Nature neuroscience最新文献_第5页

A basic role for glia in sleep homeostasis 神经胶质细胞在睡眠稳态中的基本作用

IF 25 1区医学

Nature neuroscience Pub Date : 2025-05-05 DOI: 10.1038/s41593-025-01963-w

Leonie Kirszenblat, Bruno van Swinderen

引用次数: 0

A competitive disinhibitory network for robust optic flow processing in Drosophila 果蝇稳健光流处理的竞争性去抑制网络

IF 25 1区医学

Nature neuroscience Pub Date : 2025-05-01 DOI: 10.1038/s41593-025-01948-9

Mert Erginkaya, Tomás Cruz, Margarida Brotas, André Marques, Kathrin Steck, Aljoscha Nern, Filipa Torrão, Nélia Varela, Davi D. Bock, Michael Reiser, M. Eugenia Chiappe

{"title":"A competitive disinhibitory network for robust optic flow processing in Drosophila","authors":"Mert Erginkaya, Tomás Cruz, Margarida Brotas, André Marques, Kathrin Steck, Aljoscha Nern, Filipa Torrão, Nélia Varela, Davi D. Bock, Michael Reiser, M. Eugenia Chiappe","doi":"10.1038/s41593-025-01948-9","DOIUrl":"https://doi.org/10.1038/s41593-025-01948-9","url":null,"abstract":"Many animals navigate using optic flow, detecting rotational image velocity differences between their eyes to adjust direction. Forward locomotion produces strong symmetric translational optic flow that can mask these differences, yet the brain efficiently extracts these binocular asymmetries for course control. In Drosophila melanogaster, monocular horizontal system neurons facilitate detection of binocular asymmetries and contribute to steering. To understand these functions, we reconstructed horizontal system cells’ central network using electron microscopy datasets, revealing convergent visual inputs, a recurrent inhibitory middle layer and a divergent output layer projecting to the ventral nerve cord and deeper brain regions. Two-photon imaging, GABA receptor manipulations and modeling, showed that lateral disinhibition reduces the output’s translational sensitivity while enhancing its rotational selectivity. Unilateral manipulations confirmed the role of interneurons and descending outputs in steering. These findings establish competitive disinhibition as a key circuit mechanism for detecting rotational motion during translation, supporting navigation in dynamic environments.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"38 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia 马赛克局灶性皮质发育不良的单细胞基因分型和转录组学分析

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-30 DOI: 10.1038/s41593-025-01936-z

Sara Baldassari, Esther Klingler, Lucia Gomez Teijeiro, Marion Doladilhe, Corentin Raoux, Sergi Roig-Puiggros, Sara Bizzotto, Jeanne Couturier, Alice Gilbert, Lina Sami, Théo Ribierre, Eleonora Aronica, Homa Adle-Biassette, Mathilde Chipaux, Denis Jabaudon, Stéphanie Baulac

{"title":"Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia","authors":"Sara Baldassari, Esther Klingler, Lucia Gomez Teijeiro, Marion Doladilhe, Corentin Raoux, Sergi Roig-Puiggros, Sara Bizzotto, Jeanne Couturier, Alice Gilbert, Lina Sami, Théo Ribierre, Eleonora Aronica, Homa Adle-Biassette, Mathilde Chipaux, Denis Jabaudon, Stéphanie Baulac","doi":"10.1038/s41593-025-01936-z","DOIUrl":"https://doi.org/10.1038/s41593-025-01936-z","url":null,"abstract":"Focal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy. FCDII arises from developmental somatic activating mutations in mTOR pathway genes, leading to focal cortical dyslamination and abnormal cytomegalic cells. Which cell types carry pathogenic mutations and how they affect cell-type-specific transcriptional programs remain unknown. In the present study, we combined several single-nucleus genotyping and transcriptomics approaches with spatial resolution in surgical cortical specimens from patients with genetically mosaic FCDII. Mutations were detected in distinct cell types, including glutamatergic neurons and astrocytes, and a small fraction of mutated cells exhibited cytomegalic features. Moreover, we identified cell-type-specific transcriptional dysregulations in both mutated and nonmutated FCDII cells, including synapse- and neurodevelopment-related pathways, that may account for epilepsy and dysregulation of mitochondrial metabolism pathways in cytomegalic cells. Together, these findings reveal cell-autonomous and non-cell-autonomous features of FCDII that may be leveraged for precision medicine.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"34 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene programs driving cortical neuron specifications 驱动皮层神经元规格的基因程序

