Nature nanotechnology最新文献

Discovering nanoparticle corona ligands for liver macrophage capture 发现用于肝巨噬细胞捕获的纳米颗粒冠状配体

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-15 DOI: 10.1038/s41565-025-01903-6

Bram Bussin, Marshall G. G. MacDuff, Wayne Ngo, Jamie L. Y. Wu, Zachary P. Lin, Adrian Granda Farias, Benjamin Stordy, Zahra Sepahi, Sara Ahmed, Jason Moffat, Warren C. W. Chan

{"title":"Discovering nanoparticle corona ligands for liver macrophage capture","authors":"Bram Bussin, Marshall G. G. MacDuff, Wayne Ngo, Jamie L. Y. Wu, Zachary P. Lin, Adrian Granda Farias, Benjamin Stordy, Zahra Sepahi, Sara Ahmed, Jason Moffat, Warren C. W. Chan","doi":"10.1038/s41565-025-01903-6","DOIUrl":"https://doi.org/10.1038/s41565-025-01903-6","url":null,"abstract":"Liver macrophages capture circulating nanoparticles and reduce their delivery to target organs. Serum proteins adsorb to the nanoparticle surface after administration. However, the adsorbed serum proteins and their cognate cell receptors for removing nanoparticles from the bloodstream have not been linked. Here we use a multi-omics strategy to identify the adsorbed serum proteins binding to specific liver macrophage receptors. We discovered six absorbed serum proteins that bind to two liver macrophage receptors. Nanoparticle physicochemical properties can affect the degree of the six serum proteins adsorbing to the surface, the probability of binding to cell receptors and whether the liver removes the nanoparticle from circulation. Identifying the six adsorbed proteins allowed us to engineer decoy nanoparticles that prime the liver to take up fewer therapeutic nanoparticles, enabling more nanoparticles for targeting extrahepatic tissues. Elucidating the molecular interactions governing the nanoparticle journey in vivo will enable us to control nanoparticle delivery to diseased tissues.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"232 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of multi-drug cancer nanomedicine 多药抗癌纳米药物分析

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-15 DOI: 10.1038/s41565-025-01932-1

Karina Benderski, Twan Lammers, Alexandros Marios Sofias

{"title":"Analysis of multi-drug cancer nanomedicine","authors":"Karina Benderski, Twan Lammers, Alexandros Marios Sofias","doi":"10.1038/s41565-025-01932-1","DOIUrl":"https://doi.org/10.1038/s41565-025-01932-1","url":null,"abstract":"Multi-drug nanomedicine is gaining momentum for co-delivering more than one drug to the same site at the same time. Our analysis of 273 pre-clinical tumour growth inhibition studies shows that multi-drug nanotherapy outperforms single-drug therapy, multi-drug combination therapy, and single-drug nanotherapy by 43, 29 and 30%, respectively. Combination nanotherapy also results in the best overall survival rates, with 56% of studies demonstrating complete or partial survival, versus 20–37% for control regimens. Within the multi-drug nanomedicine groups, we analysed the effect of (co-)administration schedule and strategy, passive versus active targeting, nanocarrier material and the type of therapeutic agent. Most importantly, it was found that co-encapsulating two different drugs in the same nanoformulation reduces tumour growth by a further 19% compared with the combination of two individually encapsulated nanomedicines. We finally show that the benefit of multi-drug nanotherapy is consistently observed across different cancer types, in sensitive and resistant tumours, and in xenograft and allograft models. Altogether, this meta-analysis substantiates the value of multi-drug nanomedicine as a potent strategy to improve cancer therapy.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"52 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection 基于纳米孔的酶联免疫吸附法检测癌症生物标志物

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-14 DOI: 10.1038/s41565-025-01918-z

Yakun Yi, Peng Song, Ziyi Li, Jinzhou Ju, Guixiang Sun, Qianyuan Ren, Ke Zhou, Lei Liu, Hai-Chen Wu

