2B或不2B是DC个体发生的问题

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-23 DOI:10.1038/s41590-025-02220-9

Venetia Bigley, Matthew Collin

引用次数: 0

摘要

树突状细胞（DC）异质性支持有效的免疫应答，但子集定义是复杂的。Zhu等人描述了2型常规DC和浆细胞样DC在小鼠中的发展，定义了不同的个体发生和转录因子依赖性，为统一DC子集分类提供了框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

2B or not 2B is the question in DC ontogeny

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2B or not 2B is the question in DC ontogeny

Dendritic cell (DC) heterogeneity underpins effective immune responses, but subset definition is complex. Zhu et al. delineate the development of type 2 conventional DCs and plasmacytoid DCs in mice, defining distinct ontogenies and transcription factor dependencies that provide a framework for unifying DC subset classification.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.