Nature neuroscience最新文献_第2页

A flexible hippocampal population code for experience relative to reward 一个灵活的海马体群体编码相对于奖励的经验

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-11 DOI: 10.1038/s41593-025-01985-4

Marielena Sosa, Mark H. Plitt, Lisa M. Giocomo

引用次数: 0

Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex 小鼠内侧眶额叶皮质抑制神经元集合对酗酒的抑制

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-10 DOI: 10.1038/s41593-025-01970-x

Pablo Gimenez-Gomez, Timmy Le, Max Zinter, Peter M’Angale, Violeta Duran-Laforet, Timothy G. Freels, Rebecca Pavchinskiy, Susanna Molas, Dorothy P. Schafer, Andrew R. Tapper, Travis Thomson, Gilles E. Martin

{"title":"Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex","authors":"Pablo Gimenez-Gomez, Timmy Le, Max Zinter, Peter M’Angale, Violeta Duran-Laforet, Timothy G. Freels, Rebecca Pavchinskiy, Susanna Molas, Dorothy P. Schafer, Andrew R. Tapper, Travis Thomson, Gilles E. Martin","doi":"10.1038/s41593-025-01970-x","DOIUrl":"https://doi.org/10.1038/s41593-025-01970-x","url":null,"abstract":"Alcohol consumption remains a significant global health challenge, directly and indirectly causing millions of deaths annually. Alcohol abuse causes dysregulated activity of the prefrontal cortex, yet effects on specific prefrontal circuits remain to be elucidated. Here, we identify a discrete GABAergic neuronal ensemble in the mouse medial orbitofrontal cortex (mOFC) that is selectively recruited in response to binge alcohol drinking and limits further drinking behavior. Optogenetic silencing of this population, or its ablation, results in uncontrolled binge alcohol consumption. This neuronal ensemble is specific to alcohol and is not recruited by other rewarding substances. Neurons in this ensemble project widely throughout the brain, but projections specifically to the mediodorsal thalamus regulate binge alcohol drinking. Together, these results identify a brain circuit in the mOFC that serves to protect against binge drinking by reducing alcohol intake, which may offer avenues for the development of mOFC neuronal ensemble-targeted interventions.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"21 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting 脑脊液通过小脑膜动-静脉重叠的途径可以实现大分子和液体分流

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-09 DOI: 10.1038/s41593-025-01977-4

Benjamin A. Plog, Kyungdeok Kim, Daan Verhaege, Min Woo Kim, Zachary Papadopoulos, Krikor Dikranian, Taitea Dykstra, Jay Cao, Richard J. Perrin, Katherine E. Schwetye, Jonathan Kipnis, Antoine Drieu

{"title":"A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting","authors":"Benjamin A. Plog, Kyungdeok Kim, Daan Verhaege, Min Woo Kim, Zachary Papadopoulos, Krikor Dikranian, Taitea Dykstra, Jay Cao, Richard J. Perrin, Katherine E. Schwetye, Jonathan Kipnis, Antoine Drieu","doi":"10.1038/s41593-025-01977-4","DOIUrl":"https://doi.org/10.1038/s41593-025-01977-4","url":null,"abstract":"The flow of cerebrospinal fluid (CSF) is important for conveying brain-derived macromolecules for signaling and enabling them to be drained from the brain parenchyma. The glymphatic route is the best-characterized means of this CSF flow; however, it does not permit the movement of larger macromolecules. Here, we identify in mice an alternative route whereby intra-CSF-injected macromolecules can traverse from periarterial to perivenous spaces, with transfer occurring at sites of overlap between leptomeningeal perivascular (arteriovenous) spaces dispersed across the surface of the brain’s leptomeninges. We show that intra-CSF-injected fluorescent tracers can reach the perivenous space by passing through these arteriovenous perivascular overlaps. These spaces remain functional in a mouse model of amyloidosis and are essential for clearing excess CSF volume. These anatomical structures may support brain function by allowing the drainage of brain-derived macromolecules and the shunting of excess fluid and by aiding the immune surveillance of freshly generated CSF.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"10 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex 小鼠脾后皮层循环神经动力学的空间推理

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01944-z

Jakob Voigts, Ingmar Kanitscheider, Nicholas J. Miller, Enrique H. S. Toloza, Jonathan P. Newman, Ila R. Fiete, Mark T. Harnett

