Nature neuroscience最新文献_第10页

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-11 DOI: 10.1038/s41593-024-01851-9

Lluís Fuentemilla

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Addendum: Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease 附录：髓鞘绝缘是自身免疫性脱髓鞘疾病中轴突变性的危险因素

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-11 DOI: 10.1038/s41593-025-01927-0

Erik Schäffner, Mar Bosch-Queralt, Julia M. Edgar, Maria Lehning, Judith Strauß, Niko Fleischer, Theresa Kungl, Peter Wieghofer, Stefan A. Berghoff, Tilo Reinert, Martin Krueger, Markus Morawski, Wiebke Möbius, Alonso Barrantes-Freer, Jens Stieler, Ting Sun, Gesine Saher, Markus H. Schwab, Christoph Wrede, Maximilian Frosch, Marco Prinz, Daniel S. Reich, Alexander Flügel, Christine Stadelmann, Robert Fledrich, Klaus-Armin Nave, Ruth M. Stassart

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Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis 线粒体呼吸复合体IV缺乏是肌萎缩性侧索硬化症的表现

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-11 DOI: 10.1038/s41593-025-01896-4

Man Cheng, Dan Lu, Kexin Li, Yan Wang, Xiwen Tong, Xiaolong Qi, Chuanzhu Yan, Kunqian Ji, Junlin Wang, Wei Wang, Huijiao Lv, Xu Zhang, Weining Kong, Jian Zhang, Jiaxin Ma, Keru Li, Yaheng Wang, Jingyu Feng, Panpan Wei, Qiushuang Li, Chengyong Shen, Xiang-Dong Fu, Yuanwu Ma, Xiaorong Zhang

{"title":"Mitochondrial respiratory complex IV deficiency recapitulates amyotrophic lateral sclerosis","authors":"Man Cheng, Dan Lu, Kexin Li, Yan Wang, Xiwen Tong, Xiaolong Qi, Chuanzhu Yan, Kunqian Ji, Junlin Wang, Wei Wang, Huijiao Lv, Xu Zhang, Weining Kong, Jian Zhang, Jiaxin Ma, Keru Li, Yaheng Wang, Jingyu Feng, Panpan Wei, Qiushuang Li, Chengyong Shen, Xiang-Dong Fu, Yuanwu Ma, Xiaorong Zhang","doi":"10.1038/s41593-025-01896-4","DOIUrl":"10.1038/s41593-025-01896-4","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is categorized into ~10% familial and ~90% sporadic cases. While familial ALS is caused by mutations in many genes of diverse functions, the underlying pathogenic mechanisms of ALS, especially in sporadic ALS (sALS), are largely unknown. Notably, about half of the cases with sALS showed defects in mitochondrial respiratory complex IV (CIV). To determine the causal role of this defect in ALS, we used transcription activator-like effector-based mitochondrial genome editing to introduce mutations in CIV subunits in rat neurons. Our results demonstrate that neuronal CIV deficiency is sufficient to cause a number of ALS-like phenotypes, including cytosolic TAR DNA-binding protein 43 redistribution, selective motor neuron loss and paralysis. These results highlight CIV deficiency as a potential cause of sALS and shed light on the specific vulnerability of motor neurons, marking an important advance in understanding and therapeutic development of sALS. Cheng et al. identify a mitochondrial complex IV (CIV) deficiency in the brains of patients with sporadic amyotrophic lateral sclerosis (ALS). They demonstrate that defects in mitochondrial CIV induce ALS-like phenotypes in rats and highlight CIV deficiency as a potential risk factor and therapeutic target for ALS.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 4","pages":"748-756"},"PeriodicalIF":21.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: A curious concept of CNS clearance 关于中枢神经系统清除的一个奇怪概念

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-11 DOI: 10.1038/s41593-025-01898-2

Nicholas P. Franks, William Wisden

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A curious concept of CNS clearance 中枢神经系统清除的一个奇怪概念

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-11 DOI: 10.1038/s41593-025-01897-3

Virginia Plá, Erik Kroesbergen, Saiyue Deng, Michael J. Giannetto, Lauren M. Hablitz, Evan Newbold, Antonio Ladrón-de-Guevara, Tina Esmail, Ryszard Stefan Gomolka, Yuki Mori, Steven A. Goldman, Douglas H. Kelley, John H. Thomas, Maiken Nedergaard

引用次数: 0

Study-phase reinstatement predicts subsequent recall 研究阶段的恢复预示着随后的回忆

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-11 DOI: 10.1038/s41593-025-01884-8

David J. Halpern, Bradley C. Lega, Robert E. Gross, Chengyuan Wu, Michael R. Sperling, Joshua P. Aronson, Barbara C. Jobst, Michael J. Kahana

