Nature neuroscience最新文献_第2页

Mapping human thalamocortical connectivity with electrical stimulation and recording 用电刺激和记录绘制人类丘脑皮质的连通性

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-15 DOI: 10.1038/s41593-025-02009-x

Dian Lyu, James Robert Stiger, Zoe Lusk, Vivek Buch, Josef Parvizi

{"title":"Mapping human thalamocortical connectivity with electrical stimulation and recording","authors":"Dian Lyu, James Robert Stiger, Zoe Lusk, Vivek Buch, Josef Parvizi","doi":"10.1038/s41593-025-02009-x","DOIUrl":"https://doi.org/10.1038/s41593-025-02009-x","url":null,"abstract":"The brain’s functional architecture is shaped by electrophysiological interactions between its components, encompassing both cortical and subcortical structures. In this study, we provide an atlas of electrophysiological causal connections across 4,864 brain sites in 27 human participants using repeated single-pulse electrical stimulations and recordings with intracranial electrodes implanted in cortical regions and multiple thalamic nuclei. We show distinct spectral signatures elicited by perturbations of specific brain areas. Identified features of causal connectivity exhibited highly organized yet distinct patterns, indicating that each feature may correspond to a separate mode of information transmission across brain regions. Notably, we report a new waveform with unique temporal and spatial characteristics specifically linked to thalamic stimulations, namely delayed-onset theta oscillations in both ipsilateral and contralateral cortical regions. These findings contribute to a more detailed understanding of the human brain’s functional architecture and offer valuable data for the development of biologically informed computational models.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"34 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease 阿尔茨海默病小鼠模型中具有不同染色质可及性的空间定义小胶质细胞状态的反应

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-14 DOI: 10.1038/s41593-025-02006-0

Alberto Ardura-Fabregat, Lance Fredrick Pahutan Bosch, Emile Wogram, Omar Mossad, Roman Sankowski, Philipp Aktories, Lina Kieger, James Cook, Dilara Hasavci, Hatice Ulupinar, Daniel Brock, Fang Wang, Nicola Iovino, Samuel Wald, Sebastian Preissl, Bahtiyar Yilmaz, Daniel Schnepf, Andrew J. Macpherson, Thomas Blank, Katrin Kierdorf, Marco Prinz

{"title":"Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease","authors":"Alberto Ardura-Fabregat, Lance Fredrick Pahutan Bosch, Emile Wogram, Omar Mossad, Roman Sankowski, Philipp Aktories, Lina Kieger, James Cook, Dilara Hasavci, Hatice Ulupinar, Daniel Brock, Fang Wang, Nicola Iovino, Samuel Wald, Sebastian Preissl, Bahtiyar Yilmaz, Daniel Schnepf, Andrew J. Macpherson, Thomas Blank, Katrin Kierdorf, Marco Prinz","doi":"10.1038/s41593-025-02006-0","DOIUrl":"https://doi.org/10.1038/s41593-025-02006-0","url":null,"abstract":"Microglial spatial heterogeneity remains a crucial yet not fully answered question in the context of potential cell-directed therapies for Alzheimer’s disease (AD). There is an unclear understanding of the dynamics of distinct microglia states adjacent to or far from amyloid-beta (Aβ) plaques and their contributions to neurodegenerative diseases. Here we combine multicolor fluorescence cell fate mapping, single-cell transcriptional analysis, epigenetic profiling, immunohistochemistry and computational modeling to comprehensively characterize the relation of plaque-associated microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of AD. We show that non-PAM are a distinct and highly dynamic microglial state, transitioning to PAM after Aβ plaque deposition in female mice. Non-PAM modulate the cell population expansion in response to amyloid deposition and rapidly respond to environmental cues. Indeed, Csf1 signaling modulates non-PAM-to-PAM transition during disease progression. Our data suggest that microglia states and their dynamics between each other can have distinct contributions to disease, and they may be targeted for the treatment of AD.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"7 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains 脑回畸形大脑中扩大的室下区支持出生后皮层神经元间迁移

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-14 DOI: 10.1038/s41593-025-01987-2

JaeYeon Kim, Aunoy Poddar, Kadellyn Sandoval, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, I-Ling Lu, Michael Mui, Theresa Bartels, Christian M. Wood, Susana I. Ramos, David H. Rowitch, Nadejda M. Tsankova, Hosung Kim, Chet C. Sherwood, Boris W. Kramer, Angela C. Roberts, Pablo J. Ross, Duan Xu, Nicola J. Robertson, Elizabeth A. Maga, Peng Ji, Mercedes F. Paredes

