Nature Immunology最新文献_第3页

Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections 内在免疫原性是SARS-CoV-2感染中类型特异性反应的主要决定因素

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-27 DOI: 10.1038/s41590-025-02162-2

Grace E. Quirk, Marta V. Schoenle, Kameron L. Peyton, Jennifer L. Uhrlaub, Branden Lau, Chieh-Yu Liang, Jefferey L. Burgess, Katherine Ellingson, Shawn Beitel, James Romine, Karen Lutrick, Ashley Fowlkes, Amadea Britton, Harmony L. Tyner, Alberto J. Caban-Martinez, Allison Naleway, Manjusha Gaglani, Sarang Yoon, Laura J. Edwards, Lauren Olsho, Michael Dake, Riccardo Valdez, Aubree Gordon, Michael S. Diamond, Bonnie J. LaFleur, Janko Ž. Nikolich, Ryan Sprissler, Michael Worobey, Deepta Bhattacharya

{"title":"Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections","authors":"Grace E. Quirk, Marta V. Schoenle, Kameron L. Peyton, Jennifer L. Uhrlaub, Branden Lau, Chieh-Yu Liang, Jefferey L. Burgess, Katherine Ellingson, Shawn Beitel, James Romine, Karen Lutrick, Ashley Fowlkes, Amadea Britton, Harmony L. Tyner, Alberto J. Caban-Martinez, Allison Naleway, Manjusha Gaglani, Sarang Yoon, Laura J. Edwards, Lauren Olsho, Michael Dake, Riccardo Valdez, Aubree Gordon, Michael S. Diamond, Bonnie J. LaFleur, Janko Ž. Nikolich, Ryan Sprissler, Michael Worobey, Deepta Bhattacharya","doi":"10.1038/s41590-025-02162-2","DOIUrl":"https://doi.org/10.1038/s41590-025-02162-2","url":null,"abstract":"Few type-specific antibodies that recognize drifted epitopes are made during post-vaccination exposures to SARS-CoV-2 variants1,2,3,4,5,6,7,8,9,10,11,12, perhaps due to suppression by previous immunity. We compared type-specific B cell responses in unvaccinated and vaccinated individuals with Delta and Omicron BA.1 SARS-CoV-2 variant infections. For both Delta, which is antigenically similar to the vaccine strain, and the more distant BA.1 variant, neutralizing antibodies were greater in post-vaccination variant infections than in primary variant infections. Delta type-specific memory B cells were reduced in post-vaccination Delta infections relative to primary variant infections. Yet some drifted epitopes in the Delta variant elicited minimal responses even in primary infections. For BA.1 infections, type-specific antibodies and memory B cells were mostly undetectable, irrespective of previous immunity. Thus, poor intrinsic antigenicity of drifted epitopes in Delta and BA.1 infections superseded the impact of previous immunity. Enhancing the immunogenicity of vaccine antigens may promote type-specific responses.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"14 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Location matters: defining the architecture of the bronchial wall in health and asthma 位置问题：确定健康和哮喘的支气管壁结构

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-26 DOI: 10.1038/s41590-025-02165-z

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Immunological duet between CD4+ T cells and B cells in the lung following an intranasal protein boost 鼻内蛋白增加后肺中CD4+ T细胞和B细胞之间的免疫二重奏

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-23 DOI: 10.1038/s41590-025-02168-w

Matthew Gagne, Daniel C. Douek, Robert A. Seder

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CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data CellLENS支持跨域信息融合，以增强单细胞空间组学数据中细胞种群的描绘

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-22 DOI: 10.1038/s41590-025-02163-1

Bokai Zhu, Sheng Gao, Shuxiao Chen, Yuchen Wang, Jason Yeung, Yunhao Bai, Amy Y. Huang, Yao Yu Yeo, Guanrui Liao, Shulin Mao, Zhenghui G. Jiang, Scott J. Rodig, Ka-Chun Wong, Alex K. Shalek, Garry P. Nolan, Sizun Jiang, Zongming Ma

