Nature neuroscience最新文献_第2页

Striatal tail neurons in response withholding 纹状体尾神经元的反应抑制

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-09-01 DOI: 10.1038/s41593-026-02438-2

Luis A. Mejia

引用次数: 0

Plasma biomarkers for ALS ALS的血浆生物标志物

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-09-01 DOI: 10.1038/s41593-026-02440-8

Qingzhong Ren

引用次数: 0

A new direction for neural networks 神经网络的新方向

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-09-01 DOI: 10.1038/s41593-026-02439-1

William P. Olson

引用次数: 0

Spatial mapping of RNA turnover kinetics in the mouse brain. 小鼠脑内RNA转换动力学的空间定位。

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-08-31 DOI: 10.1038/s41593-026-02420-y

Qi Qiu, Hongjie Zhang, Zijie Xia, William Gao, Julia I Leu, Dongming Liang, Ying Li, Fan Li, Yijing Su, Emily Feierman, Erin Van Horn, Guo-Li Ming, Erica Korb, Hongjun Song, Zhaolan Zhou, Hao Wu

{"title":"Spatial mapping of RNA turnover kinetics in the mouse brain.","authors":"Qi Qiu, Hongjie Zhang, Zijie Xia, William Gao, Julia I Leu, Dongming Liang, Ying Li, Fan Li, Yijing Su, Emily Feierman, Erin Van Horn, Guo-Li Ming, Erica Korb, Hongjun Song, Zhaolan Zhou, Hao Wu","doi":"10.1038/s41593-026-02420-y","DOIUrl":"10.1038/s41593-026-02420-y","url":null,"abstract":"Gene regulation requires coordinated control of RNA synthesis and degradation, yet measuring RNA turnover across intact tissues remains challenging. Here we present spatial NT-seq, a method that combines transgenesis-free metabolic RNA labeling with in situ chemical recoding on spatial transcriptomics platforms to co-map newly synthesized and pre-existing RNAs. Applying spatial NT-seq to the mouse brain reveals pronounced regional heterogeneity in RNA turnover and identifies the dentate gyrus as a spatial hotspot marked by coordinated upregulation of basal RNA synthesis and decay. Moreover, spatial NT-seq uncovers rapid, brain region-specific transcriptional and post-transcriptional responses to electroconvulsive stimulation, a clinically relevant treatment for refractory depression. Finally, we leverage computational modeling to identify sequence features and post-transcriptional regulators that shape transcriptome-wide mRNA stability across spatial and cellular contexts in the mouse brain. Together, this integrated 'in vivo timescope' framework provides a spatially resolved view of RNA turnover kinetics and reveals the regulatory architecture of RNA stability in vivo.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice. 在雄性小鼠中，社会隔离招募杏仁核-内侧前额叶皮层的投射来增加饮酒。

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-08-25 DOI: 10.1038/s41593-026-02413-x

Reesha R Patel, Kelly N Kim, Makenzie Patarino, Rachelle Pamintuan, Felix H Taschbach, Hao Li, Bitna Joo, Anna Pallé, Xianru Yu, Christopher R Lee, Aniek van Hoek, Jesse White, Rogelio Castro, Christian Cazares, Raymundo L Miranda, Caroline Jia, Jeremy Delahanty, Kanha Batra, Laurel R Keyes, Avraham Libster, Romy Wichmann, Talmo D Pereira, Marcus K Benna, Kay M Tye

