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A common computational and neural anomaly across mouse models of autism 自闭症小鼠模型中常见的计算和神经异常
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-06-03 DOI: 10.1038/s41593-025-01965-8
Jean-Paul Noel, Edoardo Balzani, Luigi Acerbi, Julius Benson, Cristina Savin, Dora E. Angelaki
{"title":"A common computational and neural anomaly across mouse models of autism","authors":"Jean-Paul Noel, Edoardo Balzani, Luigi Acerbi, Julius Benson, Cristina Savin, Dora E. Angelaki","doi":"10.1038/s41593-025-01965-8","DOIUrl":"https://doi.org/10.1038/s41593-025-01965-8","url":null,"abstract":"<p>Computational psychiatry studies suggest that individuals with autism spectrum disorder (ASD) inflexibly update their expectations. Here we leveraged high-yield rodent psychophysics, extensive behavioral modeling and brain-wide single-cell extracellular recordings to assess whether mice with different genetic perturbations associated with ASD show this same computational anomaly, and if so, what neurophysiological features are shared across genotypes. Mice harboring mutations in <i>Fmr1</i>, <i>Cntnap2</i> or <i>Shank3B</i> show a blunted update of priors during decision-making. Compared with mice that flexibly updated their priors, inflexible updating of priors was associated with a shift in the weighting of prior encoding from sensory to frontal cortices. Furthermore, frontal areas in mouse models of ASD showed more units encoding deviations from the animals’ long-run prior, and sensory responses did not differentiate between expected and unexpected observations. These findings suggest that distinct genetic instantiations of ASD may yield common neurophysiological and behavioral phenotypes.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"7 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changing genes, cells and networks to reprogram the brain after stroke 改变基因、细胞和网络,在中风后重新编程大脑
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01981-8
Wenlu Li, Paul George, Matine M. Azadian, MingMing Ning, Amar Dhand, Steven C. Cramer, S. Thomas Carmichael, Eng H. Lo
{"title":"Changing genes, cells and networks to reprogram the brain after stroke","authors":"Wenlu Li, Paul George, Matine M. Azadian, MingMing Ning, Amar Dhand, Steven C. Cramer, S. Thomas Carmichael, Eng H. Lo","doi":"10.1038/s41593-025-01981-8","DOIUrl":"https://doi.org/10.1038/s41593-025-01981-8","url":null,"abstract":"<p>Important advances have been made in reperfusion therapies for acute ischemic stroke. However, a majority of patients are either ineligible for or do not respond to treatments and continue to have considerable functional deficits. Stroke results in a pathological disruption of the neurovascular unit (NVU) that involves blood–brain barrier leakage, glial activation, neuronal damage and chronic inflammation, all of which create a microenvironment that hinders recovery. Therefore, finding ways to promote central nervous system recovery remains the holy grail of stroke research. Here we propose a conceptual framework to synthesize recent progress in the field, which is currently dispersed and disconnected in the literature. We suggest that stroke recovery requires an integrated reprogramming process throughout the brain that occurs at multiple levels, including changes in gene expression, endogenous cellular transdifferentiation within the NVU, and reorganization of larger-scale neural and social networks.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"4 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress 神经元老化导致剪接蛋白的错误定位和不受控制的细胞应激
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01952-z
Kevin Rhine, Rachel Li, Hema M. Kopalle, Katherine Rothamel, Xuezhen Ge, Elle Epstein, Orel Mizrahi, Assael A. Madrigal, Hsuan-Lin Her, Trent A. Gomberg, Anita Hermann, Joshua L. Schwartz, Amanda J. Daniels, Uri Manor, John Ravits, Robert A. J. Signer, Eric J. Bennett, Gene W. Yeo
