{"title":"The immunology of asthma","authors":"Bart N. Lambrecht, Engi Ahmed, Hamida Hammad","doi":"10.1038/s41590-025-02212-9","DOIUrl":null,"url":null,"abstract":"<p>Asthma is a chronic inflammatory disease of the airways characterized by variable airway obstruction. In some patients with severe disease there are frequent disease flares, and some individuals develop irreversible airway obstruction. The immune system has a predominant effect on many aspects of the disease. A large proportion of people with asthma have signs of type 2 immunity, rich in eosinophils, mast cells and basophils, and controlled by either type 2 helper T cells or type 2 innate lymphoid cells. Other patients have a more neutrophil-predominant disease, and some have little underlying immune dysfunction. Here we review the immunology of asthma by integrating data from mouse model studies with clinical intervention studies.</p>","PeriodicalId":19032,"journal":{"name":"Nature Immunology","volume":"24 1","pages":""},"PeriodicalIF":27.6000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Immunology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41590-025-02212-9","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Asthma is a chronic inflammatory disease of the airways characterized by variable airway obstruction. In some patients with severe disease there are frequent disease flares, and some individuals develop irreversible airway obstruction. The immune system has a predominant effect on many aspects of the disease. A large proportion of people with asthma have signs of type 2 immunity, rich in eosinophils, mast cells and basophils, and controlled by either type 2 helper T cells or type 2 innate lymphoid cells. Other patients have a more neutrophil-predominant disease, and some have little underlying immune dysfunction. Here we review the immunology of asthma by integrating data from mouse model studies with clinical intervention studies.
期刊介绍：
Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
