Nature Immunology最新文献_第2页

Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation 对预防肠道炎症至关重要的效应调节 T 细胞的终端分化和持续存在

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-02-04 DOI: 10.1038/s41590-024-02075-6

Stanislav Dikiy, Aazam P. Ghelani, Andrew G. Levine, Stephen Martis, Paolo Giovanelli, Zhong-Min Wang, Giorgi Beroshvili, Yuri Pritykin, Chirag Krishna, Xiao Huang, Ariella Glasner, Benjamin D. Greenbaum, Christina S. Leslie, Alexander Y. Rudensky

{"title":"Terminal differentiation and persistence of effector regulatory T cells essential for preventing intestinal inflammation","authors":"Stanislav Dikiy, Aazam P. Ghelani, Andrew G. Levine, Stephen Martis, Paolo Giovanelli, Zhong-Min Wang, Giorgi Beroshvili, Yuri Pritykin, Chirag Krishna, Xiao Huang, Ariella Glasner, Benjamin D. Greenbaum, Christina S. Leslie, Alexander Y. Rudensky","doi":"10.1038/s41590-024-02075-6","DOIUrl":"https://doi.org/10.1038/s41590-024-02075-6","url":null,"abstract":"Regulatory T (Treg) cells are a specialized CD4+ T cell lineage with essential anti-inflammatory functions. Analysis of Treg cell adaptations to non-lymphoid tissues that enable their specialized immunosuppressive and tissue-supportive functions raises questions about the underlying mechanisms of these adaptations and whether they represent stable differentiation or reversible activation states. Here, we characterize distinct colonic effector Treg cell transcriptional programs. Attenuated T cell receptor (TCR) signaling and acquisition of substantial TCR-independent functionality seems to facilitate the terminal differentiation of a population of colonic effector Treg cells that are distinguished by stable expression of the immunomodulatory cytokine IL-10. Functional studies show that this subset of effector Treg cells, but not their expression of IL-10, is indispensable for colonic health. These findings identify core features of the terminal differentiation of effector Treg cells in non-lymphoid tissues and their function.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"59 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143083455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-024-02074-7

Junchen Shen, Yu Zhang, Wenbo Tang, Mingxia Yang, Tong Cheng, Yihui Chen, Shi Yu, Qiuhong Guo, Limin Cao, Xun Wang, Hui Xiao, Lanfeng Wang, Chengyuan Wang, Chen-Ying Liu, Guangxun Meng

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Tolerance during infection

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-025-02083-0

Stephanie Houston

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Nutrient metabolism shapes epigenetic landscape of T cells

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-025-02080-3

Annika Poch, Daniel T. Utzschneider

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A symphony of immunity to SARS-CoV-2 in the adenoids

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-024-02060-z

Kalpana Manthiram, Qin Xu, Pamela L. Schwartzberg

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Human versus mouse PD-1

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-025-02086-x

Ioana Staicu

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Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-024-02064-9

Matthew L. Coates, Nathan Richoz, Zewen K. Tuong, Georgina S. Bowyer, Colin Y. C. Lee, John R. Ferdinand, Eleanor Gillman, Mark McClure, Lisa Dratva, Sarah A. Teichmann, David R. Jayne, Rafael Di Marco Barros, Benjamin J. Stewart, Menna R. Clatworthy

{"title":"Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge","authors":"Matthew L. Coates, Nathan Richoz, Zewen K. Tuong, Georgina S. Bowyer, Colin Y. C. Lee, John R. Ferdinand, Eleanor Gillman, Mark McClure, Lisa Dratva, Sarah A. Teichmann, David R. Jayne, Rafael Di Marco Barros, Benjamin J. Stewart, Menna R. Clatworthy","doi":"10.1038/s41590-024-02064-9","DOIUrl":"10.1038/s41590-024-02064-9","url":null,"abstract":"Adaptive immunity is generated in lymphoid organs, but how these structures defend themselves during infection in humans is unknown. The nasal epithelium is a major site of viral entry, with adenoid nasal-associated lymphoid tissue (NALT) generating early adaptive responses. In the present study, using a nasopharyngeal biopsy technique, we investigated longitudinal immune responses in NALT after a viral challenge, using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as a natural experimental model. In acute infection, infiltrating monocytes formed a subepithelial and perifollicular shield, recruiting neutrophil extracellular trap-forming neutrophils, whereas tissue macrophages expressed pro-repair molecules during convalescence to promote the restoration of tissue integrity. Germinal center B cells expressed antiviral transcripts that inversely correlated with fate-defining transcription factors. Among T cells, tissue-resident memory CD8 T cells alone showed clonal expansion and maintained cytotoxic transcriptional programs into convalescence. Together, our study provides unique insights into how human nasal adaptive immune responses are generated and sustained in the face of viral challenge. Clatworthy and colleagues examine adult nasal lymphoid tissues in response to SARS-CoV-2 infection. Longitudinal profiling reveals changes in barrier tissue to block viral entry beyond the epithelial cell layer and how tissue repair occurred after viral infection.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 2","pages":"215-229"},"PeriodicalIF":27.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-024-02064-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recruiting lymphocytes

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-025-02085-y

Laurie A. Dempsey

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Exhaustion is planned

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-025-02084-z

Nicholas J. Bernard

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Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41590-025-02077-y

Pragya Chandrakar, Cody S. Nelson, Manuel A. Podestà, Cecilia B. Cavazzoni, Maya Gempler, Jeong-Mi Lee, Sierra Richardson, Hengcheng Zhang, Snigdha Samarpita, Maria Ciofani, Talal Chatila, Vijay K. Kuchroo, Peter T. Sage

{"title":"Progressively differentiated TFH13 cells are stabilized by JunB to mediate allergen germinal center responses","authors":"Pragya Chandrakar, Cody S. Nelson, Manuel A. Podestà, Cecilia B. Cavazzoni, Maya Gempler, Jeong-Mi Lee, Sierra Richardson, Hengcheng Zhang, Snigdha Samarpita, Maria Ciofani, Talal Chatila, Vijay K. Kuchroo, Peter T. Sage","doi":"10.1038/s41590-025-02077-y","DOIUrl":"https://doi.org/10.1038/s41590-025-02077-y","url":null,"abstract":"Allergic diseases are common and affect a large proportion of the population. Interleukin-13 (IL-13)-expressing follicular helper T (TFH13) cells are a newly identified population of TFH cells that have been associated with high-affinity IgE responses. However, the origins, developmental signals, transcriptional programming and precise functions of TFH13 cells are unknown. Here, we examined the developmental signals for TFH13 cells and found a direct and progressive differentiation pathway marked by the production of IL-21. These two pathways differed in kinetics and extrinsic requirements. However, both pathways converged, forming transcriptionally similar TFH13 cells that express the transcription factor JunB as a critical stabilizing factor. Using an intersectional genetics-based TFH13-diphtheria toxin receptor model to perturb these cells, we found that TFH13 cells were essential to drive broad germinal center responses and allergen-specific IgG and IgE. Moreover, we found that IL-21 is a broad positive regulator of allergen germinal center B cells and synergizes with IL-13 produced by TFH13 cells to amplify allergic responses. Thus, TFH13 cells orchestrate multiple features of allergic inflammation.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"23 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0