Nature nanotechnology最新文献

A cascade X-ray energy converting approach toward radio-afterglow cancer theranostics 一种级联 X 射线能量转换方法，用于放射后辉光癌症疗法

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2024-11-15 DOI: 10.1038/s41565-024-01809-9

Cheng Xu, Xue Qin, Xin Wei, Jie Yu, Youjia Zhang, Yan Zhang, Dan Ding, Jibin Song, Kanyi Pu

{"title":"A cascade X-ray energy converting approach toward radio-afterglow cancer theranostics","authors":"Cheng Xu, Xue Qin, Xin Wei, Jie Yu, Youjia Zhang, Yan Zhang, Dan Ding, Jibin Song, Kanyi Pu","doi":"10.1038/s41565-024-01809-9","DOIUrl":"https://doi.org/10.1038/s41565-024-01809-9","url":null,"abstract":"Leveraging X-rays to initiate prolonged luminescence (radio-afterglow) and stimulate radiodynamic 1O2 production from optical agents provides opportunities for diagnosis and therapy at tissue depths inaccessible to light. However, X-ray-responsive organic luminescent materials are rare due to their intrinsic low X-ray conversion efficiency. Here we report a cascade X-ray energy converting approach to develop organic radio-afterglow nanoprobes (RANPs) for cancer theranostics. RANPs comprise a radiowave absorber that down-converts X-ray energy to emit radioluminescence, which is transferred to a radiosensitizer to produce singlet oxygen (1O2). 1O2 then reacts with a radio-afterglow substrate to generate an active intermediate that simultaneously decomposes to emit radio-afterglow. Through finetuning such a cascade, intraparticle radioluminescence energy transfer and the 1O2 transfer process, RANPs possess tunable wavelengths and long half-lives, and generate radio-afterglow and 1O2 at tissue depths of up to 15 cm. Moreover, we developed a biomarker-activatable nanoprobe (tRANP) that produces a tumour-specific radio-afterglow signal, leading to ultrasensitive detection and the possibility of surgical removal of diminutive tumours (1 mm3) under an X-ray dosage 20 times lower than inorganic materials. The efficient radiodynamic 1O2 generation of tRANP permits complete tumour eradication at an X-ray dosage lower than clinical radiotherapy and a drug dosage one to two orders of magnitude lower than most existing inorganic agents, leading to prolonged survival rates with minimized radiation-related adverse effects. Thus, our work reveals a generic approach to address the lack of organic radiotheranostic materials and provides molecular design towards precision cancer radiotherapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"17 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142637119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organic radio-afterglow nanoprobes for cancer theranostics 用于癌症治疗的有机放射余辉纳米探针

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2024-11-15 DOI: 10.1038/s41565-024-01810-2

引用次数: 0

Honeybee comb-inspired stiffness gradient-amplified catapult for solid particle repellency 蜂巢式刚度梯度放大弹射器，具有固体颗粒排斥性。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-16 DOI: 10.1038/s41565-023-01524-x

Wei Zhang, Wei Jiang, Chao Zhang, Xuezhi Qin, Huanxi Zheng, Wanghuai Xu, Miaomiao Cui, Bin Wang, Jianing Wu, Zuankai Wang

{"title":"Honeybee comb-inspired stiffness gradient-amplified catapult for solid particle repellency","authors":"Wei Zhang, Wei Jiang, Chao Zhang, Xuezhi Qin, Huanxi Zheng, Wanghuai Xu, Miaomiao Cui, Bin Wang, Jianing Wu, Zuankai Wang","doi":"10.1038/s41565-023-01524-x","DOIUrl":"10.1038/s41565-023-01524-x","url":null,"abstract":"Natural surfaces that repel foreign matter are ubiquitous and crucial for living organisms. Despite remarkable liquid repellency driven by surface energy in many organisms, repelling tiny solid particles from surfaces is rare. The main challenge lies in the unfavourable scaling of inertia versus adhesion in the microscale and the inability of solids to release surface energy. Here we report a previously unexplored solid repellency on a honeybee’s comb: a catapult-like effect to immediately eject pollen after grooming dirty antennae for self-cleaning. Nanoindentation tests revealed the 38-μm-long comb features a stiffness gradient spanning nearly two orders of magnitude from ~25 MPa at the tip to ~645 MPa at the base. This significantly augments the elastic energy storage and accelerates the subsequent conversion into kinetic energy. The reinforcement in energy storage and conversion allows the particle’s otherwise weak inertia to outweigh its adhesion, thereby suppressing the unfavourable scaling effect and realizing solid repellency that is impossible in conventional uniform designs. We capitalize on this to build an elastomeric bioinspired stiffness-gradient catapult and demonstrate its generality and practicality. Our findings advance the fundamental understanding of natural catapult phenomena with the potential to develop bioinspired stiffness-gradient materials, catapult-based actuators and robotic cleaners. Nanoindentation of the microscale honeybee comb reveals a stiffness gradient that spans two orders of magnitude, which amplifies the catapult effect and facilitates solid particle repellency. By leveraging this, the study presents the fabrication of scaled-up, bioinspired stiffness-gradient elastomeric catapult-like soft actuators.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 2","pages":"219-225"},"PeriodicalIF":38.3,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41236971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology for electrochemical energy storage 电化学储能的纳米技术。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-13 DOI: 10.1038/s41565-023-01529-6

