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Author Correction: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4+ T cells by preventing ferroptosis. 作者更正：激酶复合物mTORC2通过防止铁凋亡促进病毒特异性记忆CD4+ T细胞的寿命。
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-10-09 DOI: 10.1038/s41590-026-02702-4
Yifei Wang, Qin Tian, Yaxing Hao, Wei Yao, Jinjin Lu, Cheng Chen, Xiangyu Chen, Yao Lin, Qizhao Huang, Lifan Xu, Jianjun Hu, Shun Lei, Zhengping Wei, Yuan Luo, Zhirong Li, Li Hu, Jianfang Tang, Qing Wu, Xinyuan Zhou, Yuzhang Wu, Zhinan Yin, Jianqing Xu, Lilin Ye
{"title":"Author Correction: The kinase complex mTORC2 promotes the longevity of virus-specific memory CD4<sup>+</sup> T cells by preventing ferroptosis.","authors":"Yifei Wang, Qin Tian, Yaxing Hao, Wei Yao, Jinjin Lu, Cheng Chen, Xiangyu Chen, Yao Lin, Qizhao Huang, Lifan Xu, Jianjun Hu, Shun Lei, Zhengping Wei, Yuan Luo, Zhirong Li, Li Hu, Jianfang Tang, Qing Wu, Xinyuan Zhou, Yuzhang Wu, Zhinan Yin, Jianqing Xu, Lilin Ye","doi":"10.1038/s41590-026-02702-4","DOIUrl":"https://doi.org/10.1038/s41590-026-02702-4","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":" ","pages":""},"PeriodicalIF":26.5,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial–immune cell interactions 不同的感染转录重编程肠上皮和上皮-免疫细胞相互作用
IF 30.5 1区 医学
Nature Immunology Pub Date : 2026-10-07 DOI: 10.1038/s41590-026-02665-6
Andrew Hart,Maria Merolle,Christian Howard,Breanne E. Haskins,Ian S. Cohn,Suhas Bobba,Rui Xiao,Yi Yang,Ken Cadwell,Junjie Ma,Hiroshi Yano,Xiaoxiao Hou,Bethan A. Wallbank,Daniel Cutillo,Ivaylo I. Ivanov,Boris Striepen,Sunny Shin,Igor E. Brodsky,David Artis,Christopher A. Hunter,Daniel P. Beiting,on behalf of the MIST Consortium,Ivaylo I. Ivanov,David Artis
{"title":"Diverse infections transcriptionally reprogram the intestinal epithelium and epithelial–immune cell interactions","authors":"Andrew Hart,Maria Merolle,Christian Howard,Breanne E. Haskins,Ian S. Cohn,Suhas Bobba,Rui Xiao,Yi Yang,Ken Cadwell,Junjie Ma,Hiroshi Yano,Xiaoxiao Hou,Bethan A. Wallbank,Daniel Cutillo,Ivaylo I. Ivanov,Boris Striepen,Sunny Shin,Igor E. Brodsky,David Artis,Christopher A. Hunter,Daniel P. Beiting,on behalf of the MIST Consortium,Ivaylo I. Ivanov,David Artis","doi":"10.1038/s41590-026-02665-6","DOIUrl":"https://doi.org/10.1038/s41590-026-02665-6","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"1 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens 屏障免疫记忆是通过肠上皮细胞呈递细胞质递送的细菌抗原来编程的
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-09-30 DOI: 10.1038/s41590-026-02656-7
C. Garrett Wilson, M. Pragun Acharya, Laura Karsch, Lennard W. Duck, Nana Twumasi-Ankrah, Yuanyou Wang, Hongxing Shen, Blake F. Frey, Annalisse R. McKee, Vishal H. Oza, Stacey N. Harbour, Yoshiko Nagaoka-Kamata, Jeffrey R. Singer, Robin D. Hatton, Jeffrey Moffitt, Matthias Gunzer, Carlene L. Zindl, Casey T. Weaver
{"title":"Barrier immune memory is programmed by intestinal epithelial cell presentation of cytosol-delivered bacterial antigens","authors":"C. Garrett Wilson,&nbsp;M. Pragun Acharya,&nbsp;Laura Karsch,&nbsp;Lennard W. Duck,&nbsp;Nana Twumasi-Ankrah,&nbsp;Yuanyou Wang,&nbsp;Hongxing Shen,&nbsp;Blake F. Frey,&nbsp;Annalisse R. McKee,&nbsp;Vishal H. Oza,&nbsp;Stacey N. Harbour,&nbsp;Yoshiko Nagaoka-Kamata,&nbsp;Jeffrey R. Singer,&nbsp;Robin D. Hatton,&nbsp;Jeffrey Moffitt,&nbsp;Matthias Gunzer,&nbsp;Carlene L. Zindl,&nbsp;Casey T. Weaver","doi":"10.1038/s41590-026-02656-7","DOIUrl":"10.1038/s41590-026-02656-7","url":null,"abstract":"Antigen compartmentalization is known to influence CD4 and CD8 T cell recognition but its impact on immune responses to different antigens expressed by the same pathogen is poorly understood. By tracking the clonal CD4 T cell response to a single epitope shuttled between different virulence proteins of Citrobacter rodentium, we found that response magnitude and quality depended on antigen localization. Antigens