Nature Immunology最新文献_第2页

BLIMP1 tunes germinal center B cell responses to limit clonal dominance. BLIMP1调节生发中心B细胞应答以限制克隆优势。

IF 30.5 1区医学

Nature Immunology Pub Date : 2026-04-23 DOI: 10.1038/s41590-026-02508-4

引用次数: 0

Astrocyte-driven immunosuppression in the brain tumor microenvironment 星形胶质细胞驱动的脑肿瘤微环境免疫抑制。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-23 DOI: 10.1038/s41590-026-02488-5

Camilo Faust Akl, Francisco J. Quintana

引用次数: 0

ROS breaks the cofilin lock on NLRP3 ROS打破了NLRP3上的cofilin锁。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-21 DOI: 10.1038/s41590-026-02490-x

Manasa Mellacheruvu, Kate Schroder

引用次数: 0

Author Correction: Chemokine-defined macrophage niches establish spatial organization of tumor immunity. 作者更正：趋化因子定义的巨噬细胞壁龛建立肿瘤免疫的空间组织。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-21 DOI: 10.1038/s41590-026-02525-3

Soubhik Ghosh, Xin Li, Kavita Rawat, Aishwarya Dighal, Stephanie Kalinowski, Reza Hosseini, Fred W Kolling, Carol S Ringelberg, Claudia V Jakubzick

引用次数: 0

Developing a vaccine strategy to prevent the progression of pulmonary fibrosis 开发预防肺纤维化进展的疫苗策略。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-20 DOI: 10.1038/s41590-026-02487-6

R. Gisli Jenkins

引用次数: 0

BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition. BLIMP1通过在明暗区过渡过程中控制染色质可及性来塑造生发中心B细胞克隆多样性。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-20 DOI: 10.1038/s41590-026-02495-6

Godhev Kumar Manakkat Vijay, Bala Ramaswami, Steven Gierlack, Nicholas A Pease, Peter Gerges, Dianyu Chen, Kairavee Thakkar, Luis Mena Hernandez, Swapnil Keshari, Heping Xu, Nathan Salomonis, Jishnu Das, David M Rothstein, Harinder Singh

{"title":"BLIMP1 shapes germinal center B cell clonal diversity by gating chromatin accessibility during light-to-dark zone transition.","authors":"Godhev Kumar Manakkat Vijay, Bala Ramaswami, Steven Gierlack, Nicholas A Pease, Peter Gerges, Dianyu Chen, Kairavee Thakkar, Luis Mena Hernandez, Swapnil Keshari, Heping Xu, Nathan Salomonis, Jishnu Das, David M Rothstein, Harinder Singh","doi":"10.1038/s41590-026-02495-6","DOIUrl":"10.1038/s41590-026-02495-6","url":null,"abstract":"<p><p>Germinal center B cell responses are defined by many positive regulators of affinity maturation, but few components that restrain clonal dominance, notably Nr4a1, are known. We reveal an unsuspected role for BLIMP1 (Prdm1)-a plasma cell determinant-as a feedback regulator of affinity maturation. Single-cell RNA and B cell receptor (BCR) sequencing showed that B cell-specific Prdm1 loss drives an exaggerated germinal center reaction with larger clones, increased somatic hypermutation and greater clonal dominance, independent of Nr4a1. Single-cell chromatin profiling with base-resolution modeling indicated that Blimp-1 represses expression of BCR-signaling genes, gating chromatin accessibility at interferon-stimulated response elements, Ets-interferon regulatory factor composite elements, nuclear factor kappa B and Oct motifs. In the absence of BLIMP1, enhanced BCR-signaling augments activities of transcription factors that promote G1-S transition during light zone (LZ) selection and fuel dark zone (DZ) expansion. Thus, BLIMP1 attenuates BCR signaling and constrains the LZ to DZ transition, fine-tuning clonal competition, thereby maintaining repertoire diversity.</p>","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":" ","pages":""},"PeriodicalIF":27.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147729449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets 肺纤维化的免疫肽分析为确定治疗靶点提供了一个平台。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-20 DOI: 10.1038/s41590-026-02501-x

Ziyi Bai, Tianxia Lan, Weiqi Hong, Haiying Que, Min Zhu, Xin Xiao, Dandan Wan, Jiayuan Ai, Shaoxiong Huang, Jiayu Wang, Qiaonan Hong, Yanyan Liu, Chengxin Xiao, Chengjian Zhao, Xin Wang, Xiaolong Zhang, Ting Yang, Heng Xu, Lunzhi Dai, Charles A. Powell, Luca Richeldi, Fengming Luo, Haohao Dong, Yong Yuan, Qiang Pu, Xiawei Wei

