Nature neuroscience最新文献

{"title":"Author Correction: HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the β-catenin–TCF interaction","authors":"Feng Ye, Ying Chen, ThaoNguyen Hoang, Rusty L. Montgomery, Xian-hui Zhao, Hong Bu, Tom Hu, Makoto M. Taketo, Johan H. van Es, Hans Clevers, Jenny Hsieh, Rhonda Bassel-Duby, Eric N. Olson, Q. Richard Lu","doi":"10.1038/s41593-025-02034-w","DOIUrl":"10.1038/s41593-025-02034-w","url":null,"abstract":"","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1810-1811"},"PeriodicalIF":20.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02034-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy","authors":"Robert I. McGeachan, Lois Keavey, Elizabeth M. Simzer, Ya Yin Chang, Jamie L. Rose, Maxwell P. Spires-Jones, Mollie Gilmore, Kristjan Holt, Soraya Meftah, Natalia Ravingerova, Cristina Scutariu, Lewis W. Taylor, Declan King, Makis Tzioras, Jane Tulloch, Sam A. Booker, Imran Liaquat, Nicole Hindley-Pollock, Bethany Geary, Colin Smith, Paul M. Brennan, Claire S. Durrant, Tara L. Spires-Jones","doi":"10.1038/s41593-025-01992-5","DOIUrl":"10.1038/s41593-025-01992-5","url":null,"abstract":"In the neurodegenerative disease progressive supranuclear palsy (PSP), tau pathology progresses through the brain in a stereotypical spatiotemporal pattern, and where tau pathology appears, synapses are lost. We tested the hypothesis that pathological tau contributes to synapse loss and may spread through the brain by moving from presynapses to postsynapses. Using postmortem PSP brain samples and a living human brain slice culture model, we observe pathological tau in synaptic pairs and evidence that oligomeric tau can enter live human postsynapses. Proteomics revealed increased clusterin in synapses in PSP, and super-resolution imaging showed clusterin colocalized with tau in synapses in close enough proximity to be binding partners, which may mediate tau spread. Accumulation of tau in synapses correlated with synapse loss, and synaptic engulfment by astrocytes was observed, suggesting that astrocytes contribute to synapse loss. Together, these data indicate that targeting synaptic tau is a promising approach to treat PSP. McGeachan et al. observe oligomeric tau in synapses from individuals with progressive supranuclear palsy and provide evidence that tau pathology may spread through the brain via synapses.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1622-1634"},"PeriodicalIF":20.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-01992-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronization of visual perception within the human fovea","authors":"Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica B. Rosselli, Matej Znidaric, Julian Bartram, Tobias Gänswein, Roland Diggelmann, Martina De Gennaro, Cameron S. Cowan, Wolf Harmening, Andreas Hierlemann, Botond Roska, Felix Franke","doi":"10.1038/s41593-025-02011-3","DOIUrl":"10.1038/s41593-025-02011-3","url":null,"abstract":"The human brain constructs a model of the world by processing sensory signals with distinct temporal characteristics that may differ in generation and transmission speed within a single sensory modality. To perceive simultaneous events as occurring at the same time, the brain must synchronize this sensory information, yet the mechanisms underlying such synchronization remain unclear. By combining human neural recordings, behavioral measurements and modeling, we show that in the human visual system, this process begins in the fovea centralis, the retinal region used for reading and recognizing faces. Reaction times to foveal single-cone photostimulation were similar across the central visual field, although visual information from neighboring foveal cones travels along axons of highly different lengths. From direct measurements of action potential propagation speeds, axon diameters and lengths in the human fovea centralis, we found that longer foveal axons have larger diameters and increased propagation speeds. We conclude that the human brain orchestrates axonal conduction speeds of unmyelinated axons in the retina to synchronize the arrival times of sensory signals. These results suggest a previously unknown mechanism by which the human brain synchronizes perception. Combining behavioral data, electrophysiology and modeling, the authors show that the human brain synchronizes visual signals by adjusting axonal conduction speed in the retina, revealing a previously unknown mechanism for precise perceptual timing.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 9","pages":"1959-1967"},"PeriodicalIF":20.