白细胞是如何穿过组织的

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-25 DOI:10.1038/s41590-025-02242-3

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引用次数: 0

摘要

当树突状细胞通过狭窄的间隙迁移时，它们会在细胞核前短暂地组装一个机械敏感的肌动蛋白结构。这种结构向外推动周围组织，帮助拓宽通道，使庞大的细胞体可以通过。同时，它作为一个机械“电容器”，帮助细胞平衡前缘的向前突出和细胞体的向外突出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

How leukocytes push their way through tissues

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How leukocytes push their way through tissues

When dendritic cells migrate through narrow gaps, they transiently assemble a mechanosensitive actin structure in front of their nucleus. This structure pushes outward against the surrounding tissue to help widen a path so the bulky cell body can pass through. At the same time, it acts as a mechanical ‘capacitor’ that helps the cell to balance forward protrusion at the leading edge and outward protrusion at the cell body.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.