Nature Materials最新文献_第7页

Memsensing by surface ion migration within Debye length 德拜长度内表面离子迁移的Memsensing

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02312-9

Ruihan Guo, Qixin Feng, Ke Ma, Gi-Hyeok Lee, Moniruzzaman Jamal, Xiao Zhao, Karen C. Bustillo, Jiawei Wan, Duncan S. Ritchie, Linbo Shan, Yuhang Cai, Jiachen Li, Jack Shen, Kaichen Dong, Ru Huang, Yimao Cai, Feng Wang, Miquel Salmeron, Haimei Zheng, Matthew Sherburne, Mary Scott, Wanli Yang, Mark Asta, Kechao Tang, Junqiao Wu

{"title":"Memsensing by surface ion migration within Debye length","authors":"Ruihan Guo, Qixin Feng, Ke Ma, Gi-Hyeok Lee, Moniruzzaman Jamal, Xiao Zhao, Karen C. Bustillo, Jiawei Wan, Duncan S. Ritchie, Linbo Shan, Yuhang Cai, Jiachen Li, Jack Shen, Kaichen Dong, Ru Huang, Yimao Cai, Feng Wang, Miquel Salmeron, Haimei Zheng, Matthew Sherburne, Mary Scott, Wanli Yang, Mark Asta, Kechao Tang, Junqiao Wu","doi":"10.1038/s41563-025-02312-9","DOIUrl":"https://doi.org/10.1038/s41563-025-02312-9","url":null,"abstract":"Integration between electronics and biology is often facilitated by iontronics, where ion migration in aqueous media governs sensing and memory. However, the Debye screening effect limits electric fields to the Debye length, the distance over which mobile ions screen electrostatic interactions, necessitating external voltages that constrain the operation speed and device design. Here we report a high-speed in-memory sensor based on vanadium dioxide (VO2) that operates without an external voltage by leveraging built-in electric fields within the Debye length. When VO2 contacts a low-work-function metal (for example, indium) in a salt solution, electrochemical reactions generate indium ions that migrate into the VO2 surface under the native electric field, inducing a surface insulator-to-metal phase transition of VO2. The VO2 conductance increase rate reflects the salt concentration, enabling in-memory sensing, or memsensing of the solution. The memsensor mimics Caenorhabditis elegans chemosensory plasticity to guide a miniature boat for adaptive chemotaxis, illustrating low-power aquatic neurorobotics with fewer memory units.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"30 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation 白蛋白募集脂质纳米颗粒通过避免肝脏积聚增强mRNA疫苗的安全性和有效性

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02284-w

Yunxuan Feng, Wanbo Tai, Pei Huang, Shaolong Qi, Xinyang Yu, Mengfei Li, Mengyao Li, Miya Zhang, Fangfang Cao, Xiaomin Gao, Kai Yang, Bing Bai, Jiaqi Lei, Meiqi Cheng, Yongcan Li, Gong Cheng, Xiaoyuan Chen, Guocan Yu

{"title":"Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation","authors":"Yunxuan Feng, Wanbo Tai, Pei Huang, Shaolong Qi, Xinyang Yu, Mengfei Li, Mengyao Li, Miya Zhang, Fangfang Cao, Xiaomin Gao, Kai Yang, Bing Bai, Jiaqi Lei, Meiqi Cheng, Yongcan Li, Gong Cheng, Xiaoyuan Chen, Guocan Yu","doi":"10.1038/s41563-025-02284-w","DOIUrl":"https://doi.org/10.1038/s41563-025-02284-w","url":null,"abstract":"The advent of mRNA vaccines represents a breakthrough in the realm of cancer therapy and the prevention of infectious disease. Nevertheless, traditional lipid nanoparticle (LNP)-based mRNA vaccines can accumulate in the liver post-intramuscular injection, posing a risk of hepatotoxicity and reducing efficacy. Here we develop an albumin-recruiting LNP system with high lymphatic drainage and no accumulation in hepatic tissue to potentiate the efficacy and safety of mRNA vaccines. We construct a library of ionizable lipids with albumin-binding capacity as alternatives to traditional polyethylene-glycol-conjugated lipid. We identify an Evans blue-modified lipid-based LNP (EB-LNP) formulation that shows high in vivo expression, albumin-facilitated transport through intramuscular lymphatic vessels to the lymph nodes, high internalization by dendritic cells and low penetration into intramuscular blood vessels, thereby avoiding liver accumulation. EB-LNP-based mRNA vaccines demonstrate excellent antitumour and antiviral efficacy, resulting in strong cellular and humoral immune responses, including the robust activation of cytotoxic T lymphocytes and production of neutralizing antibodies post-vaccination. Overall, this system shows promise as an effective and minimally toxic platform for the development of mRNA vaccines with high efficacy and safety.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"98 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bond-centric modular design of protein assemblies 以键为中心的蛋白质组件模块化设计

