A neuroprotective role of polyunsaturated fatty acids in C9orf72-ALS/FTD

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-03-26 DOI:10.1038/s41593-025-01920-7

Sandeep Kumar Dubey, Hugo J. Bellen

引用次数: 0

Abstract

New research shows that lipid metabolism genes are downregulated in patient samples and Drosophila models of amyotrophic lateral sclerosis or frontotemporal dementia associated with expansions in C9orf72, resulting in reduced levels of phospholipids containing polyunsaturated fatty acids. Importantly, increasing polyunsaturated fatty acids through diet or genetic modulation of C9orf72 in Drosophila or induced pluripotent stem cell-derived motor neurons significantly improves neuronal survival.

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新研究表明，在肌萎缩侧索硬化症或额颞叶痴呆症患者样本和果蝇模型中，脂质代谢基因下调与 C9orf72 基因扩增有关，导致含多不饱和脂肪酸的磷脂水平降低。重要的是，通过饮食或遗传调节果蝇或诱导多能干细胞衍生运动神经元中的 C9orf72 来增加多不饱和脂肪酸，可显著提高神经元的存活率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.