{"title":"Social isolation recruits amygdala-medial prefrontal cortex projections to escalate alcohol drinking in male mice.","authors":"Reesha R Patel, Kelly N Kim, Makenzie Patarino, Rachelle Pamintuan, Felix H Taschbach, Hao Li, Bitna Joo, Anna Pallé, Xianru Yu, Christopher R Lee, Aniek van Hoek, Jesse White, Rogelio Castro, Christian Cazares, Raymundo L Miranda, Caroline Jia, Jeremy Delahanty, Kanha Batra, Laurel R Keyes, Avraham Libster, Romy Wichmann, Talmo D Pereira, Marcus K Benna, Kay M Tye","doi":"10.1038/s41593-026-02413-x","DOIUrl":"10.1038/s41593-026-02413-x","url":null,"abstract":"Social isolation profoundly alters motivation and increases vulnerability to alcohol misuse in humans, yet the underlying neural mechanisms remain unclear. Here we show that isolation escalates alcohol drinking in male mice but suppresses it in females. Whole-cell recordings revealed that neurons in the basolateral amygdala projecting to the medial prefrontal cortex (BLA-mPFC) track alcohol intake in both sexes. Isolation increased BLA-mPFC excitability in males but decreased it in females, mirroring their opposite behavioral adaptations. Given this divergence, we focused subsequent mechanistic studies on males to isolate neural pathway-level drivers of escalated alcohol intake. Cellular-resolution calcium imaging showed that activity in BLA-mPFC neurons encodes and predicts alcohol drinking, and optogenetic activation of this pathway increased alcohol intake. Simultaneous optogenetics and calcium imaging revealed that BLA-mPFC stimulation enhanced mPFC neuronal responses to alcohol, mimicking isolation-induced activity patterns, while photoinhibition reduced drinking in isolated mice. Together, these findings identify a BLA-mPFC pathway mechanism through which social isolation reconfigures prefrontal processing to promote alcohol intake.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor neurons organize Drosophila feeding sequences via a disinhibitory cascade. 运动神经元通过去抑制级联来组织果蝇的摄食序列。

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-08-24 DOI: 10.1038/s41593-026-02412-y

Xiu-Wen Sui, Jun-Jie Yi, Yao Zhou, Ye-Li Wang, Xin Zhang, Yuhai Tu, Li-Hui Cao, Dong-Gen Luo

引用次数: 0

Roles of autophagy in brain homeostasis and disease. 自噬在脑稳态和疾病中的作用。

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-08-24 DOI: 10.1038/s41593-026-02426-6

Henry Kim, Edward S Wickstead, Xiaoting Zhou, Insup Choi, Zhenyu Yue

{"title":"Roles of autophagy in brain homeostasis and disease.","authors":"Henry Kim, Edward S Wickstead, Xiaoting Zhou, Insup Choi, Zhenyu Yue","doi":"10.1038/s41593-026-02426-6","DOIUrl":"https://doi.org/10.1038/s41593-026-02426-6","url":null,"abstract":"Macroautophagy (autophagy) is a lysosome-dependent degradative pathway that encapsulates proteins and organelles within double-membraned vesicles and recycles the contents back into the cell. The interplay of autophagy with various membrane trafficking pathways is crucial for maintaining cellular homeostasis both under basal conditions and in response to environmental stress. In the CNS, neurons and glial cells rely on a spectrum of quality-control and recycling pathways, notably autophagy, to sustain the intricate functions of the brain. Genetic variants in autophagy genes are known to cause Mendelian disorders primarily affecting the human nervous system, underscoring the critical role of autophagy in brain function. We review the latest research delineating the landscape and network of autophagy in developing and mature neurons, elucidating how conserved autophagy pathways regulate neuronal homeostasis and functions at different ages. We examine the increasing evidence of dysfunctional autophagy that contributes to neurodevelopmental disorders, neurodegenerative diseases and psychiatric conditions. Recent insights into the dysregulation of autophagy provide valuable avenues for biomarker identification and therapeutic development, particularly targeting autophagy-lysosome pathways for neurological disorders.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":" ","pages":""},"PeriodicalIF":20.3,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of sensorimotor toxicity when using the clinical SMN expression cassette in scAAV9. 在scAAV9中使用临床SMN表达盒时缺乏感觉运动毒性。

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-08-24 DOI: 10.1038/s41593-026-02411-z

Maria H H Balch, Anton J Blatnik, Kaitlyn M Kray, Vicki L McGovern, Summer R Baxley, Kristen Kent, Rochelle Rodrigo, Arthur H M Burghes, W David Arnold

引用次数: 0

Cortical thickness changes precede high levels of amyloid by at least 7 years 在淀粉样蛋白水平升高之前，皮层厚度的改变至少要早7年