引用次数: 0

Tin instead of lead for stable lasers 稳定激光器用锡代替铅。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-13 DOI: 10.1038/s41565-023-01537-6

Lu Shi

引用次数: 0

Breaking the bottleneck of synthetic cells 打破合成细胞的瓶颈。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-12 DOI: 10.1038/s41565-023-01509-w

Oskar Staufer

引用次数: 0

Sensitive photoresists for high-speed two-photon lithography 用于高速双光子光刻的敏感光刻胶。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-10 DOI: 10.1038/s41565-023-01518-9

引用次数: 0

Multivalent insulin receptor activation using insulin–DNA origami nanostructures 使用胰岛素DNA折纸纳米结构激活多价胰岛素受体。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-09 DOI: 10.1038/s41565-023-01507-y

Joel Spratt, José M. Dias, Christina Kolonelou, Georges Kiriako, Enya Engström, Ekaterina Petrova, Christos Karampelias, Igor Cervenka, Natali Papanicolaou, Antonio Lentini, Björn Reinius, Olov Andersson, Elena Ambrosetti, Jorge L. Ruas, Ana I. Teixeira

{"title":"Multivalent insulin receptor activation using insulin–DNA origami nanostructures","authors":"Joel Spratt, José M. Dias, Christina Kolonelou, Georges Kiriako, Enya Engström, Ekaterina Petrova, Christos Karampelias, Igor Cervenka, Natali Papanicolaou, Antonio Lentini, Björn Reinius, Olov Andersson, Elena Ambrosetti, Jorge L. Ruas, Ana I. Teixeira","doi":"10.1038/s41565-023-01507-y","DOIUrl":"10.1038/s41565-023-01507-y","url":null,"abstract":"Insulin binds the insulin receptor (IR) and regulates anabolic processes in target tissues. Impaired IR signalling is associated with multiple diseases, including diabetes, cancer and neurodegenerative disorders. IRs have been reported to form nanoclusters at the cell membrane in several cell types, even in the absence of insulin binding. Here we exploit the nanoscale spatial organization of the IR to achieve controlled multivalent receptor activation. To control insulin nanoscale spatial organization and valency, we developed rod-like insulin–DNA origami nanostructures carrying different numbers of insulin molecules with defined spacings. Increasing the insulin valency per nanostructure markedly extended the residence time of insulin–DNA origami nanostructures at the receptors. Both insulin valency and spacing affected the levels of IR activation in adipocytes. Moreover, the multivalent insulin design associated with the highest levels of IR activation also induced insulin-mediated transcriptional responses more effectively than the corresponding monovalent insulin nanostructures. In an in vivo zebrafish model of diabetes, treatment with multivalent—but not monovalent—insulin nanostructures elicited a reduction in glucose levels. Our results show that the control of insulin multivalency and spatial organization with nanoscale precision modulates the IR responses, independent of the insulin concentration. Therefore, we propose insulin nanoscale organization as a design parameter in developing new insulin therapies. DNA-origami-based insulin assembly into well-defined nanoclusters reveals that insulin valency and spatial organization modulate insulin receptor activation and downstream responses independent of ligand concentration.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 2","pages":"237-245"},"PeriodicalIF":38.3,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41565-023-01507-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41183100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-05 DOI: 10.1038/s41565-023-01520-1

