Nature neuroscience最新文献

A revised view of the role of CaMKII in learning and memory 关于 CaMKII 在学习和记忆中的作用的新观点

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-18 DOI: 10.1038/s41593-024-01809-x

Karl Ulrich Bayer, Karl Peter Giese

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Emergence of a brainstem somatosensory tonotopic map for substrate vibration 针对底物振动的脑干体感色调图谱的出现

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-15 DOI: 10.1038/s41593-024-01821-1

Kuo-Sheng Lee, Alastair J. Loutit, Dominica de Thomas Wagner, Mark Sanders, Daniel Huber

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Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices 对人类海马切片的网络活动和光遗传干预进行多模式评估

IF 25 1区医学

Nature neuroscience Pub Date : 2024-11-15 DOI: 10.1038/s41593-024-01782-5

John P. Andrews, Jinghui Geng, Kateryna Voitiuk, Matthew A. T. Elliott, David Shin, Ash Robbins, Alex Spaeth, Albert Wang, Lin Li, Daniel Solis, Matthew G. Keefe, Jessica L. Sevetson, Julio A. Rivera de Jesús, Kevin C. Donohue, H. Hanh Larson, Drew Ehrlich, Kurtis I. Auguste, Sofie Salama, Vikaas Sohal, Tal Sharf, David Haussler, Cathryn R. Cadwell, David V. Schaffer, Edward F. Chang, Mircea Teodorescu, Tomasz Jan Nowakowski

{"title":"Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices","authors":"John P. Andrews, Jinghui Geng, Kateryna Voitiuk, Matthew A. T. Elliott, David Shin, Ash Robbins, Alex Spaeth, Albert Wang, Lin Li, Daniel Solis, Matthew G. Keefe, Jessica L. Sevetson, Julio A. Rivera de Jesús, Kevin C. Donohue, H. Hanh Larson, Drew Ehrlich, Kurtis I. Auguste, Sofie Salama, Vikaas Sohal, Tal Sharf, David Haussler, Cathryn R. Cadwell, David V. Schaffer, Edward F. Chang, Mircea Teodorescu, Tomasz Jan Nowakowski","doi":"10.1038/s41593-024-01782-5","DOIUrl":"https://doi.org/10.1038/s41593-024-01782-5","url":null,"abstract":"<p>Seizures are made up of the coordinated activity of networks of neurons, suggesting that control of neurons in the pathologic circuits of epilepsy could allow for control of the disease. Optogenetics has been effective at stopping seizure-like activity in non-human disease models by increasing inhibitory tone or decreasing excitation, although this effect has not been shown in human brain tissue. Many of the genetic means for achieving channelrhodopsin expression in non-human models are not possible in humans, and vector-mediated methods are susceptible to species-specific tropism that may affect translational potential. Here we demonstrate adeno-associated virus–mediated, optogenetic reductions in network firing rates of human hippocampal slices recorded on high-density microelectrode arrays under several hyperactivity-provoking conditions. This platform can serve to bridge the gap between human and animal studies by exploring genetic interventions on network activity in human brain tissue.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"38 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Confronting racially exclusionary practices in the acquisition and analyses of neuroimaging data 作者更正：在获取和分析神经影像学数据时面临种族排斥做法。

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-09 DOI: 10.1038/s41593-023-01516-z

J. A. Ricard, T. C. Parker, E. Dhamala, J. Kwasa, A. Allsop, A. J. Holmes

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Topological analysis of sharp-wave ripple waveforms reveals input mechanisms behind feature variations 尖锐波纹波形的拓扑分析揭示了特征变化背后的输入机制。

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-09 DOI: 10.1038/s41593-023-01471-9

Enrique R. Sebastian, Juan P. Quintanilla, Alberto Sánchez-Aguilera, Julio Esparza, Elena Cid, Liset M. de la Prida

