Nature neuroscience最新文献_第3页

A human-specific progenitor sub-domain extends neurogenesis and increases motor neuron production 人类特异性祖细胞亚域可延长神经发生过程并增加运动神经元的产生

IF 25 1区医学

Nature neuroscience Pub Date : 2024-08-29 DOI: 10.1038/s41593-024-01739-8

Sumin Jang, Elias Gumnit, Hynek Wichterle

引用次数: 0

Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells 通过分析血管和血管周围细胞揭示脑区之间血脑屏障异质性的特征

IF 25 1区医学

Nature neuroscience Pub Date : 2024-08-29 DOI: 10.1038/s41593-024-01743-y

Sarah J. Pfau, Urs H. Langen, Theodore M. Fisher, Indumathi Prakash, Faheem Nagpurwala, Ricardo A. Lozoya, Wei-Chung Allen Lee, Zhuhao Wu, Chenghua Gu

{"title":"Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells","authors":"Sarah J. Pfau, Urs H. Langen, Theodore M. Fisher, Indumathi Prakash, Faheem Nagpurwala, Ricardo A. Lozoya, Wei-Chung Allen Lee, Zhuhao Wu, Chenghua Gu","doi":"10.1038/s41593-024-01743-y","DOIUrl":"https://doi.org/10.1038/s41593-024-01743-y","url":null,"abstract":"The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB properties can vary between brain regions to support regional functions, yet how BBB heterogeneity occurs is poorly understood. Here, we used single-cell and spatial transcriptomics to compare the mouse median eminence, one of the circumventricular organs that has naturally leaky blood vessels, with the cortex. We identified hundreds of molecular differences in endothelial cells (ECs) and perivascular cells, including astrocytes, pericytes and fibroblasts. Using electron microscopy and an aqueous-based tissue-clearing method, we revealed distinct anatomical specializations and interaction patterns of ECs and perivascular cells in these regions. Finally, we identified candidate regionally enriched EC–perivascular cell ligand–receptor pairs. Our results indicate that both molecular specializations in ECs and unique EC–perivascular cell interactions contribute to BBB functional heterogeneity. This platform can be used to investigate BBB heterogeneity in other regions and may facilitate the development of central nervous system region-specific therapeutics.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":25.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142090014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Activity of nested neural circuits drives different courtship songs in Drosophila 巢状神经回路的活动驱动果蝇发出不同的求偶歌曲

IF 25 1区医学

Nature neuroscience Pub Date : 2024-08-28 DOI: 10.1038/s41593-024-01738-9

Hiroshi M. Shiozaki, Kaiyu Wang, Joshua L. Lillvis, Min Xu, Barry J. Dickson, David L. Stern

引用次数: 0

Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress. 神经胶质细胞脂滴的形成和抵抗神经元氧化应激需要 Tau。

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-08-26 DOI: 10.1038/s41593-024-01740-1

Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen

{"title":"Tau is required for glial lipid droplet formation and resistance to neuronal oxidative stress.","authors":"Lindsey D Goodman, Isha Ralhan, Xin Li, Shenzhao Lu, Matthew J Moulton, Ye-Jin Park, Pinghan Zhao, Oguz Kanca, Ziyaneh S Ghaderpour Taleghani, Julie Jacquemyn, Joshua M Shulman, Kanae Ando, Kai Sun, Maria S Ioannou, Hugo J Bellen","doi":"10.1038/s41593-024-01740-1","DOIUrl":"https://doi.org/10.1038/s41593-024-01740-1","url":null,"abstract":"The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies, defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid production and the export of toxic peroxidated lipids (LPOs). Glia uptake these LPOs and incorporate them into lipid droplets (LDs) for storage and catabolism. We found that overexpressing Tau in glia disrupts LDs in flies and rat neuron-astrocyte co-cultures, sensitizing the glia to toxic, neuronal LPOs. Using a new fly tau loss-of-function allele and RNA-mediated interference, we found that endogenous Tau is required for glial LD formation and protection against neuronal LPOs. Similarly, endogenous Tau is required in rat astrocytes and human oligodendrocyte-like cells for LD formation and the breakdown of LPOs. Behaviorally, flies lacking glial Tau have decreased lifespans and motor defects that are rescuable by administering the antioxidant N-acetylcysteine amide. Overall, this work provides insights into the important role that Tau has in glia to mitigate ROS in the brain.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomic changes in Alzheimer's disease associated with progressive Aβ plaque and tau tangle pathologies. 阿尔茨海默病的蛋白质组变化与渐进性 Aβ 斑块和 tau 纠结病理相关。

