Nature neuroscience最新文献_第7页

Large-scale high-density brain-wide neural recording in nonhuman primates 非人类灵长类动物的大规模高密度全脑神经记录

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-23 DOI: 10.1038/s41593-025-01976-5

Eric M. Trautmann, Janis K. Hesse, Gabriel M. Stine, Ruobing Xia, Shude Zhu, Daniel J. O’Shea, Bill Karsh, Jennifer Colonell, Frank F. Lanfranchi, Saurabh Vyas, Andrew Zimnik, Elom Amematsro, Natalie A. Steinemann, Daniel A. Wagenaar, Marius Pachitariu, Alexandru Andrei, Carolina Mora Lopez, John O’Callaghan, Jan Putzeys, Bogdan C. Raducanu, Marleen Welkenhuysen, Mark Churchland, Tirin Moore, Michael Shadlen, Krishna Shenoy, Doris Tsao, Barundeb Dutta, Timothy Harris

{"title":"Large-scale high-density brain-wide neural recording in nonhuman primates","authors":"Eric M. Trautmann, Janis K. Hesse, Gabriel M. Stine, Ruobing Xia, Shude Zhu, Daniel J. O’Shea, Bill Karsh, Jennifer Colonell, Frank F. Lanfranchi, Saurabh Vyas, Andrew Zimnik, Elom Amematsro, Natalie A. Steinemann, Daniel A. Wagenaar, Marius Pachitariu, Alexandru Andrei, Carolina Mora Lopez, John O’Callaghan, Jan Putzeys, Bogdan C. Raducanu, Marleen Welkenhuysen, Mark Churchland, Tirin Moore, Michael Shadlen, Krishna Shenoy, Doris Tsao, Barundeb Dutta, Timothy Harris","doi":"10.1038/s41593-025-01976-5","DOIUrl":"https://doi.org/10.1038/s41593-025-01976-5","url":null,"abstract":"High-density silicon probes have transformed neuroscience by enabling large-scale neural recordings at single-cell resolution. However, existing technologies have provided limited functionality in nonhuman primates (NHPs) such as macaques. In the present report, we describe the design, fabrication and performance of Neuropixels 1.0 NHP, a high-channel electrode array designed to enable large-scale acute recording throughout large animal brains. The probe features 4,416 recording sites distributed along a 45-mm shank. Experimenters can programmably select 384 recording channels, enabling simultaneous multi-area recording from thousands of neurons with single or multiple probes. This technology substantially increases scalability and recording access relative to existing technologies and enables new classes of experiments that involve electrophysiological mapping of brain areas at single-neuron and single-spike resolution, measurement of spike–spike correlations between cells and simultaneous brain-wide recordings at scale.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"4 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144341178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment 闭环电刺激可预防局灶性癫痫进展和长期记忆障碍

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-23 DOI: 10.1038/s41593-025-01988-1

Jose J. Ferrero, Ahnaf R. Hassan, Zelin Yu, Zifang Zhao, Liang Ma, Cynthia Wu, Shan Shao, Takeshi Kawano, Judah Engel, Werner Doyle, Orrin Devinsky, Dion Khodagholy, Jennifer N. Gelinas

{"title":"Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment","authors":"Jose J. Ferrero, Ahnaf R. Hassan, Zelin Yu, Zifang Zhao, Liang Ma, Cynthia Wu, Shan Shao, Takeshi Kawano, Judah Engel, Werner Doyle, Orrin Devinsky, Dion Khodagholy, Jennifer N. Gelinas","doi":"10.1038/s41593-025-01988-1","DOIUrl":"https://doi.org/10.1038/s41593-025-01988-1","url":null,"abstract":"Interictal epileptiform discharges (IEDs) are expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes, as most therapeutic approaches target seizures. We show, in a kindling model of progressive focal epilepsy, that IEDs produce pathological oscillatory coupling associated with prolonged, hypersynchronous neural spiking in synaptically connected cortex and expand the brain territory capable of generating IEDs. A similar relationship between IED-mediated oscillatory coupling and temporal organization of IEDs across brain regions was identified in human participants with refractory focal epilepsy. Spatiotemporally targeted closed-loop electrical stimulation triggered on hippocampal IED occurrence eliminated the abnormal cortical activity patterns, preventing the spread of the epileptic network and ameliorating long-term spatial memory deficits in rodents. These findings suggest that stimulation-based network interventions that normalize interictal dynamics may be an effective treatment of epilepsy and its comorbidities, with a low barrier to clinical translation.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"19 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144341290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging 热休克蛋白作为信号分子介导秀丽隐杆线虫衰老过程中神经元-胶质细胞间的通讯