{"title":"Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets","authors":"Ziyi Bai, Tianxia Lan, Weiqi Hong, Haiying Que, Min Zhu, Xin Xiao, Dandan Wan, Jiayuan Ai, Shaoxiong Huang, Jiayu Wang, Qiaonan Hong, Yanyan Liu, Chengxin Xiao, Chengjian Zhao, Xin Wang, Xiaolong Zhang, Ting Yang, Heng Xu, Lunzhi Dai, Charles A. Powell, Luca Richeldi, Fengming Luo, Haohao Dong, Yong Yuan, Qiang Pu, Xiawei Wei","doi":"10.1038/s41590-026-02501-x","DOIUrl":"10.1038/s41590-026-02501-x","url":null,"abstract":"Fibrosis is a severe pathological outcome of many chronic diseases, yet the therapeutic potential of targeting the altered major histocompatibility complex (MHC) class I immunopeptidome remains largely unexplored. Here we characterized the MHC class I immunopeptidomes from both fibrotic foci of human idiopathic pulmonary fibrosis lung explants and bleomycin-treated mice, identifying a diverse repertoire of fibrosis-associated peptides. Parallel profiling of bleomycin-induced pulmonary fibrosis in mice enabled the computational prioritization of therapeutic targets. In vivo, therapeutic vaccination with three candidate peptides (MAF116–124, APBB270–78 and TNS3119–127) effectively mitigated fibrosis progression in bleomycin-treated mice. Furthermore, leveraging its evolutionary conservation, we found that MAF116–124 elicited specific human cytotoxic T lymphocytes that lysed human idiopathic pulmonary fibrosis-derived myofibroblasts and M2-like macrophages. This study indicates that immunopeptidome profiling provides a robust platform for discovering translatable antifibrotic immunotherapies. Wei and colleagues characterized the MHC class I immunopeptidome in mice and humans with lung fibrosis and identified immunogenic peptides specifically expressed in fibrosis-associated lung cell subsets that blocked the progression of fibrosis in mice treated with bleomycin.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 5","pages":"923-936"},"PeriodicalIF":27.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41590-026-02501-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147726248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor-derived branched-chain α-keto acids activate Notch signaling in tumor-associated macrophages to limit immunity. 肿瘤衍生的支链α-酮酸激活肿瘤相关巨噬细胞中的Notch信号以限制免疫。

IF 30.5 1区医学

Nature Immunology Pub Date : 2026-04-14 DOI: 10.1038/s41590-026-02484-9

Qi-Xiang Ma,Ru Zhao,Jiang-Xue Han,Wen-Ying Zhu,Mi-Die Xu,Xiao-Yan Zhang,Guo-Quan Yan,Wen-Yu Wen,Guang-Chun Han,Min Luo,Miao Yin,Jin-Tao Li,Qun-Ying Lei

引用次数: 0

Purine salvage pathway protects CD8+ T cells from metabolic stress 嘌呤挽救途径保护CD8+ T细胞免受代谢应激。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-13 DOI: 10.1038/s41590-026-02491-w

Masaki Tajima, He Hao, Baihao Zhang, Yuta Matsuoka, Kazuhiro Sonomura, Koshi Imami, Yosuke Isobe, Rae Maeda, Yu-Hsien Lin, Akihiro Shimba, Ryoma Kato, Pedro Henrique Costa Cruz, Sayaka Washizu, Yosuke Ikejiri, Akiyo Morinibu, Clive Steven Barker, Jun Seita, Yibo Wu, Satomi Ito, Seiko Narushima, Rei Nakano, Mikako Maruya, Wakana Kobayashi, Sai Shanmukha Priya Narayanan, Jumana Shaheen, Hiroyuki Neyama, Ken-ichi Yamada, Makoto Arita, Yuki Sugiura, Sidonia Fagarasan

{"title":"Purine salvage pathway protects CD8+ T cells from metabolic stress","authors":"Masaki Tajima, He Hao, Baihao Zhang, Yuta Matsuoka, Kazuhiro Sonomura, Koshi Imami, Yosuke Isobe, Rae Maeda, Yu-Hsien Lin, Akihiro Shimba, Ryoma Kato, Pedro Henrique Costa Cruz, Sayaka Washizu, Yosuke Ikejiri, Akiyo Morinibu, Clive Steven Barker, Jun Seita, Yibo Wu, Satomi Ito, Seiko Narushima, Rei Nakano, Mikako Maruya, Wakana Kobayashi, Sai Shanmukha Priya Narayanan, Jumana Shaheen, Hiroyuki Neyama, Ken-ichi Yamada, Makoto Arita, Yuki Sugiura, Sidonia Fagarasan","doi":"10.1038/s41590-026-02491-w","DOIUrl":"10.1038/s41590-026-02491-w","url":null,"abstract":"Metabolic stress from a high-fat diet (HFD) impairs antitumor immunity through persistent metabolic rewiring, but its effects and long-term impact on CD8+ T cell metabolism remain unknown. Here, we found that even temporary exposure to a HFD impaired antitumor immunity 10 weeks after reversion to a normal diet. This was due to lasting metabolome changes that included enrichment in phospholipids sensitive to peroxidation and depletion of antioxidants, affecting the survival and function of CD8+ T cells. Under oxidative stress, CD8+ T cells utilized the xanthine salvage pathway to produce guanosine triphosphate, enhancing the amount of tetrahydrobiopterin. Xanthine supplementation reduced lipid peroxidation in tumor-draining lymph nodes and improved antitumor immunity in mice previously on a HFD. Our data indicate that metabolic stress in CD8+ T cells persists long after restoration of a balanced diet, and manifests as vulnerability to ferroptosis, which could be mitigated by replenishing biopterins through the xanthine salvage pathway. Tajima et al. show that a transient or continuous high-fat diet induces metabolic changes in CD8+ T cells that lead to increased vulnerability to ferroptosis and reduced antitumor responses.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"27 5","pages":"1026-1038"},"PeriodicalIF":27.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The dual role of TOX in regulating TH1 and CD8+ T cell fate TOX在调节TH1和CD8+ T细胞命运中的双重作用。

IF 27.6 1区医学

Nature Immunology Pub Date : 2026-04-13 DOI: 10.1038/s41590-026-02494-7

Yoon-Chul Kye, Vijay K. Kuchroo

引用次数: 0