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-31 DOI: 10.1038/s41563-025-02297-5

Shunzhi Wang, Andrew Favor, Ryan D. Kibler, Joshua M. Lubner, Andrew J. Borst, Nicolas Coudray, Rachel L. Redler, Huat Thart Chiang, William Sheffler, Yang Hsia, Neville P. Bethel, Zhe Li, Damian C. Ekiert, Gira Bhabha, Lilo D. Pozzo, David Baker

{"title":"Bond-centric modular design of protein assemblies","authors":"Shunzhi Wang, Andrew Favor, Ryan D. Kibler, Joshua M. Lubner, Andrew J. Borst, Nicolas Coudray, Rachel L. Redler, Huat Thart Chiang, William Sheffler, Yang Hsia, Neville P. Bethel, Zhe Li, Damian C. Ekiert, Gira Bhabha, Lilo D. Pozzo, David Baker","doi":"10.1038/s41563-025-02297-5","DOIUrl":"10.1038/s41563-025-02297-5","url":null,"abstract":"Directional interactions that generate regular coordination geometries are a powerful means of guiding molecular and colloidal self-assembly, but implementing such high-level interactions with proteins remains challenging due to their complex shapes and intricate interface properties. Here we describe a modular approach to protein nanomaterial design inspired by the rich chemical diversity that can be generated from the small number of atomic valencies. We design protein building blocks using deep learning-based generative tools, incorporating regular coordination geometries and tailorable bonding interactions that enable the assembly of diverse closed and open architectures guided by simple geometric principles. Experimental characterization confirms the successful formation of more than 20 multicomponent polyhedral protein cages, two-dimensional arrays and three-dimensional protein lattices, with a high (10%–50%) success rate and electron microscopy data closely matching the corresponding design models. Due to modularity, individual building blocks can assemble with different partners to generate distinct regular assemblies, resulting in an economy of parts and enabling the construction of reconfigurable networks for designer nanomaterials. Deep learning-based generative tools are used to design protein building blocks with well-defined directional bonding interactions, allowing the generation of a variety of scalable protein assemblies from a small set of reusable subunits.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 10","pages":"1644-1652"},"PeriodicalIF":38.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41563-025-02297-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flatland wakes based on leaky hyperbolic polaritons 基于泄漏双曲极化的平坦尾迹

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-31 DOI: 10.1038/s41563-025-02280-0

Na Chen, Hanchao Teng, Hai Hu, Min Liu, Chengyu Jiang, Zhuoxin Xue, Hualong Zhu, Jiayi Gui, Peining Li, Andrea Alù, Qing Dai

