Nature nanotechnology最新文献_第3页

Enhancing spectroscopy and microscopy with emerging methods in photon correlation and quantum illumination 利用光子相关和量子照明的新方法增强光谱学和显微学。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-08-20 DOI: 10.1038/s41565-025-01992-3

Chieh Tsao, Haonan Ling, Alex Hinkle, Yifan Chen, Keshav Kumar Jha, Zhen-Li Yan, Hendrik Utzat

{"title":"Enhancing spectroscopy and microscopy with emerging methods in photon correlation and quantum illumination","authors":"Chieh Tsao, Haonan Ling, Alex Hinkle, Yifan Chen, Keshav Kumar Jha, Zhen-Li Yan, Hendrik Utzat","doi":"10.1038/s41565-025-01992-3","DOIUrl":"10.1038/s41565-025-01992-3","url":null,"abstract":"Quantum optics has led to important advancements in our ability to prepare and detect correlations between individual photons. Its principles are increasingly translated into nanoscale characterization tools, furthering methods in spectroscopy, microscopy and metrology. In this Review, we discuss the rapid progress in this field driven by advanced technologies of single-photon detectors and quantum-light sources, including time-resolved single-photon counting cameras, superconducting nanowire single-photon detectors and entangled photon sources of increasing brightness. We emphasize emerging applications in super-resolution microscopy, measurements below classical noise limits and photon-number-resolved spectroscopy—a powerful paradigm for the characterization of nanoscale electronic materials. We conclude by discussing key technological challenges and future opportunities in materials science and bionanophotonics alike. This Review discusses single-photon detectors and quantum-light sources for super-resolution microscopy, measurements below classical noise limits and photon-number-resolved spectroscopy as emerging tools for nanoscale electronic materials characterization and bioimaging.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 8","pages":"1001-1016"},"PeriodicalIF":34.9,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144961939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing 一种能量代谢参与纳米药物维持线粒体稳态，以减轻细胞衰老。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-08-19 DOI: 10.1038/s41565-025-01972-7

Liyuan Chen, Yijie Fan, Nan Jiang, Xiaoshuai Huang, Min Yu, He Zhang, Zhengren Xu, Danqing He, Yu Wang, Chengye Ding, Xiaolan Wu, Chang Li, Shiying Zhang, Hangbo Liu, Xinmeng Shi, Fanghui Zhang, Ting Zhang, Dan Luo, Cunyu Wang, Yan Liu

{"title":"An energy metabolism-engaged nanomedicine maintains mitochondrial homeostasis to alleviate cellular ageing","authors":"Liyuan Chen, Yijie Fan, Nan Jiang, Xiaoshuai Huang, Min Yu, He Zhang, Zhengren Xu, Danqing He, Yu Wang, Chengye Ding, Xiaolan Wu, Chang Li, Shiying Zhang, Hangbo Liu, Xinmeng Shi, Fanghui Zhang, Ting Zhang, Dan Luo, Cunyu Wang, Yan Liu","doi":"10.1038/s41565-025-01972-7","DOIUrl":"10.1038/s41565-025-01972-7","url":null,"abstract":"Energy restriction is closely related to cellular senescence and species longevity. Here, based on the structure and function of ATP synthase, a key enzyme for energy generation, we develop energy metabolism-engaged nanomedicines (EM-eNMs) to rejuvenate aged stromal/stem cells, and help to prevent skeletal ageing. We show that EM-eNMs infiltrate the mitochondria of aged bone marrow mesenchymal stromal/stem cells (BMMSCs), driving mitochondrial fission, mitophagy, glycolysis and maintaining BMMSC stemness and multifunction. The EM-eNMs directly bind to the ATP synthase and promote mitophagy through induction of the dynamin-related protein 1 (DRP1) gene. Remarkably, EM-eNMs selectively target bone tissues through systemic delivery and significantly reverse osteoporotic bone loss in aged mice by enhancing mitochondrial fission and mitophagy, while simultaneously restoring the stemness and osteogenic potential of aged BMMSCs in situ. Taken together, our findings highlight the potential of the EM-eNMs as a targeted therapy to alleviate cellular senescence and age-related diseases. Through binding mitochondrial ATP synthase, engineered nanomedicines rejuvenate aged bone stem cells and restore osteogenesis, reversing osteoporosis in mice and offering a potential senolytic therapy for skeletal ageing.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 9","pages":"1332-1344"},"PeriodicalIF":34.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144883232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation. 声激活脂质体作为一种翻译纳米技术用于靶向药物传递和无创神经调节。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-08-18 DOI: 10.1038/s41565-025-01990-5