retained within bacteria elicited limited responses, whereas antigens injected into colonocyte cytosol through a type III secretion system generated robust mucosal CD4 T cell responses and promoted formation of epithelial-resident memory T cells. This process required direct presentation by infected epithelial cells. Single-cell transcriptomic analyses revealed that sustained, bidirectional communication between epithelial cells and T cells was essential to elicit both barrier-protective functions and transcriptional programs favoring tissue residency over central memory differentiation. These findings identify nonprofessional antigen-presenting cells as key regulators of CD4 T cell memory fate. Intestinal epithelial cells can present antigen to CD4 T cells. Here the authors show that epithelial cells must present translocated bacterial antigen for local CD4 resident memory T cells to be established.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 10","pages":"2117-2133"},"PeriodicalIF":26.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41590-026-02656-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal blood reshapes its home 克隆血重塑家园
IF 30.5 1区 医学
Nature Immunology Pub Date : 2026-09-30 DOI: 10.1038/s41590-026-02673-6
Xuan Zhang,Bailee N. Kain,H. Leighton Grimes
{"title":"Clonal blood reshapes its home","authors":"Xuan Zhang,Bailee N. Kain,H. Leighton Grimes","doi":"10.1038/s41590-026-02673-6","DOIUrl":"https://doi.org/10.1038/s41590-026-02673-6","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"21 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149090246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epithelial antigen presentation shapes barrier memory 上皮抗原呈递形成屏障记忆
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-09-30 DOI: 10.1038/s41590-026-02622-3
Xi Lin, Richard S. Blumberg
{"title":"Epithelial antigen presentation shapes barrier memory","authors":"Xi Lin,&nbsp;Richard S. Blumberg","doi":"10.1038/s41590-026-02622-3","DOIUrl":"10.1038/s41590-026-02622-3","url":null,"abstract":"Bacterial antigens injected into the cytosol of intestinal epithelial cells are preferentially presented by MHC II for induction of antigen-specific T cell responses and long-term epithelial cell-associated CD4 tissue-resident memory T cells.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 10","pages":"1972-1974"},"PeriodicalIF":26.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis 纤维化前骨髓微环境是克隆造血的一个标志
IF 30.5 1区 医学
Nature Immunology Pub Date : 2026-09-30 DOI: 10.1038/s41590-026-02668-3
Alicia G. Aguilar-Navarro, Gibran Edun, Mark Gower, Joan Kant, Ximing Li, Dustin Yang, Mursal Nader, Minerva Fernandez, Soheil Jahangiri, Emily Tsao, Pratik Joshi, Pathum Kossinna, Loic Cameron Caloren, John Roderick Davey, Michael G. Zywiel, R. Peter Suderman, Anoushka I. Kapoor, Margarete K. Akens, Adele Changoor, Minna Woo, Robert F. Stanley, Kira A. Young, Christine Tran, Valentin Sotov, Ben X. Wang, Sagi Abelson, Omar Abdel-Wahab, Shruti Naik, Jennifer J. Trowbridge, Robert Vanner, Kristin J. Hope, Hubert Tsui, Federico Gaiti, Anastasia N. Tikhonova
{"title":"Prefibrotic bone marrow microenvironment is a hallmark of clonal hematopoiesis","authors":"Alicia G. Aguilar-Navarro, Gibran Edun, Mark Gower, Joan Kant, Ximing Li, Dustin Yang, Mursal Nader, Minerva Fernandez, Soheil Jahangiri, Emily Tsao, Pratik Joshi, Pathum Kossinna, Loic Cameron Caloren, John Roderick Davey, Michael G. Zywiel, R. Peter Suderman, Anoushka I. Kapoor, Margarete K. Akens, Adele Changoor, Minna Woo, Robert F. Stanley, Kira A. Young, Christine Tran, Valentin Sotov, Ben X. Wang, Sagi Abelson, Omar Abdel-Wahab, Shruti Naik, Jennifer J. Trowbridge, Robert Vanner, Kristin J. Hope, Hubert Tsui, Federico Gaiti, Anastasia N. Tikhonova","doi":"10.1038/s41590-026-02668-3","DOIUrl":"https://doi.org/10.1038/s41590-026-02668-3","url":null,"abstract":"Clonal hematopoiesis