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-21 DOI: 10.1038/s41593-025-01934-1

Zhisong He, Barbara Treutlein

引用次数: 0

Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex 分子图谱的综合分析揭示了驱动人类皮层发育细胞亚型规范的模块

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-21 DOI: 10.1038/s41593-025-01933-2

Patricia R. Nano, Elisa Fazzari, Daria Azizad, Antoni Martija, Claudia V. Nguyen, Sean Wang, Vanna Giang, Ryan L. Kan, Juyoun Yoo, Brittney Wick, Maximilian Haeussler, Aparna Bhaduri

{"title":"Integrated analysis of molecular atlases unveils modules driving developmental cell subtype specification in the human cortex","authors":"Patricia R. Nano, Elisa Fazzari, Daria Azizad, Antoni Martija, Claudia V. Nguyen, Sean Wang, Vanna Giang, Ryan L. Kan, Juyoun Yoo, Brittney Wick, Maximilian Haeussler, Aparna Bhaduri","doi":"10.1038/s41593-025-01933-2","DOIUrl":"https://doi.org/10.1038/s41593-025-01933-2","url":null,"abstract":"Human brain development requires generating diverse cell types, a process explored by single-cell transcriptomics. Through parallel meta-analyses of the human cortex in development (seven datasets) and adulthood (16 datasets), we generated over 500 gene co-expression networks that can describe mechanisms of cortical development, centering on peak stages of neurogenesis. These meta-modules show dynamic cell subtype specificities throughout cortical development, with several developmental meta-modules displaying spatiotemporal expression patterns that allude to potential roles in cell fate specification. We validated the expression of these modules in primary human cortical tissues. These include meta-module 20, a module elevated in FEZF2+ deep layer neurons that includes TSHZ3, a transcription factor associated with neurodevelopmental disorders. Human cortical chimeroid experiments validated that both FEZF2 and TSHZ3 are required to drive module 20 activity and deep layer neuron specification but through distinct modalities. These studies demonstrate how meta-atlases can engender further mechanistic analyses of cortical fate specification.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"30 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-21 DOI: 10.1038/s41593-025-01943-0

Łukasz J. Sznajder, Mahreen Khan, Adam Ciesiołka, Mariam Tadross, Curtis A. Nutter, Katarzyna Taylor, Christopher E. Pearson, Mark H. Lewis, Rochelle M. Hines, Maurice S. Swanson, Krzysztof Sobczak, Ryan K. C. Yuen

{"title":"Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes","authors":"Łukasz J. Sznajder, Mahreen Khan, Adam Ciesiołka, Mariam Tadross, Curtis A. Nutter, Katarzyna Taylor, Christopher E. Pearson, Mark H. Lewis, Rochelle M. Hines, Maurice S. Swanson, Krzysztof Sobczak, Ryan K. C. Yuen","doi":"10.1038/s41593-025-01943-0","DOIUrl":"https://doi.org/10.1038/s41593-025-01943-0","url":null,"abstract":"Genome-wide enrichment of gene-specific tandem repeat expansions has been linked to autism spectrum disorder. One such mutation is the CTG tandem repeat expansion in the 3′ untranslated region of the DMPK gene, which is known to cause myotonic muscular dystrophy type 1. Although there is a clear clinical association between autism and myotonic dystrophy, the molecular basis for this connection remains unknown. Here, we report that sequestration of MBNL splicing factors by mutant DMPK RNAs with expanded CUG repeats alters the RNA splicing patterns of autism-risk genes during brain development, particularly a class of autism-relevant microexons. We demonstrate that both DMPK-CTG expansion and Mbnl null mouse models recapitulate autism-relevant mis-splicing profiles, along with social behavioral deficits and altered responses to novelty. These findings support our model that myotonic dystrophy-associated autism arises from developmental mis-splicing of autism-risk genes.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"34 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143853195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila 神经胶质和神经元的动态调节果蝇的内稳态休息、睡眠和摄食行为

