Nature Materials最新文献

Low-noise hole spin qubits in germanium 锗中的低噪声空穴自旋量子比特

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02307-6

Danielle Holmes

引用次数: 0

Defect repairing in lead bromide perovskite single crystals with biasing and bromine for X-ray photon-counting detectors 偏置溴化铅钙钛矿单晶x射线光子计数探测器缺陷的修复

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02310-x

Mingze Li, Shaojie Wang, Allen Wood, Jason D. Yeager, Sergei P. Stepanoff, Jackson C. Adler, Zhifang Shi, Jian Wang, Zhijun Li, Douglas E. Wolfe, Jinsong Huang

{"title":"Defect repairing in lead bromide perovskite single crystals with biasing and bromine for X-ray photon-counting detectors","authors":"Mingze Li, Shaojie Wang, Allen Wood, Jason D. Yeager, Sergei P. Stepanoff, Jackson C. Adler, Zhifang Shi, Jian Wang, Zhijun Li, Douglas E. Wolfe, Jinsong Huang","doi":"10.1038/s41563-025-02310-x","DOIUrl":"https://doi.org/10.1038/s41563-025-02310-x","url":null,"abstract":"The benign defect nature of iodide perovskites has gained strong momentum in understanding and application in perovskite devices; however, the understanding of defects in bromide perovskites remains elusive. Here we demonstrate that the biasing of lead bromide perovskite crystals, which has been broadly deemed as detrimental to device performance, can efficiently repair bulk point defects in them. The biasing results in a significant bromide-vacancy reduction, starting from the cathode side and progressing to the anode side across the whole crystal. The vacancies can diffuse back after several weeks of storage. By introducing bromine in crystal growth, we permanently reduce the bromide-vacancy concentration by ~1,000 times, enhancing charge transport and stability in formamidinium lead bromide crystals. The optimized formamidinium lead bromide detector exhibited a very high detection performance including an energy resolution of 0.7% under 137Cs 662-keV γ-rays measured under room-temperature, high-performance iodine K-edge X-ray detection at low agent concentrations and dramatically improved radiation hardness.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"27 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering a light-induced metastable state 工程光诱导亚稳态

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02303-w

Wei-Sheng Lee

引用次数: 0

Memsensing by surface ion migration within Debye length 德拜长度内表面离子迁移的Memsensing

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02312-9

Ruihan Guo, Qixin Feng, Ke Ma, Gi-Hyeok Lee, Moniruzzaman Jamal, Xiao Zhao, Karen C. Bustillo, Jiawei Wan, Duncan S. Ritchie, Linbo Shan, Yuhang Cai, Jiachen Li, Jack Shen, Kaichen Dong, Ru Huang, Yimao Cai, Feng Wang, Miquel Salmeron, Haimei Zheng, Matthew Sherburne, Mary Scott, Wanli Yang, Mark Asta, Kechao Tang, Junqiao Wu

{"title":"Memsensing by surface ion migration within Debye length","authors":"Ruihan Guo, Qixin Feng, Ke Ma, Gi-Hyeok Lee, Moniruzzaman Jamal, Xiao Zhao, Karen C. Bustillo, Jiawei Wan, Duncan S. Ritchie, Linbo Shan, Yuhang Cai, Jiachen Li, Jack Shen, Kaichen Dong, Ru Huang, Yimao Cai, Feng Wang, Miquel Salmeron, Haimei Zheng, Matthew Sherburne, Mary Scott, Wanli Yang, Mark Asta, Kechao Tang, Junqiao Wu","doi":"10.1038/s41563-025-02312-9","DOIUrl":"https://doi.org/10.1038/s41563-025-02312-9","url":null,"abstract":"Integration between electronics and biology is often facilitated by iontronics, where ion migration in aqueous media governs sensing and memory. However, the Debye screening effect limits electric fields to the Debye length, the distance over which mobile ions screen electrostatic interactions, necessitating external voltages that constrain the operation speed and device design. Here we report a high-speed in-memory sensor based on vanadium dioxide (VO2) that operates without an external voltage by leveraging built-in electric fields within the Debye length. When VO2 contacts a low-work-function metal (for example, indium) in a salt solution, electrochemical reactions generate indium ions that migrate into the VO2 surface under the native electric field, inducing a surface insulator-to-metal phase transition of VO2. The VO2 conductance increase rate reflects the salt concentration, enabling in-memory sensing, or memsensing of the solution. The memsensor mimics Caenorhabditis elegans chemosensory plasticity to guide a miniature boat for adaptive chemotaxis, illustrating low-power aquatic neurorobotics with fewer memory units.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"30 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation 白蛋白募集脂质纳米颗粒通过避免肝脏积聚增强mRNA疫苗的安全性和有效性

