Aberrant protein translation promotes T cell exhaustion

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-25 DOI:10.1038/s41590-025-02244-1

引用次数: 0

Abstract

Adoptive T cell therapies show limited efficacy against solid tumors owing to T cell exhaustion within the tumor microenvironment. A study now reveals that dysregulated translation, rather than transcriptional changes alone, drives T cell dysfunction by creating mitochondrial imbalance through selective protein synthesis.

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异常的蛋白质翻译促进T细胞衰竭

由于肿瘤微环境中的T细胞耗竭，过继T细胞疗法对实体瘤的疗效有限。现在的一项研究表明，翻译失调，而不是转录变化，通过选择性蛋白质合成产生线粒体失衡，从而驱动T细胞功能障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.