Nature Materials最新文献_第8页

Bioinstructive scaffolds enhance stem cell engraftment for functional tissue regeneration 生物指导性支架促进干细胞植入功能组织再生

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-17 DOI: 10.1038/s41563-025-02212-y

Di Wu, Ioannis Eugenis, Caroline Hu, Soochi Kim, Abhijnya Kanugovi, Shouzheng Yue, Joshua R. Wheeler, Iman Fathali, Sonali Feeley, Joseph B. Shrager, Ngan F. Huang, Thomas A. Rando

{"title":"Bioinstructive scaffolds enhance stem cell engraftment for functional tissue regeneration","authors":"Di Wu, Ioannis Eugenis, Caroline Hu, Soochi Kim, Abhijnya Kanugovi, Shouzheng Yue, Joshua R. Wheeler, Iman Fathali, Sonali Feeley, Joseph B. Shrager, Ngan F. Huang, Thomas A. Rando","doi":"10.1038/s41563-025-02212-y","DOIUrl":"https://doi.org/10.1038/s41563-025-02212-y","url":null,"abstract":"Stem cell therapy is a promising approach for tissue regeneration after traumatic injury, yet current applications are limited by inadequate control over the fate of stem cells after transplantation. Here we introduce a bioconstruct engineered for the staged release of growth factors, tailored to direct different phases of muscle regeneration. The bioconstruct is composed of a decellularized extracellular matrix containing polymeric nanocapsules sequentially releasing basic fibroblast growth factor and insulin-like growth factor 1, which promote the proliferation and differentiation of muscle stem cells, respectively. When applied to a volumetric muscle loss defect in an animal model, the bioconstruct enhances myofibre formation, angiogenesis, innervation and functional restoration. Further, it promotes functional muscle formation with human or aged murine muscle stem cells, highlighting the translational potential of this bioconstruct. Overall, these results highlight the potential of bioconstructs with orchestrated growth factor release for stem cell therapies in traumatic injury.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"16 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune-compatible designs of semiconducting polymers for bioelectronics with suppressed foreign-body response 抑制异物反应的生物电子学用半导体聚合物的免疫兼容设计

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-17 DOI: 10.1038/s41563-025-02213-x

Nan Li, Seounghun Kang, Zhichang Liu, Shinya Wai, Zhe Cheng, Yahao Dai, Ani Solanki, Songsong Li, Yang Li, Joseph Strzalka, Michael J. V. White, Yun-Hi Kim, Bozhi Tian, Jeffrey A. Hubbell, Sihong Wang

{"title":"Immune-compatible designs of semiconducting polymers for bioelectronics with suppressed foreign-body response","authors":"Nan Li, Seounghun Kang, Zhichang Liu, Shinya Wai, Zhe Cheng, Yahao Dai, Ani Solanki, Songsong Li, Yang Li, Joseph Strzalka, Michael J. V. White, Yun-Hi Kim, Bozhi Tian, Jeffrey A. Hubbell, Sihong Wang","doi":"10.1038/s41563-025-02213-x","DOIUrl":"https://doi.org/10.1038/s41563-025-02213-x","url":null,"abstract":"One of the greatest obstacles to achieving implantable electronics with long-term functionality and minimized inflammatory reactions is the immune-mediated foreign-body response (FBR). Recently, semiconducting polymers with mixed electron–ion conductivity have been demonstrated as promising candidates to achieve direct electrical interfacing on bio-tissues. However, there is limited understanding of their immune compatibility in vivo, and strategies for minimizing the FBR through molecular design remain underexplored. Here we introduce a set of molecular design strategies for enhancing the immune compatibility of semiconducting polymers. Specifically, we show that selenophene, when incorporated in the backbone, can mitigate the FBR by suppressing macrophage activation. In addition, side-chain functionalization with immunomodulatory groups decreases the FBR further by downregulating the expression of inflammatory biomarkers. Together, our synthesized polymers achieve suppression of the FBR by as much as 68% (as indicated by the collagen density). In the meantime, these immune-compatible designs still provide a high charge-carrier mobility of around 1 cm2 V−1 s−1. We anticipate that such immune-compatible design principles can be translated to a variety of conjugated polymers to suppress the FBR for implantable applications.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"22 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skyrmion nanodomains in ferroelectric–antiferroelectric solid solutions 铁电-反铁电固溶体中的Skyrmion纳米畴

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-15 DOI: 10.1038/s41563-025-02216-8

Weijie Zheng, Xingyue Ma, Zhentao Pang, Yifeng Ren, Hongying Chen, Jibo Xu, Chunyan Zheng, Jianyi Liu, Xiaohui Liu, Yu Deng, Yuefeng Nie, Di Wu, Laurent Bellaiche, Yurong Yang, Zheng Wen