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-08-01 DOI: 10.1038/s41563-025-02284-w

Yunxuan Feng, Wanbo Tai, Pei Huang, Shaolong Qi, Xinyang Yu, Mengfei Li, Mengyao Li, Miya Zhang, Fangfang Cao, Xiaomin Gao, Kai Yang, Bing Bai, Jiaqi Lei, Meiqi Cheng, Yongcan Li, Gong Cheng, Xiaoyuan Chen, Guocan Yu

{"title":"Albumin-recruiting lipid nanoparticle potentiates the safety and efficacy of mRNA vaccines by avoiding liver accumulation","authors":"Yunxuan Feng, Wanbo Tai, Pei Huang, Shaolong Qi, Xinyang Yu, Mengfei Li, Mengyao Li, Miya Zhang, Fangfang Cao, Xiaomin Gao, Kai Yang, Bing Bai, Jiaqi Lei, Meiqi Cheng, Yongcan Li, Gong Cheng, Xiaoyuan Chen, Guocan Yu","doi":"10.1038/s41563-025-02284-w","DOIUrl":"https://doi.org/10.1038/s41563-025-02284-w","url":null,"abstract":"The advent of mRNA vaccines represents a breakthrough in the realm of cancer therapy and the prevention of infectious disease. Nevertheless, traditional lipid nanoparticle (LNP)-based mRNA vaccines can accumulate in the liver post-intramuscular injection, posing a risk of hepatotoxicity and reducing efficacy. Here we develop an albumin-recruiting LNP system with high lymphatic drainage and no accumulation in hepatic tissue to potentiate the efficacy and safety of mRNA vaccines. We construct a library of ionizable lipids with albumin-binding capacity as alternatives to traditional polyethylene-glycol-conjugated lipid. We identify an Evans blue-modified lipid-based LNP (EB-LNP) formulation that shows high in vivo expression, albumin-facilitated transport through intramuscular lymphatic vessels to the lymph nodes, high internalization by dendritic cells and low penetration into intramuscular blood vessels, thereby avoiding liver accumulation. EB-LNP-based mRNA vaccines demonstrate excellent antitumour and antiviral efficacy, resulting in strong cellular and humoral immune responses, including the robust activation of cytotoxic T lymphocytes and production of neutralizing antibodies post-vaccination. Overall, this system shows promise as an effective and minimally toxic platform for the development of mRNA vaccines with high efficacy and safety.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"98 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144756493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bond-centric modular design of protein assemblies 以键为中心的蛋白质组件模块化设计

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-07-31 DOI: 10.1038/s41563-025-02297-5

Shunzhi Wang, Andrew Favor, Ryan D. Kibler, Joshua M. Lubner, Andrew J. Borst, Nicolas Coudray, Rachel L. Redler, Huat Thart Chiang, William Sheffler, Yang Hsia, Neville P. Bethel, Zhe Li, Damian C. Ekiert, Gira Bhabha, Lilo D. Pozzo, David Baker

{"title":"Bond-centric modular design of protein assemblies","authors":"Shunzhi Wang, Andrew Favor, Ryan D. Kibler, Joshua M. Lubner, Andrew J. Borst, Nicolas Coudray, Rachel L. Redler, Huat Thart Chiang, William Sheffler, Yang Hsia, Neville P. Bethel, Zhe Li, Damian C. Ekiert, Gira Bhabha, Lilo D. Pozzo, David Baker","doi":"10.1038/s41563-025-02297-5","DOIUrl":"https://doi.org/10.1038/s41563-025-02297-5","url":null,"abstract":"Directional interactions that generate regular coordination geometries are a powerful means of guiding molecular and colloidal self-assembly, but implementing such high-level interactions with proteins remains challenging due to their complex shapes and intricate interface properties. Here we describe a modular approach to protein nanomaterial design inspired by the rich chemical diversity that can be generated from the small number of atomic valencies. We design protein building blocks using deep learning-based generative tools, incorporating regular coordination geometries and tailorable bonding interactions that enable the assembly of diverse closed and open architectures guided by simple geometric principles. Experimental characterization confirms the successful formation of more than 20 multicomponent polyhedral protein cages, two-dimensional arrays and three-dimensional protein lattices, with a high (10%–50%) success rate and electron microscopy data closely matching the corresponding design models. Due to modularity, individual building blocks can assemble with different partners to generate distinct regular assemblies, resulting in an economy of parts and enabling the construction of reconfigurable networks for designer nanomaterials.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"27 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flatland wakes based on leaky hyperbolic polaritons 基于泄漏双曲极化的平坦尾迹

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-07-31 DOI: 10.1038/s41563-025-02280-0

