Nature nanotechnology最新文献_第4页

Molecular motors in action at interfaces 分子马达在界面上的作用

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-23 DOI: 10.1038/s41565-025-01936-x

Qi Zhang, Da-Hui Qu

引用次数: 0

Nanoinducer-mediated mitochondria-selective degradation enhances T cell immunotherapy against multiple cancers 纳米诱导剂介导的线粒体选择性降解增强T细胞免疫治疗多种癌症

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-21 DOI: 10.1038/s41565-025-01909-0

Xueting Pan, Zhihang Wang, Mixiao Tan, Ziying Fu, Guangjun Nie, Hai Wang

{"title":"Nanoinducer-mediated mitochondria-selective degradation enhances T cell immunotherapy against multiple cancers","authors":"Xueting Pan, Zhihang Wang, Mixiao Tan, Ziying Fu, Guangjun Nie, Hai Wang","doi":"10.1038/s41565-025-01909-0","DOIUrl":"https://doi.org/10.1038/s41565-025-01909-0","url":null,"abstract":"Cancer immunotherapy utilizing cytotoxic T lymphocytes has demonstrated significant promise in clinical applications, but cancer immunosuppressive mechanisms hamper further progress in T cell immunotherapy. Here we show a correlation between cancer cell mitochondrial content and their resistance to immunotherapy. Observing that cancer cells with higher mitochondrial content show increased resistance to CD8+ T cells, we developed mitochondrial nanoinducers designed to selectively target and degrade mitochondria within autophagosomes. The direct degradation of mitochondria not only enhances the recognition and activation of CD8+ T cells but also increases the susceptibility of cancer cells to CD8+ T cell-mediated cytotoxicity. We demonstrated the feasibility and efficacy of this strategy in multiple in vitro and in vivo tumour therapeutic models. This nanoinducer, designed to manipulate cellular mitochondrial degradation, holds promise as a versatile tool for enhancing adoptive T cell therapy, CAR-T cell therapy and tumour-vaccine-based immunotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"55 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Degrading cancer cell mitochondria to improve T cell-mediated killing 降解癌细胞线粒体以改善T细胞介导的杀伤

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-21 DOI: 10.1038/s41565-025-01928-x

Luca Simula, Emmanuel Donnadieu

引用次数: 0

A collagenase nanogel backpack improves CAR-T cell therapy outcomes in pancreatic cancer 胶原酶纳米凝胶背包改善胰腺癌CAR-T细胞治疗效果

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-19 DOI: 10.1038/s41565-025-01924-1

Zhipeng Zhao, Qian Li, Chenghao Qu, Zeyu Jiang, Guoqing Jia, Gongde Lan, Yuxia Luan

引用次数: 0

Electric bias-induced reversible configuration of single and heteronuclear dual-atom catalysts on 1Tʹ-MoS2 电偏压诱导的1T′-MoS2单核和异核双原子催化剂的可逆构型

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-19 DOI: 10.1038/s41565-025-01934-z

Jianhua Wu, Zhongxin Chen, Ke Yang, Xin Zhou, Huizhi Li, Zhiyong Wang, Mengyao Su, Rongrong Zhang, Tie Wang, Qikun Hu, Ning Yan, Cuibo Liu, Bin Zhang, Ming Yang, Shibo Xi, Kian Ping Loh

{"title":"Electric bias-induced reversible configuration of single and heteronuclear dual-atom catalysts on 1Tʹ-MoS2","authors":"Jianhua Wu, Zhongxin Chen, Ke Yang, Xin Zhou, Huizhi Li, Zhiyong Wang, Mengyao Su, Rongrong Zhang, Tie Wang, Qikun Hu, Ning Yan, Cuibo Liu, Bin Zhang, Ming Yang, Shibo Xi, Kian Ping Loh","doi":"10.1038/s41565-025-01934-z","DOIUrl":"https://doi.org/10.1038/s41565-025-01934-z","url":null,"abstract":"The development of substrates capable of anchoring single-atom catalysts (SACs) while enabling their dynamic reconfiguration into heteronuclear dual-atom catalysts (DACs) holds considerable promise for electrochemical synthesis, yet remains underexplored. Here we show that electrochemical desulfurization of MoS2 generates vacancy-rich 1T′ domains, which support high loadings of Cu (7.9 wt%) and Pt (6.7 wt%) SACs that are well-positioned for dynamic sintering to form DACs. Operando X-ray absorption spectroscopy and density functional theory calculations reveal a voltage-driven, reversible transformation between individual Pt/Cu SACs and Cu–Pt DAC configurations during hydrogen evolution reaction potentials. The electric-field-induced Cu–Pt DACs exhibit superior performance in the selective hydrogenation of alkynes compared with their monometallic SAC counterparts. This work underscores vacancy-enriched 1T′-MoS2 as a versatile platform for high-density SAC deposition, enabling on-demand structural reconfiguration and paving the way for tailored catalyst design in electrosynthesis.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"40 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The benefits and risks of PEGylation in nanomedicine 聚乙二醇化在纳米医学中的益处和风险

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-19 DOI: 10.1038/s41565-025-01951-y

引用次数: 0

Tumour-derived microparticles obtained through microwave irradiation induce immunogenic cell death in lung adenocarcinoma 通过微波照射获得的肿瘤源性微粒可诱导肺腺癌免疫原性细胞死亡

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-19 DOI: 10.1038/s41565-025-01922-3

Yali Wu, Wenjuan Chen, Jingjing Deng, Xinghui Cao, Zimo Yang, Jiangbin Chen, Qi Tan, E. Zhou, Minglei Li, Jiatong Liu, Mengfei Guo, Yang Jin