{"title":"Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress","authors":"Kevin Rhine, Rachel Li, Hema M. Kopalle, Katherine Rothamel, Xuezhen Ge, Elle Epstein, Orel Mizrahi, Assael A. Madrigal, Hsuan-Lin Her, Trent A. Gomberg, Anita Hermann, Joshua L. Schwartz, Amanda J. Daniels, Uri Manor, John Ravits, Robert A. J. Signer, Eric J. Bennett, Gene W. Yeo","doi":"10.1038/s41593-025-01952-z","DOIUrl":"https://doi.org/10.1038/s41593-025-01952-z","url":null,"abstract":"<p>Aging is one of the most prominent risk factors for neurodegeneration, yet the molecular mechanisms underlying the deterioration of old neurons are mostly unknown. To efficiently study neurodegeneration in the context of aging, we transdifferentiated primary human fibroblasts from aged healthy donors directly into neurons, which retained their aging hallmarks, and we verified key findings in aged human and mouse brain tissue. Here we show that aged neurons are broadly depleted of RNA-binding proteins, especially spliceosome components. Intriguingly, splicing proteins—like the dementia- and ALS-associated protein TDP-43—mislocalize to the cytoplasm in aged neurons, which leads to widespread alternative splicing. Cytoplasmic spliceosome components are typically recruited to stress granules, but aged neurons suffer from chronic cellular stress that prevents this sequestration. We link chronic stress to the malfunctioning ubiquitylation machinery, poor HSP90α chaperone activity and the failure to respond to new stress events. Together, our data demonstrate that aging-linked deterioration of RNA biology is a key driver of poor resiliency in aged neurons.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"13 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Egocentric value maps of the near-body environment 以自我为中心的近体环境价值图
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-06-02 DOI: 10.1038/s41593-025-01958-7
Rory John Bufacchi, Richard Somervail, Aoife Maria Fitzpatrick, Yusuke Murayama, Nikos Logothetis, Roberto Caminiti, Gian Domenico Iannetti
{"title":"Egocentric value maps of the near-body environment","authors":"Rory John Bufacchi, Richard Somervail, Aoife Maria Fitzpatrick, Yusuke Murayama, Nikos Logothetis, Roberto Caminiti, Gian Domenico Iannetti","doi":"10.1038/s41593-025-01958-7","DOIUrl":"https://doi.org/10.1038/s41593-025-01958-7","url":null,"abstract":"<p>Body-part-centered response fields are pervasive in single neurons, functional magnetic resonance imaging, electroencephalography and behavior, but there is no unifying formal explanation of their origins and role. In the present study, we used reinforcement learning and artificial neural networks to demonstrate that body-part-centered fields do not simply reflect stimulus configuration, but rather action value: they naturally arise from the basic assumption that agents often experience positive or negative reward after contacting environmental objects. This perspective successfully reproduces experimental findings that are foundational in the peripersonal space literature. It also suggests that peripersonal fields provide building blocks that create a modular model of the world near the agent: an egocentric value map. This concept is strongly supported by the emergent modularity that we observed in our artificial networks. The short-term, close-range, egocentric map is analogous to the long-term, long-range, allocentric hippocampal map. This perspective fits empirical data from multiple experiments, provides testable predictions and accommodates existing explanations of peripersonal fields.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"5 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microglia eliminate inhibitory synapses and drive neuronal hyperexcitability in epilepsy 小胶质细胞消除抑制性突触并驱动癫痫中的神经元高兴奋性
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-05-30 DOI: 10.1038/s41593-025-01983-6
{"title":"Microglia eliminate inhibitory synapses and drive neuronal hyperexcitability in epilepsy","authors":"","doi":"10.1038/s41593-025-01983-6","DOIUrl":"https://doi.org/10.1038/s41593-025-01983-6","url":null,"abstract":"In mouse models of epilepsy and human brain samples, hyperactive inhibitory signaling from neurons and complement signaling from astrocytes coordinate to drive microglia-mediated selective elimination of inhibitory synapses. This positive feedback mechanism disrupts the excitatory–inhibitory neurotransmission balance, which exacerbates neuronal hyperexcitability and contributes to the pathophysiology of epilepsy.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"57 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine 小鼠小肠粘膜下神经元类别的转录组、连接和发育
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-05-29 DOI: 10.1038/s41593-025-01962-x
Wei Li, Khomgrit Morarach, Ziwei Liu, Sanghita Banerjee, Yanan Chen, Ashley L. Harb, Joel M. Kosareff, Charles R. Hall, Fernando López-Redondo, Elham Jalalvand, Suad H. Mohamed, Anastassia Mikhailova, David R. Linden, Ulrika Marklund