{"title":"Study-phase reinstatement predicts subsequent recall","authors":"David J. Halpern, Bradley C. Lega, Robert E. Gross, Chengyuan Wu, Michael R. Sperling, Joshua P. Aronson, Barbara C. Jobst, Michael J. Kahana","doi":"10.1038/s41593-025-01884-8","DOIUrl":"10.1038/s41593-025-01884-8","url":null,"abstract":"Can the brain improve the retrievability of an experience after it has occurred? Systems consolidation theory proposes that item-specific cortical reactivation during post-encoding rest periods facilitates the formation of stable memory representations, a prediction supported by neural evidence in humans and animals. Such reactivation may also occur on shorter timescales, offering a potential account of classic list memory phenomena but lacking in support from neural data. Leveraging the high temporal specificity of intracranial electroencephalography (EEG), we investigate spontaneous reactivation of previously experienced items during brief intervals between individual encoding events. Across two large-scale free-recall experiments, we show that reactivation during these periods, measured by spectral intracranial EEG similarity, predicts subsequent recall. In a third experiment, we show that the same methodology can identify post-encoding reactivation that correlates with subsequent memory, consistent with previous results. Thus, spontaneous study-phase reinstatement reliably predicts memory behavior, linking psychological accounts to neural mechanisms and providing evidence for rapid consolidation processes during encoding. How can the brain improve memory for an experience after it has occurred? Halpern et al. use intracranial EEG to show that, even while processing current experiences, people reactivate old ones and re-encode them, turning thoughts into memories.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 4","pages":"883-890"},"PeriodicalIF":21.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consciousness or pseudo-consciousness? A clash of two paradigms 意识还是伪意识？两种范式的冲突

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-10 DOI: 10.1038/s41593-025-01880-y

Giulio Tononi, Larissa Albantakis, Leonardo Barbosa, Melanie Boly, Chiara Cirelli, Renzo Comolatti, Francesco Ellia, Graham Findlay, Adenauer Girardi Casali, Matteo Grasso, Andrew M. Haun, Jeremiah Hendren, Erik Hoel, Christof Koch, Alexander Maier, William Marshall, Marcello Massimini, William GP Mayner, Masafumi Oizumi, Joanna Szczotka, Naotsugu Tsuchiya, Alireza Zaeemzadeh

引用次数: 0

Constructing future behavior in the hippocampal formation through composition and replay 通过合成和回放在海马体形成中构建未来行为

IF 25 1区医学

Nature neuroscience Pub Date : 2025-03-10 DOI: 10.1038/s41593-025-01908-3

Jacob J. W. Bakermans, Joseph Warren, James C. R. Whittington, Timothy E. J. Behrens

{"title":"Constructing future behavior in the hippocampal formation through composition and replay","authors":"Jacob J. W. Bakermans, Joseph Warren, James C. R. Whittington, Timothy E. J. Behrens","doi":"10.1038/s41593-025-01908-3","DOIUrl":"https://doi.org/10.1038/s41593-025-01908-3","url":null,"abstract":"<p>The hippocampus is critical for memory, imagination and constructive reasoning. Recent models have suggested that its neuronal responses can be well explained by state spaces that model the transitions between experiences. Here we use simulations and hippocampal recordings to reconcile these views. We show that if state spaces are constructed compositionally from existing building blocks, or primitives, hippocampal responses can be interpreted as compositional memories, binding these primitives together. Critically, this enables agents to behave optimally in new environments with no new learning, inferring behavior directly from the composition. We predict a role for hippocampal replay in building and consolidating these compositional memories. We test these predictions in two datasets by showing that replay events from newly discovered landmarks induce and strengthen new remote firing fields. When the landmark is moved, replay builds a new firing field at the same vector to the new location. Together, these findings provide a framework for reasoning about compositional memories and demonstrate that such memories are formed in hippocampal replay.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"8 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What makes a theory of consciousness unscientific? 什么使意识理论不科学？

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-10 DOI: 10.1038/s41593-025-01881-x

IIT-Concerned, Michał Klincewicz, Tony Cheng, Michael Schmitz, Miguel Ángel Sebastián, Joel S. Snyder

引用次数: 0

Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts 纹状体尾部的多巴胺有助于避免威胁-奖励冲突

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-03-10 DOI: 10.1038/s41593-025-01902-9

Iku Tsutsui-Kimura, Zhiyu Melissa Tian, Ryunosuke Amo, Yizhou Zhuo, Yulong Li, Malcolm G. Campbell, Naoshige Uchida, Mitsuko Watabe-Uchida

{"title":"Dopamine in the tail of the striatum facilitates avoidance in threat–reward conflicts","authors":"Iku Tsutsui-Kimura, Zhiyu Melissa Tian, Ryunosuke Amo, Yizhou Zhuo, Yulong Li, Malcolm G. Campbell, Naoshige Uchida, Mitsuko Watabe-Uchida","doi":"10.1038/s41593-025-01902-9","DOIUrl":"10.1038/s41593-025-01902-9","url":null,"abstract":"Responding appropriately to potential threats before they materialize is critical to avoiding disastrous outcomes. Here we examine how threat-coping behavior is regulated by the tail of the striatum (TS) and its dopamine input. Mice were presented with a potential threat (a moving object) while pursuing rewards. Initially, the mice failed to obtain rewards but gradually improved in later trials. We found that dopamine in TS promoted avoidance of the threat, even at the expense of reward acquisition. Furthermore, the activity of dopamine D1 receptor-expressing neurons promoted threat avoidance and prediction. In contrast, D2 neurons suppressed threat avoidance and facilitated overcoming the potential threat. Dopamine axon activation in TS not only potentiated the responses of dopamine D1 receptor-expressing neurons to novel sensory stimuli but also boosted them acutely. These results demonstrate that an opponent interaction of D1 and D2 neurons in the TS, modulated by dopamine, dynamically regulates avoidance and overcoming potential threats. During foraging with threat–reward conflicts in mice, dopamine modulates two competing neuron types in the striatum for flexible threat coping, from initial threat avoidance to eventual overcoming of the threat.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 4","pages":"795-810"},"PeriodicalIF":21.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-025-01902-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0