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02011-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tau PET positivity in individuals with and without cognitive impairment varies with age, amyloid-β status, APOE genotype and sex","authors":"Rik Ossenkoppele, Emma M. Coomans, Liana G. Apostolova, Suzanne L. Baker, Henryk Barthel, Thomas G. Beach, Tammy L. S. Benzinger, Tobey Betthauser, Gérard N. Bischof, Michel Bottlaender, Pierick Bourgeat, Anouk den Braber, Matthias Brendel, Adam M. Brickman, David M. Cash, Maria C. Carrillo, William Coath, Bradley T. Christian, Brad C. Dickerson, Vincent Dore, Alexander Drzezga, Azadeh Feizpour, Wiesje M. van der Flier, Nicolai Franzmeier, Giovanni B. Frisoni, Valentina Garibotto, Elsmarieke van de Giessen, Juan Domingo-Gispert, Johannes Gnoerich, Yuna Gu, Yihui Guan, Bernard J. Hanseeuw, Theresa M. Harrison, Clifford R. Jack, Elena Jaeger, William J. Jagust, Willemijn J. Jansen, Renaud La Joie, Keith A. Johnson, Sterling C. Johnson, Ian A. Kennedy, Jun Pyo Kim, Koen van Laere, Julien Lagarde, Patrick Lao, José A. Luchsinger, Silke Kern, William C. Kreisl, Vincent Malotaux, Maura Malpetti, Jennifer J. Manly, Xiaoxie Mao, Niklas Mattsson-Carlgren, Mayo Clinic Study on Aging, Konstantin Messerschmidt, Carolina Minguillon, Elizabeth M. Mormino, John T. O’Brien, Sebastian Palmqvist, Debora E. Peretti, Ron C. Petersen, Yolande A. L. Pijnenburg, Michael J. Pontecorvo, Judes Poirier, PREVENT-AD Research Group, Gil D. Rabinovici, Nesrine Rahmouni, Shannon L. Risacher, Pedro Rosa-Neto, Howard Rosen, Christopher C. Rowe, James B. Rowe, Michael Rullmann, Yasmine Salman, Marie Sarazin, Andrew J. Saykin, Julie A. Schneider, Michael Schöll, Jonathan M. Schott, Sang Won Seo, Geidy E. Serrano, Sergey Shcherbinin, Mahnaz Shekari, Ingmar Skoog, Ruben Smith, Reisa A. Sperling, Laure Spruyt, Erik Stomrud, Olof Strandberg, Joseph Therriault, Fang Xie, Rik Vandenberghe, Victor L. Villemagne, Sylvia Villeneuve, Pieter Jelle Visser, Hillary Vossler, Christina B. Young, Colin Groot, Oskar Hansson","doi":"10.1038/s41593-025-02000-6","DOIUrl":"10.1038/s41593-025-02000-6","url":null,"abstract":"Tau positron emission tomography (PET) imaging allows in vivo detection of tau proteinopathy in Alzheimer’s disease, which is associated with neurodegeneration and cognitive decline. Understanding how demographic, clinical and genetic factors relate to tau PET positivity will facilitate its use for clinical practice and research. Here we conducted an analysis of 42 cohorts worldwide (N = 12,048), including 7,394 cognitively unimpaired (CU) participants, 2,177 participants with mild cognitive impairment (MCI) and 2,477 participants with dementia. We found that from age 60 years to 80 years, tau PET positivity in a temporal composite region increased from 1.1% to 4.4% among CU amyloid-β (Aβ)-negative participants and from 17.4% to 22.2% among CU Aβ-positive participants. Across the same age span, tau PET positivity decreased from 68.0% to 52.9% in participants with MCI and from 91.5% to 74.6% in participants with dementia. Age, Aβ status, APOE ε4 carriership and female sex were all associated with a higher prevalence of tau PET positivity across groups. APOE ε4 carriership in CU individuals lowered the age at onset of both Aβ positivity and tau positivity by decades. Finally, we replicated these associations in an independent autopsy dataset (N = 5,072 from 3 cohorts). Ossenkoppele, Coomans and colleagues analyzed the tau PET data of 12,048 individuals from 42 cohorts worldwide. They found that age, amyloid-β status, presence of an APOE ε4 allele and female sex are key contributors to tau PET positivity, which should aid clinical decision-making and trial designs.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1610-1621"},"PeriodicalIF":20.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02000-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping human thalamocortical connectivity with electrical stimulation and recording","authors":"Dian Lyu, James Robert Stiger, Zoe Lusk, Vivek Buch, Josef Parvizi","doi":"10.1038/s41593-025-02009-x","DOIUrl":"10.1038/s41593-025-02009-x","url":null,"abstract":"The brain’s functional architecture is shaped by electrophysiological interactions between its components, encompassing both cortical and subcortical structures. In this study, we provide an atlas of electrophysiological causal connections across 4,864 brain sites in 27 human participants using repeated single-pulse electrical stimulations and recordings with intracranial electrodes implanted in cortical regions and multiple thalamic nuclei. We show distinct spectral signatures elicited by perturbations of specific brain areas. Identified features of causal connectivity exhibited highly organized yet distinct patterns, indicating that each feature may correspond to a separate mode of information transmission across brain regions. Notably, we report a new waveform with unique temporal and spatial characteristics specifically linked to thalamic stimulations, namely delayed-onset theta oscillations in both ipsilateral and contralateral cortical regions. These findings contribute to a more detailed understanding of the human brain’s functional architecture and offer valuable data for the development of biologically informed computational models. Intracranial stimulation maps human brain causal connectivity, uncovering distinct pathways. The authors show that thalamic pulses uniquely evoke delayed theta oscillations, offering new insights into the brain’s functional architecture.