{"title":"Topological analysis of sharp-wave ripple waveforms reveals input mechanisms behind feature variations","authors":"Enrique R. Sebastian, Juan P. Quintanilla, Alberto Sánchez-Aguilera, Julio Esparza, Elena Cid, Liset M. de la Prida","doi":"10.1038/s41593-023-01471-9","DOIUrl":"10.1038/s41593-023-01471-9","url":null,"abstract":"The reactivation of experience-based neural activity patterns in the hippocampus is crucial for learning and memory. These reactivation patterns and their associated sharp-wave ripples (SWRs) are highly variable. However, this variability is missed by commonly used spectral methods. Here, we use topological and dimensionality reduction techniques to analyze the waveform of ripples recorded at the pyramidal layer of CA1. We show that SWR waveforms distribute along a continuum in a low-dimensional space, which conveys information about the underlying layer-specific synaptic inputs. A decoder trained in this space successfully links individual ripples with their expected sinks and sources, demonstrating how physiological mechanisms shape SWR variability. Furthermore, we found that SWR waveforms segregated differently during wakefulness and sleep before and after a series of cognitive tasks, with striking effects of novelty and learning. Our results thus highlight how the topological analysis of ripple waveforms enables a deeper physiological understanding of SWRs. This study applies topological analysis to hippocampal ripple waveforms, uncovering a low-dimensional continuum that encodes layer-specific synaptic input information. It also reveals how ripple waveforms vary during wakefulness, sleep and learning.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"26 12","pages":"2171-2181"},"PeriodicalIF":25.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis 自闭症谱系障碍相关基因SYNGAP1在皮层神经发生中的非突触功能。

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-09 DOI: 10.1038/s41593-023-01477-3

Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan Nguyen, Brent Wilkinson, Negar Hosseini, Sarah Nguyen, Jean-Paul Urenda, Gavin Knight, Camilo Rojas, Ilse Flores, Alexander Atamian, Roger Moore, Ritin Sharma, Patrick Pirrotte, Randolph S. Ashton, Eric J. Huang, Gavin Rumbaugh, Marcelo P. Coba, Giorgia Quadrato

{"title":"Non-synaptic function of the autism spectrum disorder-associated gene SYNGAP1 in cortical neurogenesis","authors":"Marcella Birtele, Ashley Del Dosso, Tiantian Xu, Tuan Nguyen, Brent Wilkinson, Negar Hosseini, Sarah Nguyen, Jean-Paul Urenda, Gavin Knight, Camilo Rojas, Ilse Flores, Alexander Atamian, Roger Moore, Ritin Sharma, Patrick Pirrotte, Randolph S. Ashton, Eric J. Huang, Gavin Rumbaugh, Marcelo P. Coba, Giorgia Quadrato","doi":"10.1038/s41593-023-01477-3","DOIUrl":"10.1038/s41593-023-01477-3","url":null,"abstract":"Genes involved in synaptic function are enriched among those with autism spectrum disorder (ASD)-associated rare genetic variants. Dysregulated cortical neurogenesis has been implicated as a convergent mechanism in ASD pathophysiology, yet it remains unknown how ‘synaptic’ ASD risk genes contribute to these phenotypes, which arise before synaptogenesis. Here, we show that the synaptic Ras GTPase-activating (RASGAP) protein 1 (SYNGAP1, a top ASD risk gene) is expressed within the apical domain of human radial glia cells (hRGCs). In a human cortical organoid model of SYNGAP1 haploinsufficiency, we find dysregulated cytoskeletal dynamics that impair the scaffolding and division plane of hRGCs, resulting in disrupted lamination and accelerated maturation of cortical projection neurons. Additionally, we confirmed an imbalance in the ratio of progenitors to neurons in a mouse model of Syngap1 haploinsufficiency. Thus, SYNGAP1-related brain disorders may arise through non-synaptic mechanisms, highlighting the need to study genes associated with neurodevelopmental disorders (NDDs) in diverse human cell types and developmental stages. Experiments in human cortical organoid and mouse models of SYNGAP1 haploinsufficiency, which is associated with autism spectrum disorder (ASD), reveal altered cortical neurogenesis, suggesting that a non-synaptic mechanism contributes to the disorder.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"26 12","pages":"2090-2103"},"PeriodicalIF":25.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors 转录定义的杏仁核亚群在先天社会行为中发挥着不同的作用。

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-09 DOI: 10.1038/s41593-023-01475-5

Julieta E. Lischinsky, Luping Yin, Chenxi Shi, Nandkishore Prakash, Jared Burke, Govind Shekaran, Maria Grba, Joshua G. Corbin, Dayu Lin

