Nature neuroscience最新文献

Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex 小鼠脾后皮层循环神经动力学的空间推理

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01944-z

Jakob Voigts, Ingmar Kanitscheider, Nicholas J. Miller, Enrique H. S. Toloza, Jonathan P. Newman, Ila R. Fiete, Mark T. Harnett

{"title":"Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex","authors":"Jakob Voigts, Ingmar Kanitscheider, Nicholas J. Miller, Enrique H. S. Toloza, Jonathan P. Newman, Ila R. Fiete, Mark T. Harnett","doi":"10.1038/s41593-025-01944-z","DOIUrl":"https://doi.org/10.1038/s41593-025-01944-z","url":null,"abstract":"From visual perception to language, sensory stimuli change their meaning depending on previous experience. Recurrent neural dynamics can interpret stimuli based on externally cued context, but it is unknown whether they can compute and employ internal hypotheses to resolve ambiguities. Here we show that mouse retrosplenial cortex (RSC) can form several hypotheses over time and perform spatial reasoning through recurrent dynamics. In our task, mice navigated using ambiguous landmarks that are identified through their mutual spatial relationship, requiring sequential refinement of hypotheses. Neurons in RSC and in artificial neural networks encoded mixtures of hypotheses, location and sensory information, and were constrained by robust low-dimensional dynamics. RSC encoded hypotheses as locations in activity space with divergent trajectories for identical sensory inputs, enabling their correct interpretation. Our results indicate that interactions between internal hypotheses and external sensory data in recurrent circuits can provide a substrate for complex sequential cognitive reasoning.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"9 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive reduction of neural rigidity alters autistic behaviors in humans 非侵入性的神经刚性降低改变了人类的自闭症行为

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01961-y

Takamitsu Watanabe, Hidenori Yamasue

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Author Correction: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus 作者更正：前额皮质中的生长抑素神经元启动睡眠准备行为，并通过视前丘脑和外侧下丘脑启动睡眠

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-02003-3

Kyoko Tossell, Xiao Yu, Panagiotis Giannos, Berta Anuncibay Soto, Mathieu Nollet, Raquel Yustos, Giulia Miracca, Mikal Vicente, Andawei Miao, Bryan Hsieh, Ying Ma, Alexei L. Vyssotski, Tim Constandinou, Nicholas P. Franks, William Wisden

引用次数: 0

RNA dysregulation impairs stress resilience in aged neurons RNA失调损害衰老神经元的应激恢复能力

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01953-y

引用次数: 0

Homeostasis of a representational map in the neocortex 新皮层表征图的动态平衡

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01982-7

Takahiro Noda, Eike Kienle, Jens-Bastian Eppler, Dominik F. Aschauer, Matthias Kaschube, Yonatan Loewenstein, Simon Rumpel

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Resilient cortical maps 弹性皮层图

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01957-8

Yaniv Ziv

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The brain creates action-based maps of the world near the body 大脑在身体附近创建基于动作的世界地图

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01959-6

引用次数: 0

Formation of an expanding memory representation in the hippocampus 海马体中扩展记忆表征的形成

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-04 DOI: 10.1038/s41593-025-01986-3

Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li, Jeffrey C. Magee

{"title":"Formation of an expanding memory representation in the hippocampus","authors":"Sachin P. Vaidya, Guanchun Li, Raymond A. Chitwood, Yiding Li, Jeffrey C. Magee","doi":"10.1038/s41593-025-01986-3","DOIUrl":"https://doi.org/10.1038/s41593-025-01986-3","url":null,"abstract":"How brain networks connected by labile synapses store new information without catastrophically overwriting previous memories remains poorly understood. To examine this, we tracked the same population of hippocampal CA1 place cells (PCs) as mice learned a task for 7 days. We found evidence of memory formation as both the number of PCs maintaining a stable place field and the stability of individual PCs progressively increased across the week until most of the representation was composed of long-term stable PCs. The stable PCs disproportionately represented task-related learned information, were retrieved earlier within a behavioral session and showed a strong correlation with behavioral performance. Both the initial formation of PCs and their retrieval on subsequent days were accompanied by prominent signs of behavioral timescale synaptic plasticity (BTSP), suggesting that even stable PCs were re-formed by synaptic plasticity each session. Further experimental evidence supported by a cascade-type state model indicates that CA1 PCs increase their stability each day they are active, eventually forming a highly stable population. The results suggest that CA1 memory is implemented by an increase in the likelihood of new neuron-specific synaptic plasticity, as opposed to extensive long-term synaptic weight stabilization.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"9 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A common computational and neural anomaly across mouse models of autism 自闭症小鼠模型中常见的计算和神经异常

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-03 DOI: 10.1038/s41593-025-01965-8

Jean-Paul Noel, Edoardo Balzani, Luigi Acerbi, Julius Benson, Cristina Savin, Dora E. Angelaki

{"title":"A common computational and neural anomaly across mouse models of autism","authors":"Jean-Paul Noel, Edoardo Balzani, Luigi Acerbi, Julius Benson, Cristina Savin, Dora E. Angelaki","doi":"10.1038/s41593-025-01965-8","DOIUrl":"https://doi.org/10.1038/s41593-025-01965-8","url":null,"abstract":"Computational psychiatry studies suggest that individuals with autism spectrum disorder (ASD) inflexibly update their expectations. Here we leveraged high-yield rodent psychophysics, extensive behavioral modeling and brain-wide single-cell extracellular recordings to assess whether mice with different genetic perturbations associated with ASD show this same computational anomaly, and if so, what neurophysiological features are shared across genotypes. Mice harboring mutations in Fmr1, Cntnap2 or Shank3B show a blunted update of priors during decision-making. Compared with mice that flexibly updated their priors, inflexible updating of priors was associated with a shift in the weighting of prior encoding from sensory to frontal cortices. Furthermore, frontal areas in mouse models of ASD showed more units encoding deviations from the animals’ long-run prior, and sensory responses did not differentiate between expected and unexpected observations. These findings suggest that distinct genetic instantiations of ASD may yield common neurophysiological and behavioral phenotypes.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"7 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changing genes, cells and networks to reprogram the brain after stroke 改变基因、细胞和网络，在中风后重新编程大脑

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01981-8

Wenlu Li, Paul George, Matine M. Azadian, MingMing Ning, Amar Dhand, Steven C. Cramer, S. Thomas Carmichael, Eng H. Lo

引用次数: 0