Nature Immunology最新文献

Author Correction: Peyer's patch M cells organize an epithelial niche that sustains group 3 innate lymphoid cells and IL-22. 作者更正：Peyer’s patch M细胞组织上皮生态位，维持第3组先天淋巴样细胞和IL-22。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-09-01 DOI: 10.1038/s41590-026-02669-2

Wang H J Cao, Yue You, Nancy Wang, M Zeeshan Chaudhry, Huiyang Yu, Peter T Bell, Ellesandra C Noye, Renae Denman, Byungchul Lee, Abbey Waddington, Junpeng Ye, Jaring Schreuder, Qiutong Huang, Julie Tellier, Sophie Curio, James Santiago, Daniela Amann-Zalcenstein, Nicolas Jacquelot, Peter Hickey, Stephen L Nutt, Cyril Seillet, Philip M Hansbro, Verena C Wimmer, Richard A Strugnell, Zewen Kelvin Tuong, Matthew E Ritchie, Gabrielle T Belz

引用次数: 0

Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy. 在长期抗逆转录病毒治疗期间，先天免疫印迹塑造HIV-1储存库细胞持久性。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-09-01 DOI: 10.1038/s41590-026-02637-w

Toong Seng Tan, WeiWei Sun, Ce Gao, Mathias Viard, Lucy C Walters, Melanie Lancien, Yuko Yuki, Tram N Van, Carlos Casquero, Xuan Guo, Rebecca Hoh, David W Haas, Nelson Michael, Gregory D Kirk, George Yendewa, Rajesh T Gandhi, Seble G Kassaye, Phyllis C Tien, Bruce D Walker, Michael J Peluso, Jeffrey M Jacobson, Steven G Deeks, Mary Carrington, Xu G Yu, Mathias Lichterfeld

{"title":"Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy.","authors":"Toong Seng Tan, WeiWei Sun, Ce Gao, Mathias Viard, Lucy C Walters, Melanie Lancien, Yuko Yuki, Tram N Van, Carlos Casquero, Xuan Guo, Rebecca Hoh, David W Haas, Nelson Michael, Gregory D Kirk, George Yendewa, Rajesh T Gandhi, Seble G Kassaye, Phyllis C Tien, Bruce D Walker, Michael J Peluso, Jeffrey M Jacobson, Steven G Deeks, Mary Carrington, Xu G Yu, Mathias Lichterfeld","doi":"10.1038/s41590-026-02637-w","DOIUrl":"https://doi.org/10.1038/s41590-026-02637-w","url":null,"abstract":"Host immune responses that can target and eliminate HIV-1 reservoir cells during suppressive antiretroviral therapy are poorly understood. Here, analyzing over 6,000 proviral DNA amplicons from 104 individuals on long-term antiretroviral therapy, we found that carriers of HLA-C2 allotypes, which promote NK cell education via interactions with KIR2DL1, exhibited lower frequencies of intact proviruses. No protective effects of HLA-C2 alleles were observed during untreated infection, suggesting a selective vulnerability of reservoir cells to NK-cell-mediated immune activity under antiretroviral therapy. Supporting this, frequencies of KIR2DL1+ NK cells, particularly those coexpressing the activating HLA-E receptor NKG2C, were inversely correlated with frequencies of intact proviruses. Moreover, viral protein U variants that strongly downregulate HLA-C, increasing a missing-self response by KIR2DL1+ NK cells, were associated with smaller reservoirs in carriers of HLA-C2. Infected cells surviving long-term displayed elevated HLA-C expression, consistent with in vivo selection for resistance to KIR2DL1+ NK-cell-mediated immune clearance. Immune activity of KIR2DL1+ NK cells against viral reservoir cells was enhanced by NKG2C-HLA-E interactions, as sequence variants in HLA-E-restricted HIV-1 epitopes reduced NKG2C-dependent NK cell activation and were associated with higher frequencies of intact proviruses. These findings underscore the critical influence of host and viral genetic variation on reservoir persistence and highlight opportunities for leveraging innate immunity in HIV cure strategies.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":" ","pages":""},"PeriodicalIF":26.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148875282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural killers blast HIV reservoir landscape. 自然杀手摧毁了艾滋病毒储存库景观。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-09-01 DOI: 10.1038/s41590-026-02635-y

Daniel A Armendariz, Valter Silva Monteiro, Ya-Chi Ho

引用次数: 0

Immune-mediated rheumatoid arthritis: from single-cell genomics to new therapies. 免疫介导的类风湿性关节炎：从单细胞基因组学到新疗法。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-31 DOI: 10.1038/s41590-026-02639-8

Lionel B Ivashkiv

引用次数: 0

Good neighbors make lasting memory. 好邻居留下永恒的记忆。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-31 DOI: 10.1038/s41590-026-02645-w

