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Microscopic crystallographic analysis of dislocations in molecular crystals
IF 41.2 1区 材料科学
Nature Materials Pub Date : 2025-03-03 DOI: 10.1038/s41563-025-02138-5
Sang T. Pham, Natalia Koniuch, Emily Wynne, Andy Brown, Sean M. Collins
{"title":"Microscopic crystallographic analysis of dislocations in molecular crystals","authors":"Sang T. Pham, Natalia Koniuch, Emily Wynne, Andy Brown, Sean M. Collins","doi":"10.1038/s41563-025-02138-5","DOIUrl":"https://doi.org/10.1038/s41563-025-02138-5","url":null,"abstract":"<p>Organic molecular crystals encompass a vast range of materials from pharmaceuticals to organic optoelectronics, proteins and waxes in biological and industrial settings. Crystal defects from grain boundaries to dislocations are known to play key roles in mechanisms of growth<sup>1,2</sup> and in the functional properties of molecular crystals<sup>3,4,5</sup>. In contrast to the precise analysis of individual defects in metals, ceramics and inorganic semiconductors enabled by electron microscopy, substantially greater ambiguity remains in the experimental determination of individual dislocation character and slip systems in molecular materials<sup>3</sup>. In large part, nanoscale dislocation analysis in molecular crystals has been hindered by the low electron doses required to avoid irreversibly degrading these crystals<sup>6</sup>. Here we present a low-dose, single-exposure approach enabling nanometre-resolved analysis of individual dislocations in molecular crystals. We demonstrate the approach for a range of crystal types to reveal dislocation character and operative slip systems unambiguously.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"10 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A dynamic view of frozen excitons
IF 37.2 1区 材料科学
Nature Materials Pub Date : 2025-03-03 DOI: 10.1038/s41563-025-02174-1
Nadine Leisgang, Andrés M. Mier Valdivia
{"title":"A dynamic view of frozen excitons","authors":"Nadine Leisgang,&nbsp;Andrés M. Mier Valdivia","doi":"10.1038/s41563-025-02174-1","DOIUrl":"10.1038/s41563-025-02174-1","url":null,"abstract":"Moiré superlattices formed from semiconducting transition metal dichalcogenides have become an exciting platform for visualizing Hubbard physics in hybrid fermionic and bosonic systems.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 4","pages":"476-477"},"PeriodicalIF":37.2,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics
IF 41.2 1区 材料科学
Nature Materials Pub Date : 2025-02-28 DOI: 10.1038/s41563-024-02116-3
Yufen Xiao, Xizhen Lian, Yehui Sun, Yun-Chieh Sung, Amogh Vaidya, Zexiang Chen, Ankit Gupta, Sumanta Chatterjee, Lining Zheng, Erick Guerrero, Xu Wang, Lukas Farbiak, Yangyang Yang, Marc I. Diamond, Cecilia Leal, Jeffrey G. McDonald, Daniel J. Siegwart
{"title":"High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics","authors":"Yufen Xiao, Xizhen Lian, Yehui Sun, Yun-Chieh Sung, Amogh Vaidya, Zexiang Chen, Ankit Gupta, Sumanta Chatterjee, Lining Zheng, Erick Guerrero, Xu Wang, Lukas Farbiak, Yangyang Yang, Marc I. Diamond, Cecilia Leal, Jeffrey G. McDonald, Daniel J. Siegwart","doi":"10.1038/s41563-024-02116-3","DOIUrl":"https://doi.org/10.1038/s41563-024-02116-3","url":null,"abstract":"<p>Messenger RNA lipid-nanoparticle-based therapies represent an emerging class of medicines for a variety of applications. However, anti-poly(ethylene glycol) (anti-PEG) antibodies generated by widely used PEGylated medicines and lipid nanoparticles hinder therapeutic efficacy upon repeated dosing. Here we report the chemical design, synthesis and optimization of high-density brush-shaped polymer lipids that reduce anti-PEG antibody