Nature neuroscience最新文献_第3页

Homeostasis of a representational map in the neocortex 新皮层表征图的动态平衡

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01982-7

Takahiro Noda, Eike Kienle, Jens-Bastian Eppler, Dominik F. Aschauer, Matthias Kaschube, Yonatan Loewenstein, Simon Rumpel

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Resilient cortical maps 弹性皮层图

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01957-8

Yaniv Ziv

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The brain creates action-based maps of the world near the body 大脑在身体附近创建基于动作的世界地图

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01959-6

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Formation of an expanding memory representation in the hippocampus 海马体中扩展记忆表征的形成

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-04 DOI: 10.1038/s41593-025-01986-3

Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li, Jeffrey C. Magee

{"title":"Formation of an expanding memory representation in the hippocampus","authors":"Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li, Jeffrey C. Magee","doi":"10.1038/s41593-025-01986-3","DOIUrl":"https://doi.org/10.1038/s41593-025-01986-3","url":null,"abstract":"How brain networks connected by labile synapses store new information without catastrophically overwriting previous memories remains poorly understood. To examine this, we tracked the same population of hippocampal CA1 place cells (PCs) as mice learned a task for 7 days. We found evidence of memory formation as both the number of PCs maintaining a stable place field and the stability of individual PCs progressively increased across the week until most of the representation was composed of long-term stable PCs. The stable PCs disproportionately represented task-related learned information, were retrieved earlier within a behavioral session and showed a strong correlation with behavioral performance. Both the initial formation of PCs and their retrieval on subsequent days were accompanied by prominent signs of behavioral timescale synaptic plasticity (BTSP), suggesting that even stable PCs were re-formed by synaptic plasticity each session. Further experimental evidence supported by a cascade-type state model indicates that CA1 PCs increase their stability each day they are active, eventually forming a highly stable population. The results suggest that CA1 memory is implemented by an increase in the likelihood of new neuron-specific synaptic plasticity, as opposed to extensive long-term synaptic weight stabilization.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"9 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A common computational and neural anomaly across mouse models of autism 自闭症小鼠模型中常见的计算和神经异常

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-03 DOI: 10.1038/s41593-025-01965-8

Jean-Paul Noel, Edoardo Balzani, Luigi Acerbi, Julius Benson, Cristina Savin, Dora E. Angelaki

{"title":"A common computational and neural anomaly across mouse models of autism","authors":"Jean-Paul Noel, Edoardo Balzani, Luigi Acerbi, Julius Benson, Cristina Savin, Dora E. Angelaki","doi":"10.1038/s41593-025-01965-8","DOIUrl":"https://doi.org/10.1038/s41593-025-01965-8","url":null,"abstract":"Computational psychiatry studies suggest that individuals with autism spectrum disorder (ASD) inflexibly update their expectations. Here we leveraged high-yield rodent psychophysics, extensive behavioral modeling and brain-wide single-cell extracellular recordings to assess whether mice with different genetic perturbations associated with ASD show this same computational anomaly, and if so, what neurophysiological features are shared across genotypes. Mice harboring mutations in Fmr1, Cntnap2 or Shank3B show a blunted update of priors during decision-making. Compared with mice that flexibly updated their priors, inflexible updating of priors was associated with a shift in the weighting of prior encoding from sensory to frontal cortices. Furthermore, frontal areas in mouse models of ASD showed more units encoding deviations from the animals’ long-run prior, and sensory responses did not differentiate between expected and unexpected observations. These findings suggest that distinct genetic instantiations of ASD may yield common neurophysiological and behavioral phenotypes.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"7 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Changing genes, cells and networks to reprogram the brain after stroke 改变基因、细胞和网络，在中风后重新编程大脑

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01981-8

Wenlu Li, Paul George, Matine M. Azadian, MingMing Ning, Amar Dhand, Steven C. Cramer, S. Thomas Carmichael, Eng H. Lo

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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress 神经元老化导致剪接蛋白的错误定位和不受控制的细胞应激

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01952-z

Kevin Rhine, Rachel Li, Hema M. Kopalle, Katherine Rothamel, Xuezhen Ge, Elle Epstein, Orel Mizrahi, Assael A. Madrigal, Hsuan-Lin Her, Trent A. Gomberg, Anita Hermann, Joshua L. Schwartz, Amanda J. Daniels, Uri Manor, John Ravits, Robert A. J. Signer, Eric J. Bennett, Gene W. Yeo

