抗原呈递细胞作为粘膜耐受和免疫的仲裁者。

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-10-17 DOI:10.1038/s41590-025-02320-6

Tilman L B Hoelting,Tyler Park,Chrysothemis C Brown

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引用次数: 0

摘要

在肠道内，免疫系统会遇到大量的微生物抗原，以及饮食成分。抗原呈递细胞（APCs）在定制适当的免疫反应中发挥关键作用，确保对无害抗原的耐受性和对病原体的保护。单细胞转录组学研究的爆炸式增长揭示了粘膜组织和淋巴结中apc的新亚群，尤其是在肠道中。在口服疫苗接种或炎症或过敏性疾病中恢复耐受性时，充分利用它们的潜力来引发保护性免疫，需要深入了解它们独特的功能角色和分化程序。在本文中，我们回顾了对APC异质性的日益了解，并讨论了不同亚群之间的平衡和合作如何影响粘膜免疫、炎症和耐受性。

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Antigen-presenting cells as arbiters of mucosal tolerance and immunity.

Within the intestine, the immune system encounters a vast array of microbial antigens, as well as dietary components. Antigen-presenting cells (APCs) play a critical role in tailoring an appropriate immune response, ensuring both tolerance to innocuous antigens and protection from pathogens. An explosion of single-cell transcriptomic studies has revealed new subsets of APCs within mucosal tissues and lymph nodes, most notably within the gut. Harnessing their full potential to elicit protective immunity during oral vaccination or restoration of tolerance in inflammatory or allergic diseases requires an in-depth understanding of their unique functional roles and differentiation programs. Here we review the growing understanding of APC heterogeneity and discuss how balance and cooperation between distinct subsets shape mucosal immunity, inflammation and tolerance.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.