Nature Immunology最新文献_第2页

β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-08 DOI: 10.1038/s41590-024-02041-2

Nargis Khan, Kim A. Tran, Raphael Chevre, Veronica Locher, Mathis Richter, Sarah Sun, Mina Sadeghi, Erwan Pernet, Andrea Herrero-Cervera, Alexandre Grant, Ahmed Saif, Jeffrey Downey, Eva Kaufmann, Shabaana Abdul Khader, Philippe Joubert, Luis B. Barreiro, Bryan G. Yipp, Oliver Soehnlein, Maziar Divangahi

{"title":"β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus","authors":"Nargis Khan, Kim A. Tran, Raphael Chevre, Veronica Locher, Mathis Richter, Sarah Sun, Mina Sadeghi, Erwan Pernet, Andrea Herrero-Cervera, Alexandre Grant, Ahmed Saif, Jeffrey Downey, Eva Kaufmann, Shabaana Abdul Khader, Philippe Joubert, Luis B. Barreiro, Bryan G. Yipp, Oliver Soehnlein, Maziar Divangahi","doi":"10.1038/s41590-024-02041-2","DOIUrl":"https://doi.org/10.1038/s41590-024-02041-2","url":null,"abstract":"Disease tolerance is an evolutionarily conserved host defense strategy that preserves tissue integrity and physiology without affecting pathogen load. Unlike host resistance, the mechanisms underlying disease tolerance remain poorly understood. In the present study, we investigated whether an adjuvant (β-glucan) can reprogram innate immunity to provide protection against influenza A virus (IAV) infection. β-Glucan treatment reduces the morbidity and mortality against IAV infection, independent of host resistance. The enhanced survival is the result of increased recruitment of neutrophils via RoRγt+ T cells in the lung tissue. β-Glucan treatment promotes granulopoiesis in a type 1 interferon-dependent manner that leads to the generation of a unique subset of immature neutrophils utilizing a mitochondrial oxidative metabolism and producing interleukin-10. Collectively, our data indicate that β-glucan reprograms hematopoietic stem cells to generate neutrophils with a new ‘regulatory’ function, which is required for promoting disease tolerance and maintaining lung tissue integrity against viral infection.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"30 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Profibrotic monocyte-derived alveolar macrophages are expanded in patients with persistent respiratory symptoms and radiographic abnormalities after COVID-19

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-07 DOI: 10.1038/s41590-025-02076-z

Joseph I. Bailey, Connor H. Puritz, Karolina J. Senkow, Nikolay S. Markov, Estefani Diaz, Emmy Jonasson, Zhan Yu, Suchitra Swaminathan, Ziyan Lu, Samuel Fenske, Rogan A. Grant, Hiam Abdala-Valencia, Ruben J. Mylvaganam, Amy Ludwig, Janet Miller, R. Ian Cumming, Robert M. Tighe, Kymberly M. Gowdy, Ravi Kalhan, Manu Jain, Ankit Bharat, Chitaru Kurihara, Ruben San Jose Estepar, Raul San Jose Estepar, George R. Washko, Ali Shilatifard, Jacob I. Sznajder, Karen M. Ridge, G. R. Scott Budinger, Rosemary Braun, Alexander V. Misharin, Marc A. Sala

引用次数: 0

Retraction Note: Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-07 DOI: 10.1038/s41590-024-02070-x

Hanh Chi Do-Umehara, Cong Chen, Daniela Urich, Liang Zhou, Ju Qiu, Samuel Jang, Alia Zander, Margaret A. Baker, Martin Eilers, Peter H. S. Sporn, Karen M. Ridge, Jacob I. Sznajder, G. R. Scott Budinger, Gökhan M. Mutlu, Anning Lin, Jing Liu

引用次数: 0

The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity

IF 30.5 1区医学

Nature Immunology Pub Date : 2025-01-06 DOI: 10.1038/s41590-024-02047-w

Bolin Xiang, Meiling Zhang, Kai Li, Zijian Zhang, Yutong Liu, Minling Gao, Xiyong Wang, Xiangling Xiao, Yishuang Sun, Chuan He, Jie Shi, Hongzeng Fan, Xixin Xing, Gaoshan Xu, Yingmeng Yao, Gang Chen, Haichuan Zhu, Chengqi Yi, Jinfang Zhang

