抗肿瘤免疫通过tgf β驱动的组织驻留的丧失而增强

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-29 DOI:10.1038/s41590-025-02224-5

Dongmei Zhao, Hai-Hui Xue

引用次数: 0

摘要

肿瘤浸润性CD8+ T细胞获得HOBIT表达和组织驻留记忆细胞的特征。这种tgf - β驱动的过程对于通过免疫检查点阻断控制肿瘤是必不可少的，但在表达hobit的肿瘤浸润淋巴细胞中破坏tgf - β信号可以增强抗肿瘤免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anti-tumor immunity is boosted by loss of TGFβ-driven tissue residency

Tumor-infiltrating CD8+ T cells acquire HOBIT expression and features of tissue-resident memory cells. This TGFβ-driven process is dispensable for tumor control by immune checkpoint blockade, but disrupting TGFβ signaling in HOBIT-expressing tumor-infiltrating lymphocytes enhances anti-tumor immunity.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.