Nature neuroscience最新文献

Astrocytes make room for microglia 星形胶质细胞为小胶质细胞腾出空间

IF 2 1区医学

Nature neuroscience Pub Date : 2025-10-06 DOI: 10.1038/s41593-025-02082-2

Rebecca Wright

引用次数: 0

Brain-wide activity across labs 跨实验室的全脑活动

IF 2 1区医学

Nature neuroscience Pub Date : 2025-10-06 DOI: 10.1038/s41593-025-02084-0

Luis A. Mejia

引用次数: 0

Poised for action 准备行动

IF 2 1区医学

Nature neuroscience Pub Date : 2025-10-06 DOI: 10.1038/s41593-025-02083-1

William P. Olson

引用次数: 0

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models. 肌源性miR-126调节ALS模型中TDP-43轴突局部合成和NMJ完整性。

IF 25 1区医学

Nature neuroscience Pub Date : 2025-10-03 DOI: 10.1038/s41593-025-02062-6

Ariel Ionescu,Lior Ankol,Anand Ganapathy Subramaniam,Topaz Altman,Iddo Magen,Yahel Cohen,Yehuda Danino,Tal Gradus-Pery,Yoav Niv,Ori Bar Avi,Danielle Geller,Amjd Ibraheem,Ruilei Cheng,Noam Steinberg,Leenor Alfahel,Pauline Duc,Zeynep Ergul-Ulger,Doruk Arslan,Ersin Tan,Florence Rage,Nilo Riva,Angello Quattrini,Can Ebru Bekircan-Kurt,Adrian Israelson,Amir Dori,Eran Hornstein,Eran Perlson

{"title":"Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models.","authors":"Ariel Ionescu,Lior Ankol,Anand Ganapathy Subramaniam,Topaz Altman,Iddo Magen,Yahel Cohen,Yehuda Danino,Tal Gradus-Pery,Yoav Niv,Ori Bar Avi,Danielle Geller,Amjd Ibraheem,Ruilei Cheng,Noam Steinberg,Leenor Alfahel,Pauline Duc,Zeynep Ergul-Ulger,Doruk Arslan,Ersin Tan,Florence Rage,Nilo Riva,Angello Quattrini,Can Ebru Bekircan-Kurt,Adrian Israelson,Amir Dori,Eran Hornstein,Eran Perlson","doi":"10.1038/s41593-025-02062-6","DOIUrl":"https://doi.org/10.1038/s41593-025-02062-6","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is characterized by neuromuscular junction (NMJ) disruption and neurodegeneration. Recent findings highlight a pivotal role for TAR DNA-binding protein 43 (TDP-43) in forming axonal pathological condensates and facilitating NMJ disruption through inhibition of local protein synthesis. However, the mechanisms that drive local TDP-43 accumulation remain unknown. Here we identify that the TDP-43 axonal accumulation in peripheral nerves of SOD1 patients and mice stems from its aberrant local synthesis. This is a non-cell-autonomous process driven by muscle-derived miR-126a-5p extracellular vesicles (EVs). Inhibiting muscle secretion of miR-126a-5p prompts presynaptic TDP-43 synthesis and accumulation, which disrupts axonal translation and causes NMJ degeneration. Introducing miR-126 to SOD1G93A mice, primary co-cultures and human induced pluripotent stem cell (iPSC)-derived co-cultures with ALS mutations exhibits neuroprotective effects and delays motor decline. These findings identify a transcellular communication axis between muscles and motor neurons that regulates axonal local synthesis and NMJ maintenance, offering insights into ALS onset and progression.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"18 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape. 脑肿瘤可引起广泛的颅骨破坏和颅骨骨髓免疫景观的改变。