binding to improve protein production consistency in repeated dosing. Brush-shaped polymer lipid parameters, including side chain length, degree of polymerization, anchor alkyl length and surface regimes on lipid nanoparticles modulate anti-PEG antibody binding affinity and control their blood circulation pharmacokinetics. Compared to widely used 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, lipid nanoparticles containing brush-shaped polymer lipids generate superior therapeutic outcomes in protein replacement therapy and genome editing models, reformulating structure–activity guidelines for the design of PEG lipid substitutes. Overall, these findings contribute to the general effort in the development of lipid nanoparticles with low immunogenicity to overcome current roadblocks to nucleic acid medicines.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"32 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Operando-informed precatalyst programming towards reliable high-current-density electrolysis
IF 41.2 1区 材料科学
Nature Materials Pub Date : 2025-02-28 DOI: 10.1038/s41563-025-02128-7
Lu Xia, Bruna Ferreira Gomes, Wulyu Jiang, Daniel Escalera-López, Yang Wang, Yang Hu, Alaa Y. Faid, Kaiwen Wang, Tengyu Chen, Kaiqi Zhao, Xu Zhang, Yingtang Zhou, Ranit Ram, Barbara Polesso, Anku Guha, Jiaqi Su, Carlos M. S. Lobo, Michael Haumann, Robert Spatschek, Svein Sunde, Lin Gan, Ming Huang, Xiaoyuan Zhou, Christina Roth, Werner Lehnert, Serhiy Cherevko, Liyong Gan, F. Pelayo García de Arquer, Meital Shviro
{"title":"Operando-informed precatalyst programming towards reliable high-current-density electrolysis","authors":"Lu Xia, Bruna Ferreira Gomes, Wulyu Jiang, Daniel Escalera-López, Yang Wang, Yang Hu, Alaa Y. Faid, Kaiwen Wang, Tengyu Chen, Kaiqi Zhao, Xu Zhang, Yingtang Zhou, Ranit Ram, Barbara Polesso, Anku Guha, Jiaqi Su, Carlos M. S. Lobo, Michael Haumann, Robert Spatschek, Svein Sunde, Lin Gan, Ming Huang, Xiaoyuan Zhou, Christina Roth, Werner Lehnert, Serhiy Cherevko, Liyong Gan, F. Pelayo García de Arquer, Meital Shviro","doi":"10.1038/s41563-025-02128-7","DOIUrl":"https://doi.org/10.1038/s41563-025-02128-7","url":null,"abstract":"<p>Electrocatalysts support crucial industrial processes and emerging decarbonization technologies, but their design is hindered by structural and compositional changes during operation, especially at application-relevant current densities. Here we use operando X-ray spectroscopy and modelling to track, and eventually direct, the reconstruction of iron sulfides and oxides for the oxygen evolution reaction. We show that inappropriate activation protocols lead to uncontrollable Fe oxidation and irreversible catalyst degradation, compromising stability and reliability and precluding predictive design. Based on these, we develop activation programming strategies that, considering the thermodynamics and kinetics of surface reconstruction, offer control over precatalyst oxidation. This enables reliable predictions and the design of active and stable electrocatalysts. In a Ni<sub><i>x</i></sub>Fe<sub>1−<i>x</i></sub>S<sub>2</sub> model system, this leads to a threefold improvement in durability after programmed activation, with a cell degradation rate of 0.12 mV h<sup>−</sup><sup>1</sup> over 550 h (standard operation: 0.29 mV h<sup>−</sup><sup>1</sup>, constrained to 200 h), in an anion exchange membrane water electrolyser operating at 1 A cm<sup>−</sup><sup>2</sup>. This work bridges predictive modelling and experimental design, improving the electrocatalyst reliability for industrial water electrolysis and beyond at high current densities.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"85 3 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High electrostrain due to a chemopiezoelectric effect
