Nature Immunology最新文献_第9页

Advancements in pathogen immunity and signaling 病原体免疫和信号传递方面的进展

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-15 DOI: 10.1038/s41590-024-01905-x

Mads Gyrd-Hansen, Anna Kajaste-Rudnitski, Nicolas Manel, Jan Rehwinkel, Annemarthe G. van der Veen, Matteo Iannacone

引用次数: 0

Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis 特定 CD4+ T 细胞表型与 "抵抗 "结核分枝杆菌感染者的细菌控制有关

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-12 DOI: 10.1038/s41590-024-01897-8

Meng Sun, Jolie M. Phan, Nathan S. Kieswetter, Huang Huang, Krystle K. Q. Yu, Malisa T. Smith, Yiran E. Liu, Chuanqi Wang, Sanjana Gupta, Gerlinde Obermoser, Holden Terry Maecker, Akshaya Krishnan, Sundari Suresh, Neha Gupta, Mary Rieck, Peter Acs, Mustafa Ghanizada, Shin-Heng Chiou, Purvesh Khatri, W. Henry Boom, Thomas R. Hawn, Catherine M. Stein, Harriet Mayanja-Kizza, Mark M. Davis, Chetan Seshadri

{"title":"Specific CD4+ T cell phenotypes associate with bacterial control in people who ‘resist’ infection with Mycobacterium tuberculosis","authors":"Meng Sun, Jolie M. Phan, Nathan S. Kieswetter, Huang Huang, Krystle K. Q. Yu, Malisa T. Smith, Yiran E. Liu, Chuanqi Wang, Sanjana Gupta, Gerlinde Obermoser, Holden Terry Maecker, Akshaya Krishnan, Sundari Suresh, Neha Gupta, Mary Rieck, Peter Acs, Mustafa Ghanizada, Shin-Heng Chiou, Purvesh Khatri, W. Henry Boom, Thomas R. Hawn, Catherine M. Stein, Harriet Mayanja-Kizza, Mark M. Davis, Chetan Seshadri","doi":"10.1038/s41590-024-01897-8","DOIUrl":"10.1038/s41590-024-01897-8","url":null,"abstract":"A subset of individuals exposed to Mycobacterium tuberculosis (Mtb) that we refer to as ‘resisters’ (RSTR) show evidence of IFN-γ− T cell responses to Mtb-specific antigens despite serially negative results on clinical testing. Here we found that Mtb-specific T cells in RSTR were clonally expanded, confirming the priming of adaptive immune responses following Mtb exposure. RSTR CD4+ T cells showed enrichment of TH17 and regulatory T cell-like functional programs compared to Mtb-specific T cells from individuals with latent Mtb infection. Using public datasets, we showed that these TH17 cell-like functional programs were associated with lack of progression to active tuberculosis among South African adolescents with latent Mtb infection and with bacterial control in nonhuman primates. Our findings suggested that RSTR may successfully control Mtb following exposure and immune priming and established a set of T cell biomarkers to facilitate further study of this clinical phenotype. Seshadri, Davis and colleagues show that individuals who do not develop an infection with Mycobacterium tuberculosis (Mtb), despite exposure to the bacteria and expansion of CD4+ T cell clones specific to Mtb antigens, show enrichment of TH17 cell and T regulatory functional programs.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-024-01897-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes 胸腺先天性类 T 细胞直接呈现炎症相关的自身抗原，诱导自身反应性 CD8+胸腺细胞的清除

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-11 DOI: 10.1038/s41590-024-01899-6

Yuanyuan You, Josefine Dunst, Kewei Ye, Patrick A. Sandoz, Annika Reinhardt, Inga Sandrock, Natalia R. Comet, Rupak Dey Sarkar, Emily Yang, Estelle Duprez, Judith Agudo, Brian D. Brown, Paul J. Utz, Wolfgang Kastenmüller, Carmen Gerlach, Immo Prinz, Björn Önfelt, Taras Kreslavsky

