Nature nanotechnology最新文献

Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-21 DOI: 10.1038/s41565-025-01867-7

Felix Alonso-Valenteen, Simoun Mikhael, HongQiang Wang, Jessica Sims, Michael Taguiam, James Teh, Sam Sances, Michelle Wong, Tianxin Miao, Dustin Srinivas, Nelyda Gonzalez-Almeyda, Ryan H. Cho, Romny Sanchez, Kimngan Nguyenle, Erik Serrano, Briana Ondatje, Rebecca L. Benhaghnazar, Harry B. Gray, Zeev Gross, John Yu, Clive N. Svendsen, Ravinder Abrol, Lali K. Medina-Kauwe

{"title":"Systemic HER3 ligand-mimicking nanobioparticles enter the brain and reduce intracranial tumour growth","authors":"Felix Alonso-Valenteen, Simoun Mikhael, HongQiang Wang, Jessica Sims, Michael Taguiam, James Teh, Sam Sances, Michelle Wong, Tianxin Miao, Dustin Srinivas, Nelyda Gonzalez-Almeyda, Ryan H. Cho, Romny Sanchez, Kimngan Nguyenle, Erik Serrano, Briana Ondatje, Rebecca L. Benhaghnazar, Harry B. Gray, Zeev Gross, John Yu, Clive N. Svendsen, Ravinder Abrol, Lali K. Medina-Kauwe","doi":"10.1038/s41565-025-01867-7","DOIUrl":"https://doi.org/10.1038/s41565-025-01867-7","url":null,"abstract":"Crossing the blood–brain barrier (BBB) and reaching intracranial tumours is a clinical challenge for current targeted interventions including antibody-based therapies, contributing to poor patient outcomes. Increased cell surface density of human epidermal growth factor receptor 3 (HER3) is associated with a growing number of metastatic tumour types and is observed on tumour cells that acquire resistance to a growing number of clinical targeted therapies. Here we describe the evaluation of HER3-homing nanobiological particles (nanobioparticles (NBPs)) on such tumours in preclinical models and our discovery that systemic NBPs could be found in the brain even in the absence of such tumours. Our subsequent studies described here show that HER3 is prominently associated with both mouse and human brain endothelium and with extravasation of systemic NBPs in mice and in human-derived BBB chips in contrast to non-targeted agents. In mice, systemically delivered NBPs carrying tumoricidal agents reduced the growth of intracranial triple-negative breast cancer cells, which also express HER3, with improved therapeutic profile compared to current therapies and compared to agents using traditional BBB transport routes. As HER3 associates with a growing number of metastatic tumours, the NBPs described here may offer targeted efficacy especially when such tumours localize to the brain.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-21 DOI: 10.1038/s41565-025-01865-9

Camilla Di Mino, Thomas F. Headen, Nadir S. Basma, David J. Buckley, Patrick L. Cullen, Martin C. Wilding, Milo S. P. Shaffer, Neal T. Skipper, Adam J. Clancy, Christopher A. Howard

{"title":"Intermediate-range solvent templating and counterion behaviour at charged carbon nanotube surfaces","authors":"Camilla Di Mino, Thomas F. Headen, Nadir S. Basma, David J. Buckley, Patrick L. Cullen, Martin C. Wilding, Milo S. P. Shaffer, Neal T. Skipper, Adam J. Clancy, Christopher A. Howard","doi":"10.1038/s41565-025-01865-9","DOIUrl":"https://doi.org/10.1038/s41565-025-01865-9","url":null,"abstract":"The ordering of ions and solvent molecules around nanostructures is of profound fundamental importance, from understanding biological processes to the manipulation of nanomaterials to optimizing electrochemical devices. Classical models commonly used to describe these systems treat the solvent simplistically, an approach that endures, in part, due to the extreme difficulty of attaining experimental measurements that challenge this approximation. Here we perform total neutron scattering experiments on model systems—concentrated amide solutions of negatively charged carbon nanotubes and sodium counterions—and measure remarkably complex intermediate-range molecular solvent ordering. The charged surface orders the solvents up to ∼40 Å, even beyond its dense concentric solvation shells. Notably, the molecular orientation of solvent in direct contact with the nanotube surface itself is distinct, lying near-parallel and not interacting with desolvated sodium counterions. In contrast, beyond this layer the ordering of solvent is perpendicular to the surface. Our results underscore the critical importance of multibody interactions in solvated nanoscale systems and charged surfaces, highlighting competing ion/surface solvation effects.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"47 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular dehydrogenation catalysis leads to reductive stress and immunosuppression