{"title":"Tumour-derived microparticles obtained through microwave irradiation induce immunogenic cell death in lung adenocarcinoma","authors":"Yali Wu, Wenjuan Chen, Jingjing Deng, Xinghui Cao, Zimo Yang, Jiangbin Chen, Qi Tan, E. Zhou, Minglei Li, Jiatong Liu, Mengfei Guo, Yang Jin","doi":"10.1038/s41565-025-01922-3","DOIUrl":"https://doi.org/10.1038/s41565-025-01922-3","url":null,"abstract":"Tumour-derived microparticles (TMPs), extracellular vesicles traditionally obtained upon ultraviolet (UV) radiation of tumour cells, hold promise in tumour immunotherapies and vaccines and have demonstrated potential as drug delivery systems for tumour treatment. However, concerns remain regarding the limited efficacy and safety of UV-derived TMPs. Here we introduce a microwave (MW)-assisted method for preparing TMPs, termed MW-TMPs. Brief exposure of tumour cells to short-wavelength MW radiation promotes the release of TMPs showing superior in vivo antitumour activity and safety compared with UV-TMPs. MW-TMPs induce immunogenic cell death and reprogramme suppressive tumour immune microenvironments in different lung tumour models, enabling dual targeting of tumour cells by natural killer and T cells. We show that they can efficiently deliver methotrexate to tumours, synergistically boosting the efficacy of PD-L1 blockade. This MW-TMP development strategy is simpler, more efficient and safer than traditional UV-TMP methods.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"30 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering pyroptotic vesicles as personalized cancer vaccines 工程热噬囊泡作为个体化癌症疫苗

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-16 DOI: 10.1038/s41565-025-01931-2

Zhaoting Li, Yixin Wang, Fanyi Mo, Tyler Wolter, Rachel Hong, Allie Barrett, Nathaniel Richmond, Fengyuan Liu, Yu Chen, Xicheng Yang, Lauren Dempsey, Quanyin Hu

{"title":"Engineering pyroptotic vesicles as personalized cancer vaccines","authors":"Zhaoting Li, Yixin Wang, Fanyi Mo, Tyler Wolter, Rachel Hong, Allie Barrett, Nathaniel Richmond, Fengyuan Liu, Yu Chen, Xicheng Yang, Lauren Dempsey, Quanyin Hu","doi":"10.1038/s41565-025-01931-2","DOIUrl":"https://doi.org/10.1038/s41565-025-01931-2","url":null,"abstract":"Tumour vaccines are designed to stimulate the host’s immune system against existing tumours or tumour recurrence. However, individual differences, tumour heterogeneity and side effects hinder the applications of current tumour vaccines and require the development of personalized cancer vaccines. To overcome these challenges, we engineered pyroptotic vesicles—extracellular vesicles formed during tumour cell pyroptosis—as a tumour vaccine platform. The extracted pyroptotic vesicles possess abundant tumour antigens and potent immune-stimulating ability and, loaded into a biocompatible hydrogel, they can be implanted into post-surgical tumour cavities to prevent tumour recurrence. The pyroptotic-vesicle-based vaccine outperforms both exosome- and apoptotic-body-based vaccines in inhibiting tumour recurrence and metastasis in different post-surgical mouse models. Mechanistic studies reveal that the pyroptotic-vesicle-based vaccine could stimulate robust antigen-specific dendritic cell and T cell immune responses against both artificial OVA antigens and cancer neoantigens. In sum, our vaccine platform can be tailored to stimulate robust antitumour immune responses for treating individual cancer patients.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"10 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A magnetically programmable mesoporous nanoreactor 磁性可编程介孔纳米反应器

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-16 DOI: 10.1038/s41565-025-01910-7

Songyue Chen, Xiujun Fan, Zhaoqi Duan, Yang Luo, Jun Chen

引用次数: 0

Discovering nanoparticle corona ligands for liver macrophage capture 发现用于肝巨噬细胞捕获的纳米颗粒冠状配体

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-15 DOI: 10.1038/s41565-025-01903-6

Bram Bussin, Marshall G. G. MacDuff, Wayne Ngo, Jamie L. Y. Wu, Zachary P. Lin, Adrian Granda Farias, Benjamin Stordy, Zahra Sepahi, Sara Ahmed, Jason Moffat, Warren C. W. Chan

{"title":"Discovering nanoparticle corona ligands for liver macrophage capture","authors":"Bram Bussin, Marshall G. G. MacDuff, Wayne Ngo, Jamie L. Y. Wu, Zachary P. Lin, Adrian Granda Farias, Benjamin Stordy, Zahra Sepahi, Sara Ahmed, Jason Moffat, Warren C. W. Chan","doi":"10.1038/s41565-025-01903-6","DOIUrl":"https://doi.org/10.1038/s41565-025-01903-6","url":null,"abstract":"Liver macrophages capture circulating nanoparticles and reduce their delivery to target organs. Serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloodstream have not been linked. Here we use a multi-omics strategy to identify the adsorbed serum proteins binding to specific liver macrophage receptors. We discovered six absorbed serum proteins that bind to two liver macrophage receptors. Nanoparticle physicochemical properties can affect the degree of the six serum proteins adsorbing to the surface, the probability of binding to cell receptors and whether the liver removes the nanoparticle from circulation. Identifying the six adsorbed proteins allowed us to engineer decoy nanoparticles that prime the liver to take up fewer therapeutic nanoparticles, enabling more nanoparticles for targeting extrahepatic tissues. Elucidating the molecular interactions governing the nanoparticle journey in vivo will enable us to control nanoparticle delivery to diseased tissues.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"232 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0