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-18 DOI: 10.1038/s41593-025-01989-0

Jieyu Wu, Victoria R. Yarmey, Olivia Jiaming Yang, Erik J. Soderblom, Adriana San-Miguel, Dong Yan

{"title":"Heat shock proteins function as signaling molecules to mediate neuron–glia communication in C. elegans during aging","authors":"Jieyu Wu, Victoria R. Yarmey, Olivia Jiaming Yang, Erik J. Soderblom, Adriana San-Miguel, Dong Yan","doi":"10.1038/s41593-025-01989-0","DOIUrl":"https://doi.org/10.1038/s41593-025-01989-0","url":null,"abstract":"The nervous system is primarily composed of neurons and glia, and the communication between them has profound roles in regulating the development and function of the brain. Neuron–glia signal transduction is known to be mediated by secreted signals through ligand–receptor interactions on the cell membrane. Here we show a new mechanism for neuron–glia signal transduction, wherein neurons transmit proteins to glia through extracellular vesicles, activating glial signaling pathways. We find that in the amphid sensory organ of Caenorhabditis elegans, different sensory neurons exhibit varying aging rates. This discrepancy in aging is governed by the cross-talk between neurons and glia. We demonstrate that early aged neurons can transmit heat shock proteins to glia via extracellular vesicles. These neuronal heat shock proteins activate the glial IRE1–XBP1 pathway, leading to the transcriptional regulation of chondroitin synthases to protect glia-embedded neurons from aging-associated functional decline. Therefore, our studies unveil a new mechanism for neuron–glia communication in the nervous system and provide new insights into our understanding of brain aging.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"93 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144312249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges of the inconsistent neurorights framework in Latin America 拉丁美洲不一致的神经权利框架的挑战

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-18 DOI: 10.1038/s41593-025-02001-5

Diego Borbón

{"title":"Challenges of the inconsistent neurorights framework in Latin America","authors":"Diego Borbón","doi":"10.1038/s41593-025-02001-5","DOIUrl":"https://doi.org/10.1038/s41593-025-02001-5","url":null,"abstract":"The integration of neurotechnology into society has prompted urgent discussions on neurorights (new lists of human rights to regulate neurotechnology) and has led to varied legislative responses across the region that leads this debate: Latin America. Although some countries have responded by pursuing constitutional amendments, others have proposed varied legal reforms, adopted different principles or adopted non-binding soft-law approaches, such as recommendations and guidelines. This diversity of responses has resulted in a fragmented landscape of neurorights protections that poses challenges for regional coherence. This Comment briefly discusses the divergent strategies of Latin American countries for integrating neurorights into their respective legal frameworks, highlighting inconsistencies and proposing ways to navigate these complexities alongside informed scholarship.Neurorights have emerged as ethical necessities in response to advanced neurotechnology, with varied propositions by leading scholars. Marcello Ienca and Roberto Andorno in 2017 defined four key neurorights: cognitive liberty, mental privacy, mental integrity, and psychological continuity1, each designed to protect individuals from unethical uses of neurotechnology. Concurrently, the Neurorights Foundation led by Rafael Yuste emphasized the importance of creating novel neurorights to mental privacy, personal identity, free will, equitable access to cognitive augmentation, and bias protection (https://neurorightsfoundation.org/mission). These new rights aim to address ethical issues by setting regulatory and protective standards to govern the application of emerging neurotechnologies2.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"26 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain 亚细胞蛋白质组学和人和小鼠脑成像揭示阿尔茨海默病髓磷脂-轴突界面易感性

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-13 DOI: 10.1038/s41593-025-01973-8

Yifei Cai, Iguaracy Pinheiro-de-Sousa, Mykhaylo Slobodyanyuk, Fuyi Chen, Tram Huynh, Jean Kanyo, Peiyang Tang, Lukas A. Fuentes, Amber Braker, Rachel Welch, Anita Huttner, Lei Tong, Peng Yuan, TuKiet T. Lam, Evangelia Petsalaki, Jüri Reimand, Angus C. Nairn, Jaime Grutzendler