Mahaveer P Purohit, Brenda J Yu, Kanchan Sinha Roy, Yun Xiang, Sedona N Ewbank, Matine M Azadian, Alex R Hart, Gabriella P B Muwanga, Payton J Martinez, Jeffrey B Wang, Ali K Taoube, Eric Markarian, Nicholas Macedo, Audrey K Kwan, Diego Gomez Lopez, Raag D Airan

{"title":"Acoustically activatable liposomes as a translational nanotechnology for site-targeted drug delivery and noninvasive neuromodulation.","authors":"Mahaveer P Purohit, Brenda J Yu, Kanchan Sinha Roy, Yun Xiang, Sedona N Ewbank, Matine M Azadian, Alex R Hart, Gabriella P B Muwanga, Payton J Martinez, Jeffrey B Wang, Ali K Taoube, Eric Markarian, Nicholas Macedo, Audrey K Kwan, Diego Gomez Lopez, Raag D Airan","doi":"10.1038/s41565-025-01990-5","DOIUrl":"10.1038/s41565-025-01990-5","url":null,"abstract":"Stimulus-responsive drug delivery nanotechnologies promise noninvasive activation of the right drug at the right place at the right time. However, these systems often incorporate non-validated pharmaceutical excipients and other features that limit their clinical translation. Here we engineer the responsiveness of liposomes to a pulsed, low-intensity ultrasound activating stimulus by incorporating a generally regarded as safe excipient that alters the acoustic properties of the liposome core medium. We show that this approach permits loading and ultrasound-induced release of four drugs in vitro. We then leverage this performance to enable drug-mediated noninvasive neuromodulation of each of the central and the peripheral nervous system in vivo. These acoustically activatable liposomes formulated with common and validated pharmaceutical excipients and production processes provide a versatile system for stimulus-responsive site-targeted drug delivery and noninvasive neuromodulation, with high clinical translation potential.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":" ","pages":""},"PeriodicalIF":34.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Compact optoelectronic emulator for visual processing 用于视觉处理的紧凑光电仿真器

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-08-15 DOI: 10.1038/s41565-025-01985-2

Nazek El-Atab

引用次数: 0

High-order dynamics in an ultra-adaptive neuromorphic vision device 超自适应神经形态视觉装置的高阶动力学

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-08-15 DOI: 10.1038/s41565-025-01984-3

Jiayi Xu, Biyi Jiang, Weizhen Wang, Zhifeng Guo, Junsen Gao, Xinyan Hu, Jingkai Qin, Liang Ran, Longyang Lin, Songhua Cai, Yida Li, Feichi Zhou