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-08-26 DOI: 10.1038/s41593-024-01737-w

Alexa Pichet Binette, Chris Gaiteri, Malin Wennström, Atul Kumar, Ines Hristovska, Nicola Spotorno, Gemma Salvadó, Olof Strandberg, Hansruedi Mathys, Li-Huei Tsai, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Jacob W Vogel, Oskar Hansson

{"title":"Proteomic changes in Alzheimer's disease associated with progressive Aβ plaque and tau tangle pathologies.","authors":"Alexa Pichet Binette, Chris Gaiteri, Malin Wennström, Atul Kumar, Ines Hristovska, Nicola Spotorno, Gemma Salvadó, Olof Strandberg, Hansruedi Mathys, Li-Huei Tsai, Sebastian Palmqvist, Niklas Mattsson-Carlgren, Shorena Janelidze, Erik Stomrud, Jacob W Vogel, Oskar Hansson","doi":"10.1038/s41593-024-01737-w","DOIUrl":"10.1038/s41593-024-01737-w","url":null,"abstract":"Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer's disease (AD). Combining radioligands measuring β-amyloid (Aβ) plaques and tau tangles with cerebrospinal fluid proteomics, we uncover molecular events mirroring different stages of AD pathology in living humans. We found 127 differentially abundant proteins (DAPs) across the AD spectrum. The strongest Aβ-related proteins were mainly expressed in glial cells and included SMOC1 and ITGAM. A dozen proteins linked to ATP metabolism and preferentially expressed in neurons were independently associated with tau tangle load and tau accumulation. Only 20% of the DAPs were also altered in other neurodegenerative diseases, underscoring AD's distinct proteome. Two co-expression modules related, respectively, to protein metabolism and microglial immune response encompassed most DAPs, with opposing, staggered trajectories along the AD continuum. We unveil protein signatures associated with Aβ and tau proteinopathy in vivo, offering insights into complex neural responses and potential biomarkers and therapeutics targeting different disease stages.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventral attention network connectivity is linked to cortical maturation and cognitive ability in childhood 腹侧注意力网络连接与皮层成熟和儿童期认知能力有关

IF 25 1区医学

Nature neuroscience Pub Date : 2024-08-23 DOI: 10.1038/s41593-024-01736-x

Hao-Ming Dong, Xi-Han Zhang, Loïc Labache, Shaoshi Zhang, Leon Qi Rong Ooi, B. T. Thomas Yeo, Daniel S. Margulies, Avram J. Holmes, Xi-Nian Zuo

{"title":"Ventral attention network connectivity is linked to cortical maturation and cognitive ability in childhood","authors":"Hao-Ming Dong, Xi-Han Zhang, Loïc Labache, Shaoshi Zhang, Leon Qi Rong Ooi, B. T. Thomas Yeo, Daniel S. Margulies, Avram J. Holmes, Xi-Nian Zuo","doi":"10.1038/s41593-024-01736-x","DOIUrl":"https://doi.org/10.1038/s41593-024-01736-x","url":null,"abstract":"The human brain experiences functional changes through childhood and adolescence, shifting from an organizational framework anchored within sensorimotor and visual regions into one that is balanced through interactions with later-maturing aspects of association cortex. Here, we link this profile of functional reorganization to the development of ventral attention network connectivity across independent datasets. We demonstrate that maturational changes in cortical organization link preferentially to within-network connectivity and heightened degree centrality in the ventral attention network, whereas connectivity within network-linked vertices predicts cognitive ability. This connectivity is associated closely with maturational refinement of cortical organization. Children with low ventral attention network connectivity exhibit adolescent-like topographical profiles, suggesting that attentional systems may be relevant in understanding how brain functions are refined across development. These data suggest a role for attention networks in supporting age-dependent shifts in cortical organization and cognition across childhood and adolescence.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":25.0,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142042670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jim Simons (1938–2024) 吉姆-西蒙斯（1938-2024）