Na Chen, Hanchao Teng, Hai Hu, Min Liu, Chengyu Jiang, Zhuoxin Xue, Hualong Zhu, Jiayi Gui, Peining Li, Andrea Alù, Qing Dai

{"title":"Flatland wakes based on leaky hyperbolic polaritons","authors":"Na Chen, Hanchao Teng, Hai Hu, Min Liu, Chengyu Jiang, Zhuoxin Xue, Hualong Zhu, Jiayi Gui, Peining Li, Andrea Alù, Qing Dai","doi":"10.1038/s41563-025-02280-0","DOIUrl":"https://doi.org/10.1038/s41563-025-02280-0","url":null,"abstract":"Hyperbolic polaritons facilitate nanoscale light manipulation, but strong field confinement limits their transmission across interfaces. Conversely, leaky waves can convert radiation from confined sources towards the far field. Here we combine hyperbolic polaritons and leaky wave radiation to demonstrate flatland leaky polaritonic wakes. We employ a mixed-dimensional van der Waals heterostructure consisting of a nanoscale waveguide strip on a van der Waals film. The waveguide mode, confined inside the hyperbolic light cone of the background film, enables efficient directional in-plane emission of fast phonon polaritons. The constructive interference of these leaky polaritons generates highly directional polaritonic wakes. Their spatial symmetry can be tailored through the orientation of the heterostructure with respect to the hyperbolic film dispersion. Leveraging van der Waals stacking, we also demonstrate effective acceleration and deceleration of polaritonic wakes by locally tailoring the leaky nano-waveguide dispersion through gradient thickness design. Our findings demonstrate that polaritonic wakes hold promise for integrated nanophotonic circuits.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"8 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational design of bifaceted protein nanomaterials 二维蛋白质纳米材料的计算设计

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-07-31 DOI: 10.1038/s41563-025-02295-7

Sanela Rankovic, Kenneth D. Carr, Justin Decarreau, Rebecca Skotheim, Ryan D. Kibler, Sebastian Ols, Sangmin Lee, Jung-Ho Chun, Marti R. Tooley, Justas Dauparas, Helen E. Eisenach, Matthias Glögl, Connor Weidle, Andrew J. Borst, David Baker, Neil P. King

{"title":"Computational design of bifaceted protein nanomaterials","authors":"Sanela Rankovic, Kenneth D. Carr, Justin Decarreau, Rebecca Skotheim, Ryan D. Kibler, Sebastian Ols, Sangmin Lee, Jung-Ho Chun, Marti R. Tooley, Justas Dauparas, Helen E. Eisenach, Matthias Glögl, Connor Weidle, Andrew J. Borst, David Baker, Neil P. King","doi":"10.1038/s41563-025-02295-7","DOIUrl":"https://doi.org/10.1038/s41563-025-02295-7","url":null,"abstract":"Advances in computational methods have led to considerable progress in the design of protein nanomaterials. However, nearly all nanoparticles designed so far exhibit strict point group symmetry, which limits structural diversity and precludes anisotropic functionalization. Here we describe a computational strategy for designing multicomponent bifaceted protein nanomaterials with two distinctly addressable sides. The method centres on docking pseudosymmetric hetero-oligomeric building blocks in architectures with dihedral symmetry and designing an asymmetric protein–protein interface between them. We obtain an initial 30-subunit assembly with pseudo-D5 symmetry and generate variants in which we alter the size and morphology of the bifaceted nanoparticles by designing extensions to one of the subunits. Functionalization of the two nanoparticle faces with protein minibinders enables the specific colocalization of two populations of polystyrene microparticles coated with the target protein receptors. The ability to accurately design anisotropic protein nanoparticles could be broadly useful in applications requiring the colocalization of distinct target moieties.","PeriodicalId":19058,"journal":{"name":"Nature Materials","volume":"7 1","pages":""},"PeriodicalIF":41.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amorphous chalcogenides in two dimensions 二维无定形硫族化合物

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-07-30 DOI: 10.1038/s41563-025-02291-x

Volker L. Deringer

引用次数: 0

Publisher Correction: Highly reversible extrinsic electrocaloric effects over a wide temperature range in epitaxially strained SrTiO3 films 出版者更正：外延应变SrTiO3薄膜在宽温度范围内的高度可逆的外部电热效应

IF 41.2 1区材料科学

Nature Materials Pub Date : 2025-07-30 DOI: 10.1038/s41563-025-02321-8

S. Zhang, J. Deliyore-Ramírez, S. Deng, B. Nair, D. Pesquera, Q. Jing, M. E. Vickers, S. Crossley, M. Ghidini, S. Kar-Narayan, G. G. Guzmán-Verri, X. Moya, N. D. Mathur

引用次数: 0