{"title":"The epitranscriptional factor PCIF1 orchestrates CD8+ T cell ferroptosis and activation to control antitumor immunity","authors":"Bolin Xiang, Meiling Zhang, Kai Li, Zijian Zhang, Yutong Liu, Minling Gao, Xiyong Wang, Xiangling Xiao, Yishuang Sun, Chuan He, Jie Shi, Hongzeng Fan, Xixin Xing, Gaoshan Xu, Yingmeng Yao, Gang Chen, Haichuan Zhu, Chengqi Yi, Jinfang Zhang","doi":"10.1038/s41590-024-02047-w","DOIUrl":"https://doi.org/10.1038/s41590-024-02047-w","url":null,"abstract":"T cell-based immunotherapies have revolutionized cancer treatment, yet durable responses remain elusive. Here we show that PCIF1, an RNA N6 2′-O-dimethyladenosine (m6Am) methyltransferase, negatively regulates CD8+ T cell antitumor responses. Whole-body or T cell-specific Pcif1 knockout (KO) reduced tumor growth in mice. Single-cell RNA sequencing shows an increase in the number of tumor-infiltrating cytotoxic CD8+ T cells in Pcif1-deficient mice. Mechanistically, proteomic and m6Am-sequencing analyses pinpoint that Pcif1 KO elevates m6Am-modified targets, specifically ferroptosis suppressor genes (Fth1, Slc3a2), and the T cell activation gene Cd69, imparting resistance to ferroptosis and enhancing CD8+ T cell activation. Of note, Pcif1-deficient mice had enhanced responses to anti-PD-1 immunotherapy, and Pcif1 KO chimeric antigen receptor T cells improved tumor control. Clinically, cancer patients with low PCIF1 expression in T cells have enhanced responses to immunotherapies. These findings suggest that PCIF1 suppresses CD8+ T cell activation and targeting PCIF1 is a promising strategy to boost antitumor immunity.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"3 1","pages":""},"PeriodicalIF":30.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate immune barrier against oncogenic transformation

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02043-0

引用次数: 0

System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02036-z

Mario Cortese, Thomas Hagan, Nadine Rouphael, Sheng-Yang Wu, Xia Xie, Dmitri Kazmin, Florian Wimmers, Shakti Gupta, Robbert van der Most, Margherita Coccia, Prabhu S. Aranuchalam, Helder I. Nakaya, Yating Wang, Elizabeth Coyle, Shu Horiuchi, Hanchih Wu, Mary Bower, Aneesh Mehta, Clifford Gunthel, Steve E. Bosinger, Yuri Kotliarov, Foo Cheung, Pamela L. Schwartzberg, Ronald N. Germain, John Tsang, Shuzhao Li, Randy Albrecht, Hideki Ueno, Shankar Subramaniam, Mark J. Mulligan, Surender Khurana, Hana Golding, Bali Pulendran

{"title":"System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans","authors":"Mario Cortese, Thomas Hagan, Nadine Rouphael, Sheng-Yang Wu, Xia Xie, Dmitri Kazmin, Florian Wimmers, Shakti Gupta, Robbert van der Most, Margherita Coccia, Prabhu S. Aranuchalam, Helder I. Nakaya, Yating Wang, Elizabeth Coyle, Shu Horiuchi, Hanchih Wu, Mary Bower, Aneesh Mehta, Clifford Gunthel, Steve E. Bosinger, Yuri Kotliarov, Foo Cheung, Pamela L. Schwartzberg, Ronald N. Germain, John Tsang, Shuzhao Li, Randy Albrecht, Hideki Ueno, Shankar Subramaniam, Mark J. Mulligan, Surender Khurana, Hana Golding, Bali Pulendran","doi":"10.1038/s41590-024-02036-z","DOIUrl":"10.1038/s41590-024-02036-z","url":null,"abstract":"We performed a systems vaccinology analysis to investigate immune responses in humans to an H5N1 influenza vaccine, with and without the AS03 adjuvant, to identify factors influencing antibody response magnitude and durability. Our findings revealed a platelet and adhesion-related blood transcriptional signature on day 7 that predicted the longevity of the antibody response, suggesting a potential role for platelets in modulating antibody response durability. As platelets originate from megakaryocytes, we explored the effect of thrombopoietin (TPO)-mediated megakaryocyte activation on antibody response longevity. We found that TPO administration enhanced the durability of vaccine-induced antibody responses. TPO-activated megakaryocytes also promoted survival of human bone-marrow plasma cells through integrin β1/β2-mediated cell–cell interactions, along with survival factors APRIL and the MIF–CD74 axis. Using machine learning, we developed a classifier based on this platelet-associated signature, which predicted antibody response longevity across six vaccines from seven independent trials, highlighting a conserved mechanism for vaccine durability. Pulendran and colleagues define a molecular signature that can be used to predict the durability of antibody responses to vaccination and reveal important insights into the mechanisms by which vaccines induce durable immunity.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"116-130"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02028-z