{"title":"Nanopore-based enzyme-linked immunosorbent assay for cancer biomarker detection","authors":"Yakun Yi, Peng Song, Ziyi Li, Jinzhou Ju, Guixiang Sun, Qianyuan Ren, Ke Zhou, Lei Liu, Hai-Chen Wu","doi":"10.1038/s41565-025-01918-z","DOIUrl":"https://doi.org/10.1038/s41565-025-01918-z","url":null,"abstract":"Enzyme-linked immunosorbent assay (ELISA) has been widely used in cancer diagnostics due to its specificity, sensitivity and high throughput. However, conventional ELISA is semiquantitative and has an insufficiently low detection limit for applications requiring ultrahigh sensitivity. In this study, we developed an α-hemolysin-nanopore-based ELISA for detecting cancer biomarkers. After forming the immuno-sandwich complex, peptide probes carrying enzymatic cleavage sites are introduced, where they interact with enzymes conjugated to the detection antibodies within the complex. These probes generate distinct current signatures when translocated through the nanopore after enzymatic cleavage, enabling precise biomarker quantification. This approach offers a low detection limit of up to 0.03 fg ml–1 and the simultaneous detection of six biomarkers, including antigen and antibody biomarkers in blood samples. Overall, the nanopore-based ELISA demonstrates high sensitivity and multiplexing capability, making it suitable for next-generation diagnostic and point-of-care testing applications.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"4 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A modular mRNA vaccine platform encoding antigen-presenting capsid virus-like particles enhances the immunogenicity of the malaria antigen Pfs25 编码抗原呈递衣壳病毒样颗粒的模块化mRNA疫苗平台增强了疟疾抗原Pfs25的免疫原性

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-14 DOI: 10.1038/s41565-025-01889-1

Cyrielle Fougeroux, Sven Hendrik Hagen, Louise Goksøyr, Kara-Lee Aves, Anna Kathrine Okholm, Candice Morin, Abhijeet Girish Lokras, Saahil Sandeep Baghel, Camilla Foged, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Matthijs M. Jore, Elena Ethel Vidal-Calvo, Tobias Gustavsson, Ali Salanti, Thor Grundtvig Theander, Morten Agertoug Nielsen, Willem Adriaan de Jongh, Adam Frederik Sander Bertelsen

{"title":"A modular mRNA vaccine platform encoding antigen-presenting capsid virus-like particles enhances the immunogenicity of the malaria antigen Pfs25","authors":"Cyrielle Fougeroux, Sven Hendrik Hagen, Louise Goksøyr, Kara-Lee Aves, Anna Kathrine Okholm, Candice Morin, Abhijeet Girish Lokras, Saahil Sandeep Baghel, Camilla Foged, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Matthijs M. Jore, Elena Ethel Vidal-Calvo, Tobias Gustavsson, Ali Salanti, Thor Grundtvig Theander, Morten Agertoug Nielsen, Willem Adriaan de Jongh, Adam Frederik Sander Bertelsen","doi":"10.1038/s41565-025-01889-1","DOIUrl":"https://doi.org/10.1038/s41565-025-01889-1","url":null,"abstract":"The COVID-19 pandemic has emphasized the potential of mRNA vaccines in fighting pandemics, owing to their rapid development, strong immunogenicity and adaptability. However, a drawback is their dose-limiting reactogenicity and inability to generate durable humoral immunity. Here we introduce a modular nucleotide vaccine platform combining the advantages of genetic and capsid virus-like-particle-based vaccines. This platform allows for the display of various antigens on different capsid virus-like particles, improving the magnitude, quality and longevity of the vaccine-induced immune responses. We applied this technology to enhance the immunogenicity of the Pfs25 antigen. Immunization with lipid-nanoparticle-formulated mRNA encoding Pfs25 capsid virus-like particles resulted in higher and potentially more durable anti-Pfs25 antibody responses, along with enhanced functional activity, compared with an mRNA vaccine encoding soluble Pfs25. By improving both humoral and cellular immune responses, this approach may reduce the dose and number of administrations required for effective protection. As a result, it can improve the feasibility of both DNA- and mRNA-based vaccines targeting pandemic and endemic infectious diseases.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"29 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143945955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Better the devil you know than the devil you don’t — PEG challenges in nanomedicine 知道的魔鬼总比不知道的魔鬼好——纳米医学中的聚乙二醇挑战