{"title":"Transcriptionally defined amygdala subpopulations play distinct roles in innate social behaviors","authors":"Julieta E. Lischinsky, Luping Yin, Chenxi Shi, Nandkishore Prakash, Jared Burke, Govind Shekaran, Maria Grba, Joshua G. Corbin, Dayu Lin","doi":"10.1038/s41593-023-01475-5","DOIUrl":"10.1038/s41593-023-01475-5","url":null,"abstract":"Social behaviors are innate and supported by dedicated neural circuits, but the molecular identities of these circuits and how they are established developmentally and shaped by experience remain unclear. Here we show that medial amygdala (MeA) cells originating from two embryonically parcellated developmental lineages have distinct response patterns and functions in social behavior in male mice. MeA cells expressing the transcription factor Foxp2 (MeAFoxp2) are specialized for processing male conspecific cues and are essential for adult inter-male aggression. By contrast, MeA cells derived from the Dbx1 lineage (MeADbx1) respond broadly to social cues, respond strongly during ejaculation and are not essential for male aggression. Furthermore, MeAFoxp2 and MeADbx1 cells show differential anatomical and functional connectivity. Altogether, our results suggest a developmentally hardwired aggression circuit at the MeA level and a lineage-based circuit organization by which a cell’s embryonic transcription factor profile determines its social information representation and behavioral relevance during adulthood. The authors describe the connectivity, response profile and behavioral roles of two transcriptionally defined amygdala populations from separate embryonic lineages and show how responses of one population change with social experience.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"26 12","pages":"2131-2146"},"PeriodicalIF":25.0,"publicationDate":"2023-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72014900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioral read-out from population value signals in primate orbitofrontal cortex 灵长类动物眶额皮层群体价值信号的行为读数。

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-06 DOI: 10.1038/s41593-023-01473-7

Vincent B. McGinty, Shira M. Lupkin

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Dopamine retunes for romance 多巴胺回归浪漫。

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-02 DOI: 10.1038/s41593-023-01491-5

Charlotte Arlt

引用次数: 0

IF 25 1区医学

Nature neuroscience Pub Date : 2023-11-02 DOI: 10.1038/s41593-023-01451-z

Carola I. Radulescu, Nazanin Doostdar, Nawal Zabouri, Leire Melgosa-Ecenarro, Xingjian Wang, Sadra Sadeh, Pavlina Pavlidi, Joe Airey, Maksym Kopanitsa, Claudia Clopath, Samuel J. Barnes

{"title":"Age-related dysregulation of homeostatic control in neuronal microcircuits","authors":"Carola I. Radulescu, Nazanin Doostdar, Nawal Zabouri, Leire Melgosa-Ecenarro, Xingjian Wang, Sadra Sadeh, Pavlina Pavlidi, Joe Airey, Maksym Kopanitsa, Claudia Clopath, Samuel J. Barnes","doi":"10.1038/s41593-023-01451-z","DOIUrl":"10.1038/s41593-023-01451-z","url":null,"abstract":"Neuronal homeostasis prevents hyperactivity and hypoactivity. Age-related hyperactivity suggests homeostasis may be dysregulated in later life. However, plasticity mechanisms preventing age-related hyperactivity and their efficacy in later life are unclear. We identify the adult cortical plasticity response to elevated activity driven by sensory overstimulation, then test how plasticity changes with age. We use in vivo two-photon imaging of calcium-mediated cellular/synaptic activity, electrophysiology and c-Fos-activity tagging to show control of neuronal activity is dysregulated in the visual cortex in late adulthood. Specifically, in young adult cortex, mGluR5-dependent population-wide excitatory synaptic weakening and inhibitory synaptogenesis reduce cortical activity following overstimulation. In later life, these mechanisms are downregulated, so that overstimulation results in synaptic strengthening and elevated activity. We also find overstimulation disrupts cognition in older but not younger animals. We propose that specific plasticity mechanisms fail in later life dysregulating neuronal microcircuit homeostasis and that the age-related response to overstimulation can impact cognitive performance. Radulescu et al. show that homeostatic mechanisms that reduce cortical activity following overstimulation are dysregulated later in life, such that overstimulation results in synaptic strengthening, elevated activity and cognitive impairment.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"26 12","pages":"2158-2170"},"PeriodicalIF":25.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71425376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0