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-20 DOI: 10.1038/s41565-025-01870-y

Jie Jiang, Huizhen Zheng, Zhenzhen Wang, Xinlian Wang, Qianqian Xie, Xi Liu, Qing Yang, Xiaoming Cai, Xingfa Gao, Ruibin Li, Chunying Chen

{"title":"Intracellular dehydrogenation catalysis leads to reductive stress and immunosuppression","authors":"Jie Jiang, Huizhen Zheng, Zhenzhen Wang, Xinlian Wang, Qianqian Xie, Xi Liu, Qing Yang, Xiaoming Cai, Xingfa Gao, Ruibin Li, Chunying Chen","doi":"10.1038/s41565-025-01870-y","DOIUrl":"https://doi.org/10.1038/s41565-025-01870-y","url":null,"abstract":"Imbalanced redox homeostasis, involving either oxidative stress or reductive stress, can profoundly impact cellular functions, contributing to various diseases. While the implications of oxidative stress in the adverse effects of nanoparticles have been extensively studied, our comprehension of reductive stress within the context of nano-redox system interactions remains limited. Here we illuminate a domino effect initiated by the dehydrogenase-like activity of transition metal borides. Specifically, seven transition metal borides were identified to emulate the enzymatic activity of natural dehydrogenases, resulting in heightened levels of reductive constituents within critical biological redox pairs in cells. Mass cytometry analysis provides compelling evidence that reductive stress initiates an immunosuppressive environment within lung tissues, promoting the metastasis of breast cancer cells to the lungs. In summary, our study unveils the chemical basis of nano-induced reductive stress and establishes a mechanistic axis that interlinks dehydrogenase-like activity, reductive stress, immunosuppression and tumour metastasis.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"25 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Momentum tunnelling across quantum barriers

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-20 DOI: 10.1038/s41565-025-01868-6

Zhiping Xu

引用次数: 0

Grover’s algorithm in a four-qubit silicon processor above the fault-tolerant threshold

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-20 DOI: 10.1038/s41565-024-01853-5

I. Thorvaldson, D. Poulos, C. M. Moehle, S. H. Misha, H. Edlbauer, J. Reiner, H. Geng, B. Voisin, M. T. Jones, M. B. Donnelly, L. F. Peña, C. D. Hill, C. R. Myers, J. G. Keizer, Y. Chung, S. K. Gorman, L. Kranz, M. Y. Simmons

{"title":"Grover’s algorithm in a four-qubit silicon processor above the fault-tolerant threshold","authors":"I. Thorvaldson, D. Poulos, C. M. Moehle, S. H. Misha, H. Edlbauer, J. Reiner, H. Geng, B. Voisin, M. T. Jones, M. B. Donnelly, L. F. Peña, C. D. Hill, C. R. Myers, J. G. Keizer, Y. Chung, S. K. Gorman, L. Kranz, M. Y. Simmons","doi":"10.1038/s41565-024-01853-5","DOIUrl":"https://doi.org/10.1038/s41565-024-01853-5","url":null,"abstract":"Spin qubits in silicon are strong contenders for the realization of a practical quantum computer. Single- and two-qubit gates have shown fidelities above the fault-tolerant threshold, and entanglement of three qubits has been achieved. Furthermore, high-fidelity operation of two-qubit algorithms is possible. Here we implement a four-qubit silicon processor with all control fidelities above the fault-tolerant threshold. We demonstrate a three-qubit Grover’s search algorithm with a ~95% probability of finding the marked state. To this end, we fabricate the processor from three phosphorus atoms precision-patterned into isotopically pure silicon. We define three phosphorus nuclear spin qubits and one electron spin qubit. The long coherence times of the qubits enable single-qubit fidelities above 99.9% for all qubits. Moreover, the efficient single-pulse multi-qubit operation enabled by the electron–nuclear hyperfine interaction facilitates controlled-Z gates with above 99% fidelity between all pairs of nuclear spins when using the electron as an ancilla. These control fidelities, combined with high-fidelity non-demolition readout of all nuclear spins, allows the creation of a three-qubit Greenberger–Horne–Zeilinger state with 96.2% fidelity. Looking ahead, coupling neighbouring nuclear spin registers, as the one shown here, via electron–electron exchange may enable larger, yet fault-tolerant, quantum processors.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"11 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular-scale CO spillover on a dual-site electrocatalyst enhances methanol production from CO2 reduction

