Nature Immunology最新文献_第10页

Innate immune barrier against oncogenic transformation 抗致癌转化的先天免疫屏障

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02043-0

引用次数: 0

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans 人类对多种疫苗抗体反应持久性的预测因子和机制的系统疫苗学分析

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02036-z

Mario Cortese, Thomas Hagan, Nadine Rouphael, Sheng-Yang Wu, Xia Xie, Dmitri Kazmin, Florian Wimmers, Shakti Gupta, Robbert van der Most, Margherita Coccia, Prabhu S. Aranuchalam, Helder I. Nakaya, Yating Wang, Elizabeth Coyle, Shu Horiuchi, Hanchih Wu, Mary Bower, Aneesh Mehta, Clifford Gunthel, Steve E. Bosinger, Yuri Kotliarov, Foo Cheung, Pamela L. Schwartzberg, Ronald N. Germain, John Tsang, Shuzhao Li, Randy Albrecht, Hideki Ueno, Shankar Subramaniam, Mark J. Mulligan, Surender Khurana, Hana Golding, Bali Pulendran

{"title":"System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans","authors":"Mario Cortese, Thomas Hagan, Nadine Rouphael, Sheng-Yang Wu, Xia Xie, Dmitri Kazmin, Florian Wimmers, Shakti Gupta, Robbert van der Most, Margherita Coccia, Prabhu S. Aranuchalam, Helder I. Nakaya, Yating Wang, Elizabeth Coyle, Shu Horiuchi, Hanchih Wu, Mary Bower, Aneesh Mehta, Clifford Gunthel, Steve E. Bosinger, Yuri Kotliarov, Foo Cheung, Pamela L. Schwartzberg, Ronald N. Germain, John Tsang, Shuzhao Li, Randy Albrecht, Hideki Ueno, Shankar Subramaniam, Mark J. Mulligan, Surender Khurana, Hana Golding, Bali Pulendran","doi":"10.1038/s41590-024-02036-z","DOIUrl":"10.1038/s41590-024-02036-z","url":null,"abstract":"We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity. We found that TPO administration enhanced the durability of vaccine-induced antibody responses. TPO-activated megakaryocytes also promoted survival of human bone-marrow plasma cells through integrin β1/β2-mediated cell–cell interactions, along with survival factors APRIL and the MIF–CD74 axis. Using machine learning, we developed a classifier based on this platelet-associated signature, which predicted antibody response longevity across six vaccines from seven independent trials, highlighting a conserved mechanism for vaccine durability. Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"116-130"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis 基质炎性小体Ras预防myc驱动的淋巴瘤发生

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02028-z

Andrew Kent, Kristel Joy Yee Mon, Zachary Hutchins, Gregory Putzel, Dmitry Zhigarev, Alexander Grier, Baosen Jia, Roderik M. Kortlever, Gaetan Barbet, Gerard I. Evan, J. Magarian Blander

{"title":"A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis","authors":"Andrew Kent, Kristel Joy Yee Mon, Zachary Hutchins, Gregory Putzel, Dmitry Zhigarev, Alexander Grier, Baosen Jia, Roderik M. Kortlever, Gaetan Barbet, Gerard I. Evan, J. Magarian Blander","doi":"10.1038/s41590-024-02028-z","DOIUrl":"10.1038/s41590-024-02028-z","url":null,"abstract":"The inflammasome plays multifaceted roles in cancer, but less is known about its function during premalignancy upon initial cell transformation. We report a homeostatic function of the inflammasome in suppressing malignant transformation through Ras inhibition. We identified increased hematopoietic stem cell (HSC) proliferation within the bone marrow of inflammasome-deficient mice. HSCs within an inflammasome-deficient stroma expressed a Ras signature associated with increased Ras pathway- and cancer-related transcripts and heightened levels of cytokine, chemokine and growth factor receptors. Stromal inflammasome deficiency established a poised Ras-dependent mitogenic state within HSCs, which fueled progeny B cell lymphomagenesis upon Myc deregulation in a spontaneous model of B cell lymphoma, and shortened its premalignant stage leading to faster onset of malignancy. Thus, the stromal inflammasome preserves tissue balance by restraining Ras to disrupt the most common oncogenic Myc–Ras cooperation and establish a natural defense against transition to malignancy. These findings should inform preventative therapies against hematological malignancies. Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"53-67"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate immune cells link dietary cues to normal and abnormal metabolic regulation 先天免疫细胞将饮食线索与正常和异常的代谢调节联系起来