IF 25 1区医学

Nature neuroscience Pub Date : 2025-10-03 DOI: 10.1038/s41593-025-02064-4

Abhishek Dubey,Erika Yamashita,Biljana Stangeland,Imane Abbas,David Fooksman,Robert A Harris,Gregory M Palmer,Wade R Koba,Jinghang Zhang,Benjamin T Himes,Olivia R Lu,Winson S Ho,Raoul V Kuiper,Derek Huffman,Zhiping Wu,Yutaka Uchida,Masaru Ishii,Rachel L Welch,Alexander F Fiedler,David Reynolds,S A Mohieb Hosainey,Kostantin Dobrenis,Qinge Ye,Kevin Fisher,Nathaniel Killian,E Richard Stanley,Emad Eskandar,Jinan Behnan

{"title":"Brain tumors induce widespread disruption of calvarial bone and alteration of skull marrow immune landscape.","authors":"Abhishek Dubey,Erika Yamashita,Biljana Stangeland,Imane Abbas,David Fooksman,Robert A Harris,Gregory M Palmer,Wade R Koba,Jinghang Zhang,Benjamin T Himes,Olivia R Lu,Winson S Ho,Raoul V Kuiper,Derek Huffman,Zhiping Wu,Yutaka Uchida,Masaru Ishii,Rachel L Welch,Alexander F Fiedler,David Reynolds,S A Mohieb Hosainey,Kostantin Dobrenis,Qinge Ye,Kevin Fisher,Nathaniel Killian,E Richard Stanley,Emad Eskandar,Jinan Behnan","doi":"10.1038/s41593-025-02064-4","DOIUrl":"https://doi.org/10.1038/s41593-025-02064-4","url":null,"abstract":"The skull marrow niche has recently been identified as a reservoir that supplies the brain with monocytes and neutrophils in the context of disease and injury, but its role in brain cancers remains unknown. Here we show that glioblastoma, the most malignant type of brain tumor, induces calvarial bone abnormalities in murine models and patients with glioblastoma, altering osteoclast activities and increasing the number of skull channels in mice. Single-cell RNA sequencing revealed glioblastoma-mediated alterations in the immune landscape of skull marrow and femoral bone marrow, including expansion of neutrophils and deterioration of various B cell subsets. In vivo inhibition of bone resorption reduced bone abnormalities, but promoted tumor progression in mesenchymal subtype tumors. This also abolished the survival benefit of the checkpoint inhibitor anti-PD-L1, by reducing activated T cell and increasing inflammatory neutrophil numbers. Together, these data provide insight into how brain tumors affect skull bone and the immune environment.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"8 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145215799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-dose psilocybin rapidly and sustainably relieves allodynia and anxiodepressive-like behaviors in mouse models of chronic pain. 单剂量裸盖菇素快速、持续地缓解慢性疼痛小鼠模型的异常性疼痛和焦虑抑郁样行为。

IF 25 1区医学

Nature neuroscience Pub Date : 2025-10-02 DOI: 10.1038/s41593-025-02068-0

Ahmad Hammo,Stephen Wisser,Joseph Cichon

引用次数: 0

Facial expressions in mice reveal latent cognitive variables and their neural correlates. 小鼠的面部表情揭示了潜在的认知变量及其神经关联。

IF 2 1区医学

Nature neuroscience Pub Date : 2025-09-30 DOI: 10.1038/s41593-025-02071-5

Fanny Cazettes, Davide Reato, Elisabete Augusto, Raphael Steinfeld, Alfonso Renart, Zachary F Mainen

引用次数: 0

Towards the implementation of Indigenous data governance in neurogenomics research. 在神经基因组学研究中实现本土数据治理。

IF 25 1区医学

Nature neuroscience Pub Date : 2025-09-29 DOI: 10.1038/s41593-025-02070-6

Nicole Edwards,Lauren W Yowelunh McLester-Davis,Cassie Kline,Alex Brown,Nadine R Caron,Louise C Parr-Brownlie

引用次数: 0

Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals. 激素环境影响整个月经周期的全脑结构动态使用密集采样在多个个体。

