糖衣炮弹

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-04-04 DOI:10.1038/s41593-025-01939-w

Shari Wiseman

引用次数: 0

摘要

衰老和神经退行性疾病通常涉及血脑屏障（BBB）功能障碍，导致脑血管渗漏。糖萼层是由蛋白聚糖、糖蛋白和糖脂组成的网状结构，它沿着血脑屏障管腔包裹着脑内皮细胞，从而形成血脑屏障和血液之间的界面。在《自然》杂志最近发表的一篇论文中，Shi等人描述了老龄（21个月）小鼠与幼龄（3个月）小鼠相比，脑血管中糖萼层的分解和细胞表面糖基化的变化。作者选择关注一种特定类型的与衰老相关的糖基化，粘蛋白O型糖基化，并发现其水平在老年小鼠的血管中降低。在幼龄小鼠中，酶促减少黏液O型糖基化降低了糖花苞层的厚度，增加了血脑屏障的通透性，破坏了紧密连接的形成，最终导致脑出血。相反，在Y迷宫和恐惧条件反射测试中，促进老年（17个月）小鼠黏液型O糖基化可降低血脑屏障通透性，提高学习和记忆表现。这些数据表明，脑血管糖萼层是衰老相关变性的重要部位，可能是恢复性治疗的靶点。原始参考文献：Nature https://www.nature.com/articles/s41586-025-08589-9 （2025）

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Sugar-coating the BBB

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.