of indeterminate potential is associated with systemic inflammation and increased malignant risk in humans, yet understanding of how it reshapes the bone marrow (BM) microenvironment has been limited. Using single-cell transcriptomic profiling of freshly isolated BM samples, combined with histological and spatial transcriptomic analyses, we identified fibro-inflammatory remodeling as a hallmark of clonal hematopoiesis of indeterminate potential. Fibroblasts were markedly expanded and acquired cancer-associated fibroblast-like transcriptional states, while mesenchymal and vascular cells upregulated collagen production and extracellular matrix remodeling pathways. Spatial transcriptomics revealed discrete fiber-enriched regions populated by active and CXCL12+ fibroblasts, macrophages and lymphoid cells. These regions exhibited major enrichment of proinflammatory pathways, including transforming growth factor-beta and tumor necrosis factor signaling, identifying them as spatially confined inflammatory hubs within the BM. Collectively, these findings establish fibro-inflammatory BM remodeling as a defining feature of clonal hematopoiesis of indeterminate potential, linking it to prefibrotic stromal changes and niche reorganization that may facilitate progression to overt malignancy.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"3 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149087891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autoantibody source 自身抗体的来源。
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-09-25 DOI: 10.1038/s41590-026-02676-3
Ioana Staicu
{"title":"Autoantibody source","authors":"Ioana Staicu","doi":"10.1038/s41590-026-02676-3","DOIUrl":"10.1038/s41590-026-02676-3","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 10","pages":"1971-1971"},"PeriodicalIF":26.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Presenting astrocytes 星形胶质细胞。
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-09-25 DOI: 10.1038/s41590-026-02677-2
Stephanie Houston
{"title":"Presenting astrocytes","authors":"Stephanie Houston","doi":"10.1038/s41590-026-02677-2","DOIUrl":"10.1038/s41590-026-02677-2","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 10","pages":"1971-1971"},"PeriodicalIF":26.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Line targeting AID 针对AID的线路。
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-09-25 DOI: 10.1038/s41590-026-02678-1
Laurie A. Dempsey
{"title":"Line targeting AID","authors":"Laurie A. Dempsey","doi":"10.1038/s41590-026-02678-1","DOIUrl":"10.1038/s41590-026-02678-1","url":null,"abstract":"","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 10","pages":"1971-1971"},"PeriodicalIF":26.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149062941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remodeling of a distal IRF4 element spurs human regulatory T cell instability under inflammatory conditions 在炎症条件下，远端IRF4元件的重塑刺激人类调节性T细胞不稳定。
IF 26.5 1区 医学
Nature Immunology Pub Date : 2026-09-24 DOI: 10.1038/s41590-026-02663-8
{"title":"Remodeling of a distal IRF4 element spurs human regulatory T cell instability under inflammatory conditions","authors":"","doi":"10.1038/s41590-026-02663-8","DOIUrl":"10.1038/s41590-026-02663-8","url":null,"abstract":"In an in vitro model, human regulatory T cells undergo inflammatory cytokine-driven reprogramming, resulting in increased chromatin accessibility at AP-1-binding sites, increased IRF4 expression and, ultimately, loss of lineage identity and suppressive function. Deletion of an open chromatin region distal to IRF4 protects cells from this cytokine-induced destabilization.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 10","pages":"1992-1993"},"PeriodicalIF":26.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149040130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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