{"title":"Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain","authors":"Yifei Cai, Iguaracy Pinheiro-de-Sousa, Mykhaylo Slobodyanyuk, Fuyi Chen, Tram Huynh, Jean Kanyo, Peiyang Tang, Lukas A. Fuentes, Amber Braker, Rachel Welch, Anita Huttner, Lei Tong, Peng Yuan, TuKiet T. Lam, Evangelia Petsalaki, Jüri Reimand, Angus C. Nairn, Jaime Grutzendler","doi":"10.1038/s41593-025-01973-8","DOIUrl":"https://doi.org/10.1038/s41593-025-01973-8","url":null,"abstract":"Myelin ensheathment is essential for rapid axonal conduction, metabolic support and neuronal plasticity. In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. We implemented proximity labeling subcellular proteomics of the myelin–axon interface in postmortem human brains from AD donors and 15-month-old male and female 5XFAD mice. We uncovered multiple dysregulated signaling pathways and ligand–receptor interactions, including those linked to amyloid-β processing, axonal outgrowth and lipid metabolism. Expansion microscopy confirmed the subcellular localization of top proteomic hits and revealed amyloid-β aggregation within the internodal periaxonal space and paranodal/juxtaparanodal channels. Although overall myelin coverage is preserved, we found reduced paranode density, aberrant myelination and altered paranode positioning around amyloid-plaque-associated dystrophic axons. These findings suggest that the myelin–axon interface is a critical site of protein aggregation and disrupted neuro-glial signaling in AD.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"53 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The brain works at more than 10 bits per second 大脑的工作速度超过每秒10比特

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-13 DOI: 10.1038/s41593-025-01997-0

Britton A. Sauerbrei, J. Andrew Pruszynski

引用次数: 0

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing 单核rna测序揭示阿尔茨海默病小鼠齿状回的保护性运动反应

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-12 DOI: 10.1038/s41593-025-01971-w

Joana F. da Rocha, Michelle L. Lance, Renhao Luo, Pius Schlachter, Luis Moreira, Mohamed Ariff Iqbal, Paula Kuhn, Robert S. Gardner, Sophia Valaris, Mohammad R. Islam, Gabriele M. Gassner, Sofia Mazuera, Kaela Healy, Sanjana Shastri, Nathaniel B. Hibbert, Kristen V. Moran-Figueroa, Erin B. Haley, Ryan D. Pfeiffer, Sema Aygar, Ksenia V. Kastanenka, Logan Brase, Oscar Harari, Bruno A. Benitez, Nathan R. Tucker, Christiane D. Wrann

{"title":"Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing","authors":"Joana F. da Rocha, Michelle L. Lance, Renhao Luo, Pius Schlachter, Luis Moreira, Mohamed Ariff Iqbal, Paula Kuhn, Robert S. Gardner, Sophia Valaris, Mohammad R. Islam, Gabriele M. Gassner, Sofia Mazuera, Kaela Healy, Sanjana Shastri, Nathaniel B. Hibbert, Kristen V. Moran-Figueroa, Erin B. Haley, Ryan D. Pfeiffer, Sema Aygar, Ksenia V. Kastanenka, Logan Brase, Oscar Harari, Bruno A. Benitez, Nathan R. Tucker, Christiane D. Wrann","doi":"10.1038/s41593-025-01971-w","DOIUrl":"https://doi.org/10.1038/s41593-025-01971-w","url":null,"abstract":"Exercise’s protective effects in Alzheimer’s disease (AD) are well recognized, but cell-specific contributions to this phenomenon remain unclear. Here we used single-nucleus RNA sequencing (snRNA-seq) to dissect the response to exercise (free-wheel running) in the neurogenic stem-cell niche of the hippocampal dentate gyrus in male APP/PS1 transgenic AD model mice. Transcriptomic responses to exercise were distinct between wild-type and AD mice, and most prominent in immature neurons. Exercise restored the transcriptional profiles of a proportion of AD-dysregulated genes in a cell type-specific manner. We identified a neurovascular-associated astrocyte subpopulation, the abundance of which was reduced in AD, whereas its gene expression signature was induced with exercise. Exercise also enhanced the gene expression profile of disease-associated microglia. Oligodendrocyte progenitor cells were the cell type with the highest proportion of dysregulated genes recovered by exercise. Last, we validated our key findings in a human AD snRNA-seq dataset. Together, these data present a comprehensive resource for understanding the molecular mediators of neuroprotection by exercise in AD.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"90 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A flexible hippocampal population code for experience relative to reward 一个灵活的海马体群体编码相对于奖励的经验

