris, Fumitaka Inoue, Manolis Kellis, Ariel Levine, Mo Lotfollahi, Chongyuan Luo, Kristen R. Maynard, Mor Nitzan, Vijay Ramani, Rahul Satijia, Lucas Schirmer, Yin Shen, Na Sun, Gilad S. Green, Fabian Theis, Xiao Wang, Joshua D. Welch, Ozgun Gokce, Genevieve Konopka, Shane Liddelow, Evan Macosko, Omer Ali Bayraktar, Naomi Habib, Tomasz J. Nowakowski
{"title":"Author Correction: Opportunities and challenges of single-cell and spatially resolved genomics methods for neuroscience discovery","authors":"Boyan Bonev, Gonçalo Castelo-Branco, Fei Chen, Simone Codeluppi, M. Ryan Corces, Jean Fan, Myriam Heiman, Kenneth Harris, Fumitaka Inoue, Manolis Kellis, Ariel Levine, Mo Lotfollahi, Chongyuan Luo, Kristen R. Maynard, Mor Nitzan, Vijay Ramani, Rahul Satijia, Lucas Schirmer, Yin Shen, Na Sun, Gilad S. Green, Fabian Theis, Xiao Wang, Joshua D. Welch, Ozgun Gokce, Genevieve Konopka, Shane Liddelow, Evan Macosko, Omer Ali Bayraktar, Naomi Habib, Tomasz J. Nowakowski","doi":"10.1038/s41593-024-01858-2","DOIUrl":"10.1038/s41593-024-01858-2","url":null,"abstract":"","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 1","pages":"216-216"},"PeriodicalIF":21.2,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-024-01858-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaxin Wang, Fangang Meng, Cuiping Xu, Yanyang Zhang, Kun Liang, Chunlei Han, Yuan Gao, Xinguang Yu, Zizhou Li, Xiaoyu Zeng, Jun Ni, Huixin Tan, Jiaxin Yang, Yina Ma
{"title":"Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation","authors":"Jiaxin Wang, Fangang Meng, Cuiping Xu, Yanyang Zhang, Kun Liang, Chunlei Han, Yuan Gao, Xinguang Yu, Zizhou Li, Xiaoyu Zeng, Jun Ni, Huixin Tan, Jiaxin Yang, Yina Ma","doi":"10.1038/s41593-024-01824-y","DOIUrl":"10.1038/s41593-024-01824-y","url":null,"abstract":"Cooperative interactions profoundly shape individual and collective behaviors of social animals. Successful cooperation requires coordinated efforts by cooperators toward collective goals. However, the underlying behavioral dynamics and neuronal mechanisms within and between cooperating brains remain largely unknown. We recorded intracranial electrophysiological signals from human pairs engaged in a cooperation game. We show that teammate coordination and goal pursuit make distinct contributions to the behavioral cooperation dynamics. Increases and decreases in high-gamma activity in the temporoparietal junction (TPJ) and amygdala distinguish between establishing and maintaining cooperation and forecast transitions between these two states. High-gamma activity from distinct neuronal populations encodes teammate coordination and goal pursuit motives, with populations of TPJ neurons preferentially tracking dominant motives of different cooperation states. Across cooperating brains, high-gamma activity in the TPJ and amygdala synchronizes in a state-dependent manner that predicts how well cooperators coordinate. These findings provide fine-grained understandings of human cooperation dynamics as a state-dependent process with distinctive neurocognitive profiles of each state. Using intracranial recordings in pairs of humans cooperating in interactive games, this study shows fine-grained cooperation dynamics featured by state-dependent motives and the intrabrain and interbrain profiles of high-gamma activity in the amygdala and temporoparietal junction.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 1","pages":"161-173"},"PeriodicalIF":21.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel E. Marsh, Alec J. Walker, Tushar Kamath, Lasse Dissing-Olesen, Timothy R. Hammond, T. Yvanka de Soysa, Adam M. H. Young, Sarah Murphy, Abdulraouf Abdulraouf, Naeem Nadaf, Connor Dufort, Alicia C. Walker, Liliana E. Lucca, Velina Kozareva, Charles Vanderburg, Soyon Hong, Harry Bulstrode, Peter J. Hutchinson, Daniel J. Gaffney, David A. Hafler, Robin J. M. Franklin, Evan Z. Macosko, Beth Stevens
{"title":"Author Correction: Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain","authors":"Samuel E. Marsh, Alec J. Walker, Tushar Kamath, Lasse Dissing-Olesen, Timothy R. Hammond, T. Yvanka de Soysa, Adam M. H. Young, Sarah Murphy, Abdulraouf Abdulraouf, Naeem Nadaf, Connor Dufort, Alicia C. Walker, Liliana E. Lucca, Velina Kozareva, Charles Vanderburg, Soyon Hong, Harry Bulstrode, Peter J. Hutchinson, Daniel J. Gaffney, David A. Hafler, Robin J. M. Franklin, Evan Z. Macosko, Beth Stevens","doi":"10.1038/s41593-024-01855-5","DOIUrl":"10.1038/s41593-024-01855-5","url":null,"abstract":"","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 1","pages":"215-215"},"PeriodicalIF":21.2,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-024-01855-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayla Aksoy-Aksel, Francesco Ferraguti, Andrew Holmes, Andreas Lüthi, Ingrid Ehrlich
{"title":"Amygdala intercalated cells form an evolutionarily conserved system orchestrating brain networks","authors":"Ayla Aksoy-Aksel, Francesco Ferraguti, Andrew Holmes, Andreas Lüthi, Ingrid Ehrlich","doi":"10.1038/s41593-024-01836-8","DOIUrl":"https://doi.org/10.1038/s41593-024-01836-8","url":null,"abstract":"<p>The amygdala attributes valence and emotional salience to environmental stimuli and regulates how these stimuli affect behavior. Within the amygdala, a distinct class of evolutionarily conserved neurons form the intercalated cell (ITC) clusters, mainly located around the boundaries of the lateral and basal nuclei. Here, we review the anatomical, physiological and molecular characteristics of ITCs, and detail the organization of ITC clusters and their connectivity with one another and other brain regions. We describe how ITCs undergo experience-dependent plasticity and discuss emerging evidence demonstrating how ITCs are innervated and functionally regulated by neuromodulatory systems. We summarize recent findings showing that experience alters the balance of activity between different ITC clusters, thereby determining prevailing behavioral output. Finally, we propose a model in which ITCs form a key system for integrating divergent inputs and orchestrating brain-wide circuits to generate behavioral states attuned to current environmental circumstances and internal needs.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"39 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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