IF 37.2 1区 材料科学
Nature Materials Pub Date : 2025-02-26 DOI: 10.1038/s41563-025-02149-2
Dragan Damjanovic
{"title":"High electrostrain due to a chemopiezoelectric effect","authors":"Dragan Damjanovic","doi":"10.1038/s41563-025-02149-2","DOIUrl":"10.1038/s41563-025-02149-2","url":null,"abstract":"Hopping of oxygen vacancies under an alternating field generates a large and robust electrostrain in lead-free piezoelectrics.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 4","pages":"484-486"},"PeriodicalIF":37.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rapid self-strengthening in double-network hydrogels triggered by bond scission
IF 37.2 1区 材料科学
Nature Materials Pub Date : 2025-02-26 DOI: 10.1038/s41563-025-02137-6
Zhi Jian Wang, Wei Li, Xueyu Li, Tasuku Nakajima, Michael Rubinstein, Jian Ping Gong
{"title":"Rapid self-strengthening in double-network hydrogels triggered by bond scission","authors":"Zhi Jian Wang,&nbsp;Wei Li,&nbsp;Xueyu Li,&nbsp;Tasuku Nakajima,&nbsp;Michael Rubinstein,&nbsp;Jian Ping Gong","doi":"10.1038/s41563-025-02137-6","DOIUrl":"10.1038/s41563-025-02137-6","url":null,"abstract":"The scission of chemical bonds in materials can lead to catastrophic failure, with weak bonds typically undermining the materials’ strength. Here we demonstrate how weak bonds can be leveraged to achieve self-strengthening in polymer network materials. These weak sacrificial bonds trigger mechanochemical reactions, forming new networks rapidly enough to reinforce the material during deformation and significantly improve crack resistance. This rapid strengthening exhibits strong rate dependence, dictated by the interplay between bond breaking and the kinetics of force-induced network formation. As the network formation is generally applicable to diverse monomers and crosslinkers with different kinetics, a wide range of mechanical properties can be obtained. These findings may inspire the design of tough polymer materials with on-demand, rate-dependent mechanical behaviours through mechanochemistry, broadening their applications across various fields. Weak bonds enable self-strengthening in polymers by triggering mechanochemical reactions during deformation, forming new networks that enhance strength and crack resistance. This rate-dependent process allows custom design of tough polymers.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 4","pages":"607-614"},"PeriodicalIF":37.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High electrostrain in a lead-free piezoceramic from a chemopiezoelectric effect
IF 37.2 1区 材料科学
Nature Materials Pub Date : 2025-02-26 DOI: 10.1038/s41563-024-02092-8
Ze Xu, Xiaoming Shi, Yi-Xuan Liu, Danyang Wang, Hao-Cheng Thong, Yuqi Jiang, Zijie Sha, Zhao Li, Fang-Zhou Yao, Xian-Xian Cai, Hao-Feng Huang, Zhanpeng Xu, Xinyu Jin, Chen-Bo-Wen Li, Xin Zhang, Xiaowei Ren, Zhihao Dong, Chaofeng Wu, Peter Kabakov, Fangyuan Zhu, Feng Chen, Peng Tan, Hao Tian, Haozhi Sha, Rong Yu, Ben Xu, Wen Gong, Xiaohui Wang, Jing-Feng Li, Stephen J. Skinner, Ming Li, Houbing Huang, Shujun Zhang, Ke Wang
{"title":"High electrostrain in a lead-free piezoceramic from a chemopiezoelectric effect","authors":"Ze Xu,&nbsp;Xiaoming Shi,&nbsp;Yi-Xuan Liu,&nbsp;Danyang Wang,&nbsp;Hao-Cheng Thong,&nbsp;Yuqi Jiang,&nbsp;Zijie Sha,&nbsp;Zhao Li,&nbsp;Fang-Zhou Yao,&nbsp;Xian-Xian Cai,&nbsp;Hao-Feng Huang,&nbsp;Zhanpeng Xu,&nbsp;Xinyu Jin,&nbsp;Chen-Bo-Wen Li,&nbsp;Xin Zhang,&nbsp;Xiaowei Ren,&nbsp;Zhihao Dong,&nbsp;Chaofeng Wu,&nbsp;Peter Kabakov,&nbsp;Fangyuan Zhu,&nbsp;Feng Chen,&nbsp;Peng Tan,&nbsp;Hao Tian,&nbsp;Haozhi Sha,&nbsp;Rong Yu,&nbsp;Ben Xu,&nbsp;Wen Gong,&nbsp;Xiaohui