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-08-23 DOI: 10.1038/s41593-024-01723-2

Gerald D. Fischbach

引用次数: 0

Distinct active zone protein machineries mediate Ca2+ channel clustering and vesicle priming at hippocampal synapses 不同的活性区蛋白机制介导海马突触的 Ca2+ 通道集群和囊泡启动

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-08-19 DOI: 10.1038/s41593-024-01720-5

Javier Emperador-Melero, Jonathan W. Andersen, Sarah R. Metzbower, Aaron D. Levy, Poorna A. Dharmasri, Giovanni de Nola, Thomas A. Blanpied, Pascal S. Kaeser

{"title":"Distinct active zone protein machineries mediate Ca2+ channel clustering and vesicle priming at hippocampal synapses","authors":"Javier Emperador-Melero, Jonathan W. Andersen, Sarah R. Metzbower, Aaron D. Levy, Poorna A. Dharmasri, Giovanni de Nola, Thomas A. Blanpied, Pascal S. Kaeser","doi":"10.1038/s41593-024-01720-5","DOIUrl":"10.1038/s41593-024-01720-5","url":null,"abstract":"Action potentials trigger neurotransmitter release at the presynaptic active zone with spatiotemporal precision. This is supported by protein machinery that mediates synaptic vesicle priming and clustering of CaV2 Ca2+ channels nearby. One model posits that scaffolding proteins directly tether vesicles to CaV2s; however, here we find that at mouse hippocampal synapses, CaV2 clustering and vesicle priming are executed by separate machineries. CaV2 nanoclusters are positioned at variable distances from those of the priming protein Munc13. The active zone organizer RIM anchors both proteins but distinct interaction motifs independently execute these functions. In transfected cells, Liprin-α and RIM form co-assemblies that are separate from CaV2-organizing complexes. At synapses, Liprin-α1–Liprin-α4 knockout impairs vesicle priming but not CaV2 clustering. The cell adhesion protein PTPσ recruits Liprin-α, RIM and Munc13 into priming complexes without co-clustering CaV2s. We conclude that active zones consist of distinct machineries to organize CaV2s and prime vesicles, and Liprin-α and PTPσ specifically support priming site assembly. The active zone primes synaptic vesicles and clusters voltage-gated Ca2+ channels fast neurotransmitter release. Here the authors dissect the underlying molecular architecture and show that distinct protein machineries execute these functions.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":null,"pages":null},"PeriodicalIF":21.2,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142002823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Publisher Correction: Nested compressed co-representations of multiple sequential experiences during sleep 出版商更正：睡眠中多重连续经验的嵌套压缩共表征

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-08-15 DOI: 10.1038/s41593-024-01751-y

Kefei Liu, Jeremie Sibille, George Dragoi

引用次数: 0

Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE 作者更正：TREM2 功能缺失会增加淀粉样蛋白播种，但会减少斑块相关载脂蛋白E。

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-08-14 DOI: 10.1038/s41593-024-01752-x

Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F. Lichtenthaler, Stephan A. Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahirovic, Jochen Herms, Michael Willem, Nadine Pettkus, Oleg Butovsky, Peter Bartenstein, Dieter Edbauer, Axel Rominger, Ali Ertürk, Stefan A. Grathwohl, Jonas J. Neher, David M. Holtzman, Melanie Meyer-Luehmann, Christian Haass

引用次数: 0