{"title":"Direct presentation of inflammation-associated self-antigens by thymic innate-like T cells induces elimination of autoreactive CD8+ thymocytes","authors":"Yuanyuan You, Josefine Dunst, Kewei Ye, Patrick A. Sandoz, Annika Reinhardt, Inga Sandrock, Natalia R. Comet, Rupak Dey Sarkar, Emily Yang, Estelle Duprez, Judith Agudo, Brian D. Brown, Paul J. Utz, Wolfgang Kastenmüller, Carmen Gerlach, Immo Prinz, Björn Önfelt, Taras Kreslavsky","doi":"10.1038/s41590-024-01899-6","DOIUrl":"10.1038/s41590-024-01899-6","url":null,"abstract":"Upregulation of diverse self-antigens that constitute components of the inflammatory response overlaps spatially and temporally with the emergence of pathogen-derived foreign antigens. Therefore, discrimination between these inflammation-associated self-antigens and pathogen-derived molecules represents a unique challenge for the adaptive immune system. Here, we demonstrate that CD8+ T cell tolerance to T cell-derived inflammation-associated self-antigens is efficiently induced in the thymus and supported by redundancy in cell types expressing these molecules. In addition to thymic epithelial cells, this included thymic eosinophils and innate-like T cells, a population that expressed molecules characteristic for all major activated T cell subsets. We show that direct T cell-to-T cell antigen presentation by minute numbers of innate-like T cells was sufficient to eliminate autoreactive CD8+ thymocytes. Tolerance to such effector molecules was of critical importance, as its breach caused by decreased thymic abundance of a single model inflammation-associated self-antigen resulted in autoimmune elimination of an entire class of effector T cells. The thymus harbors a complex constitutively active inflammatory network with innate-like T cells representing one of its central nodes. Here, the authors show that these cells can induce tolerance to inflammation-associated self-antigens, a class of molecules that otherwise largely mirrors the spatial and temporal distribution of pathogen-derived antigens.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41590-024-01899-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141584268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Author Correction: Distinct developmental pathways generate functionally distinct populations of natural killer cells 作者更正：不同的发育途径会产生功能截然不同的自然杀伤细胞群。

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-10 DOI: 10.1038/s41590-024-01917-7

Yi Ding, Marieke Lavaert, Simon Grassmann, Victor I. Band, Liang Chi, Arundhoti Das, Sumit Das, Christelle Harly, Susannah C. Shissler, Justin Malin, Dingkang Peng, Yongge Zhao, Jinfang Zhu, Yasmine Belkaid, Joseph C. Sun, Avinash Bhandoola

引用次数: 0

Chameleon impersonation of NK cells and ILC1s 变色龙冒充 NK 细胞和 ILC1s

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-09 DOI: 10.1038/s41590-024-01886-x

M. Zeeshan Chaudhry, Gabrielle T. Belz

引用次数: 0

Stimulation history is epigenetically imprinted in memory B cells 刺激史在记忆 B 细胞中留下了表观遗传印记

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-09 DOI: 10.1038/s41590-024-01903-z

引用次数: 0

B cells instruct their own fate through IL-12 B 细胞通过 IL-12 指示自己的命运

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-09 DOI: 10.1038/s41590-024-01887-w

Iñaki Sanz

引用次数: 0

Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge 对刺激历史的表观遗传记录揭示了 BLIMP1-BACH2 在决定回忆挑战时记忆 B 细胞命运方面的平衡。

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-05 DOI: 10.1038/s41590-024-01900-2

Wen Shao, Yifeng Wang, Qian Fang, Wenjuan Shi, Hai Qi

{"title":"Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge","authors":"Wen Shao, Yifeng Wang, Qian Fang, Wenjuan Shi, Hai Qi","doi":"10.1038/s41590-024-01900-2","DOIUrl":"10.1038/s41590-024-01900-2","url":null,"abstract":"Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon antigen recall. How this decision is programmed is not understood. We found that the relative strength between two antagonistic transcription factors, B lymphocyte-induced maturation protein 1 (BLIMP1) and BTB domain and CNC homolog 2 (BACH2), progressively increases in favor of BLIMP1 in antigen-responding B cells through the course of primary responses. MBC subsets that preferentially produce secondary GCs expressed comparatively higher BACH2 but lower BLIMP1 than those predisposed for PC development. Skewing the BLIMP1–BACH2 balance in otherwise fate-predisposed MBC subsets could switch their fate preferences. Underlying the changing BLIMP1-over-BACH2 balance, we observed progressively increased accessibilities at chromatin loci that are specifically opened in PCs, particularly those that contain interferon-sensitive response elements (ISREs) and are controlled by interferon regulatory factor 4 (IRF4). IRF4 is upregulated by B cell receptor, CD40 or innate receptor signaling and it induces graded levels of PC-specifying epigenetic imprints according to the strength of stimulation. By analyzing history-stamped GC B cells, we found progressively increased chromatin accessibilities at PC-specific, IRF4-controlled gene loci over time. Therefore, the cumulative stimulation history of B cells is epigenetically recorded in an IRF4-dependent manner, determines the relative strength between BLIMP1 and BACH2 in individual MBCs and dictates their probabilities to develop into GCs or PCs upon restimulation. Qi and colleagues generate reporter mice that can track the stimulation history of individual B cells, a record epigenetically stored as progressive chromatin changes. This recording system revealed that the balance of B lymphocyte-induced maturation protein 1 (BLIMP1) to BTB domain and CNC homolog 2 (BACH2) predicts the fate of memory B cells upon recall challenge.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells B 细胞中的 PI3Kγ 促进抗体反应和抗体分泌细胞的生成