Andrew Kent, Kristel Joy Yee Mon, Zachary Hutchins, Gregory Putzel, Dmitry Zhigarev, Alexander Grier, Baosen Jia, Roderik M. Kortlever, Gaetan Barbet, Gerard I. Evan, J. Magarian Blander

{"title":"A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis","authors":"Andrew Kent, Kristel Joy Yee Mon, Zachary Hutchins, Gregory Putzel, Dmitry Zhigarev, Alexander Grier, Baosen Jia, Roderik M. Kortlever, Gaetan Barbet, Gerard I. Evan, J. Magarian Blander","doi":"10.1038/s41590-024-02028-z","DOIUrl":"10.1038/s41590-024-02028-z","url":null,"abstract":"The inflammasome plays multifaceted roles in cancer, but less is known about its function during premalignancy upon initial cell transformation. We report a homeostatic function of the inflammasome in suppressing malignant transformation through Ras inhibition. We identified increased hematopoietic stem cell (HSC) proliferation within the bone marrow of inflammasome-deficient mice. HSCs within an inflammasome-deficient stroma expressed a Ras signature associated with increased Ras pathway- and cancer-related transcripts and heightened levels of cytokine, chemokine and growth factor receptors. Stromal inflammasome deficiency established a poised Ras-dependent mitogenic state within HSCs, which fueled progeny B cell lymphomagenesis upon Myc deregulation in a spontaneous model of B cell lymphoma, and shortened its premalignant stage leading to faster onset of malignancy. Thus, the stromal inflammasome preserves tissue balance by restraining Ras to disrupt the most common oncogenic Myc–Ras cooperation and establish a natural defense against transition to malignancy. These findings should inform preventative therapies against hematological malignancies. Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"53-67"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innate immune cells link dietary cues to normal and abnormal metabolic regulation

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02037-y

Peng Zhang, Kosuke Watari, Michael Karin

{"title":"Innate immune cells link dietary cues to normal and abnormal metabolic regulation","authors":"Peng Zhang, Kosuke Watari, Michael Karin","doi":"10.1038/s41590-024-02037-y","DOIUrl":"10.1038/s41590-024-02037-y","url":null,"abstract":"A slew of common metabolic disorders, including type 2 diabetes, metabolic dysfunction-associated steatotic liver disease and steatohepatitis, are exponentially increasing in our sedentary and overfed society. While macronutrients directly impact metabolism and bioenergetics, new evidence implicates immune cells as critical sensors of nutritional cues and important regulators of metabolic homeostasis. A deeper interrogation of the intricate and multipartite interactions between dietary components, immune cells and metabolically active tissues is needed for a better understanding of metabolic regulation and development of new treatments for common metabolic diseases. Responding to macronutrients and micronutrients, immune cells play pivotal roles in interorgan communication between the microbiota, small intestine, metabolically active cells including hepatocytes and adipocytes, and the brain, which controls feeding behavior and energy expenditure. This Review focuses on the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control. Karin and colleagues review the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"26 1","pages":"29-41"},"PeriodicalIF":27.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet partnerships and lasting memories

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02040-3

Petter Brodin

引用次数: 0

Latent HIV-1 induction

IF 27.7 1区医学

Nature Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41590-024-02055-w

Paula Jauregui

引用次数: 0