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-11 DOI: 10.1038/s41593-025-01985-4

Marielena Sosa, Mark H. Plitt, Lisa M. Giocomo

引用次数: 0

Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex 小鼠内侧眶额叶皮质抑制神经元集合对酗酒的抑制

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-10 DOI: 10.1038/s41593-025-01970-x

Pablo Gimenez-Gomez, Timmy Le, Max Zinter, Peter M’Angale, Violeta Duran-Laforet, Timothy G. Freels, Rebecca Pavchinskiy, Susanna Molas, Dorothy P. Schafer, Andrew R. Tapper, Travis Thomson, Gilles E. Martin

{"title":"Suppression of binge alcohol drinking by an inhibitory neuronal ensemble in the mouse medial orbitofrontal cortex","authors":"Pablo Gimenez-Gomez, Timmy Le, Max Zinter, Peter M’Angale, Violeta Duran-Laforet, Timothy G. Freels, Rebecca Pavchinskiy, Susanna Molas, Dorothy P. Schafer, Andrew R. Tapper, Travis Thomson, Gilles E. Martin","doi":"10.1038/s41593-025-01970-x","DOIUrl":"https://doi.org/10.1038/s41593-025-01970-x","url":null,"abstract":"Alcohol consumption remains a significant global health challenge, directly and indirectly causing millions of deaths annually. Alcohol abuse causes dysregulated activity of the prefrontal cortex, yet effects on specific prefrontal circuits remain to be elucidated. Here, we identify a discrete GABAergic neuronal ensemble in the mouse medial orbitofrontal cortex (mOFC) that is selectively recruited in response to binge alcohol drinking and limits further drinking behavior. Optogenetic silencing of this population, or its ablation, results in uncontrolled binge alcohol consumption. This neuronal ensemble is specific to alcohol and is not recruited by other rewarding substances. Neurons in this ensemble project widely throughout the brain, but projections specifically to the mediodorsal thalamus regulate binge alcohol drinking. Together, these results identify a brain circuit in the mOFC that serves to protect against binge drinking by reducing alcohol intake, which may offer avenues for the development of mOFC neuronal ensemble-targeted interventions.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"21 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144252309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting 脑脊液通过小脑膜动-静脉重叠的途径可以实现大分子和液体分流

IF 25 1区医学

Nature neuroscience Pub Date : 2025-06-09 DOI: 10.1038/s41593-025-01977-4

Benjamin A. Plog, Kyungdeok Kim, Daan Verhaege, Min Woo Kim, Zachary Papadopoulos, Krikor Dikranian, Taitea Dykstra, Jay Cao, Richard J. Perrin, Katherine E. Schwetye, Jonathan Kipnis, Antoine Drieu

{"title":"A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting","authors":"Benjamin A. Plog, Kyungdeok Kim, Daan Verhaege, Min Woo Kim, Zachary Papadopoulos, Krikor Dikranian, Taitea Dykstra, Jay Cao, Richard J. Perrin, Katherine E. Schwetye, Jonathan Kipnis, Antoine Drieu","doi":"10.1038/s41593-025-01977-4","DOIUrl":"https://doi.org/10.1038/s41593-025-01977-4","url":null,"abstract":"The flow of cerebrospinal fluid (CSF) is important for conveying brain-derived macromolecules for signaling and enabling them to be drained from the brain parenchyma. The glymphatic route is the best-characterized means of this CSF flow; however, it does not permit the movement of larger macromolecules. Here, we identify in mice an alternative route whereby intra-CSF-injected macromolecules can traverse from periarterial to perivenous spaces, with transfer occurring at sites of overlap between leptomeningeal perivascular (arteriovenous) spaces dispersed across the surface of the brain’s leptomeninges. We show that intra-CSF-injected fluorescent tracers can reach the perivenous space by passing through these arteriovenous perivascular overlaps. These spaces remain functional in a mouse model of amyloidosis and are essential for clearing excess CSF volume. These anatomical structures may support brain function by allowing the drainage of brain-derived macromolecules and the shunting of excess fluid and by aiding the immune surveillance of freshly generated CSF.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"10 1","pages":""},"PeriodicalIF":25.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0