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-03 DOI: 10.1038/s41590-024-01890-1

Stephen M. Lanahan, Lucas Yang, Kate M. Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y. Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P. Wymann, Steven H. Kleinstein, V. Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S. Abraham, Carrie L. Lucas

{"title":"PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells","authors":"Stephen M. Lanahan, Lucas Yang, Kate M. Jones, Zhihong Qi, Emylette Cruz Cabrera, Lauren Y. Cominsky, Anjali Ramaswamy, Anis Barmada, Gisela Gabernet, Dinesh Babu Uthaya Kumar, Lan Xu, Peiying Shan, Matthias P. Wymann, Steven H. Kleinstein, V. Koneti Rao, Peter Mustillo, Neil Romberg, Roshini S. Abraham, Carrie L. Lucas","doi":"10.1038/s41590-024-01890-1","DOIUrl":"10.1038/s41590-024-01890-1","url":null,"abstract":"The differentiation of naive and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for phosphoinositide 3-kinase-delta (PI3Kδ) to support B cell biology has been investigated intensively; however, specific functions of the related phosphoinositide 3-kinase-gamma (PI3Kγ) complex in B lineage cells have not. In the present study, we report that PI3Kγ promotes robust antibody responses induced by T cell-dependent antigens. The inborn error of immunity caused by human deficiency in PI3Kγ results in broad humoral defects, prompting our investigation of roles for this kinase in antibody responses. Using mouse immunization models, we found that PI3Kγ functions cell intrinsically within activated B cells in a kinase activity-dependent manner to transduce signals required for the transcriptional program supporting differentiation of ASCs. Furthermore, ASC fate choice coincides with upregulation of PIK3CG expression and is impaired in the context of PI3Kγ disruption in naive B cells on in vitro CD40-/cytokine-driven activation, in memory B cells on toll-like receptor activation, or in human tonsillar organoids. Taken together, our study uncovers a fundamental role for PI3Kγ in supporting humoral immunity by integrating signals instructing commitment to the ASC fate. Lucas and colleagues show that differentiating B cells switch expression of PI3Kδ to PI3Kγ and that this switch is required for optimal T cell-dependent IgG antibody production in both mice and humans.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diversity of group 1 innate lymphoid cells in human tissues 人体组织中第 1 组先天性淋巴细胞的多样性

IF 27.7 1区医学

Nature Immunology Pub Date : 2024-07-02 DOI: 10.1038/s41590-024-01885-y

Natalia Jaeger, Alina Ulezko Antonova, Daniel Kreisel, Florence Roan, Erica Lantelme, Steven F. Ziegler, Marina Cella, Marco Colonna

{"title":"Diversity of group 1 innate lymphoid cells in human tissues","authors":"Natalia Jaeger, Alina Ulezko Antonova, Daniel Kreisel, Florence Roan, Erica Lantelme, Steven F. Ziegler, Marina Cella, Marco Colonna","doi":"10.1038/s41590-024-01885-y","DOIUrl":"10.1038/s41590-024-01885-y","url":null,"abstract":"Group 1 innate lymphoid cells (ILC1s) are cytotoxic and interferon gamma-producing lymphocytes lacking antigen-specific receptors, which include ILC1s and natural killer (NK) cells. In mice, ILC1s differ from NK cells, as they develop independently of the NK-specifying transcription factor EOMES, while requiring the repressor ZFP683 (ZNF683 in humans) for tissue residency. Here we identify highly variable ILC1 subtypes across tissues through investigation of human ILC1 diversity by single-cell RNA sequencing and flow cytometry. The intestinal epithelium contained abundant mature EOMES− ILC1s expressing PRDM1 rather than ZNF683, alongside a few immature TCF7+PRDM1− ILC1s. Other tissues harbored NK cells expressing ZNF683 and EOMES transcripts; however, EOMES protein content was variable. These ZNF683+ NK cells are tissue-imprinted NK cells phenotypically resembling ILC1s. The tissue ILC1-NK spectrum also encompassed conventional NK cells and NK cells distinguished by PTGDS expression. These findings establish a foundation for evaluating phenotypic and functional changes within the NK-ILC1 spectrum in diseases. Colonna and colleagues analyze human ILC1 diversity by scRNA-seq and flow cytometry in various human tissues.","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":null,"pages":null},"PeriodicalIF":27.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141489209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0