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-18 DOI: 10.1038/s41565-025-01866-8

Jing Li, Quansong Zhu, Alvin Chang, Seonjeong Cheon, Yuanzuo Gao, Bo Shang, Huan Li, Conor L. Rooney, Longtao Ren, Zhan Jiang, Yongye Liang, Zhenxing Feng, Shize Yang, L. Robert Baker, Hailiang Wang

{"title":"Molecular-scale CO spillover on a dual-site electrocatalyst enhances methanol production from CO2 reduction","authors":"Jing Li, Quansong Zhu, Alvin Chang, Seonjeong Cheon, Yuanzuo Gao, Bo Shang, Huan Li, Conor L. Rooney, Longtao Ren, Zhan Jiang, Yongye Liang, Zhenxing Feng, Shize Yang, L. Robert Baker, Hailiang Wang","doi":"10.1038/s41565-025-01866-8","DOIUrl":"https://doi.org/10.1038/s41565-025-01866-8","url":null,"abstract":"Cobalt phthalocyanine (CoPc) is recognized for catalysing electrochemical CO2 reduction into methanol at high Faradaic efficiency but is subject to deactivation. Cobalt tetraaminophthalocyanine (CoPc-NH2) shows improved stability, but its methanol Faradaic efficiency is below 30%. This study addresses these limitations in selectivity, reactivity and stability by rationally designing a dual-site cascade catalyst. Here we quantify the local concentration of CO, a key intermediate of the reaction, near a working CoPc-NH2 catalyst and show that co-loading nickel tetramethoxyphthalocyanine (NiPc-OCH3) with CoPc-NH2 on multiwalled carbon nanotubes increases the generation and local concentration of CO. This dual-site cascade catalyst exhibits substantially higher performance than the original single-site CoPc-NH2/carbon nanotube catalyst, reaching a partial current density of 150 mA cm−2 and a Faradaic efficiency of 50% for methanol production. Kinetic analysis and in situ sum-frequency generation vibrational spectroscopy attribute this notable performance improvement to molecular-scale CO spillover from NiPc-OCH3 sites to methanol-active CoPc-NH2 sites.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"8 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Welcome to Technology Features

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2025-02-18 DOI: 10.1038/s41565-025-01883-7

引用次数: 0

Tandem-controlled lysosomal assembly of nanofibres induces pyroptosis for cancer immunotherapy

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-18 DOI: 10.1038/s41565-025-01857-9

Junya Zhang, Yuxuan Hu, Xidan Wen, Zeyue Yang, Ziyi Wang, Zhiyuan Feng, He Bai, Qi Xue, Yinxing Miao, Tian Tian, Peng Zheng, Jingjing Zhang, Jie Li, Ling Qiu, Jing-Juan Xu, Deju Ye