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02037-y

Peng Zhang, Kosuke Watari, Michael Karin

{"title":"Innate immune cells link dietary cues to normal and abnormal metabolic regulation","authors":"Peng Zhang, Kosuke Watari, Michael Karin","doi":"10.1038/s41590-024-02037-y","DOIUrl":"10.1038/s41590-024-02037-y","url":null,"abstract":"A slew of common metabolic disorders, including type 2 diabetes, metabolic dysfunction-associated steatotic liver disease and steatohepatitis, are exponentially increasing in our sedentary and overfed society. While macronutrients directly impact metabolism and bioenergetics, new evidence implicates immune cells as critical sensors of nutritional cues and important regulators of metabolic homeostasis. A deeper interrogation of the intricate and multipartite interactions between dietary components, immune cells and metabolically active tissues is needed for a better understanding of metabolic regulation and development of new treatments for common metabolic diseases. Responding to macronutrients and micronutrients, immune cells play pivotal roles in interorgan communication between the microbiota, small intestine, metabolically active cells including hepatocytes and adipocytes, and the brain, which controls feeding behavior and energy expenditure. This Review focuses on the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control. Karin and colleagues review the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"29-41"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet partnerships and lasting memories 血小板的伙伴关系和持久的记忆

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02040-3

Petter Brodin

引用次数: 0

Latent HIV-1 induction 潜伏HIV-1诱导

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02055-w

Paula Jauregui

引用次数: 0

Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response 抗原经历史指导CD8+ CAR - T细胞在抗白血病反应中的不同功能状态

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02034-1

Kole R. DeGolier, Etienne Danis, Marc D’Antonio, Jennifer Cimons, Michael Yarnell, Ross M. Kedl, M. Eric Kohler, James P. Scott-Browne, Terry J. Fry

{"title":"Antigen experience history directs distinct functional states of CD8+ CAR T cells during the antileukemia response","authors":"Kole R. DeGolier, Etienne Danis, Marc D’Antonio, Jennifer Cimons, Michael Yarnell, Ross M. Kedl, M. Eric Kohler, James P. Scott-Browne, Terry J. Fry","doi":"10.1038/s41590-024-02034-1","DOIUrl":"10.1038/s41590-024-02034-1","url":null,"abstract":"Although chimeric antigen receptor (CAR) T cells are effective against B-lineage malignancies, post-CAR relapse is common, and efficacy in other tumors is limited. These challenges may be addressed through rational manipulations to control CAR T cell function. Here we examine the impact of cognate T cell antigen experience on subsequent CD8+ CAR T cell activity. Prior antigen encounter resulted in superior effector function against leukemia expressing low target antigen density at the expense of reduced proliferative capacity and susceptibility to dysfunction at limiting CAR doses. Distinctive temporal transcriptomic and epigenetic profiles in naive-derived and memory-derived CAR T cells identified RUNX family transcription factors as potential targets to augment the function of naive-derived CD8+ CAR T cells. RUNX2 overexpression enhanced antitumor efficacy of mouse CAR T cells, dependent on prior cell state, and heightened human CAR T cell functions. Our data demonstrate that prior antigen experience of CAR T cells determines functional attributes and amenability to transcription factor-mediated functional enhancement. Here, Fry and colleagues examine the impact of antigen experience on subsequent CD8+ CAR T cell activity during the antileukemia response and show that RUNX2 overexpression enhances antitumor activity of these cells.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"68-81"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-024-02034-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Creation Game: of AI and human creativity 创造游戏：人工智能和人类的创造力

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02026-1

Bali Pulendran

引用次数: 0

Past interactions of T cells with antigens shape CAR T cell responses 过去T细胞与抗原的相互作用形成CAR - T细胞反应

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02048-9

引用次数: 0

KEAP1 maintains stemness KEAP1保持干性

IF 27.7 1区医学