Mohammad Heidarian, Vladimir P Badovinac

引用次数: 0

Monocyte-derived galectin-1^hi cells provide innate immune help in the generation of functional memory CD8⁺ T cells. 单核细胞来源的半凝集素-1hi细胞在功能记忆CD8+ T细胞的产生中提供先天免疫帮助。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-31 DOI: 10.1038/s41590-026-02638-9

Kihong Lim, Ankit Dahal, Xiurui Lv, Kyun-Do Kim, Blake A Evans, Herman Li, Laurie A Steiner, Minsoo Kim

{"title":"Monocyte-derived galectin-1hi cells provide innate immune help in the generation of functional memory CD8+ T cells.","authors":"Kihong Lim, Ankit Dahal, Xiurui Lv, Kyun-Do Kim, Blake A Evans, Herman Li, Laurie A Steiner, Minsoo Kim","doi":"10.1038/s41590-026-02638-9","DOIUrl":"https://doi.org/10.1038/s41590-026-02638-9","url":null,"abstract":"After viral infections, tissue-resident memory T cells (TRM cells) are generated and reactivated rapidly upon re-exposure to previously encountered viral pathogens, providing immediate immune effector functions to limit infection at the site of viral entry. Here we found that a subset of newly recruited CCR2+ monocytes differentiated into memory-stage CCR2-tdTomato+ cells and persisted in the lung for more than 4 months after infection with the influenza virus. Selective depletion of the memory-stage CCR2-tdTomato+ cells reduced significantly the formation of lung CD8+ TRM cells and compromised secondary heterosubtypic immune protection. Memory-stage CCR2-tdTomato+ cells colocalized with lung CD8+ TRM cells and secreted galectin-1, which activated CD8+ T cells directly and enhanced transforming growth factor-β sensing. Intranasal administration of recombinant galectin-1 as an adjuvant for the influenza vaccine induced superior memory CD8+ T cell responses. Thus, the presence of a unique memory-like monocyte-derived subset provided crucial signals to establish and maintain functional CD8+ TRM cells in the lung.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":" ","pages":""},"PeriodicalIF":26.5,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148866052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth. 作者更正：caspase-3裂解产生的短IL-18可动员NK细胞抑制肿瘤生长。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-26 DOI: 10.1038/s41590-026-02662-9

Junchen Shen, Yu Zhang, Wenbo Tang, Mingxia Yang, Tong Cheng, Yihui Chen, Shi Yu, Qiuhong Guo, Limin Cao, Xun Wang, Hui Xiao, Lanfeng Wang, Chengyuan Wang, Chen-Ying Liu, Guangxun Meng

引用次数: 0

ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer. ID2通过在多效性Zeb2增强子上拮抗E蛋白来确保cDC1的特异性。

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-25 DOI: 10.1038/s41590-026-02632-1

Feiya Ou, Tian-Tian Liu, Siling Du, Jing Chen, Magdalena Kraft, Giri Nam, Bishan Bhattarai, Hyeyoon Shin, Alyssa R Koch, Theresa L Murphy, Kenneth M Murphy

{"title":"ID2 secures cDC1 specification by antagonizing E proteins at a pleiotropic Zeb2 enhancer.","authors":"Feiya Ou, Tian-Tian Liu, Siling Du, Jing Chen, Magdalena Kraft, Giri Nam, Bishan Bhattarai, Hyeyoon Shin, Alyssa R Koch, Theresa L Murphy, Kenneth M Murphy","doi":"10.1038/s41590-026-02632-1","DOIUrl":"10.1038/s41590-026-02632-1","url":null,"abstract":"The transcriptional regulator ID2 is required for type 1 classical dendritic cell (cDC1) specification, yet the mechanism has remained obscure. We previously identified the Zeb2 -165-kb enhancer as key to normal hematopoiesis, controlled by competing CEBP and NFIL3 inputs during myeloid dendritic cell divergence. Here we uncover an unprecedented role for E proteins in myelopoiesis and demonstrate that ID2 promotes cDC1 development by antagonizing E protein activity at E-boxes within the Zeb2 enhancer. Deleting these E-boxes abolishes B cell and plasmacytoid dendritic cell development while skewing myelopoiesis toward cDC1s. Remarkably, E-box deletion rescues cDC1 development in Id2-deficient mice. These findings support a two-step model in which NFIL3 transiently represses Zeb2, followed by ID2-mediated inhibition of E proteins to stabilize cDC1 fate specification. Further, this work defines a paradigm of 'site-specific pleiotropy', wherein distinct transcription factor motifs-E-boxes and CEBP sites-within a single enhancer direct diverse cell fates.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":" ","pages":""},"PeriodicalIF":26.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microglia effects 小胶质细胞的影响

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-25 DOI: 10.1038/s41590-026-02649-6

Ioana Staicu

引用次数: 0

Aging by impaired efferocytosis 由胞浆功能受损引起的衰老

IF 26.5 1区医学

Nature Immunology Pub Date : 2026-08-25 DOI: 10.1038/s41590-026-02647-8

Stephanie Houston

引用次数: 0