IF 25 1区医学

Nature neuroscience Pub Date : 2025-09-26 DOI: 10.1038/s41593-025-02066-2

Carina Heller,Daniel Güllmar,Lejla Colic,Laura Pritschet,Martin Gell,Nooshin Javaheripour,Feliberto de la Cruz,Philine Rojczyk,Carina J Koeppel,Bart Larsen,Habib Ganjgahi,Frederik J Lange,Ann-Christine Buck,Tim L Jesgarzewsky,Robert Dahnke,Michael Kiehntopf,Emily G Jacobs,Zora Kikinis,Martin Walter,Ilona Croy,Christian Gaser

{"title":"Hormonal milieu influences whole-brain structural dynamics across the menstrual cycle using dense sampling in multiple individuals.","authors":"Carina Heller,Daniel Güllmar,Lejla Colic,Laura Pritschet,Martin Gell,Nooshin Javaheripour,Feliberto de la Cruz,Philine Rojczyk,Carina J Koeppel,Bart Larsen,Habib Ganjgahi,Frederik J Lange,Ann-Christine Buck,Tim L Jesgarzewsky,Robert Dahnke,Michael Kiehntopf,Emily G Jacobs,Zora Kikinis,Martin Walter,Ilona Croy,Christian Gaser","doi":"10.1038/s41593-025-02066-2","DOIUrl":"https://doi.org/10.1038/s41593-025-02066-2","url":null,"abstract":"Gonadal hormone receptors are widely distributed across the brain, yet their influence on brain structure remains understudied. Here, using precision imaging, we examined four females, including one with endometriosis and one using oral contraceptives (OC), across a monthly period. Whole-brain analyses revealed spatiotemporal patterns of brain volume changes, with substantial variations across the monthly period. In typical cycles, spatiotemporal patterns were associated with serum progesterone levels, while in cycles with endometriosis and during OC intake, patterns were associated with serum estradiol levels. The volume changes were widely distributed rather than region-specific, suggesting a widespread but coordinated influence of hormonal fluctuations. These findings underscore the importance of considering diverse hormonal milieus beyond typical menstrual cycles in understanding structural brain dynamics and suggest that hormonal rhythms may drive widespread structural brain changes.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"17 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bottom-up septal inhibitory circuit mediates anticipatory control of drinking. 自下而上的中隔抑制回路介导对饮酒的预期控制。

IF 25 1区医学

Nature neuroscience Pub Date : 2025-09-22 DOI: 10.1038/s41593-025-02056-4

Lingyu Xu,Yuhao Sun,Chenyuan Huang,Yanrong Zheng,Jialu Chen,Xiaolong Ma,Qiujie Shi,Mengting Liu,Xiaoyun Qiu,Qikun Zhao,Chenshu Gao,Jie Liao,Yi Wang,Zhong Chen

{"title":"A bottom-up septal inhibitory circuit mediates anticipatory control of drinking.","authors":"Lingyu Xu,Yuhao Sun,Chenyuan Huang,Yanrong Zheng,Jialu Chen,Xiaolong Ma,Qiujie Shi,Mengting Liu,Xiaoyun Qiu,Qikun Zhao,Chenshu Gao,Jie Liao,Yi Wang,Zhong Chen","doi":"10.1038/s41593-025-02056-4","DOIUrl":"https://doi.org/10.1038/s41593-025-02056-4","url":null,"abstract":"Drinking behavior is not only homeostatically regulated but also rapidly adjusted before any changes in blood osmolality occur, known as anticipatory thirst satiation. Homeostatic and anticipatory signals converge in the subfornical organ (SFO); however, the neural pathways conveying peripheral information to the SFO before changes in blood composition are incompletely understood. Here we reveal an inhibitory pathway from the medial septum (MS) to the SFO that is involved in the control of anticipatory drinking behavior in mice. MS γ-aminobutyric acid (GABA)ergic neurons encode water-satiation signals by integrating cues from the oral cavity and tracking gastrointestinal signals. These neurons receive inputs from the parabrachial nucleus and relay to SFOCaMKII neurons, forming a bottom-up pathway with activity that prevents overhydration. Disruption of this circuit leads to excessive water intake and hyponatremia. Our findings reveal a septal pathway that integrates multiple layers of presystemic signals to fine-tune drinking behavior.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"24 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145117061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0