{"title":"CellLENS enables cross-domain information fusion for enhanced cell population delineation in single-cell spatial omics data","authors":"Bokai Zhu, Sheng Gao, Shuxiao Chen, Yuchen Wang, Jason Yeung, Yunhao Bai, Amy Y. Huang, Yao Yu Yeo, Guanrui Liao, Shulin Mao, Zhenghui G. Jiang, Scott J. Rodig, Ka-Chun Wong, Alex K. Shalek, Garry P. Nolan, Sizun Jiang, Zongming Ma","doi":"10.1038/s41590-025-02163-1","DOIUrl":"https://doi.org/10.1038/s41590-025-02163-1","url":null,"abstract":"Delineating cell populations is crucial for understanding immune function in health and disease. Spatial omics technologies offer insights by capturing three complementary domains: single-cell molecular biomarker expression, cellular spatial relationships and tissue architecture. However, current computational methods often fail to fully integrate these multidimensional data, particularly for immune cell populations and intrinsic functional states. We introduce Cell Local Environment and Neighborhood Scan (CellLENS), a self-supervised computational method that learns cellular representations by fusing information across three spatial omics domains (expression, neighborhood and image). CellLENS markedly enhances de novo discovery of biologically relevant immune cell populations at fine granularity by integrating individual cells’ molecular profiles with their neighborhood context and tissue localization. By applying CellLENS to diverse spatial proteomic and transcriptomic datasets across multiple tissue types and disease settings, we uncover unique immune cell populations functionally stratified according to their spatial contexts. Our work demonstrates the power of multi-domain data integration in spatial omics to reveal insights into immune cell heterogeneity and tissue-specific functions.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"19 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Enhanced antiviral innate immunity supports the bat reservoir of Marburg virus 增强抗病毒先天免疫支持蝙蝠马尔堡病毒库

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-21 DOI: 10.1038/s41590-025-02170-2

Jennifer Tisoncik-Go, Michael Gale

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A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma 气道壁的单细胞空间图揭示了促炎细胞生态系统及其在健康和哮喘中的相互作用

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-21 DOI: 10.1038/s41590-025-02161-3

Régis Joulia, Sara Patti, William J. Traves, Lola Loewenthal, Laura Yates, Simone A. Walker, Franz Puttur, May Al-Sahaf, Katherine N. Cahill, Juying Lai, Salman Siddiqui, Joshua A. Boyce, Elliot Israel, Clare M. Lloyd

{"title":"A single-cell spatial chart of the airway wall reveals proinflammatory cellular ecosystems and their interactions in health and asthma","authors":"Régis Joulia, Sara Patti, William J. Traves, Lola Loewenthal, Laura Yates, Simone A. Walker, Franz Puttur, May Al-Sahaf, Katherine N. Cahill, Juying Lai, Salman Siddiqui, Joshua A. Boyce, Elliot Israel, Clare M. Lloyd","doi":"10.1038/s41590-025-02161-3","DOIUrl":"https://doi.org/10.1038/s41590-025-02161-3","url":null,"abstract":"Determining spatial location of cells within tissues gives vital insight into the interactions between resident and inflammatory cells and is a critical factor for uncoupling the mechanisms driving disease. Here, we apply single-cell spatial transcriptomics to reveal the airway wall landscape in health and during asthma. We identified proinflammatory cellular ecosystems that exist within discrete spatial niches in healthy and asthma samples. These cellular hubs are characterized by a high level of chemokine and alarmin expression, along with unique combinations of stromal cells. Mechanistically, we demonstrated that receptors, such as ACKR1, retain immune mediators locally, while amphiregulin-expressing mast cells are prominent within these proinflammatory hubs. Despite anti-inflammatory treatments, the asthma airway mucosa exhibited a distinct remodeling program within these cellular ecosystems, marked by increased proximity between key cell types. This study provides an unprecedented view of the topography of the airway wall, revealing distinct, specific ecosystems within spatial niches to target for therapeutic intervention.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"63 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal neuron-associated macrophages in health and disease 肠道神经元相关巨噬细胞在健康和疾病中的作用

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-21 DOI: 10.1038/s41590-025-02150-6

Nathalie Stakenborg, Maria Francesca Viola, Guy Boeckxstaens

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Cholinergic regulation of thymocyte negative selection 胸腺细胞阴性选择的胆碱能调控

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-21 DOI: 10.1038/s41590-025-02152-4

Shaofeng Liu, Chunxing Zheng, Robert Nechanitzky, Ping Luo, Parameswaran Ramachandran, Dat Nguyen, Andrew J. Elia, Soode Moghadas Jafari, Rhoda Law, Bryan E. Snow, Andrew C. Wakeham, Thorsten Berger, Hui Chen, Kyle T. Gill, Ryan Mcwilliam, Jerome Fortin, Nastaran Fazel Modares, Mary E. Saunders, Kiichi Murakami, Yangmin Qiu, Zhiwei You, Mahmood Mohtashami, Hai Qi, Pamela S. Ohashi, Juan Carlos Zúñiga-Pflücker, Tak W. Mak