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-13 DOI: 10.1038/s41565-025-01925-0

Marina A. Dobrovolskaia

引用次数: 0

Balancing stealth and targeting to improve nanomedicine efficacy 平衡隐身与靶向，提高纳米药物疗效

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-13 DOI: 10.1038/s41565-025-01926-z

Yi Ju, Stephen John Kent

引用次数: 0

Paddle-like self-stirring nanoreactors with multi-chambered mesoporous branches for enhanced dual-dynamic cascade reactions 具有多室介孔分支的桨状自搅拌纳米反应器用于增强双动态级联反应

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-13 DOI: 10.1038/s41565-025-01915-2

Yuzhu Ma, Peiting Guo, Bing Ma, Hongjin Zhang, Jinying Li, Linlin Duan, Wei Zhang, Shenghong Guo, Aixia Wang, Xin Pu, Jia Jia, Yan Ai, You-Liang Zhu, Zhongyuan Lu, Xiaomin Li, Jian Liu, Dongyuan Zhao

{"title":"Paddle-like self-stirring nanoreactors with multi-chambered mesoporous branches for enhanced dual-dynamic cascade reactions","authors":"Yuzhu Ma, Peiting Guo, Bing Ma, Hongjin Zhang, Jinying Li, Linlin Duan, Wei Zhang, Shenghong Guo, Aixia Wang, Xin Pu, Jia Jia, Yan Ai, You-Liang Zhu, Zhongyuan Lu, Xiaomin Li, Jian Liu, Dongyuan Zhao","doi":"10.1038/s41565-025-01915-2","DOIUrl":"https://doi.org/10.1038/s41565-025-01915-2","url":null,"abstract":"Developing artificial nanomaterial systems that can convert external stimuli to achieve nanoscale self-sustainable motion (for example, self-rotation), and simultaneously integrate and deploy the spatial localization of multiple active sites to unravel the intraparticle diffusion patterns of molecules, is of great importance for green synthetic chemistry. Here we show a paddle-like self-stirring mesoporous silica nanoreactor system with separated chambers and controllable proximity of active sites. The nanoreactors are designed by encapsulating magnetic Fe3O4 (~20 nm) in the first chamber, and meantime, Au and Pd nanocrystals are spatially isolated in different domains. Such a nanoreactor generates nanoscale rotation under the rotating magnetic fields and exhibits an order of magnitude activity enhancement in the cascade synthesis of 5,6-dimethylphenanthridinium (96.4% selectivity) compared with conventional macro-stirring. Meanwhile, we quantitatively uncovered the rotation-induced enhancement in sequential and reverse transfer of reactive intermediates, consequently revealing the relevance of self-rotation and proximity effects in controlling the catalytic performance.","PeriodicalId":18915,"journal":{"name":"Nature nanotechnology","volume":"137 1","pages":""},"PeriodicalIF":38.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143939971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Battery research needs more reliable, representative and reproducible synchrotron characterizations 电池研究需要更可靠、更具代表性和可重复性的同步加速器特性

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-13 DOI: 10.1038/s41565-025-01921-4

Jakub Drnec, Sandrine Lyonnard

引用次数: 0

Heterogeneities across electrode|polymer electrolyte interfaces contribute to battery failure 电极|聚合物电解质界面的非均质性会导致电池失效

IF 38.3 1区材料科学

Nature nanotechnology Pub Date : 2025-05-08 DOI: 10.1038/s41565-025-01886-4

引用次数: 0

Electromagnetic wireless remote control of mammalian transgene expression 哺乳动物转基因表达的电磁无线遥控

IF 38.3 1区材料科学