{"title":"Skyrmion nanodomains in ferroelectric–antiferroelectric solid solutions","authors":"Weijie Zheng, Xingyue Ma, Zhentao Pang, Yifeng Ren, Hongying Chen, Jibo Xu, Chunyan Zheng, Jianyi Liu, Xiaohui Liu, Yu Deng, Yuefeng Nie, Di Wu, Laurent Bellaiche, Yurong Yang, Zheng Wen","doi":"10.1038/s41563-025-02216-8","DOIUrl":"https://doi.org/10.1038/s41563-025-02216-8","url":null,"abstract":"Polar skyrmions have demonstrated rich physics and exotic properties for developing novel functionalities. However, so far, skyrmion nanodomains exist only in a few material systems, such as ferroelectric/dielectric superlattices, free-standing PbTiO3/SrTiO3 epitaxial bilayers and ultrathin Pb(Zr,Ti)O3/SrTiO3/Pb(Zr,Ti)O3 sandwiches. These heterostructures are fabricated with elaborately designed boundary conditions to meet the delicate energy balance for stabilizing topological phases. This requirement limits the broad applications of skyrmions in electronic devices. Here we show widespread skyrmion nanodomains in ferroelectric–antiferroelectric solid solutions, composed of ferroelectric PbTiO3 and one antiferroelectric PbSnO3 (Pb(Ti1–xSnx)O3), PbHfO3 (Pb(Ti1–xHfx)O3) or PbZrO3 (Pb(Ti1–xZrx)O3). The skyrmionic textures are formed by engineering dipole–dipole and antiferrodistortive–dipole couplings in competition between ferroelectric and antiferroelectric polar orderings, allowing the stabilization of topological phases. A phase diagram is built for the three solid solution series, revealing the stabilization regions of skyrmion nanodomains. In addition, the non-trivial domains also exhibit improved switching character, reversible writing/erasure and long-term retention for the electrical manipulation of polar configurations. These findings open an avenue for the investigation and exploitation of polar skyrmions in ferroelectric-based materials, providing opportunities in topological electronics.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"26 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Locating dislocations in organic crystals 定位有机晶体中的位错

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-11 DOI: 10.1038/s41563-025-02203-z

Oliver Lin, Zhichu Tang, Qian Chen

引用次数: 0

Shedding light on quantum geometry 揭示量子几何

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-10 DOI: 10.1038/s41563-025-02172-3

Praveen Pai, Fan Zhang

引用次数: 0

A non-fullerene acceptor for perovskites 过氧化物的非富勒烯受体

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-10 DOI: 10.1038/s41563-025-02189-8

Ahmed Ali Said, Stefaan De Wolf

引用次数: 0

Bridging the gap between precatalysts and electrocatalysts 弥合了预催化剂和电催化剂之间的差距

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-10 DOI: 10.1038/s41563-025-02210-0

Tristan Asset

引用次数: 0

DNA photofluids show life-like motion DNA光流体显示出类似生命的运动

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-09 DOI: 10.1038/s41563-025-02202-0

Qi-Hong Zhao, Jin-Ying Qi, Nan-Nan Deng

{"title":"DNA photofluids show life-like motion","authors":"Qi-Hong Zhao, Jin-Ying Qi, Nan-Nan Deng","doi":"10.1038/s41563-025-02202-0","DOIUrl":"https://doi.org/10.1038/s41563-025-02202-0","url":null,"abstract":"As active matter, cells exhibit non-equilibrium structures and behaviours such as reconfiguration, motility and division. These capabilities arise from the collective action of biomolecular machines continuously converting photoenergy or chemical energy into mechanical energy. Constructing similar dynamic processes in vitro presents opportunities for developing life-like intelligent soft materials. Here we report an active fluid formed from the liquid–liquid phase separation of photoresponsive DNA nanomachines. The photofluids can orchestrate and amplify nanoscale mechanical movements by orders of magnitude to produce macroscopic cell-like behaviours including elongation, division and rotation. We identify two dissipative processes in the DNA droplets, photoalignment and photofibrillation, which are crucial for harnessing stochastic molecular motions cooperatively. Our results demonstrate an active liquid molecular system that consumes photoenergy to create ordered out-of-equilibrium structures and behaviours. This system may help elucidate the physical principles underlying cooperative motion in active matter and pave the way for developing programmable interactive materials.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"96 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced energy storage in high-entropy ferroelectric polymers 增强高熵铁电聚合物的储能能力

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-09 DOI: 10.1038/s41563-025-02211-z

Chenyi Li, Yang Liu, Bo Li, Ze Yuan, Tiannan Yang, Yuquan Liu, Hanxiao Gao, Linxiao Xu, Xiang Yu, Quan Luo, Shengfei Tang, Minghai Yao, Yutie Gong, Zekai Fei, Long-Qing Chen, Haibo Zhang, Huamin Zhou, Qing Wang

{"title":"Enhanced energy storage in high-entropy ferroelectric polymers","authors":"Chenyi Li, Yang Liu, Bo Li, Ze Yuan, Tiannan Yang, Yuquan Liu, Hanxiao Gao, Linxiao Xu, Xiang Yu, Quan Luo, Shengfei Tang, Minghai Yao, Yutie Gong, Zekai Fei, Long-Qing Chen, Haibo Zhang, Huamin Zhou, Qing Wang","doi":"10.1038/s41563-025-02211-z","DOIUrl":"https://doi.org/10.1038/s41563-025-02211-z","url":null,"abstract":"Relaxor ferroelectrics have been intensively studied during the past two decades for capacitive energy storage in modern electronics and electrical power systems. However, the energy density of relaxor ferroelectrics is fundamentally limited by early polarization saturation and largely reduced polarization despite high dielectric constants. To overcome this challenge, here we report the formation of a high-entropy superparaelectric phase in relaxor ferroelectric polymers induced by low-dose proton irradiation, which exhibits delayed polarization saturation, reduced ferroelectric loss and markedly improved polarizability. Our combined theoretical and experimental results reveal that new chemical bonds generated by the irradiation-induced chemical reactions are essential to the formation of the high-entropy state in ferroelectric polymers. The high-entropy superparaelectric phase endows the polymer with a substantially enhanced intrinsic energy density of 45.7 J cm–3 at room temperature, outperforming the current ferroelectric polymers and nanocomposites under the same electric field. Our work widens the high-entropy concept in ferroelectrics and lays the foundation for the future exploration of high-performance ferroelectric polymers.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"21 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spin chains enter their heavy-metal phase 自旋链进入重金属阶段

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-04-08 DOI: 10.1038/s41563-025-02208-8

Joel E. Moore

引用次数: 0