Tonghang Han, Zhengguang Lu, Giovanni Scuri, Jiho Sung, Jue Wang, Tianyi Han, Kenji Watanabe, Takashi Taniguchi, Hongkun Park, Long Ju

{"title":"Correlated insulator and Chern insulators in pentalayer rhombohedral-stacked graphene","authors":"Tonghang Han, Zhengguang Lu, Giovanni Scuri, Jiho Sung, Jue Wang, Tianyi Han, Kenji Watanabe, Takashi Taniguchi, Hongkun Park, Long Ju","doi":"10.1038/s41565-023-01520-1","DOIUrl":"10.1038/s41565-023-01520-1","url":null,"abstract":"Rhombohedral-stacked multilayer graphene hosts a pair of flat bands touching at zero energy, which should give rise to correlated electron phenomena that can be tuned further by an electric field. Moreover, when electron correlation breaks the isospin symmetry, the valley-dependent Berry phase at zero energy may give rise to topologically non-trivial states. Here we measure electron transport through hexagonal boron nitride-encapsulated pentalayer graphene down to 100 mK. We observed a correlated insulating state with resistance at the megaohm level or greater at charge density n = 0 and displacement field D = 0. Tight-binding calculations predict a metallic ground state under these conditions. By increasing D, we observed a Chern insulator state with C = −5 and two other states with C = −3 at a magnetic field of around 1 T. At high D and n, we observed isospin-polarized quarter- and half-metals. Hence, rhombohedral pentalayer graphene exhibits two different types of Fermi-surface instability, one driven by a pair of flat bands touching at zero energy, and one induced by the Stoner mechanism in a single flat band. Our results establish rhombohedral multilayer graphene as a suitable system for exploring intertwined electron correlation and topology phenomena in natural graphitic materials without the need for moiré superlattice engineering. Pentalayer graphene in the rhombohedral stacking order exhibits rich phases including a correlated insulator, isospin-polarized metals and Chern insulators. These findings demonstrate electron-correlated and topological states in crystalline 2D materials without the need for a moiré superlattice.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"19 2","pages":"181-187"},"PeriodicalIF":38.3,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41127100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical gain and lasing from bulk cadmium sulfide nanocrystals through bandgap renormalization 大块硫化镉纳米晶体通过带隙重整化的光学增益和激光。

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2023-10-05 DOI: 10.1038/s41565-023-01521-0

Ivo Tanghe, Margarita Samoli, Isabella Wagner, Servet Ataberk Cayan, Ali Hossain Khan, Kai Chen, Justin Hodgkiss, Iwan Moreels, Dries Van Thourhout, Zeger Hens, Pieter Geiregat

{"title":"Optical gain and lasing from bulk cadmium sulfide nanocrystals through bandgap renormalization","authors":"Ivo Tanghe, Margarita Samoli, Isabella Wagner, Servet Ataberk Cayan, Ali Hossain Khan, Kai Chen, Justin Hodgkiss, Iwan Moreels, Dries Van Thourhout, Zeger Hens, Pieter Geiregat","doi":"10.1038/s41565-023-01521-0","DOIUrl":"10.1038/s41565-023-01521-0","url":null,"abstract":"Strongly confined colloidal quantum dots have been investigated for low-cost light emission and lasing for nearly two decades. However, known materials struggle to combine technologically relevant metrics of low-threshold and long inverted-state lifetime with a material gain coefficient fit to match cavity losses, particularly under electrical excitation. Here we show that bulk nanocrystals of CdS combine an exceptionally large material gain of 50,000 cm−1 with best-in-class gain thresholds below a single exciton per nanocrystal and 3 ns gain lifetimes not limited by non-radiative Auger processes. We quantitatively account for these findings by invoking a strong bandgap renormalization effect, unobserved in nanocrystals to date, to the best of our knowledge. Next, we demonstrate broadband amplified spontaneous emission and lasing under quasi-continuous-wave conditions. Our results highlight the prospects of bulk nanocrystals for lasing from solution-processable materials. Solution-processable CdS ‘bulk’ nanocrystals show efficient on-chip lasing under quasi-continuous-wave conditions with excellent beam quality and pump thresholds.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"18 12","pages":"1423-1429"},"PeriodicalIF":38.3,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0