Wang,&nbsp;Jing-Feng Li,&nbsp;Stephen J. Skinner,&nbsp;Ming Li,&nbsp;Houbing Huang,&nbsp;Shujun Zhang,&nbsp;Ke Wang","doi":"10.1038/s41563-024-02092-8","DOIUrl":"10.1038/s41563-024-02092-8","url":null,"abstract":"Piezoelectric materials are indispensable in electromechanical actuators, which require a large electrostrain with a fast and precise response. By designing a chemopiezoelectric effect, we developed an approach to achieve a high electrostrain of 1.9% under −3 kV mm−1, at 1 Hz, corresponding to an effective piezoelectric coefficient of &gt;6,300 pm V−1 at room temperature in lead-free potassium sodium niobate piezoceramics. This electrostrain has satisfactory fatigue resistance and thermal stability, and low hysteresis, far outperforming existing lead-based and lead-free perovskite counterparts. From tracer diffusion, atomic optical emission spectrometry experiments, combined with machine-learning molecular dynamics and phase-field simulations, we attribute the high electrostrain to short-range hopping of oxygen vacancies near ceramic surfaces under an alternating electric field, which is supported by strain levels reaching 3.0% under the same applied field when the sample was annealed at a low oxygen partial pressure. These findings provide an additional degree of freedom for designing materials on the basis of defect engineering, which will favour not only the electrostrain of piezoelectrics but also the functional properties of a broader range of oxide-based materials. The authors demonstrate a chemopiezoelectric effect in which the displacive migration of oxygen vacancies driven by an electric field induces a large strain in the surface layer of thin (K,Na)NbO3 ceramics. They achieve an electrostrain of 1.9% under a field of −3 kV mm−1, with thermal stability up to 200 °C.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 4","pages":"565-573"},"PeriodicalIF":37.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flat optics for augmented-reality headsets
IF 37.2 1区 材料科学
Nature Materials Pub Date : 2025-02-24 DOI: 10.1038/s41563-025-02140-x
T. D. Wilkinson
{"title":"Flat optics for augmented-reality headsets","authors":"T. D. Wilkinson","doi":"10.1038/s41563-025-02140-x","DOIUrl":"10.1038/s41563-025-02140-x","url":null,"abstract":"A soft plastic replication process akin to the fabrication of compact discs enables the fabrication of achromatic metalenses suitable for the mass production of holographic near-eye displays.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"24 4","pages":"478-479"},"PeriodicalIF":37.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemiluminescent tactile visual synapse enabling in situ health monitoring
IF 41.2 1区 材料科学
Nature Materials Pub Date : 2025-02-24 DOI: 10.1038/s41563-025-02124-x
Woojoong Kim, Kyuho Lee, Sanghyeon Choi, Eunje Park, Gwanho Kim, Jebong Ha, Yeeun Kim, Jihye Jang, Ji Hye Oh, HoYeon Kim, Wei Jiang, Jioh Yoo, Taebin Kim, Yeonji Kim, Kwan-Nyeong Kim, Juntaek Hong, Ali Javey, Dong-wook Rha, Tae-Woo Lee, Keehoon Kang, Gunuk Wang, Cheolmin Park
{"title":"Electrochemiluminescent tactile visual synapse enabling in situ health monitoring","authors":"Woojoong Kim, Kyuho Lee, Sanghyeon Choi, Eunje Park, Gwanho Kim, Jebong Ha, Yeeun Kim, Jihye Jang, Ji Hye Oh, HoYeon Kim, Wei Jiang, Jioh Yoo, Taebin Kim, Yeonji Kim, Kwan-Nyeong Kim, Juntaek Hong, Ali Javey, Dong-wook Rha, Tae-Woo Lee, Keehoon Kang, Gunuk Wang, Cheolmin Park","doi":"10.1038/s41563-025-02124-x","DOIUrl":"https://doi.org/10.1038/s41563-025-02124-x","url":null,"abstract":"<p>Tactile visual synapses combine the functionality of tactile artificial synapses with the ability to visualize their activity in real time and provide a direct