Nature nanotechnology最新文献

Black phosphorus nanosheets boost mitochondrial oxidative phosphorylation improving immunotherapy outcomes. 黑磷纳米片促进线粒体氧化磷酸化，改善免疫治疗结果。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-10-22 DOI: 10.1038/s41565-025-02022-y

Yuedi Yang,Mingda Zhao,Jiadong Li,Ruiling Xu,Jie Liang,Qing Jiang,Xingchen Peng,Aiping Tong,Li Min,Yunfeng Lin,Xingdong Zhang,Yujiang Fan,Yong Sun

{"title":"Black phosphorus nanosheets boost mitochondrial oxidative phosphorylation improving immunotherapy outcomes.","authors":"Yuedi Yang,Mingda Zhao,Jiadong Li,Ruiling Xu,Jie Liang,Qing Jiang,Xingchen Peng,Aiping Tong,Li Min,Yunfeng Lin,Xingdong Zhang,Yujiang Fan,Yong Sun","doi":"10.1038/s41565-025-02022-y","DOIUrl":"https://doi.org/10.1038/s41565-025-02022-y","url":null,"abstract":"Regulating intracellular phosphorus may affect multiple biosynthetic processes and modulate cancer cell progression. Here we show that exogenous PEGylated black phosphorus nanosheets (BPP) are metabolized into phosphate in tumor cells, where they boost mitochondrial oxidative phosphorylation. This results in the modulation of several signalling pathways, with the attenuation of prosurvival gene expression and reduction in PD-L1 protein expression in melanoma cells, leading to impaired cancer progression. We also reveal that BPP promote the activation of immune regulation, confirmed by the increased proinflammatory cytokine content in serum, high expression of tumour-infiltrating lymphocyte CD8+ T cells and lower expression of CD4+ regulatory T cells in tumour and lymph nodes. In the spleen, BPP mediate a significant increase in the concentration of effector memory CD8+ T cells, inducing a 'positive regulation' of the immune microenvironment. The introduction of a PD-1/PD-L1 inhibitor further enhances the immunopotentiation effect. These findings may define BPP as a dual-function tumour chemotherapeutic and immunopotentiator.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"8 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145339063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible metamorphosis of hierarchical DNA-inorganic crystals. 等级dna -无机晶体的可逆变态。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-10-20 DOI: 10.1038/s41565-025-02026-8

Yuan Gao,Wenzheng Shi,Stephen J Klawa,Margaret L Daly,Edward T Samulski,Ehssan Nazockdast,Ronit Freeman

{"title":"Reversible metamorphosis of hierarchical DNA-inorganic crystals.","authors":"Yuan Gao,Wenzheng Shi,Stephen J Klawa,Margaret L Daly,Edward T Samulski,Ehssan Nazockdast,Ronit Freeman","doi":"10.1038/s41565-025-02026-8","DOIUrl":"https://doi.org/10.1038/s41565-025-02026-8","url":null,"abstract":"Living systems transform their shapes via reversible formation of macromolecular structural complexes, leading to deformations at localized sites. Here we report DNA-inorganic flower-shaped crystals with inscribed deformation modes that enable flowers to shrink and bend reversibly. Template-independent DNA polymerization of pH-responsive and inert blocks tune the hierarchical assembly and spatial localization of DNA within flowers. Experiments and simulations demonstrate that reversible, pH-triggered folding of intraflower DNA strands drives reconfiguration of flowers. By contrast, the subflower localization of these contractile DNA motifs dictates the mode of shape change. As microscale flowers close and open, their nanoscale crystal organization changes reversibly, suggesting that mechanical metamorphosis of flowers is transduced across multiple organizational length scales. The adaptability of flowers to environmental changes activates cascaded biocatalytic reactions and reveals gel-encrypted information. Further variation of the DNA polymer sequence, its subcrystal localization and its reversible folding advances a new class of organic-inorganic shape-shifters.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"66 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145331904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in cancer vaccines enabled by nanotechnology. 纳米技术使癌症疫苗取得进展。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-10-17 DOI: 10.1038/s41565-025-02021-z

B J Kim,Nouran S Abdelfattah,Alexander Hostetler,Darrell J Irvine

引用次数: 0

Author Correction: Nanoscale C-H/C-D mapping of organic materials using electron spectroscopy. 作者更正：利用电子能谱对有机材料进行纳米尺度C-H/C-D制图。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-10-17 DOI: 10.1038/s41565-025-02040-w

Ryosuke Senga,Katsumi Hagita,Tomohiro Miyata,Hsiao-Fang Wang,Koichi Mayumi,Hiroshi Jinnai,Kazu Suenaga

引用次数: 0

Fast vortices excite short magnons. 快速涡流激发短磁振子。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-10-16 DOI: 10.1038/s41565-025-02023-x

Haiming Yu

引用次数: 0

Moving Abrikosov vortex lattices generate sub-40-nm magnons. 移动的阿布里科索夫涡旋晶格产生低于40纳米的磁振子。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-10-16 DOI: 10.1038/s41565-025-02024-w

Oleksandr V Dobrovolskiy,Qi Wang,Denis Yu Vodolazov,Roland Sachser,Michael Huth,Sebastian Knauer,Alexander I Buzdin