{"title":"Cholinergic regulation of thymocyte negative selection","authors":"Shaofeng Liu, Chunxing Zheng, Robert Nechanitzky, Ping Luo, Parameswaran Ramachandran, Dat Nguyen, Andrew J. Elia, Soode Moghadas Jafari, Rhoda Law, Bryan E. Snow, Andrew C. Wakeham, Thorsten Berger, Hui Chen, Kyle T. Gill, Ryan Mcwilliam, Jerome Fortin, Nastaran Fazel Modares, Mary E. Saunders, Kiichi Murakami, Yangmin Qiu, Zhiwei You, Mahmood Mohtashami, Hai Qi, Pamela S. Ohashi, Juan Carlos Zúñiga-Pflücker, Tak W. Mak","doi":"10.1038/s41590-025-02152-4","DOIUrl":"https://doi.org/10.1038/s41590-025-02152-4","url":null,"abstract":"The immune and nervous systems use a common chemical language for communication, namely, the cholinergic signaling involving acetylcholine (ACh) and its receptors (AChRs). Whether and how this language also regulates the development of the immune system is poorly understood. Here, we show that mouse CD4+CD8+ double-positive thymocytes express high levels of α9 nicotinic AChR (nAChR) and that this receptor controls thymic negative selection. α9 nAChR-deficient mice show an altered T cell receptor (TCR) repertoire and reduced CD4+ and CD8+ T cells in a mixed bone marrow chimera setting. α9 nAChR-mediated signaling regulates TCR strength and thymocyte survival. Thymic tuft cells, B cells and some T cells express choline acetyltransferase and are potential ACh sources, with ACh derived from T cells having the most important role. Furthermore, α9 nAChR deficiency during thymocyte development contributes to the altered development of autoimmune diseases in mice. Our results thus reveal a mechanism controlling immune cell development that involves cholinergic signaling.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"56 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bat organoids reveal antiviral responses at epithelial surfaces 蝙蝠类器官在上皮表面显示抗病毒反应

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-21 DOI: 10.1038/s41590-025-02155-1

Max J. Kellner, Vanessa M. Monteil, Patrick Zelger, Gang Pei, Jie Jiao, Masahiro Onji, Komal Nayak, Matthias Zilbauer, Anne Balkema-Buschmann, Anca Dorhoi, Ali Mirazimi, Josef M. Penninger

{"title":"Bat organoids reveal antiviral responses at epithelial surfaces","authors":"Max J. Kellner, Vanessa M. Monteil, Patrick Zelger, Gang Pei, Jie Jiao, Masahiro Onji, Komal Nayak, Matthias Zilbauer, Anne Balkema-Buschmann, Anca Dorhoi, Ali Mirazimi, Josef M. Penninger","doi":"10.1038/s41590-025-02155-1","DOIUrl":"https://doi.org/10.1038/s41590-025-02155-1","url":null,"abstract":"Bats can host viruses of pandemic concern without developing disease. The mechanisms underlying their exceptional resilience to viral infections are largely unresolved, necessitating the development of physiologically relevant and genetically tractable research models. Here, we developed respiratory and intestinal organoids that recapitulated the cellular diversity of the in vivo epithelium present in Rousettus aegyptiacus, the natural reservoir for the highly pathogenic Marburg virus (MARV). In contrast to human counterparts, bat organoids and mucosal tissue exhibited elevated constitutive expression of innate immune effectors, including type I interferon-ε (IFNε) and IFN-stimulated genes (ISGs). Upon infection with diverse zoonotic viruses, including MARV, bat organoids strongly induced type I and III IFN responses, which conferred robust antiviral protection. Type III IFNλ3 additionally displayed virus-independent self-amplification, acting as an ISG to enhance antiviral immunity. Our organoid platform reveals key features of bat epithelial antiviral immunity that may inform therapeutic strategies for viral disease resilience.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"3 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Antibiotics, microbiota and the calibration of infant vaccine responses 抗生素、微生物群和婴儿疫苗反应的校准

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-05-19 DOI: 10.1038/s41590-025-02169-9

Yupeng Feng, Bali Pulendran

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