{"title":"Spatial reasoning via recurrent neural dynamics in mouse retrosplenial cortex","authors":"Jakob Voigts, Ingmar Kanitscheider, Nicholas J. Miller, Enrique H. S. Toloza, Jonathan P. Newman, Ila R. Fiete, Mark T. Harnett","doi":"10.1038/s41593-025-01944-z","DOIUrl":"https://doi.org/10.1038/s41593-025-01944-z","url":null,"abstract":"From visual perception to language, sensory stimuli change their meaning depending on previous experience. Recurrent neural dynamics can interpret stimuli based on externally cued context, but it is unknown whether they can compute and employ internal hypotheses to resolve ambiguities. Here we show that mouse retrosplenial cortex (RSC) can form several hypotheses over time and perform spatial reasoning through recurrent dynamics. In our task, mice navigated using ambiguous landmarks that are identified through their mutual spatial relationship, requiring sequential refinement of hypotheses. Neurons in RSC and in artificial neural networks encoded mixtures of hypotheses, location and sensory information, and were constrained by robust low-dimensional dynamics. RSC encoded hypotheses as locations in activity space with divergent trajectories for identical sensory inputs, enabling their correct interpretation. Our results indicate that interactions between internal hypotheses and external sensory data in recurrent circuits can provide a substrate for complex sequential cognitive reasoning.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"9 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep cycles process memories 睡眠周期处理记忆

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01996-1

William P. Olson

引用次数: 0

Tuning arousal 调优兴奋

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01994-3

Laura Zelenka

{"title":"Tuning arousal","authors":"Laura Zelenka","doi":"10.1038/s41593-025-01994-3","DOIUrl":"https://doi.org/10.1038/s41593-025-01994-3","url":null,"abstract":"The locus coeruleus (LC), a major source of noradrenaline in the brain, plays a crucial role in regulating arousal and behavior. Despite its known functions, the mechanisms that control LC activity, particularly the influence of local GABAergic (γ-aminobutyric acid-producing) neurons, remain poorly understood. In a study published in Nature, Luskin, Li et al. identified a heterogeneous population of peri-LCGABA neurons that directly inhibit LC neurons, thereby modulating arousal and avoidance behaviors. Using optogenetic and chemogenetic approaches in mice, the authors demonstrated that activation of peri-LCGABA neurons markedly suppresses arousal and exploration, whereas inhibiting them heightens anxiety-like and avoidance behaviors. They further revealed the molecular diversity of neuronal populations within both the peri-LC and LC regions by using single-nucleus and spatial transcriptomic analyses in behaving mice. Subsequent experiments uncovered distinct neural responses to various stimuli in specific neuropeptide-expressing subpopulations and implicated these subpopulations in modulating arousal and avoidance behaviors. Together, these findings highlight peri-LCGABA neurons as key regulators of LC activity, linking them to arousal-related behaviors and suggesting potential therapeutic targets for neuropsychiatric disorders.Original reference: Nature https://doi.org/10.1038/s41586-025-08952-w (2025)","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"10 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopamine says do that again 多巴胺说再来一次

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01995-2

Luis A. Mejia

{"title":"Dopamine says do that again","authors":"Luis A. Mejia","doi":"10.1038/s41593-025-01995-2","DOIUrl":"https://doi.org/10.1038/s41593-025-01995-2","url":null,"abstract":"Repeated actions may be reinforced through action prediction error — the difference between an executed action and its prediction given a particular state — but experimental evidence for such a movement-based, value-free teaching signal has been lacking. Greenstreet, Martinez Vergara, Johansson et al. trained mice on an auditory discrimination task and found that dopamine in the tail of the striatum (TS) is needed for learning, and that TS dopamine levels correlate with movement, but not reward, on the choice task. The movement-related dopamine signal in TS decreased over the course of learning, increased when an unfamiliar stimulus was used, and reinforced stimulus–action associations on the choice task; these findings are consistent with dopamine encoding a value-free action prediction error. A dual-controller model incorporating both value-based (reward prediction error via ventral striatum) and value-free (action prediction error via TS) systems learned the task faster than a value-based controller alone and implicated a role for TS during the later stages of learning. These findings suggest that movement-related dopamine signals in TS, and perhaps in other parts of the dorsal striatum, encode a value-free teaching signal that reinforces state–action associations, promoting the repetition of actions. Action prediction error may thus serve as the basis for the implementation of habitual behavior.Original reference: Nature https://doi.org/10.1038/s41586-025-09008-9 (2025)","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"523 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive reduction of neural rigidity alters autistic behaviors in humans 非侵入性的神经刚性降低改变了人类的自闭症行为

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-06 DOI: 10.1038/s41593-025-01961-y

Takamitsu Watanabe, Hidenori Yamasue

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Author Correction: Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus 作者更正：前额皮质中的生长抑素神经元启动睡眠准备行为，并通过视前丘脑和外侧下丘脑启动睡眠

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-02003-3

Kyoko Tossell, Xiao Yu, Panagiotis Giannos, Berta Anuncibay Soto, Mathieu Nollet, Raquel Yustos, Giulia Miracca, Mikal Vicente, Andawei Miao, Bryan Hsieh, Ying Ma, Alexei L. Vyssotski, Tim Constandinou, Nicholas P. Franks, William Wisden

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RNA dysregulation impairs stress resilience in aged neurons RNA失调损害衰老神经元的应激恢复能力

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-05 DOI: 10.1038/s41593-025-01953-y

引用次数: 0