IF 20.3 1区医学

Nature neuroscience Pub Date : 2026-08-19 DOI: 10.1038/s41593-026-02363-4

James M. Roe, William J. Jagust, Susan M. Landau, Theresa M. Harrison, Håkon Grydeland, Maksim Slivka, José-Luis Alatorre-Warren, Pablo F. Garrido, Øystein Sørensen, Edvard O. S. Grødem, Tyler J. Ward, Esten H. Leonardsen, Alice Murphy, JiaQie Lee, Tormod Fladby, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell, Didac Vidal-Piñeiro, Yunpeng Wang

{"title":"Cortical thickness changes precede high levels of amyloid by at least 7 years","authors":"James M. Roe, William J. Jagust, Susan M. Landau, Theresa M. Harrison, Håkon Grydeland, Maksim Slivka, José-Luis Alatorre-Warren, Pablo F. Garrido, Øystein Sørensen, Edvard O. S. Grødem, Tyler J. Ward, Esten H. Leonardsen, Alice Murphy, JiaQie Lee, Tormod Fladby, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell, Didac Vidal-Piñeiro, Yunpeng Wang","doi":"10.1038/s41593-026-02363-4","DOIUrl":"10.1038/s41593-026-02363-4","url":null,"abstract":"Alzheimer’s disease is now defined by underlying pathology, with elevated amyloid-beta (Aβ) sufficient for diagnosis in the absence of cognitive symptoms. We combined longitudinal magnetic resonance imaging and Aβ positron emission tomography data from three cognitively healthy cohorts to examine cortical thickness trajectories in individuals who later converted to Aβ-positive status, using magnetic resonance images acquired years before conversion. Individuals who subsequently developed elevated Aβ showed a thicker cortex and reduced cortical thinning, detectable up to 7 years before conversion. Many effects persisted after accounting for quantitative Aβ levels, suggesting some cortical thickness changes may be partly independent of Aβ. Differences in cortical thickness and its change showed moderate spatial correspondence with Aβ deposition patterns, and the timing of thickness changes tracked the progression of Aβ accumulation. These findings indicate that cortical thickness alterations can precede positron emission tomography-detectable amyloid positivity by several years, suggesting high amyloid burden may not represent the earliest imaging marker of Alzheimer’s disease. Longitudinal MRI reveals that the cortex becomes relatively thicker years before amyloid positivity is detected on PET, providing insight into the earliest brain changes and potential consequences of amyloid accumulation in Alzheimer’s disease.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"29 9","pages":"2164-2175"},"PeriodicalIF":20.3,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-026-02363-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strong and localized recurrence controls the dimensionality of neural activity across brain areas 强烈的局部复发控制着跨脑区神经活动的维度

IF 25 1区医学

Nature neuroscience Pub Date : 2026-08-19 DOI: 10.1038/s41593-026-02395-w

David Dahmen, Stefano Recanatesi, Xiaoxuan Jia, Gabriel K. Ocker, Nilufar Lahiji, Simon Musall, Luke Campagnola, Stephanie Seeman, Tim Jarsky, Moritz Helias, Eric Shea-Brown

{"title":"Strong and localized recurrence controls the dimensionality of neural activity across brain areas","authors":"David Dahmen, Stefano Recanatesi, Xiaoxuan Jia, Gabriel K. Ocker, Nilufar Lahiji, Simon Musall, Luke Campagnola, Stephanie Seeman, Tim Jarsky, Moritz Helias, Eric Shea-Brown","doi":"10.1038/s41593-026-02395-w","DOIUrl":"https://doi.org/10.1038/s41593-026-02395-w","url":null,"abstract":"The brain contains an astronomical number of neurons, but it is their collective activity that underlies brain function. The number of degrees of freedom that this activity explores (its dimensionality) is therefore a fundamental signature of neural dynamics. However, it is not known what controls dimensionality in the biological brain. Through analysis of high-density Neuropixels recordings, here, we argue that areas across the mouse cortex predominantly operate in a sensitive regime that gives recurrent synaptic networks a strong role in regulating dimensionality. This control is expressed across time, as cortical activity transitions among states with different dimensionalities. Moreover, this control is mediated through highly tractable features of synaptic networks (network motifs). Analyzing a massive synaptic physiology dataset, we find that motifs impacting dimensionality are prevalent in both mouse and human brains. Thus, local circuitry scales up systematically to help control the degrees of freedom that brain networks may explore and exploit.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"131 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148769319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0