{"title":"Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress","authors":"Kevin Rhine, Rachel Li, Hema M. Kopalle, Katherine Rothamel, Xuezhen Ge, Elle Epstein, Orel Mizrahi, Assael A. Madrigal, Hsuan-Lin Her, Trent A. Gomberg, Anita Hermann, Joshua L. Schwartz, Amanda J. Daniels, Uri Manor, John Ravits, Robert A. J. Signer, Eric J. Bennett, Gene W. Yeo","doi":"10.1038/s41593-025-01952-z","DOIUrl":"https://doi.org/10.1038/s41593-025-01952-z","url":null,"abstract":"Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged healthy donors directly into neurons, which retained their aging hallmarks, and we verified key findings in aged human and mouse brain tissue. Here we show that aged neurons are broadly depleted of RNA-binding proteins, especially spliceosome components. Intriguingly, splicing proteins—like the dementia- and ALS-associated protein TDP-43—mislocalize to the cytoplasm in aged neurons, which leads to widespread alternative splicing. Cytoplasmic spliceosome components are typically recruited to stress granules, but aged neurons suffer from chronic cellular stress that prevents this sequestration. We link chronic stress to the malfunctioning ubiquitylation machinery, poor HSP90α chaperone activity and the failure to respond to new stress events. Together, our data demonstrate that aging-linked deterioration of RNA biology is a key driver of poor resiliency in aged neurons.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"13 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Egocentric value maps of the near-body environment 以自我为中心的近体环境价值图

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01958-7

Rory John Bufacchi, Richard Somervail, Aoife Maria Fitzpatrick, Yusuke Murayama, Nikos Logothetis, Roberto Caminiti, Gian Domenico Iannetti

{"title":"Egocentric value maps of the near-body environment","authors":"Rory John Bufacchi, Richard Somervail, Aoife Maria Fitzpatrick, Yusuke Murayama, Nikos Logothetis, Roberto Caminiti, Gian Domenico Iannetti","doi":"10.1038/s41593-025-01958-7","DOIUrl":"https://doi.org/10.1038/s41593-025-01958-7","url":null,"abstract":"Body-part-centered response fields are pervasive in single neurons, functional magnetic resonance imaging, electroencephalography and behavior, but there is no unifying formal explanation of their origins and role. In the present study, we used reinforcement learning and artificial neural networks to demonstrate that body-part-centered fields do not simply reflect stimulus configuration, but rather action value: they naturally arise from the basic assumption that agents often experience positive or negative reward after contacting environmental objects. This perspective successfully reproduces experimental findings that are foundational in the peripersonal space literature. It also suggests that peripersonal fields provide building blocks that create a modular model of the world near the agent: an egocentric value map. This concept is strongly supported by the emergent modularity that we observed in our artificial networks. The short-term, close-range, egocentric map is analogous to the long-term, long-range, allocentric hippocampal map. This perspective fits empirical data from multiple experiments, provides testable predictions and accommodates existing explanations of peripersonal fields.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"5 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Microglia eliminate inhibitory synapses and drive neuronal hyperexcitability in epilepsy 小胶质细胞消除抑制性突触并驱动癫痫中的神经元高兴奋性

IF 25 1区医学

Nature neuroscience Pub Date : 2025-05-30 DOI: 10.1038/s41593-025-01983-6

引用次数: 0

The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine 小鼠小肠粘膜下神经元类别的转录组、连接和发育

IF 25 1区医学

Nature neuroscience Pub Date : 2025-05-29 DOI: 10.1038/s41593-025-01962-x

Wei Li, Khomgrit Morarach, Ziwei Liu, Sanghita Banerjee, Yanan Chen, Ashley L. Harb, Joel M. Kosareff, Charles R. Hall, Fernando López-Redondo, Elham Jalalvand, Suad H. Mohamed, Anastassia Mikhailova, David R. Linden, Ulrika Marklund

{"title":"The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine","authors":"Wei Li, Khomgrit Morarach, Ziwei Liu, Sanghita Banerjee, Yanan Chen, Ashley L. Harb, Joel M. Kosareff, Charles R. Hall, Fernando López-Redondo, Elham Jalalvand, Suad H. Mohamed, Anastassia Mikhailova, David R. Linden, Ulrika Marklund","doi":"10.1038/s41593-025-01962-x","DOIUrl":"https://doi.org/10.1038/s41593-025-01962-x","url":null,"abstract":"The enteric submucosal plexus regulates essential digestive functions, yet its neuronal composition remains incompletely understood. We identified two putative secretomotor neuron classes and a previously unrecognized submucosal intrinsic primary afferent neuron class through single-cell RNA sequencing in the mouse small intestine. Using viral-mediated labeling of each class, we uncovered their morphologies and neural projections in the submucosa–mucosa context, finding connections among all classes and an unexpected close association with enterochromaffin cells. Further transcriptome analysis at the postnatal stage and lineage tracing revealed that neuron identities in the submucosal plexus emerge through an initial binary fate split at neurogenesis, followed by phenotypic diversification, akin to the developmental process of the myenteric plexus. We propose a unified developmental framework for neuronal diversification across the gut wall. Our study offers comprehensive molecular, developmental and morphological insights into submucosal neurons, opening new avenues for exploring physiological functions, circuit dynamics and formation of the submucosal plexus.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"8 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0