{"title":"The transcriptomes, connections and development of submucosal neuron classes in the mouse small intestine","authors":"Wei Li, Khomgrit Morarach, Ziwei Liu, Sanghita Banerjee, Yanan Chen, Ashley L. Harb, Joel M. Kosareff, Charles R. Hall, Fernando López-Redondo, Elham Jalalvand, Suad H. Mohamed, Anastassia Mikhailova, David R. Linden, Ulrika Marklund","doi":"10.1038/s41593-025-01962-x","DOIUrl":"https://doi.org/10.1038/s41593-025-01962-x","url":null,"abstract":"<p>The enteric submucosal plexus regulates essential digestive functions, yet its neuronal composition remains incompletely understood. We identified two putative secretomotor neuron classes and a previously unrecognized submucosal intrinsic primary afferent neuron class through single-cell RNA sequencing in the mouse small intestine. Using viral-mediated labeling of each class, we uncovered their morphologies and neural projections in the submucosa–mucosa context, finding connections among all classes and an unexpected close association with enterochromaffin cells. Further transcriptome analysis at the postnatal stage and lineage tracing revealed that neuron identities in the submucosal plexus emerge through an initial binary fate split at neurogenesis, followed by phenotypic diversification, akin to the developmental process of the myenteric plexus. We propose a unified developmental framework for neuronal diversification across the gut wall. Our study offers comprehensive molecular, developmental and morphological insights into submucosal neurons, opening new avenues for exploring physiological functions, circuit dynamics and formation of the submucosal plexus.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"8 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development 小鼠脑发育过程中脉络丛大汗液分泌影响脑脊液蛋白质组
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-05-28 DOI: 10.1038/s41593-025-01972-9
Ya’el Courtney, Joshua P. Head, Neil Dani, Olga V. Chechneva, Frederick B. Shipley, Yong Zhang, Michael J. Holtzman, Cameron Sadegh, Towia A. Libermann, Maria K. Lehtinen
{"title":"Choroid plexus apocrine secretion shapes CSF proteome during mouse brain development","authors":"Ya’el Courtney, Joshua P. Head, Neil Dani, Olga V. Chechneva, Frederick B. Shipley, Yong Zhang, Michael J. Holtzman, Cameron Sadegh, Towia A. Libermann, Maria K. Lehtinen","doi":"10.1038/s41593-025-01972-9","DOIUrl":"https://doi.org/10.1038/s41593-025-01972-9","url":null,"abstract":"<p>The choroid plexus (ChP) regulates cerebrospinal fluid (CSF) composition, providing essential molecular cues for brain development; yet, embryonic ChP secretory mechanisms remain poorly defined. Here we identify apocrine secretion by embryonic ChP epithelial cells as a key regulator of the CSF proteome and neurodevelopment in male and female mice. We demonstrate that the activation of serotonergic 5-HT<sub>2C</sub> receptors (by WAY-161503) triggers sustained Ca<sup>2+</sup> signaling, driving high-volume apocrine secretion in mouse and human ChP. This secretion alters the CSF proteome, stimulating neural progenitors lining the brain’s ventricles and shifting their developmental trajectory. Inducing ChP secretion in utero in mice disrupts neural progenitor dynamics, cerebral cortical architecture and offspring behavior. Additionally, illness or lysergic acid diethylamide exposure during pregnancy provokes coordinated ChP secretion in the mouse embryo. Our findings reveal a fundamental secretory pathway in the ChP that shapes brain development, highlighting how its disruption can have lasting consequences for brain health.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"4 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs 下丘脑-脑干回路控制着安全优先于基本需求
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-05-28 DOI: 10.1038/s41593-025-01975-6
Nathalie Krauth, Lara K. Sach, Giacomo Sitzia, Christoffer Clemmensen, Ole Kiehn