{"title":"High-order dynamics in an ultra-adaptive neuromorphic vision device","authors":"Jiayi Xu, Biyi Jiang, Weizhen Wang, Zhifeng Guo, Junsen Gao, Xinyan Hu, Jingkai Qin, Liang Ran, Longyang Lin, Songhua Cai, Yida Li, Feichi Zhou","doi":"10.1038/s41565-025-01984-3","DOIUrl":"https://doi.org/10.1038/s41565-025-01984-3","url":null,"abstract":"Neuromorphic hardware for artificial general vision intelligence holds the potential to match and surpass biological visual systems by processing complex visual dynamics with high adaptability and efficiency. However, current implementations rely on multiple complementary metal–oxide–semiconductor or neuromorphic elements, leading to significant area and power inefficiencies and system complexity. This is owing to a key challenge that no single electronic device, to our knowledge, has yet been demonstrated that can integrate retina-like and cortex-like spiking and graded neuronal dynamics operable across both optical and electrical domains. Here we report a single ultra-adaptive neuromorphic vision device (IxTyO1–x–y/CuOx/Pd) by ingeniously tailoring its electronic properties, enabling uniquely controlled interface and bulk dynamics by charged particles, including electrons, oxygen ions and vacancies. The device highly amalgamates broadband retinal spiking neuron and non-spiking graded neuron, and cortical synapse and neuron dynamics, with ultralow power consumption. Real-time optoelectronic dynamics is elucidated through in situ scanning transmission electron microscopy and validated by technology computer-aided design simulations. An artificial general vision intelligence system based on homogeneous ultra-adaptive neuromorphic vision device arrays is constructed, adaptively supporting both asynchronous event-driven and synchronous frame-driven paradigms for versatile cognitive imaging demands, with superior power efficiency of up to 67.89 trillion operations per second per watt and area efficiency of up to 3.96 mega operations per second per feature size (MOPS/F2).","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing lipid nanoparticles using a transformer-based neural network 利用基于变压器的神经网络设计脂质纳米颗粒

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-08-15 DOI: 10.1038/s41565-025-01975-4

Alvin Chan, Ameya R. Kirtane, Qing Rui Qu, Xisha Huang, Jonathan Woo, Deepak A. Subramanian, Rajib Dey, Rika Semalty, Joshua D. Bernstock, Taksim Ahmed, Rowan Honeywell, Charles Hanhurst, Isaac Diaz Becdach, Leah S. Prizant, Ashley K. Brown, Hao Song, Justin Law Cobb, Louis B. DeRidder, Bruna Santos, Miguel Jimenez, Michelle Sun, Yuebin Huang, Ceara Byrne, Giovanni Traverso

{"title":"Designing lipid nanoparticles using a transformer-based neural network","authors":"Alvin Chan, Ameya R. Kirtane, Qing Rui Qu, Xisha Huang, Jonathan Woo, Deepak A. Subramanian, Rajib Dey, Rika Semalty, Joshua D. Bernstock, Taksim Ahmed, Rowan Honeywell, Charles Hanhurst, Isaac Diaz Becdach, Leah S. Prizant, Ashley K. Brown, Hao Song, Justin Law Cobb, Louis B. DeRidder, Bruna Santos, Miguel Jimenez, Michelle Sun, Yuebin Huang, Ceara Byrne, Giovanni Traverso","doi":"10.1038/s41565-025-01975-4","DOIUrl":"https://doi.org/10.1038/s41565-025-01975-4","url":null,"abstract":"The RNA medicine revolution has been spurred by lipid nanoparticles (LNPs). The effectiveness of an LNP is determined by its lipid components and their ratios; however, experimental optimization is laborious and does not explore the full design space. Computational approaches such as deep learning can be greatly beneficial, but the composite nature of LNPs limits the effectiveness of existing single molecule-based algorithms to LNPs. Addressing this, our approach integrates the multi-component and multimodal features of composite formulations such as LNPs to predict their performance in an end-to-end manner. Here we generate one of the largest LNP datasets (LANCE) by varying LNP formulations to train our deep learning model, COMET. This transformer-based neural network not only accurately predicts the efficacy of LNPs but is adaptable to non-canonical LNP formulations such as those with two ionizable lipids and polymeric materials. Furthermore, COMET can predict LNP performance in a cell line outside of LANCE and predict LNP stability during lyophilization using only small training datasets. Experimental validation showed that our approach can identify LNPs that exhibit strong protein expression in vitro and in vivo, promising accelerated development of nucleic acid therapies with extensive potential across therapeutic and manufacturing applications.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"134 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient and tunable photochemical charge transfer via long-lived Bloch surface wave polaritons 通过长寿命的布洛赫表面波极化子进行有效和可调谐的光化学电荷转移

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-08-14 DOI: 10.1038/s41565-025-01995-0

Kamyar Rashidi, Evripidis Michail, Bernardo Salcido-Santacruz, Yamuna Paudel, Vinod M. Menon, Matthew Y. Sfeir