{"title":"An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains","authors":"JaeYeon Kim, Aunoy Poddar, Kadellyn Sandoval, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, I-Ling Lu, Michael Mui, Theresa Bartels, Christian M. Wood, Susana I. Ramos, David H. Rowitch, Nadejda M. Tsankova, Hosung Kim, Chet C. Sherwood, Boris W. Kramer, Angela C. Roberts, Pablo J. Ross, Duan Xu, Nicola J. Robertson, Elizabeth A. Maga, Peng Ji, Mercedes F. Paredes","doi":"10.1038/s41593-025-01987-2","DOIUrl":"https://doi.org/10.1038/s41593-025-01987-2","url":null,"abstract":"Cortical GABAergic interneurons generated in the ventral developing brain travel long distances to their final destinations. While there are examples of interneuron migration in the neonatal human brain, the extent of postnatal migration across species and how it contributes to cortical interneuron composition remains unknown. Here we demonstrate that neonatal gyrencephalic brains, including humans, nonhuman primates and piglets, harbor an elaborate subventricular zone, termed the Arc, due to its curved morphology and expanded neuroblast populations. The Arc is absent in lissencephalic marmoset and mouse brains. Transcriptomic and histological approaches revealed that Arc neurons are diverse interneurons from the medial and caudal ganglionic eminences that migrate into the frontal, cingulate and temporal cortex. Arc–cortical targets exhibit an increase in VIP+ neuronal density compared to other regions. Our findings reveal that the Arc is a developmental structure that supports the expansion of postnatal neuronal migration for cortical interneuron patterning in gyrencephalic brains.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"23 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct interactions between the human insula and hippocampus during memory encoding 人类脑岛与海马体在记忆编码过程中的直接相互作用

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-14 DOI: 10.1038/s41593-025-02005-1

Weichen Huang, Dian Lyu, James R. Stieger, Ian H. Gotlib, Vivek Buch, Anthony D. Wagner, Josef Parvizi

{"title":"Direct interactions between the human insula and hippocampus during memory encoding","authors":"Weichen Huang, Dian Lyu, James R. Stieger, Ian H. Gotlib, Vivek Buch, Anthony D. Wagner, Josef Parvizi","doi":"10.1038/s41593-025-02005-1","DOIUrl":"https://doi.org/10.1038/s41593-025-02005-1","url":null,"abstract":"The hippocampus is critical for encoding episodic memories, but how it interacts with cortical regions during this process remains unclear. In this study, 16 participants with implanted electrodes in the insula (217 sites) and hippocampus (131 sites) viewed emotionally valenced words and attempted to recall them. During encoding, one subset of insular neuronal populations showed changes in aperiodic activity that predicted successful recall. These insular changes followed hippocampal theta but preceded hippocampal ripples. Another subset of insular sites responded to word valence, unrelated to memory performance. Direct electrical stimulation of memory-related insular sites evoked early responses in the ipsilateral hippocampus, whereas stimulation of valence-related sites did not. Conversely, stimulating hippocampal sites produced slow, variable signals across all insular sites, suggesting asymmetric communication between the hippocampus and the insula. These findings provide a glimpse of mesoscale hippocampal interactions with functionally selective neuronal populations within a given cortical structure.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"9 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment 交叉蛋白和亲内蛋白凝聚主要突触囊泡释放位点补充

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-08 DOI: 10.1038/s41593-025-02002-4

Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe

{"title":"Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment","authors":"Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe","doi":"10.1038/s41593-025-02002-4","DOIUrl":"https://doi.org/10.1038/s41593-025-02002-4","url":null,"abstract":"Following synaptic vesicle fusion, vacated release sites are replenished immediately by new vesicles for subsequent neurotransmission. These replacement vesicles are assumed to be located near release sites and used by chance. Here we find in mouse hippocampal excitatory synapses that replacement vesicles are clustered near the active zone where release sites reside by intersectin-1. Specifically, intersectin-1 forms dynamic molecular condensates with endophilin A1 and sequesters vesicles around this region. In the absence of intersectin-1, fewer vesicles cluster within 20 nm of the plasma membrane, and consequently vacated sites cannot be replenished rapidly, leading to synaptic depression. Mutations in intersectin-1 that disrupt endophilin A1 binding result in similar phenotypes. In the absence of endophilin A1, intersectin-1 is mislocalized, and this replacement pool of vesicles cannot be accessed, suggesting that endophilin A1 is needed to mobilize these vesicles. Thus, our work describes the replacement zone within a synapse, where replacement vesicles are stored for replenishment of the release site.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"688 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice 祖细胞能力的时间控制决定了小鼠gaba能神经元发育的成熟