{"title":"A hypothalamus–brainstem circuit governs the prioritization of safety over essential needs","authors":"Nathalie Krauth, Lara K. Sach, Giacomo Sitzia, Christoffer Clemmensen, Ole Kiehn","doi":"10.1038/s41593-025-01975-6","DOIUrl":"https://doi.org/10.1038/s41593-025-01975-6","url":null,"abstract":"<p>Animals continuously adapt their behavior to balance survival and fulfilling essential needs. This balancing act involves prioritization of safety over the pursuit of other needs. However, the specific deep brain circuits that regulate safety-seeking behaviors in conjunction with motor circuits remain poorly understood. Here, we identify a class of glutamatergic neurons in the mouse lateral hypothalamic area (LHA) that target the midbrain locomotor-promoting pedunculopontine nucleus (PPN). Following activation, this LHA–PPN pathway orchestrates context-dependent locomotion, prioritizing safety-directed movement over other essential needs such as foraging or social contact. Remarkably, the neuronal activity of this circuit correlates directly with safety-seeking behavior. The circuit may respond to both intrinsic and extrinsic cues, having a pivotal role in ensuring survival. Our findings uncover a circuit motif within the lateral hypothalamus that, when recruited, prioritizes critical needs through the recruitment of an appropriate motor action.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"51 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What dopamine teaches depends on what the brain believes 多巴胺教什么取决于大脑相信什么
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-05-28 DOI: 10.1038/s41593-025-01980-9
Eleonora Bano, Steven Ryu, Adam Kepecs
{"title":"What dopamine teaches depends on what the brain believes","authors":"Eleonora Bano, Steven Ryu, Adam Kepecs","doi":"10.1038/s41593-025-01980-9","DOIUrl":"https://doi.org/10.1038/s41593-025-01980-9","url":null,"abstract":"How does the brain learn to predict rewards? In this issue of Nature Neuroscience, Qian, Burrell et al. show that understanding how dopamine guides learning requires knowledge of how animals interpret tasks — what they believe is happening and when. By carefully manipulating cue–reward contingencies, the authors show that dopamine responses track belief-state reward prediction errors. These findings reaffirm — against recent challenges — that mesolimbic dopamine neurons signal prediction errors in line with the temporal difference learning rule, a core algorithm that bridges neuroscience and artificial intelligence.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"33 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy gaba依赖性的抑制性突触的小胶质消除是癫痫中神经元高兴奋性的基础
IF 25 1区 医学
Nature neuroscience Pub Date : 2025-05-27 DOI: 10.1038/s41593-025-01979-2
Zhang-Peng Chen, Xiansen Zhao, Suji Wang, Ruolan Cai, Qiangqiang Liu, Haojie Ye, Meng-Ju Wang, Shi-Yu Peng, Wei-Xuan Xue, Yang-Xun Zhang, Wei Li, Hua Tang, Tengfei Huang, Qipeng Zhang, Liang Li, Lixia Gao, Hong Zhou, Chunhua Hang, Jing-Ning Zhu, Xinjian Li, Xiangyu Liu, Qifei Cong, Chao Yan
{"title":"GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy","authors":"Zhang-Peng Chen, Xiansen Zhao, Suji Wang, Ruolan Cai, Qiangqiang Liu, Haojie Ye, Meng-Ju Wang, Shi-Yu Peng, Wei-Xuan Xue, Yang-Xun Zhang, Wei Li, Hua Tang, Tengfei Huang, Qipeng Zhang, Liang Li, Lixia Gao, Hong Zhou, Chunhua Hang, Jing-Ning Zhu, Xinjian Li, Xiangyu Liu, Qifei Cong, Chao Yan","doi":"10.1038/s41593-025-01979-2","DOIUrl":"https://doi.org/10.1038/s41593-025-01979-2","url":null,"abstract":"<p>Neuronal hyperexcitability is a common pathophysiological feature of many neurological diseases. Neuron–glia interactions underlie this process but the detailed mechanisms remain unclear. Here, we reveal a critical role of microglia-mediated selective elimination of inhibitory synapses in driving neuronal hyperexcitability. In epileptic mice of both sexes, hyperactive inhibitory neurons directly activate surveilling microglia via GABAergic signaling. In response, these activated microglia preferentially phagocytose inhibitory synapses, disrupting the balance between excitatory and inhibitory synaptic transmission and amplifying network excitability. This feedback mechanism depends on both GABA–GABA<sub>B</sub> receptor-mediated microglial activation and complement C3–C3aR-mediated microglial engulfment of inhibitory synapses, as pharmacological or genetic blockage of both pathways effectively prevents inhibitory synapse loss and ameliorates seizure symptoms in mice. Additionally, putative cell–cell interaction analyses of brain tissues from males and females with temporal lobe epilepsy reveal that inhibitory neurons induce microglial phagocytic states and inhibitory synapse loss. Our findings demonstrate that inhibitory neurons can directly instruct microglial states to control inhibitory synaptic transmission through a feedback mechanism, leading to the development of neuronal hyperexcitability in temporal lobe epilepsy.</p>","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"133 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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