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-21 DOI: 10.1038/s41593-025-01942-1

Andres Flores-Valle, Ivan Vishniakou, Johannes D. Seelig

引用次数: 0

Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina 功能上不同的gaba能无突细胞类型调节小鼠视网膜的时空编码

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-15 DOI: 10.1038/s41593-025-01935-0

Akihiro Matsumoto, Jacqueline Morris, Loren L. Looger, Keisuke Yonehara

{"title":"Functionally distinct GABAergic amacrine cell types regulate spatiotemporal encoding in the mouse retina","authors":"Akihiro Matsumoto, Jacqueline Morris, Loren L. Looger, Keisuke Yonehara","doi":"10.1038/s41593-025-01935-0","DOIUrl":"https://doi.org/10.1038/s41593-025-01935-0","url":null,"abstract":"GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in the mammalian central nervous system. GABAergic neuronal types play important roles in neural processing and the etiology of neurological disorders; however, there is no comprehensive understanding of their functional diversity. Here we perform two-photon imaging of GABA release in the inner plexiform layer of male and female mice retinae (8–16 weeks old) using the GABA sensor iGABASnFR2. By applying varied light stimuli to isolated retinae, we reveal over 40 different GABA-releasing neuron types. Individual types show layer-specific visual encoding within inner plexiform layer sublayers. Synaptic input and output sites are aligned along specific retinal orientations. The combination of cell type-specific spatial structure and unique release kinetics enables inhibitory neurons to sculpt excitatory signals in response to a wide range of behaviorally relevant motion structures. Our findings emphasize the importance of functional diversity and intricate specialization of GABAergic neurons in the central nervous system.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"40 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially clustered neurons in the bat midbrain encode vocalization categories 蝙蝠中脑中的空间集群神经元编码发声类别

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-14 DOI: 10.1038/s41593-025-01932-3

Jennifer Lawlor, Melville J. Wohlgemuth, Cynthia F. Moss, Kishore V. Kuchibhotla

{"title":"Spatially clustered neurons in the bat midbrain encode vocalization categories","authors":"Jennifer Lawlor, Melville J. Wohlgemuth, Cynthia F. Moss, Kishore V. Kuchibhotla","doi":"10.1038/s41593-025-01932-3","DOIUrl":"https://doi.org/10.1038/s41593-025-01932-3","url":null,"abstract":"Rapid categorization of vocalizations enables adaptive behavior across species. While categorical perception is thought to arise in the neocortex, humans and animals could benefit from a functional organization tailored to ethologically relevant sound processing earlier in the auditory pathway. Here we developed two-photon calcium imaging in the awake echolocating bat (Eptesicus fuscus) to study the representation of vocalizations in the inferior colliculus, which is as few as two synapses from the inner ear. Echolocating bats rely on frequency-sweep-based vocalizations for social communication and navigation. Auditory playback experiments demonstrated that individual neurons responded selectively to social or navigation calls, enabling robust population-level decoding across categories. When social calls were morphed into navigation calls in equidistant step-wise increments, individual neurons showed switch-like properties and population-level response patterns sharply transitioned at the category boundary. Strikingly, category-selective neurons formed spatial clusters, independent of tonotopy within the dorsal cortex of the inferior colliculus. These findings support a revised view of categorical processing in which specified channels for ethologically relevant sounds are spatially segregated early in the auditory hierarchy, enabling rapid subcortical organization into categorical primitives.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"183 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143827147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hippocampal output suppresses orbitofrontal cortex schema cell formation 海马输出抑制眶额皮质图式细胞的形成

IF 25 1区医学

Nature neuroscience Pub Date : 2025-04-14 DOI: 10.1038/s41593-025-01928-z

Wenhui Zong, Jingfeng Zhou, Matthew P. H. Gardner, Zhewei Zhang, Kauê Machado Costa, Geoffrey Schoenbaum

引用次数: 0