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-08 DOI: 10.1038/s41593-025-01999-y

Ann Rose Bright, Yana Kotlyarenko, Florian Neuhaus, Diana Rodrigues, Chao Feng, Christian Peters, Ilaria Vitali, Elif Dönmez, Michael H. Myoga, Elena Dvoretskova, Christian Mayer

{"title":"Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice","authors":"Ann Rose Bright, Yana Kotlyarenko, Florian Neuhaus, Diana Rodrigues, Chao Feng, Christian Peters, Ilaria Vitali, Elif Dönmez, Michael H. Myoga, Elena Dvoretskova, Christian Mayer","doi":"10.1038/s41593-025-01999-y","DOIUrl":"https://doi.org/10.1038/s41593-025-01999-y","url":null,"abstract":"Diverse types of GABAergic projection neuron and interneurons of the telencephalon derive from progenitors in a ventral germinal zone called the ganglionic eminence. Using single-cell transcriptomics, chromatin accessibility profiling, lineage tracing, birthdating, transplantation across developmental stages and perturbation sequencing in mouse embryos, we investigated how progenitor competence influences the maturation and differentiation of these neurons. We found that the temporal progression of neurogenesis shapes maturation competence in ganglionic eminence progenitors, influencing how their progeny progress toward mature states. By contrast, differentiation competence—defined as the ability of progenitors to produce diverse transcriptomic identities—was maintained throughout neurogenesis. Chromatin remodeling, together with a regulatory module composed of the transcription factor NFIB and its target genes, influenced maturation competence in late-born neurons. These findings reveal how transcriptional programs and chromatin accessibility govern neuronal maturation and the diversification of GABAergic neuron subtypes during neurodevelopment.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"51 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fructose-induced anxiety Fructose-induced焦虑

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-07 DOI: 10.1038/s41593-025-02019-9

Laura Zelenka

{"title":"Fructose-induced anxiety","authors":"Laura Zelenka","doi":"10.1038/s41593-025-02019-9","DOIUrl":"https://doi.org/10.1038/s41593-025-02019-9","url":null,"abstract":"The Western diet, which is rich in high-fructose (HF) foods and beverages, has been linked to adverse health outcomes, including neurodevelopmental disorders. In a study published in Nature, Wang et al. show that prenatal or neonatal exposure to HF impairs microglial phagocytic activity in mice. This results in reduced phagocytosis of synaptosomes and apoptotic neurons, which is a key process in healthy brain development. Notably, the number, morphology, and phagocytic function of microglia were preserved in neonatal mice lacking GLUT5, the primary fructose transporter, despite being born to and nursed by HF-fed dams. In vitro, wild-type mouse and human microglia cultured in HF conditions had impaired phagocytosis, but this was not observed in GLUT5-deficient microglia. Further experiments indicated that HF reduced phagocytic function by increasing GLUT5-dependent fructose uptake and conversion to fructose 6-phosphate, thereby altering microglial metabolism toward a non-phagocytic state in part by increasing mitochondrial hexokinase 2 localization. Neonatal HF consumption was associated with impairments in novel-object recognition and fear extinction in adolescent wild-type, but not GLUT5-deficient, mice. These findings suggest that early-life HF exposure disrupts microglial function and might affect neurodevelopment, underscoring the importance of limiting dietary fructose during pregnancy and early life.Original reference: Nature https://doi.org/10.1038/s41586-025-09098-5 (2025)","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"21 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancers hit their targets 增强剂击中目标

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-07 DOI: 10.1038/s41593-025-02018-w

William P. Olson

{"title":"Enhancers hit their targets","authors":"William P. Olson","doi":"10.1038/s41593-025-02018-w","DOIUrl":"https://doi.org/10.1038/s41593-025-02018-w","url":null,"abstract":"Genetic tools for accessing neuron subtypes have enabled countless discoveries about circuit structure and function. Compared to the highly specific tools available for nematodes and fruit flies, the mammalian toolkit lacks both precision and systematic coverage. In a new paper published in Cell, a team of researchers at the Allen Institute and partner institutions unveil an unprecedented suite of targeting tools for mammalian cortical circuits. Leveraging single-cell transcriptomic and epigenomic data, this team generated and screened over a thousand enhancer AAVs targeted to precise cell-type subclasses identified in recent cortical taxonomies. To maximize potential use across species, the authors selected enhancer sequences that are conserved across mouse and human genomes. They demonstrated improved specificity over prior methods in targeting an interneuron subclass that is critical for sleep, as well as novel access to numerous other subclasses. A group of papers co-published with this study demonstrate the utility of these tools for neural circuit research and report toolkits for targeting striatal and spinal cord populations. As these tools are publicly available, they provide a powerful new set of precision approaches for mammalian circuit dissection and control.Original reference: Cell https://doi.org/10.1016/j.cell.2025.05.002 (2025)","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"2 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding dialogue is a matter of time 解码对话只是时间问题