{"title":"Flatland wakes based on leaky hyperbolic polaritons","authors":"Na Chen, Hanchao Teng, Hai Hu, Min Liu, Chengyu Jiang, Zhuoxin Xue, Hualong Zhu, Jiayi Gui, Peining Li, Andrea Alù, Qing Dai","doi":"10.1038/s41563-025-02280-0","DOIUrl":"10.1038/s41563-025-02280-0","url":null,"abstract":"Hyperbolic polaritons facilitate nanoscale light manipulation, but strong field confinement limits their transmission across interfaces. Conversely, leaky waves can convert radiation from confined sources towards the far field. Here we combine hyperbolic polaritons and leaky wave radiation to demonstrate flatland leaky polaritonic wakes. We employ a mixed-dimensional van der Waals heterostructure consisting of a nanoscale waveguide strip on a van der Waals film. The waveguide mode, confined inside the hyperbolic light cone of the background film, enables efficient directional in-plane emission of fast phonon polaritons. The constructive interference of these leaky polaritons generates highly directional polaritonic wakes. Their spatial symmetry can be tailored through the orientation of the heterostructure with respect to the hyperbolic film dispersion. Leveraging van der Waals stacking, we also demonstrate effective acceleration and deceleration of polaritonic wakes by locally tailoring the leaky nano-waveguide dispersion through gradient thickness design. Our findings demonstrate that polaritonic wakes hold promise for integrated nanophotonic circuits. The authors combine the strong confinement of hyperbolic polaritons with leaky nano-waveguides to demonstrate directional in-plane emission of fast phonon polaritons and their acceleration and deceleration by tailoring waveguide dispersion.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 10","pages":"1569-1575"},"PeriodicalIF":38.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational design of bifaceted protein nanomaterials 二维蛋白质纳米材料的计算设计

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-31 DOI: 10.1038/s41563-025-02295-7

Sanela Rankovic, Kenneth D. Carr, Justin Decarreau, Rebecca Skotheim, Ryan D. Kibler, Sebastian Ols, Sangmin Lee, Jung-Ho Chun, Marti R. Tooley, Justas Dauparas, Helen E. Eisenach, Matthias Glögl, Connor Weidle, Andrew J. Borst, David Baker, Neil P. King

{"title":"Computational design of bifaceted protein nanomaterials","authors":"Sanela Rankovic, Kenneth D. Carr, Justin Decarreau, Rebecca Skotheim, Ryan D. Kibler, Sebastian Ols, Sangmin Lee, Jung-Ho Chun, Marti R. Tooley, Justas Dauparas, Helen E. Eisenach, Matthias Glögl, Connor Weidle, Andrew J. Borst, David Baker, Neil P. King","doi":"10.1038/s41563-025-02295-7","DOIUrl":"10.1038/s41563-025-02295-7","url":null,"abstract":"Advances in computational methods have led to considerable progress in the design of protein nanomaterials. However, nearly all nanoparticles designed so far exhibit strict point group symmetry, which limits structural diversity and precludes anisotropic functionalization. Here we describe a computational strategy for designing multicomponent bifaceted protein nanomaterials with two distinctly addressable sides. The method centres on docking pseudosymmetric hetero-oligomeric building blocks in architectures with dihedral symmetry and designing an asymmetric protein–protein interface between them. We obtain an initial 30-subunit assembly with pseudo-D5 symmetry and generate variants in which we alter the size and morphology of the bifaceted nanoparticles by designing extensions to one of the subunits. Functionalization of the two nanoparticle faces with protein minibinders enables the specific colocalization of two populations of polystyrene microparticles coated with the target protein receptors. The ability to accurately design anisotropic protein nanoparticles could be broadly useful in applications requiring the colocalization of distinct target moieties. Predictive protein design and experiments are combined to develop anisotropic bifaceted protein nanomaterials using pseudosymmetric hetero-oligomeric building blocks.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 10","pages":"1635-1643"},"PeriodicalIF":38.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41563-025-02295-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amorphous chalcogenides in two dimensions 二维无定形硫族化合物

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-30 DOI: 10.1038/s41563-025-02291-x

Volker L. Deringer

引用次数: 0

Publisher Correction: Highly reversible extrinsic electrocaloric effects over a wide temperature range in epitaxially strained SrTiO3 films 出版者更正：外延应变SrTiO3薄膜在宽温度范围内的高度可逆的外部电热效应

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-30 DOI: 10.1038/s41563-025-02321-8

S. Zhang, J. Deliyore-Ramírez, S. Deng, B. Nair, D. Pesquera, Q. Jing, M. E. Vickers, S. Crossley, M. Ghidini, S. Kar-Narayan, G. G. Guzmán-Verri, X. Moya, N. D. Mathur

引用次数: 0

Making data openly available 公开提供数据

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-30 DOI: 10.1038/s41563-025-02318-3