{"title":"Moving Abrikosov vortex lattices generate sub-40-nm magnons.","authors":"Oleksandr V Dobrovolskiy,Qi Wang,Denis Yu Vodolazov,Roland Sachser,Michael Huth,Sebastian Knauer,Alexander I Buzdin","doi":"10.1038/s41565-025-02024-w","DOIUrl":"https://doi.org/10.1038/s41565-025-02024-w","url":null,"abstract":"Magnons, the quasi-particles of spin waves, are promising candidates for developing wave-based computing and hybrid quantum technologies. However, generating short-wavelength magnons through microwave excitation becomes increasingly challenging because the excitation efficiency decreases as the antenna size shrinks. Here we demonstrate an alternative approach and generate magnons in a Co-Fe strip using magnetic flux quanta, that is, Abrikosov vortices, moving in an adjacent Nb-C superconductor at velocities exceeding 1 km s-1. The moving vortex lattice acts on the magnetic layer via both static and dynamic stray fields. Our experiments showcase the unidirectional excitation of sub-40-nm wavelength magnons and their coherent interaction with the moving vortices. In turn, the Nb-C sustains its low-resistive state because the magnon creation removes energy from the superconductor. This discovery enables high-speed on-chip electrically driven magnon generation and validates an alternative means of magnon excitation. Our approach could be adapted to other wave excitations, such as surface acoustic waves, for integration into advanced electronic and hybrid quantum systems.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"1 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wearable biomolecular sensing nanotechnologies in chronic disease management 可穿戴生物分子传感纳米技术在慢性疾病管理中的应用。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-10-15 DOI: 10.1038/s41565-025-02010-2

Jiaobing Tu, Connor D. Flynn, Jeonghee Yeom, Zhenwei Wu, Shana O. Kelley, Wei Gao

{"title":"Wearable biomolecular sensing nanotechnologies in chronic disease management","authors":"Jiaobing Tu, Connor D. Flynn, Jeonghee Yeom, Zhenwei Wu, Shana O. Kelley, Wei Gao","doi":"10.1038/s41565-025-02010-2","DOIUrl":"10.1038/s41565-025-02010-2","url":null,"abstract":"Over the past decade, consumer wearable sensors have become increasingly ubiquitous in health monitoring, enabling the widespread tracking of key biophysical parameters. The transition towards next-generation body-interfaced biomolecular sensing technologies, fuelled by the integration of reagentless sensing strategies with advanced nanomaterials, marks the next substantial leap forward. These innovations enable unobtrusive, multimodal monitoring of both physiological parameters and biochemical disease markers in real time. This Review examines the current generation of body-interfaced biomolecular sensing technologies, with a particular emphasis on materials innovation and nanotechnological advancements, and discusses their pivotal role in chronic disease monitoring. The discussion extends to the challenges and prospects in this rapidly evolving field, highlighting the potential for materials-focused approaches to transform the landscape of chronic disease monitoring and management with body-interfaced bioelectronics. By harnessing the power of materials and nanotechnological innovations, these biomolecular sensing technologies promise to enhance diagnostic capabilities and foster a more proactive, personalized approach to combating these diseases. This Review examines recent advances in body-interfaced biomolecular sensors for chronic disease monitoring, highlighting relevant biomarkers and nanomaterial-enabled sensing modalities, wearable form factors, clinical applications and challenges to real-world translation.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"20 10","pages":"1388-1404"},"PeriodicalIF":34.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A push towards disruptive biosensing technologies 推动颠覆性生物传感技术的发展。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-10-15 DOI: 10.1038/s41565-025-02050-8

引用次数: 0

Towards the next generation of nanobiosensors 迈向下一代纳米生物传感器。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-10-15 DOI: 10.1038/s41565-025-02038-4

Arben Merkoçi

引用次数: 0

Hand-powered interfacial electric-field-enhanced water disinfection system. 手动界面电场增强水消毒系统。

IF 34.9 1区材料科学

Nature nanotechnology Pub Date : 2025-10-15 DOI: 10.1038/s41565-025-02033-9

Zhidi Chen, Yajing Zhang, Panjing Lv, Tongwei Wu, Jianing He, Jinyan Du, Qiangqiang Sun, Qianbao Wu, Jinlong Yang, Yiming Zhang, Yanning Zhang, Fei He, Chunhua Cui, Gonghua Hong, Hongyu Zhu, Yan Li, Junling Guo, Xu Deng

{"title":"Hand-powered interfacial electric-field-enhanced water disinfection system.","authors":"Zhidi Chen, Yajing Zhang, Panjing Lv, Tongwei Wu, Jianing He, Jinyan Du, Qiangqiang Sun, Qianbao Wu, Jinlong Yang, Yiming Zhang, Yanning Zhang, Fei He, Chunhua Cui, Gonghua Hong, Hongyu Zhu, Yan Li, Junling Guo, Xu Deng","doi":"10.1038/s41565-025-02033-9","DOIUrl":"https://doi.org/10.1038/s41565-025-02033-9","url":null,"abstract":"Mechanical-energy-driven portable water disinfection has attracted attention for its electricity-free operation, but this approach generally faces bottlenecks such as a high mechanical activation threshold, energy dispersion and low interfacial reaction efficiency, making it difficult to achieve rapid and stable pathogen inactivation in practical scenarios. Here we report a manually operated portable water disinfection system that can inactivate 99.9999% of Vibrio cholerae within 1 min and demonstrate broad-spectrum disinfection against bacteria, fungi, parasites and viruses. Amino-modified SiO2 nanoparticles loaded with Au nanoparticles capture hydrated electrons and transfer them to the electret surface to generate localized nanoscale electric fields, which are further strengthened by hydrophobic fluorinated groups. This interfacial architecture not only promotes charge accumulation and transfer, but also leverages the intensified electric field to actively drive reactive oxygen species generation at the solid-liquid-air interface, thereby markedly enhancing the disinfection rate and efficacy compared with existing contact-electrification-based disinfection technologies. Owing to its ease of operation, our interfacial electric-field-enhanced disinfection system is readily deployable in disaster relief and resource-constrained regions.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":" ","pages":""},"PeriodicalIF":34.9,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145302031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0