IF 25 1区医学

Nature neuroscience Pub Date : 2025-07-07 DOI: 10.1038/s41593-025-02017-x

Henrietta Howells

{"title":"Decoding dialogue is a matter of time","authors":"Henrietta Howells","doi":"10.1038/s41593-025-02017-x","DOIUrl":"https://doi.org/10.1038/s41593-025-02017-x","url":null,"abstract":"Human conversation requires integration of language production and comprehension. However, the neural mechanisms at play during real-time conversations remain largely unexplored. A study by Yamashita and colleagues in Nature Human Behaviour has investigated the neural representation of conversational content across multiple timescales and across the brain. Participants lay in an MRI scanner engaging in conversations about 27 topics with the experimenter while functional MRI was recorded. The authors extracted contextual embeddings from conversation transcriptions — using a GPT model fine-tuned for interactive language tasks — and these were used to predict changes brain activity. Neural linguistic representations were partially shared between speech production and comprehension, but the topographic organization of these shared representations was modulated by timescales. Representations of words and single sentences (1–4 s long) were localized in association cortices, whereas those of longer contexts (16–32 s) were more unique and widespread. For language production, mean variance across regions was best explained by shorter context lengths, whereas longer contexts were best for language comprehension. These findings suggest that language production and comprehension have distinct temporal integration processes, reflecting the need for production to operate dynamically, whereas comprehension integrates linguistic input with broader contextual information.Original reference: Nat. Hum. Behav. https://doi.org/10.1038/s41562-025-02231-4 (2025)","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"154 16 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity. 人类丘脑皮质结构的连通性发展与皮层可塑性的层次轴一致。

IF 21.2 1区医学

Nature neuroscience Pub Date : 2025-07-04 DOI: 10.1038/s41593-025-01991-6

Valerie J Sydnor, Joëlle Bagautdinova, Bart Larsen, Michael J Arcaro, Deanna M Barch, Dani S Bassett, Aaron F Alexander-Bloch, Philip A Cook, Sydney Covitz, Alexandre R Franco, Raquel E Gur, Ruben C Gur, Allyson P Mackey, Kahini Mehta, Steven L Meisler, Michael P Milham, Tyler M Moore, Eli J Müller, David R Roalf, Taylor Salo, Gabriel Schubiner, Jakob Seidlitz, Russell T Shinohara, James M Shine, Fang-Cheng Yeh, Matthew Cieslak, Theodore D Satterthwaite

{"title":"Human thalamocortical structural connectivity develops in line with a hierarchical axis of cortical plasticity.","authors":"Valerie J Sydnor, Joëlle Bagautdinova, Bart Larsen, Michael J Arcaro, Deanna M Barch, Dani S Bassett, Aaron F Alexander-Bloch, Philip A Cook, Sydney Covitz, Alexandre R Franco, Raquel E Gur, Ruben C Gur, Allyson P Mackey, Kahini Mehta, Steven L Meisler, Michael P Milham, Tyler M Moore, Eli J Müller, David R Roalf, Taylor Salo, Gabriel Schubiner, Jakob Seidlitz, Russell T Shinohara, James M Shine, Fang-Cheng Yeh, Matthew Cieslak, Theodore D Satterthwaite","doi":"10.1038/s41593-025-01991-6","DOIUrl":"https://doi.org/10.1038/s41593-025-01991-6","url":null,"abstract":"Human cortical development follows a hierarchical, sensorimotor-to-association sequence. The brain's capacity to enact this sequence indicates that it relies on unknown mechanisms to regulate regional differences in the timing of cortical maturation. Given evidence from animal systems that thalamic axons mechanistically regulate periods of cortical plasticity, here we evaluate in humans whether the development of structural connections between the thalamus and cortex aligns with cortical maturational heterochronicity. By deriving a new tractography atlas of human thalamic connections and applying it to diffusion data from three youth samples (8-23 years; total n = 2,676), we demonstrate that thalamocortical connectivity matures in a generalizable manner along the cortex's sensorimotor-association axis. Associative cortical regions with thalamic connections that take the longest to mature exhibit neurochemical, structural and functional signatures of protracted developmental plasticity as well as heightened sensitivity to the socioeconomic environment. This work highlights the role of the thalamus in the expression of hierarchical periods of cortical developmental plasticity and environmental receptivity.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":" ","pages":""},"PeriodicalIF":21.2,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0