The impact of genetic immune disorders on infections including COVID-19, inflammatory bowel disease and cancer

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-28 DOI:10.1038/s41590-025-02225-4

Chen Xiang, Ann Y. Park, Sarah E. Weber, Michael J. Lenardo, Ahmet Ozen, Jing Cui

引用次数: 0

Abstract

Inborn errors of immunity (IEIs) are rare genetic anomalies that cause defective immune function. Over 500 IEIs have been identified to date, affecting millions of patients globally. These IEIs reveal the complex interplay between genetics, the environment and microorganisms that determine immune disease phenotypes. Progress in understanding the molecular and cellular mechanisms of IEIs provides a genetic framework for a functional understanding of the human immune system, disease pathogenesis and successful therapeutic interventions. This Review describes how IEIs impact infectious diseases, particularly coronavirus disease 2019, inflammatory bowel disease and cancer.

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遗传免疫疾病对感染的影响，包括COVID-19、炎症性肠病和癌症

先天性免疫缺陷（IEIs）是一种罕见的导致免疫功能缺陷的遗传异常。迄今为止，已经确定了500多个肠内感染，影响到全球数百万患者。这些iei揭示了决定免疫疾病表型的遗传、环境和微生物之间复杂的相互作用。了解iei的分子和细胞机制的进展为了解人类免疫系统、疾病发病机制和成功的治疗干预提供了一个遗传学框架。本综述描述了IEIs如何影响传染病，特别是2019冠状病毒病、炎症性肠病和癌症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.