引用次数: 0

Achieving small singlet–triplet energy gaps in polycyclic heteroaromatic emitters 在多环杂芳烃发射体中实现小的单重态-三重态能隙

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-25 DOI: 10.1038/s41563-025-02309-4

Rajat Walia, Xin Xiong, Xiao-Chun Fan, Ting-Feng Chen, Hui Wang, Kai Wang, Yi-Zhong Shi, Xun Tang, Jean-Luc Bredas, Chihaya Adachi, Xian-Kai Chen, Xiao-Hong Zhang

{"title":"Achieving small singlet–triplet energy gaps in polycyclic heteroaromatic emitters","authors":"Rajat Walia, Xin Xiong, Xiao-Chun Fan, Ting-Feng Chen, Hui Wang, Kai Wang, Yi-Zhong Shi, Xun Tang, Jean-Luc Bredas, Chihaya Adachi, Xian-Kai Chen, Xiao-Hong Zhang","doi":"10.1038/s41563-025-02309-4","DOIUrl":"10.1038/s41563-025-02309-4","url":null,"abstract":"In polycyclic heteroaromatic (PHA) emitters, which possess great potential for application in ultrahigh-definition displays, the origin of a small singlet–triplet energy gap (ΔES1T1) and its relationship with the molecular structure still remain poorly established. Here we derive an effective expression for ΔES1T1, in which ΔES1T1 positively depends on 2KHL (where KHL is the exchange energy between the highest occupied molecular orbital and the lowest unoccupied molecular orbital (LUMO)) and on the energy gap between LUMO and LUMO + 1 (ΔELUMO–LUMO+1). This expression for ΔES1T1 is validated over a series of 100 reported PHA emitters. It allows us to easily identify various molecular design approaches for managing ΔES1T1 by synergistically regulating 2KHL and ΔELUMO–LUMO+1. The proof-of-concept PHA molecules were synthesized and characterized to further confirm the validity of this expression for ΔES1T1. Overall, our work provides a physical picture to not only modulate ΔES1T1 in emerging PHA emitters but also design and screen such materials with small ΔES1T1. Insight into the singlet–triplet energy gap and molecular structure relationship in polycyclic heteroaromatic molecules enables organic light-emitting diodes based on multiresonance thermally activated delayed fluorescence, with improved efficiency and roll-off.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 10","pages":"1576-1583"},"PeriodicalIF":38.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Observation of non-Hermitian topology from optical loss modulation 光损耗调制的非厄米拓扑观察

IF 38.5 1区材料科学

Nature Materials Pub Date : 2025-07-23 DOI: 10.1038/s41563-025-02278-8

Amin Hashemi, Elizabeth Louis Pereira, Hongwei Li, Jose L. Lado, Andrea Blanco-Redondo

{"title":"Observation of non-Hermitian topology from optical loss modulation","authors":"Amin Hashemi, Elizabeth Louis Pereira, Hongwei Li, Jose L. Lado, Andrea Blanco-Redondo","doi":"10.1038/s41563-025-02278-8","DOIUrl":"10.1038/s41563-025-02278-8","url":null,"abstract":"Understanding the interplay of non-Hermiticity and topology is crucial given the intrinsic openness of most natural and engineered systems, and has important ramifications in topological lasers and sensors. Recently, it has been theoretically proposed that topological features could originate solely from a system’s non-Hermiticity in photonic platforms. Here we experimentally demonstrate the appearance of non-Hermitian topology exclusively from loss modulation in a photonic system that is topologically trivial in the absence of loss. We do this by implementing a non-Hermitian generalization of an Aubry–André–Harper model with purely imaginary potential in a programmable integrated photonics platform, which allows us to investigate different periodic and quasiperiodic configurations of the model. In both cases, we show the emergence of topological edge modes and explore their resilience to different kinds of disorder. Our work highlights loss engineering as a mechanism to generate topological properties. Using a reconfigurable integrated photonic platform, the authors reveal the appearance of non-Hermitian topology and the existence of edge modes emerging exclusively from optical loss modulation.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 9","pages":"1393-1399"},"PeriodicalIF":38.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0