{"title":"Tandem-controlled lysosomal assembly of nanofibres induces pyroptosis for cancer immunotherapy","authors":"Junya Zhang, Yuxuan Hu, Xidan Wen, Zeyue Yang, Ziyi Wang, Zhiyuan Feng, He Bai, Qi Xue, Yinxing Miao, Tian Tian, Peng Zheng, Jingjing Zhang, Jie Li, Ling Qiu, Jing-Juan Xu, Deju Ye","doi":"10.1038/s41565-025-01857-9","DOIUrl":"https://doi.org/10.1038/s41565-025-01857-9","url":null,"abstract":"Pyroptosis has emerged as a promising approach for cancer immunotherapy. However, current pyroptosis inducers lack specificity for cancer cells and have a weak antitumour immune response. Here we report a tumour-specific nanoparticle (NP-NH-D5) that activates pyroptosis by disrupting lysosomes for cancer immunotherapy. NP-NH-D5 undergoes negative-to-positive charge reversal and nanoparticle-to-nanofibre transformation within tumour cell lysosomes through tandem response to extracellular matrix metallopeptidase-2 and intracellular reducing agents. The as-formed non-peptide nanofibres efficiently break the lysosomes and trigger gasdermin-D-mediated pyroptosis, leading to strong immunogenic cell death and alleviation of the immunosuppressive tumour microenvironment. In vivo, NP-NH-D5 inhibits orthotopic 4T1 breast tumours, prevents metastasis and recurrence, and prolongs survival without systemic side effects. Furthermore, it greatly enhances the effectiveness of PD-L1 antibody immunotherapy in the 4T1 late-stage lung metastasis and aggressive orthotopic Pan02 pancreatic tumour models. Our research may open pathways for developing stimuli-responsive pyroptosis inducers for precise cancer immunotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"12 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Size-driven phase evolution in ultrathin relaxor films

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-02-11 DOI: 10.1038/s41565-025-01863-x

Jieun Kim, Yubo Qi, Abinash Kumar, Yun-Long Tang, Michael Xu, Hiroyuki Takenaka, Menglin Zhu, Zishen Tian, Ramamoorthy Ramesh, James M. LeBeau, Andrew M. Rappe, Lane W. Martin

{"title":"Size-driven phase evolution in ultrathin relaxor films","authors":"Jieun Kim, Yubo Qi, Abinash Kumar, Yun-Long Tang, Michael Xu, Hiroyuki Takenaka, Menglin Zhu, Zishen Tian, Ramamoorthy Ramesh, James M. LeBeau, Andrew M. Rappe, Lane W. Martin","doi":"10.1038/s41565-025-01863-x","DOIUrl":"https://doi.org/10.1038/s41565-025-01863-x","url":null,"abstract":"Relaxor ferroelectrics (relaxors) are a special class of ferroelectrics with polar nanodomains (PNDs), which present characteristics such as slim hysteresis loops and strong dielectric relaxation. Applications such as nanoelectromechanical systems, capacitive-energy storage and pyroelectric-energy harvesters require thin-film relaxors. Hence, understanding relaxor behaviour in the ultrathin limit is of both fundamental and technological importance. Here the evolution of relaxor phases and PNDs with thickness is explored in prototypical thin relaxor films. Epitaxial 0.68PbMg1/3Nb2/3O3-0.32PbTiO3 films of various nanometre thicknesses are grown by pulsed-laser deposition and characterized by ferroelectric and dielectric measurements, temperature-dependent synchrotron X-ray diffuse scattering, scanning transmission electron microscopy and molecular dynamics simulations. As the film thickness approaches the length of the long axis of the PNDs (25–30 nm), electrostatically driven phase instabilities induce their rotation towards the plane of the films, stabilize the relaxor behaviour and give rise to anisotropic phase evolution along the out-of-plane and in-plane directions. The complex anisotropic evolution of relaxor properties ends in a collapse of the relaxor behaviour when the film thickness reaches the smallest dimension of the PNDs (6–10 nm). These findings establish that PNDs define the critical length scale for the evolution of relaxor behaviour at the nanoscale.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"52 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electron correlation strengthened in multilayer rhombohedral graphite

IF 38.1 1区材料科学

Nature nanotechnology Pub Date : 2025-02-10 DOI: 10.1038/s41565-024-01839-3

Péter Nemes-Incze

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