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1797-1809"},"PeriodicalIF":20.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease","authors":"Alberto Ardura-Fabregat, Lance Fredrick Pahutan Bosch, Emile Wogram, Omar Mossad, Roman Sankowski, Philipp Aktories, Lina Kieger, James Cook, Dilara Hasavci, Hatice Ulupinar, Daniel Brock, Fang Wang, Nicola Iovino, Samuel Wald, Sebastian Preissl, Bahtiyar Yilmaz, Daniel Schnepf, Andrew J. Macpherson, Thomas Blank, Katrin Kierdorf, Marco Prinz","doi":"10.1038/s41593-025-02006-0","DOIUrl":"10.1038/s41593-025-02006-0","url":null,"abstract":"Microglial spatial heterogeneity remains a crucial yet not fully answered question in the context of potential cell-directed therapies for Alzheimer’s disease (AD). There is an unclear understanding of the dynamics of distinct microglia states adjacent to or far from amyloid-beta (Aβ) plaques and their contributions to neurodegenerative diseases. Here we combine multicolor fluorescence cell fate mapping, single-cell transcriptional analysis, epigenetic profiling, immunohistochemistry and computational modeling to comprehensively characterize the relation of plaque-associated microglia (PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of AD. We show that non-PAM are a distinct and highly dynamic microglial state, transitioning to PAM after Aβ plaque deposition in female mice. Non-PAM modulate the cell population expansion in response to amyloid deposition and rapidly respond to environmental cues. Indeed, Csf1 signaling modulates non-PAM-to-PAM transition during disease progression. Our data suggest that microglia states and their dynamics between each other can have distinct contributions to disease, and they may be targeted for the treatment of AD. The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response to amyloid deposition, and Csf1 signaling regulates their transition to the amyloid-associated state.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1688-1703"},"PeriodicalIF":20.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02006-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An expanded subventricular zone supports postnatal cortical interneuron migration in gyrencephalic brains","authors":"JaeYeon Kim, Aunoy Poddar, Kadellyn Sandoval, Julia Chu, Emma Horton, Di Cui, Keira Nakamura, I-Ling Lu, Michael Mui, Theresa Bartels, Christian M. Wood, Susana I. Ramos, David H. Rowitch, Nadejda M. Tsankova, Hosung Kim, Chet C. Sherwood, Boris W. Kramer, Angela C. Roberts, Pablo J. Ross, Duan Xu, Nicola J. Robertson, Elizabeth A. Maga, Peng Ji, Mercedes F. Paredes","doi":"10.1038/s41593-025-01987-2","DOIUrl":"10.1038/s41593-025-01987-2","url":null,"abstract":"Cortical GABAergic interneurons generated in the ventral developing brain travel long distances to their final destinations. While there are examples of interneuron migration in the neonatal human brain, the extent of postnatal migration across species and how it contributes to cortical interneuron composition remains unknown. Here we demonstrate that neonatal gyrencephalic brains, including humans, nonhuman primates and piglets, harbor an elaborate subventricular zone, termed the Arc, due to its curved morphology and expanded neuroblast populations. The Arc is absent in lissencephalic marmoset and mouse brains. Transcriptomic and histological approaches revealed that Arc neurons are diverse interneurons from the medial and caudal ganglionic eminences that migrate into the frontal, cingulate and temporal cortex. Arc–cortical targets exhibit an increase in VIP+ neuronal density compared to other regions. Our findings reveal that the Arc is a developmental structure that supports the expansion of postnatal neuronal migration for cortical interneuron patterning in gyrencephalic brains. Neonatal gyrated brains harbor an elaborate subventricular zone, termed the Arc, supporting cortical migratory streams of diverse interneurons.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1598-1609"},"PeriodicalIF":20.