T cells require mitochondria to proliferate, function and generate memory

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-07-22 DOI:10.1038/s41590-025-02226-3

引用次数: 0

Abstract

Using genetic modifications to dissect mitochondrial functions, we found that, on acute stimulation, CD8+ T cells require mitochondrial metabolism to sustain proliferation and prevent exhaustion. Mitochondria-derived reactive oxygen species are also needed to generate memory CD8+ T cells.

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T细胞需要线粒体来增殖、发挥功能和产生记忆

利用基因修饰来解剖线粒体功能，我们发现，在急性刺激下，CD8+ T细胞需要线粒体代谢来维持增殖并防止衰竭。线粒体来源的活性氧也需要产生记忆性CD8+ T细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.