Nature neuroscience最新文献_第6页

Alcohol’s necessary accessory 酒精的必需品

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-04 DOI: 10.1038/s41593-024-01802-4

Shari Wiseman

引用次数: 0

The role of motor cortex in motor sequence execution depends on demands for flexibility 运动皮层在运动序列执行中的作用取决于对灵活性的要求

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-04 DOI: 10.1038/s41593-024-01792-3

Kevin G. C. Mizes, Jack Lindsey, G. Sean Escola, Bence P. Ölveczky

{"title":"The role of motor cortex in motor sequence execution depends on demands for flexibility","authors":"Kevin G. C. Mizes, Jack Lindsey, G. Sean Escola, Bence P. Ölveczky","doi":"10.1038/s41593-024-01792-3","DOIUrl":"10.1038/s41593-024-01792-3","url":null,"abstract":"The role of the motor cortex in executing motor sequences is widely debated, with studies supporting disparate views. Here we probe the degree to which the motor cortex’s engagement depends on task demands, specifically whether its role differs for highly practiced, or ‘automatic’, sequences versus flexible sequences informed by external cues. To test this, we trained rats to generate three-element motor sequences either by overtraining them on a single sequence or by having them follow instructive visual cues. Lesioning motor cortex showed that it is necessary for flexible cue-driven motor sequences but dispensable for single automatic behaviors trained in isolation. However, when an automatic motor sequence was practiced alongside the flexible task, it became motor cortex dependent, suggesting that an automatic motor sequence fails to consolidate subcortically when the same sequence is produced also in a flexible context. A simple neural network model recapitulated these results and offered a circuit-level explanation. Our results critically delineate the role of the motor cortex in motor sequence execution, describing the conditions under which it is engaged and the functions it fulfills, thus reconciling seemingly conflicting views about motor cortex’s role in motor sequence generation. Motor cortex is required for flexible motor sequences informed by sensory cues but not for single automatic sequences. However, training automatic sequences alongside flexible ones interferes with their subcortical consolidation.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"27 12","pages":"2466-2475"},"PeriodicalIF":21.2,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142574472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The fly’s neural blueprint 苍蝇的神经蓝图

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-04 DOI: 10.1038/s41593-024-01804-2

Henrietta Howells

引用次数: 0

Astrocytes facilitate brain metastases 星形胶质细胞有助于脑转移

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-04 DOI: 10.1038/s41593-024-01805-1

George Andrew S. Inglis

引用次数: 0

Smelling a concept 嗅觉概念

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-04 DOI: 10.1038/s41593-024-01803-3

Leonie Welberg

引用次数: 0

Dissecting human brain connectivity across biophysical scales 跨生物物理尺度剖析人脑连通性

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-11-01 DOI: 10.1038/s41593-024-01789-y

引用次数: 0

Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity 跨生物物理尺度的整合确定了人脑连通性中人与人之间差异的分子和细胞相关性

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-10-31 DOI: 10.1038/s41593-024-01788-z

Bernard Ng, Shinya Tasaki, Kelsey M. Greathouse, Courtney K. Walker, Ada Zhang, Sydney Covitz, Matt Cieslak, Audrey J. Weber, Ashley B. Adamson, Julia P. Andrade, Emily H. Poovey, Kendall A. Curtis, Hamad M. Muhammad, Jakob Seidlitz, Ted Satterthwaite, David A. Bennett, Nicholas T. Seyfried, Jacob Vogel, Chris Gaiteri, Jeremy H. Herskowitz

{"title":"Integration across biophysical scales identifies molecular and cellular correlates of person-to-person variability in human brain connectivity","authors":"Bernard Ng, Shinya Tasaki, Kelsey M. Greathouse, Courtney K. Walker, Ada Zhang, Sydney Covitz, Matt Cieslak, Audrey J. Weber, Ashley B. Adamson, Julia P. Andrade, Emily H. Poovey, Kendall A. Curtis, Hamad M. Muhammad, Jakob Seidlitz, Ted Satterthwaite, David A. Bennett, Nicholas T. Seyfried, Jacob Vogel, Chris Gaiteri, Jeremy H. Herskowitz","doi":"10.1038/s41593-024-01788-z","DOIUrl":"10.1038/s41593-024-01788-z","url":null,"abstract":"Brain connectivity arises from interactions across biophysical scales, ranging from molecular to cellular to anatomical to network level. To date, there has been little progress toward integrated analysis across these scales. To bridge this gap, from a unique cohort of 98 individuals, we collected antemortem neuroimaging and genetic data, as well as postmortem dendritic spine morphometric, proteomic and gene expression data from the superior frontal and inferior temporal gyri. Through the integration of the molecular and dendritic spine morphology data, we identified hundreds of proteins that explain interindividual differences in functional connectivity and structural covariation. These proteins are enriched for synaptic structures and functions, energy metabolism and RNA processing. By integrating data at the genetic, molecular, subcellular and tissue levels, we link specific biochemical changes at synapses to connectivity between brain regions. These results demonstrate the feasibility of integrating data from vastly different biophysical scales to provide a more comprehensive understanding of brain connectivity. Integration of postmortem molecular and dendritic spine morphological measurements enables the detection of microscale molecules associated with person-to-person variability in macroscale brain connectivity estimated from antemortem neuroimaging.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"27 11","pages":"2240-2252"},"PeriodicalIF":21.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41593-024-01788-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142555823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ernest Arenas (1962–2024) 欧内斯特-阿雷纳斯（1962-2024）

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-10-28 DOI: 10.1038/s41593-024-01797-y

Patrik Ernfors, Gonçalo Castelo-Branco, Per Uhlén, Sten Linnarsson, Ulrika Marklund, Jens Hjerling-Leffler, Onur Dagliyan

引用次数: 0

A trainee-informed model for undergraduate neuroscience research programs serving marginalized students 为边缘化学生服务的神经科学本科生研究项目的受训者知情模式

IF 21.2 1区医学

Nature neuroscience Pub Date : 2024-10-25 DOI: 10.1038/s41593-024-01790-5

Christian Cazares, Maribel Patiño, Minerva Contreras, Julia C. Gorman, Jillybeth Burgado, Sana A. Ali, Quirine van Engen, Eena L. Kosik, Pamela Riviere, Emily T. Baltz, Chimuanya K. Agba, Michael Preston, Akshay Nagarajan, Jianna Cressy, Natalie Paredes, Chiaki Santiago, Kevin L. White

引用次数: 0

Rastermap: a discovery method for neural population recordings Rastermap：神经群记录的发现方法

IF 25 1区医学

Nature neuroscience Pub Date : 2024-10-16 DOI: 10.1038/s41593-024-01783-4

Carsen Stringer, Lin Zhong, Atika Syeda, Fengtong Du, Maria Kesa, Marius Pachitariu

引用次数: 0