{"title":"Efficient and tunable photochemical charge transfer via long-lived Bloch surface wave polaritons","authors":"Kamyar Rashidi, Evripidis Michail, Bernardo Salcido-Santacruz, Yamuna Paudel, Vinod M. Menon, Matthew Y. Sfeir","doi":"10.1038/s41565-025-01995-0","DOIUrl":"https://doi.org/10.1038/s41565-025-01995-0","url":null,"abstract":"Hybrid light–matter molecular exciton–polariton states have been proposed as a strategy to directly modify the efficiency and rate of photoinduced molecular charge transfer reactions. However, the efficacy of polariton-driven photochemistry remains an open question owing to the experimental challenges to tease out this effect. Here we demonstrate conditions under which photoinduced polaritonic charge transfer can be achieved and visualized using momentum-resolved ultrafast spectroscopy. Key conditions for charge transfer are satisfied using Bloch surface wave polaritons, which exhibit favourable dispersion characteristics that permit the selective pumping of hybrid states with long lifetimes (100–400 fs) that permit vibrationally assisted charge transfer between a donor and an acceptor molecule dispersed in a polymer matrix. Using this approach, we tune the energetic driving force for charge separation, reducing it by as much as 0.5 eV compared with the bare exciton pumping with an internal quantum efficiency of 0.77. These results corroborate the notion that tunable and efficient polariton-driven molecular charge transfer is indeed possible using carefully constructed photonic systems.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"16 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growing moiré with DNA 随着DNA的增长

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-08-13 DOI: 10.1038/s41565-025-01994-1

Max Ladabaum, Grigory Tikhomirov

引用次数: 0

Fundamentals first, technology second 基本面第一，技术第二

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-08-13 DOI: 10.1038/s41565-025-02002-2

引用次数: 0

Ultrabroadband nonlinear Hall rectifier using SnTe 基于SnTe的超宽带非线性霍尔整流器

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-08-11 DOI: 10.1038/s41565-025-01993-2

Fanrui Hu, Pengnan Zhao, Lihuan Yang, Shishun Zhao, Jiayu Lei, Weijian Li, Jiamin Lai, Zhonghai Yu, Hanbum Park, Chengquan Wong, Raghav Sharma, Goki Eda, Shengyuan A. Yang, Xiaohong Xu, Fei Wang, Hyunsoo Yang

{"title":"Ultrabroadband nonlinear Hall rectifier using SnTe","authors":"Fanrui Hu, Pengnan Zhao, Lihuan Yang, Shishun Zhao, Jiayu Lei, Weijian Li, Jiamin Lai, Zhonghai Yu, Hanbum Park, Chengquan Wong, Raghav Sharma, Goki Eda, Shengyuan A. Yang, Xiaohong Xu, Fei Wang, Hyunsoo Yang","doi":"10.1038/s41565-025-01993-2","DOIUrl":"https://doi.org/10.1038/s41565-025-01993-2","url":null,"abstract":"The rapid expansion of self-powered electronics in the Internet of Things, 6G communication and millimetre-wave systems calls for rectifiers capable of operating across ultrabroadband frequencies and at extremely low input power levels. However, conventional rectifiers based on semiconductor junctions face fundamental limitations such as parasitic capacitance and threshold voltages, preventing effective operation under broadband and ambient radio-frequency conditions. Here we present an ultrabroadband, zero-bias rectifier based on the nonlinear Hall effect in wafer-scale (001)-oriented topological crystalline insulator SnTe thin film. This material exhibits a large second-order conductivity of ~0.004 Ω⁻1 V⁻1, surpassing that of other wafer-scale materials. The nonlinear Hall effect arises primarily from a Berry curvature dipole, evidenced by angular-resolved transport measurements and first-principles calculations. The device demonstrates rectification from 23 MHz to 1 THz, with sensitivity down to –60 dBm in key radio-frequency bands, without any external bias. Rectified output power is scalable through series- and parallel-array topologies and can be enhanced using rectenna designs. As a proof of concept, we achieve the wireless powering of a thermistor using harvested radio-frequency energy, validating the potential of this material platform and nonlinear Hall effect for next-generation energy-autonomous microsystems.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"8 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144813091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0