and intuitive visualization of the activity, offering an efficient route for in situ health monitoring. Herein we present a tactile visual synapse that enables in situ monitoring of finger rehabilitation and electrocardiogram analysis. Repetitive finger flexion and various arrhythmias are monitored and visually guided using the developed tactile visual synapse combined with an electrical and optical output feedback algorithm. The tactile visual synapse has the structure of an electrochemical transistor comprising an elastomeric top gate as a tactile receptor and an electrochemiluminescent ion gel as a light-emitting layer stacked on a polymeric semiconductor layer, forming an electrical synaptic channel between source and drain electrodes. The low-power (~34 μW) visualization of the tactile synaptic activity associated with the repetitive motions of fingers and heartbeats enables the development of a convenient and efficient personalized healthcare system.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"30 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On-patient medical record and mRNA therapeutics using intradermal microneedles
IF 41.2 1区 材料科学
Nature Materials Pub Date : 2025-02-24 DOI: 10.1038/s41563-024-02115-4
Jooli Han, Maria Kanelli, Yang Liu, John L. Daristotle, Apurva Pardeshi, Timothy A. Forster, Ari Karchin, Brandon Folk, Lukas Murmann, Lisa H. Tostanoski, Sebastian E. Carrasco, Shahad K. Alsaiari, Erika Yan Wang, Khanh Tran, Linzixuan Zhang, Behnaz Eshaghi, Lauren Levy, Sydney Pyon, Charles Sloane, Stacey Qiaohui Lin, Alicia Lau, Collin F. Perkinson, Moungi G. Bawendi, Dan H. Barouch, Frédo Durand, Robert Langer, Ana Jaklenec
{"title":"On-patient medical record and mRNA therapeutics using intradermal microneedles","authors":"Jooli Han, Maria Kanelli, Yang Liu, John L. Daristotle, Apurva Pardeshi, Timothy A. Forster, Ari Karchin, Brandon Folk, Lukas Murmann, Lisa H. Tostanoski, Sebastian E. Carrasco, Shahad K. Alsaiari, Erika Yan Wang, Khanh Tran, Linzixuan Zhang, Behnaz Eshaghi, Lauren Levy, Sydney Pyon, Charles Sloane, Stacey Qiaohui Lin, Alicia Lau, Collin F. Perkinson, Moungi G. Bawendi, Dan H. Barouch, Frédo Durand, Robert Langer, Ana Jaklenec","doi":"10.1038/s41563-024-02115-4","DOIUrl":"https://doi.org/10.1038/s41563-024-02115-4","url":null,"abstract":"<p>Medical interventions often require timed series of doses, thus necessitating accurate medical record-keeping. In many global settings, these records are unreliable or unavailable at the point of care, leading to less effective treatments or disease prevention. Here we present an invisible-to-the-naked-eye on-patient medical record-keeping technology that accurately stores medical information in the patient skin as part of microneedles that are used for intradermal therapeutics. We optimize the microneedle design for both a reliable delivery of messenger RNA (mRNA) therapeutics and the near-infrared fluorescent microparticles that encode the on-patient medical record-keeping. Deep learning-based image processing enables encoding and decoding of the information with excellent temporal and spatial robustness. Long-term studies in a swine model demonstrate the safety, efficacy and reliability of this approach for the co-delivery of on-patient medical record-keeping and the mRNA vaccine encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This technology could help healthcare workers make informed decisions in circumstances where reliable record-keeping is unavailable, thus contributing to global healthcare equity.</p>","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"31 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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