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-01987-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Direct interactions between the human insula and hippocampus during memory encoding","authors":"Weichen Huang, Dian Lyu, James R. Stieger, Ian H. Gotlib, Vivek Buch, Anthony D. Wagner, Josef Parvizi","doi":"10.1038/s41593-025-02005-1","DOIUrl":"10.1038/s41593-025-02005-1","url":null,"abstract":"The hippocampus is critical for encoding episodic memories, but how it interacts with cortical regions during this process remains unclear. In this study, 16 participants with implanted electrodes in the insula (217 sites) and hippocampus (131 sites) viewed emotionally valenced words and attempted to recall them. During encoding, one subset of insular neuronal populations showed changes in aperiodic activity that predicted successful recall. These insular changes followed hippocampal theta but preceded hippocampal ripples. Another subset of insular sites responded to word valence, unrelated to memory performance. Direct electrical stimulation of memory-related insular sites evoked early responses in the ipsilateral hippocampus, whereas stimulation of valence-related sites did not. Conversely, stimulating hippocampal sites produced slow, variable signals across all insular sites, suggesting asymmetric communication between the hippocampus and the insula. These findings provide a glimpse of mesoscale hippocampal interactions with functionally selective neuronal populations within a given cortical structure. The hippocampus and insula communicate when processing emotional memories. Discrete sites in the human insular cortex showed changes that predicted later memory recall, while others responded to emotional content.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1763-1771"},"PeriodicalIF":20.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment","authors":"Tyler H. Ogunmowo, Christian Hoffmann, Chintan Patel, Renee Pepper, Han Wang, Sindhuja Gowrisankaran, Johanna Idel, Annie Ho, Sumana Raychaudhuri, Brady J. Maher, Benjamin H. Cooper, Ira Milosevic, Dragomir Milovanovic, Shigeki Watanabe","doi":"10.1038/s41593-025-02002-4","DOIUrl":"10.1038/s41593-025-02002-4","url":null,"abstract":"Following synaptic vesicle fusion, vacated release sites are replenished immediately by new vesicles for subsequent neurotransmission. These replacement vesicles are assumed to be located near release sites and used by chance. Here we find in mouse hippocampal excitatory synapses that replacement vesicles are clustered near the active zone where release sites reside by intersectin-1. Specifically, intersectin-1 forms dynamic molecular condensates with endophilin A1 and sequesters vesicles around this region. In the absence of intersectin-1, fewer vesicles cluster within 20 nm of the plasma membrane, and consequently vacated sites cannot be replenished rapidly, leading to synaptic depression. Mutations in intersectin-1 that disrupt endophilin A1 binding result in similar phenotypes. In the absence of endophilin A1, intersectin-1 is mislocalized, and this replacement pool of vesicles cannot be accessed, suggesting that endophilin A1 is needed to mobilize these vesicles. Thus, our work describes the replacement zone within a synapse, where replacement vesicles are stored for replenishment of the release site. Time-resolved electron microscopy reveals that intersectin-1 and endophilin A1 condensates hold replacement synaptic vesicles close to release sites. Without this, replacement vesicles are unavailable for immediate use, causing synaptic depression in response to stimulation trains.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1649-1662"},"PeriodicalIF":20.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-02002-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice","authors":"Ann Rose Bright, Yana Kotlyarenko, Florian Neuhaus, Diana Rodrigues, Chao Feng, Christian Peters, Ilaria Vitali, Elif Dönmez, Michael H. Myoga, Elena Dvoretskova, Christian Mayer","doi":"10.1038/s41593-025-01999-y","DOIUrl":"10.1038/s41593-025-01999-y","url":null,"abstract":"Diverse types of GABAergic projection neuron and interneurons of the telencephalon derive from progenitors in a ventral germinal zone called the ganglionic eminence. Using single-cell transcriptomics, chromatin accessibility profiling, lineage tracing, birthdating, transplantation across developmental stages and perturbation sequencing in mouse embryos, we investigated how progenitor competence influences the maturation and differentiation of these neurons. We found that the temporal progression of neurogenesis shapes maturation competence in ganglionic eminence progenitors, influencing how their progeny progress toward mature states. By contrast, differentiation competence—defined as the ability of progenitors to produce diverse transcriptomic identities—was maintained throughout neurogenesis. Chromatin remodeling, together with a regulatory module composed of the transcription factor NFIB and its target genes, influenced maturation competence in late-born neurons. These findings reveal how transcriptional programs and chromatin accessibility govern neuronal maturation and the diversification of GABAergic neuron subtypes during neurodevelopment. Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor maturation is gated by developmental timing, revealing a distinct regulatory logic underlying the development of inhibitory neurons.","PeriodicalId":19076,"journal":{"name":"Nature neuroscience","volume":"28 8","pages":"1663-1675"},"PeriodicalIF":20.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41593-025-01999-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}